Experiment set2S593 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv2044c		-4.0	-1.3	Conserved hypothetical protein
Rv1421		-2.9	-3.4	Conserved protein
Rv0392c		-1.8	-1.7	Probable membrane NADH dehydrogenase NdhA
Rv3033		-1.8	-1.2	Unknown protein
Rv1116A		-1.7	-2.0	Conserved hypothetical protein (fragment)
Rv3171c		-1.7	-1.3	Possible non-heme haloperoxidase Hpx
Rv3277		-1.5	-1.3	Probable conserved transmembrane protein
Rv2650c		-1.4	-1.1	Possible PhiRv2 prophage protein
Rv1010		-1.4	-2.0	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv0437c		-1.3	-1.1	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv3920c		-1.3	-1.3	Conserved protein similar to jag protein
Rv3513c		-1.2	-1.4	Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv1062		-1.1	-0.9	Conserved hypothetical protein
Rv2049c		-1.1	-1.4	Conserved hypothetical protein
Rv0892		-1.0	-1.6	Probable monooxygenase
Rv3283		-0.9	-2.3	Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
Rv3643		-0.9	-1.4	Hypothetical protein
Rv3650		-0.9	-0.8	PE family protein PE33
Rv1025		-0.9	-0.9	Conserved protein
Rv2317		-0.9	-0.9	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv3486		-0.9	-1.7	Conserved protein
Rv3358		-0.9	-1.9	Toxin RelK
Rv2581c		-0.8	-1.1	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv0130		-0.8	-1.2	Probable 3-hydroxyl-thioester dehydratase
Rv1420		-0.8	-1.7	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv0208c		-0.8	-2.1	Hypothetical methlytransferase (methylase)
Rv2173		-0.8	-1.8	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv0622		-0.8	-2.8	Possible membrane protein
Rv3584		-0.8	-1.8	Possible conserved lipoprotein LpqE
Rv3414c		-0.8	-1.9	Probable alternative RNA polymerase sigma-D factor SigD
Rv0741		-0.7	-1.9	Probable transposase (fragment)
Rv3715c		-0.7	-1.2	Probable recombination protein RecR
Rv2462c		-0.7	-3.0	Probable trigger factor (TF) protein Tig
Rv0852		-0.7	-1.9	Possible fatty-acid-CoA ligase FadD16 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv0019c		-0.7	-3.1	Conserved protein with FHA domain, FhaB
Rv0135c		-0.7	-1.8	Possible transcriptional regulatory protein
Rv0395		-0.7	-1.9	Hypothetical protein
Rv0441c		-0.7	-2.2	Hypothetical protein
Rv3251c		-0.7	-0.8	Probable rubredoxin RubA
Rv0649		-0.6	-1.7	Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT)
Rv0219		-0.6	-1.4	Probable conserved transmembrane protein
Rv3810		-0.6	-0.7	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv3647c		-0.6	-0.7	Conserved hypothetical protein
Rv3828c		-0.6	-1.4	Possible resolvase
Rv1745c		-0.6	-2.5	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv3787c		-0.6	-1.8	Conserved hypothetical protein
Rv3278c		-0.6	-2.2	Probable conserved transmembrane protein
Rv2376c		-0.6	-0.8	Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Rv1621c		-0.6	-2.2	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv1324		-0.6	-0.8	Possible thioredoxin
Rv0452		-0.6	-1.4	Possible transcriptional regulatory protein
Rv0887c		-0.6	-0.7	Conserved hypothetical protein
Rv0003		-0.6	-1.9	DNA replication and repair protein RecF (single-strand DNA binding protein)
Rv3334		-0.6	-1.6	Probable transcriptional regulatory protein (probably MerR-family)
Rv2863		-0.6	-1.7	Possible toxin VapC23
Rv2369c		-0.6	-0.7	Hypothetical protein
Rv0531		-0.6	-0.9	Possible conserved membrane protein
Rv2801A		-0.6	-1.3	Possible antitoxin MazE9
Rv0598c		-0.6	-1.2	Possible toxin VapC27. Contains PIN domain.
Rv3209		-0.6	-2.8	Conserved hypothetical threonine and proline rich protein
Rv1291c		-0.6	-0.9	Conserved hypothetical secreted protein
Rv0911		-0.6	-2.4	Conserved protein
Rv3311		-0.6	-2.9	Conserved protein
Rv2366c		-0.6	-1.3	Probable conserved transmembrane protein
Rv2991		-0.6	-1.3	Conserved protein
Rv3081		-0.6	-0.7	Conserved hypothetical protein
Rv2086		-0.6	-1.4	Conserved hypothetical protein
Rv1620c		-0.6	-1.8	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv0734		-0.5	-1.8	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv1332		-0.5	-0.7	Probable transcriptional regulatory protein
Rv0157A		-0.5	-1.1	Conserved protein
Rv1516c		-0.5	-1.8	Probable sugar transferase
Rv2558		-0.5	-1.5	Conserved protein
Rv2714		-0.5	-1.9	Conserved alanine and leucine rich protein
Rv0212c		-0.5	-1.9	Possible transcriptional regulatory protein NadR (probably AsnC-family)
Rv3306c		-0.5	-0.6	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv3687c		-0.5	-0.5	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv0034		-0.5	-1.6	Conserved hypothetical protein
Rv1004c		-0.5	-1.3	Probable membrane protein
Rv0374c		-0.5	-1.5	Probable carbon monoxyde dehydrogenase (small chain)
Rv0200		-0.5	-0.9	Possible conserved transmembrane protein
Rv3196A		-0.5	-1.3	Unknown protein
Rv1282c		-0.5	-1.7	Probable oligopeptide-transport integral membrane protein ABC transporter OppC
Rv3073c		-0.5	-0.9	Conserved hypothetical protein
Rv3304		-0.5	-1.8	Conserved protein
Rv3149		-0.5	-1.8	Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E)
Rv3747		-0.5	-1.9	Conserved protein
Rv0959		-0.5	-0.7	Conserved hypothetical protein
Rv1030		-0.5	-1.5	Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B)
Rv0832		-0.5	-0.9	PE-PGRS family protein PE_PGRS12
Rv0857		-0.5	-0.8	Conserved hypothetical protein
Rv1009		-0.5	-1.7	Probable resuscitation-promoting factor RpfB
Rv2739c		-0.5	-1.4	Possible alanine rich transferase
Rv1082		-0.5	-2.2	Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase)
Rv0469		-0.5	-2.5	Possible mycolic acid synthase UmaA
Rv0556		-0.5	-0.8	Probable conserved transmembrane protein
Rv2175c		-0.5	-1.0	Conserved regulatory protein
Rv1926c		-0.5	-1.0	Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein)
Rv2251		-0.5	-1.6	Possible flavoprotein
Rv1044		-0.5	-2.1	Conserved hypothetical protein
Rv2410c		-0.5	-2.1	Conserved protein
Rv0549c		-0.5	-1.1	Possible toxin VapC3
Rv3313c		-0.5	-2.0	Probable adenosine deaminase Add (adenosine aminohydrolase)
Rv3200c		-0.5	-1.1	Possible transmembrane cation transporter
Rv3813c		-0.5	-0.9	Conserved protein
Rv2931		-0.5	-3.9	Phenolpthiocerol synthesis type-I polyketide synthase PpsA
Rv0919		-0.5	-0.9	GCN5-related N-acetyltransferase
Rv1410c		-0.5	-2.8	Aminoglycosides/tetracycline-transport integral membrane protein
Rv2687c		-0.5	-1.1	Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter
Rv2930		-0.4	-4.1	Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Rv2934		-0.4	-3.8	Phenolpthiocerol synthesis type-I polyketide synthase PpsD
Rv0764c		-0.4	-1.7	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)
Rv2510c		-0.4	-1.5	Conserved protein
Rv3433c		-0.4	-1.1	Conserved protein
Rv0916c		-0.4	-0.5	PE family protein PE7
Rv0203		-0.4	-1.4	Possible exported protein
Rv2372c		-0.4	-0.7	Conserved hypothetical protein
Rv0561c		-0.4	-0.8	Possible oxidoreductase
Rv3544c		-0.4	-2.1	Probable acyl-CoA dehydrogenase FadE28
Rv1355c		-0.4	-1.4	Possible molybdopterin biosynthesis protein MoeY
Rv0586		-0.4	-1.2	Probable transcriptional regulatory protein Mce2R (GntR-family)
Rv0791c		-0.4	-1.8	Conserved protein
Rv2935		-0.4	-3.6	Phenolpthiocerol synthesis type-I polyketide synthase PpsE
Rv2932		-0.4	-3.4	Phenolpthiocerol synthesis type-I polyketide synthase PpsB
Rv2940c		-0.4	-3.8	Probable multifunctional mycocerosic acid synthase membrane-associated Mas
Rv0499		-0.4	-0.7	Conserved hypothetical protein
Rv1913		-0.4	-1.6	Conserved hypothetical protein
Rv2274c		-0.4	-0.8	Possible toxin MazF8
Rv2657c		-0.4	-0.6	Probable PhiRv2 prophage protein
Rv2630		-0.4	-0.4	Hypothetical protein
Rv0949		-0.4	-0.4	Probable ATP-dependent DNA helicase II UvrD1
Rv3815c		-0.4	-2.5	Possible acyltransferase
Rv1221		-0.4	-1.6	Alternative RNA polymerase sigma factor SigE
Rv0145		-0.4	-2.2	Possible S-adenosylmethionine-dependent methyltransferase
Rv0745		-0.4	-1.7	Conserved hypothetical protein
Rv2976c		-0.4	-0.5	Probable uracil-DNA glycosylase Ung (UDG)
Rv1290A		-0.4	-0.5	Hypothetical protein
Rv0964c		-0.4	-1.0	Hypothetical protein
Rv3412		-0.4	-1.6	Conserved hypothetical protein
Rv3340		-0.4	-1.0	Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase)
Rv0161		-0.4	-0.9	Possible oxidoreductase
Rv1072		-0.4	-0.7	Probable conserved transmembrane protein
Rv2606c		-0.4	-2.2	Possible pyridoxine biosynthesis protein SnzP
Rv2812		-0.4	-1.0	Probable transposase
Rv2222c		-0.4	-1.2	Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II)
Rv3040c		-0.4	-1.7	Conserved protein
Rv0821c		-0.4	-1.4	Probable phosphate-transport system transcriptional regulatory protein PhoY2
Rv0819		-0.4	-1.1	GCN5-related N-acetyltransferase, MshD
Rv1577c		-0.4	-0.5	Probable PhiRv1 phage protein
Rv2026c		-0.4	-0.5	Universal stress protein family protein
Rv0028		-0.4	-1.6	Conserved hypothetical protein
Rv3610c		-0.4	-0.6	Membrane-bound protease FtsH (cell division protein)
Rv3198c		-0.4	-0.5	Probable ATP-dependent DNA helicase II UvrD2
Rv0924c		-0.4	-1.8	Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP)
Rv2344c		-0.4	-2.2	Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase)
Rv1946c		-0.4	-0.9	Possible lipoprotein
Rv2855		-0.4	-1.2	NADPH-dependent mycothiol reductase Mtr
Rv3550		-0.4	-0.9	Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2589		-0.4	-2.7	4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at)
Rv2216		-0.4	-1.3	Conserved protein
Rv0017c		-0.4	-1.3	Probable cell division protein RodA
Rv2232		-0.4	-1.0	Protein tyrosine kinase transcriptional regulatory protein PtkA
Rv2137c		-0.4	-1.3	Conserved hypothetical protein
Rv3309c		-0.4	-0.9	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Rv3536c		-0.4	-2.2	Probable hydratase
Rv2025c		-0.4	-1.6	Conserved membrane protein
Rv3510c		-0.4	-1.9	Conserved protein
Rv1003		-0.4	-0.3	Conserved protein
Rv3333c		-0.4	-1.9	Hypothetical proline rich protein
Rv0257		-0.4	-1.6	Conserved hypothetical protein
Rv0986		-0.4	-1.1	Probable adhesion component transport ATP-binding protein ABC transporter
Rv3657c		-0.4	-1.0	Possible conserved alanine rich membrane protein
Rv0936		-0.4	-1.7	Phosphate-transport integral membrane ABC transporter PstA2
Rv0955		-0.4	-0.5	Probable conserved integral membrane protein
Rv3218		-0.4	-2.3	Conserved protein
Rv1490		-0.4	-1.0	Probable membrane protein
Rv3007c		-0.4	-1.1	Possible oxidoreductase
Rv2571c		-0.4	-0.9	Probable transmembrane alanine and valine and leucine rich protein
Rv0573c		-0.4	-2.1	Nicotinic acid phosphoribosyltransferase PncB2
Rv1687c		-0.4	-1.7	Probable conserved ATP-binding protein ABC transporter
Rv0065		-0.4	-0.9	Possible toxin VapC1
Rv2961		-0.4	-1.3	Probable transposase
Rv2721c		-0.4	-2.1	Possible conserved transmembrane alanine and glycine rich protein
Rv1435c		-0.3	-1.5	Probable conserved proline, glycine, valine-rich secreted protein
Rv0460		-0.3	-0.5	Conserved hydrophobic protein
Rv1205		-0.3	-1.8	Conserved hypothetical protein
Rv2728c		-0.3	-1.5	Conserved alanine rich protein
Rv2064		-0.3	-1.3	Precorrin-3B synthase CobG
Rv3284		-0.3	-0.9	Conserved hypothetical protein
Rv2656c		-0.3	-1.3	Possible PhiRv2 prophage protein
Rv3004		-0.3	-1.0	Low molecular weight protein antigen 6 (CFP-6)
Rv2573		-0.3	-1.4	Conserved hypothetical protein
Rv0375c		-0.3	-0.6	Probable carbon monoxyde dehydrogenase (medium chain)
Rv2189c		-0.3	-1.3	Conserved hypothetical protein
Rv1513		-0.3	-1.0	Conserved protein
Rv3357		-0.3	-1.4	Antitoxin RelJ
Rv0930		-0.3	-1.9	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv3891c		-0.3	-1.2	Possible ESAT-6 like protein EsxD
Rv2680		-0.3	-0.7	Conserved protein
Rv2647		-0.3	-0.5	Hypothetical protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Sulfaquinoxaline across organisms