Experiment set2S593 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv0642c		+1.8	2.1	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv0758		+1.4	3.9	Possible two component system response sensor kinase membrane associated PhoR
Rv0757		+1.3	2.7	Possible two component system response transcriptional positive regulator PhoP
Rv3631		+1.3	1.5	Possible transferase (possibly glycosyltransferase)
Rv3207c		+1.3	7.1	Conserved protein
Rv0497		+1.2	2.2	Probable conserved transmembrane protein
Rv2586c		+1.2	2.7	Probable protein-export membrane protein SecF
Rv3101c		+1.2	2.7	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv1626		+1.2	5.1	Probable two-component system transcriptional regulator
Rv2869c		+1.1	2.8	Membrane bound metalloprotease
Rv3220c		+1.1	3.9	Probable two component sensor kinase
Rv1962A		+1.1	2.9	Possible antitoxin VapB35
Rv2272		+1.1	1.0	Probable conserved transmembrane protein
Rv1798		+1.1	1.5	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv1366A		+1.0	1.6	Conserved protein
Rv2696c		+1.0	2.2	Conserved alanine and glycine and valine rich protein
Rv3136		+1.0	4.5	PPE family protein PPE51
Rv1531		+1.0	2.1	Conserved protein
Rv2302		+1.0	0.6	Conserved protein
Rv0939		+1.0	1.2	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv1303		+1.0	1.6	Conserved hypothetical transmembrane protein
Rv1102c		+1.0	2.0	Toxin MazF3
Rv0070c		+1.0	2.2	Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2)
Rv3314c		+0.9	1.8	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)
Rv0324		+0.9	2.0	Possible transcriptional regulatory protein (possibly ArsR-family)
Rv3445c		+0.9	2.4	ESAT-6 like protein EsxU
Rv2408		+0.9	2.3	Possible PE family-related protein PE24
Rv1422		+0.9	1.3	Conserved hypothetical protein
Rv0726c		+0.9	2.4	Possible S-adenosylmethionine-dependent methyltransferase
Rv0043c		+0.9	1.9	Probable transcriptional regulatory protein (probably GntR-family)
Rv3908		+0.8	2.2	Possible mutator protein MutT4
Rv0841		+0.8	2.1	Probable conserved transmembrane protein
Rv3193c		+0.8	1.6	Probable conserved transmembrane protein
Rv0805		+0.8	1.5	Class III cyclic nucleotide phosphodiesterase (cNMP PDE)
Rv1930c		+0.8	1.1	Conserved hypothetical protein
Rv2476c		+0.8	3.1	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv2378c		+0.8	1.4	Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)
Rv1169c		+0.7	1.8	PE family protein. Possible lipase LipX.
Rv3770B		+0.7	1.8	Probable remnant of a transposase
Rv3256c		+0.7	1.7	Conserved protein
Rv2663		+0.7	2.2	Hypothetical protein
Rv2583c		+0.7	2.1	Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Rv2414c		+0.7	1.8	Conserved hypothetical protein
Rv2708c		+0.7	2.3	Conserved hypothetical protein
Rv2683		+0.7	0.7	Conserved protein
Rv0089		+0.7	3.0	Possible methyltransferase/methylase
Rv0665		+0.7	1.9	Possible toxin VapC8
Rv0748		+0.7	0.9	Possible antitoxin VapB31
Rv2609c		+0.7	2.3	Probable conserved membrane protein
Rv3835		+0.7	1.5	Conserved membrane protein
Rv3230c		+0.7	3.7	Hypothetical oxidoreductase
Rv2662		+0.7	1.9	Hypothetical protein
Rv0550c		+0.7	1.7	Possible antitoxin VapB3
Rv2270		+0.6	2.0	Probable lipoprotein LppN
Rv3672c		+0.6	1.1	Conserved hypothetical protein
Rv1512		+0.6	0.7	Probable nucleotide-sugar epimerase EpiA
Rv2042c		+0.6	1.0	Conserved protein
Rv1234		+0.6	1.4	Probable transmembrane protein
Rv1791		+0.6	1.5	PE family protein PE19
Rv3377c		+0.6	3.8	Halimadienyl diphosphate synthase
Rv2801c		+0.6	0.8	Toxin MazF9
Rv2348c		+0.6	0.7	Hypothetical protein
Rv1284		+0.6	0.5	Beta-carbonic anhydrase
Rv2237A		+0.6	0.8	Conserved protein
Rv3085		+0.6	0.7	Probable short-chain type dehydrogenase/reductase
Rv0990c		+0.6	0.7	Hypothetical protein
Rv2171		+0.6	1.7	Probable conserved lipoprotein LppM
Rv1717		+0.6	1.1	Conserved hypothetical protein
Rv0353		+0.6	2.3	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv1941		+0.6	1.3	Probable short-chain type dehydrogenase/reductase
Rv2798c		+0.6	2.1	Conserved hypothetical protein
Rv3104c		+0.6	1.7	Possible conserved transmembrane protein
Rv3287c		+0.6	0.8	Anti-sigma factor RsbW (sigma negative effector)
Rv0084		+0.6	1.1	Possible formate hydrogenlyase HycD (FHL)
Rv0274		+0.6	2.4	Conserved protein
Rv2384		+0.6	1.3	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
Rv1565c		+0.6	4.0	Conserved hypothetical membrane protein
Rv2750		+0.6	1.7	Probable dehydrogenase
Rv0972c		+0.6	1.8	Acyl-CoA dehydrogenase FadE12
Rv0868c		+0.6	1.2	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv3819		+0.6	0.4	Unknown protein
Rv0361		+0.6	0.9	Probable conserved membrane protein
Rv2975c		+0.6	0.9	Conserved hypothetical protein
Rv1164		+0.6	2.3	Probable respiratory nitrate reductase (gamma chain) NarI
Rv1046c		+0.6	1.3	Hypothetical protein
Rv1259		+0.6	0.9	Probable uracil DNA glycosylase, UdgB
Rv3419c		+0.6	1.1	Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
Rv3058c		+0.6	2.4	Possible transcriptional regulatory protein (probably TetR-family)
Rv0950c		+0.6	3.0	Conserved hypothetical protein
Rv0881		+0.6	1.3	Possible rRNA methyltransferase (rRNA methylase)
Rv3182		+0.6	0.6	Conserved hypothetical protein
Rv3420c		+0.5	2.5	Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
Rv3098c		+0.5	1.9	Hypothetical protein
Rv0660c		+0.5	1.4	Possible antitoxin MazE2
Rv2551c		+0.5	1.2	Conserved hypothetical protein
Rv3716c		+0.5	0.6	Conserved protein
Rv0579		+0.5	2.4	Conserved hypothetical protein
Rv1140		+0.5	1.7	Probable integral membrane protein
Rv3771c		+0.5	1.2	Conserved hypothetical protein
Rv0912		+0.5	1.1	Probable conserved transmembrane protein
Rv1269c		+0.5	2.2	Conserved probable secreted protein
Rv1591		+0.5	2.5	Probable transmembrane protein
Rv3208A		+0.5	0.8	Conserved protein TB9.4
Rv2292c		+0.5	0.8	Hypothetical protein
Rv1566c		+0.5	1.5	Possible Inv protein
Rv2038c		+0.5	1.2	Probable sugar-transport ATP-binding protein ABC transporter
Rv3695		+0.5	2.6	Possible conserved membrane protein
Rv2335		+0.5	1.0	Probable serine acetyltransferase CysE (sat)
Rv2021c		+0.5	1.3	Transcriptional regulatory protein
Rv3874		+0.5	0.9	10 kDa culture filtrate antigen EsxB (LHP) (CFP10)
Rv3435c		+0.5	1.8	Probable conserved transmembrane protein
Rv3103c		+0.5	2.9	Hypothetical proline-rich protein
Rv2575		+0.5	2.5	Possible conserved membrane glycine rich protein
Rv1444c		+0.5	0.9	Unknown protein
Rv2088		+0.5	0.9	Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J)
Rv1825		+0.5	1.7	Conserved protein
Rv0436c		+0.5	1.0	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv3162c		+0.5	1.0	Possible integral membrane protein
Rv1151c		+0.5	2.0	Transcriptional regulatory protein
Rv3170		+0.5	1.7	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)
Rv2993c		+0.5	0.9	Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase)
Rv1707		+0.5	2.2	Probable conserved transmembrane protein
Rv3651		+0.5	1.0	Conserved hypothetical protein
Rv0272c		+0.5	1.8	Unknown protein
Rv2307A		+0.5	0.7	Hypothetical glycine rich protein
Rv2033c		+0.5	1.7	Conserved hypothetical protein
Rv3135		+0.5	2.1	PPE family protein PPE50
Rv1495		+0.5	0.8	Possible toxin MazF4
Rv1792		+0.5	0.8	ESAT-6 like protein EsxM
Rv1534		+0.5	1.4	Probable transcriptional regulator
Rv2802c		+0.5	2.2	Hypothetical arginine and alanine rich protein
Rv2280		+0.5	1.8	Probable dehydrogenase
Rv0876c		+0.5	1.3	Possible conserved transmembrane protein
Rv1710		+0.5	0.8	Possible segregation and condensation protein ScpB
Rv3843c		+0.5	1.3	Probable conserved transmembrane protein
Rv2324		+0.5	1.3	Probable transcriptional regulatory protein (probably AsnC-family)
Rv0275c		+0.5	1.3	Possible transcriptional regulatory protein (possibly TetR-family)
Rv1514c		+0.5	2.2	Conserved hypothetical protein
Rv0501		+0.4	2.3	Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
Rv2887		+0.4	0.8	Probable transcriptional regulatory protein
Rv2956		+0.4	1.0	Conserved protein
Rv2989		+0.4	0.6	Probable transcriptional regulatory protein
Rv2170		+0.4	0.8	GCN5-related N-acetyltransferase
Rv2624c		+0.4	0.7	Universal stress protein family protein
Rv3538		+0.4	0.8	Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.
Rv3338		+0.4	0.8	Conserved hypothetical protein
Rv2224c		+0.4	3.4	Probable carboxylesterase CaeA
Rv3855		+0.4	1.8	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv1590		+0.4	2.2	Conserved hypothetical protein
Rv1646		+0.4	1.3	PE family protein PE17
Rv0116c		+0.4	2.2	Probable L,D-transpeptidase LdtA
Rv0333		+0.4	1.3	Unknown protein
Rv2374c		+0.4	1.3	Probable heat shock protein transcriptional repressor HrcA
Rv0451c		+0.4	0.7	Probable conserved membrane protein MmpS4
Rv0408		+0.4	1.6	Probable phosphate acetyltransferase Pta (phosphotransacetylase)
Rv0201c		+0.4	0.9	Conserved protein
Rv3546		+0.4	0.9	Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase)
Rv0900		+0.4	2.1	Possible membrane protein
Rv2061c		+0.4	1.5	Conserved protein
Rv1986		+0.4	0.9	Probable conserved integral membrane protein
Rv3165c		+0.4	0.7	Unknown protein
Rv2360c		+0.4	1.6	Unknown protein
Rv3478		+0.4	1.5	PE family protein PPE60
Rv0523c		+0.4	0.9	Conserved protein
Rv3518c		+0.4	1.6	Probable cytochrome P450 monooxygenase 142 Cyp142
Rv1614		+0.4	1.2	Possible prolipoprotein diacylglyceryl transferases Lgt
Rv0481c		+0.4	2.6	Hypothetical protein
Rv2796c		+0.4	1.0	Probable conserved lipoprotein LppV
Rv2567		+0.4	1.7	Conserved hypothetical alanine and leucine rich protein
Rv1245c		+0.4	1.7	Probable short-chain type dehydrogenase/reductase
Rv3717		+0.4	1.8	Conserved hypothetical protein
Rv3194c		+0.4	2.4	Possible conserved secreted protein
Rv0367c		+0.4	0.5	Hypothetical protein
Rv0889c		+0.4	1.8	Probable citrate synthase II CitA
Rv1951c		+0.4	1.5	Conserved hypothetical protein
Rv3236c		+0.4	1.0	Probable conserved integral membrane transport protein
Rv3453		+0.4	0.8	Possible conserved transmembrane protein
Rv3091		+0.4	1.3	Conserved protein
Rv1957		+0.4	0.5	Hypothetical protein
Rv1892		+0.4	1.6	Probable membrane protein
Rv3693		+0.4	1.0	Possible conserved membrane protein
Rv1821		+0.4	1.9	Possible preprotein translocase ATPase SecA2
Rv1114		+0.4	2.1	Possible toxin VapC32. Contains PIN domain.
Rv3766		+0.4	1.1	Hypothetical protein
Rv1468c		+0.4	0.8	PE-PGRS family protein PE_PGRS29
Rv1097c		+0.4	1.4	Probable membrane glycine and proline rich protein
Rv0729		+0.4	1.6	Possible D-xylulose kinase XylB (xylulokinase) (xylulose kinase)
Rv3102c		+0.4	1.0	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv2009		+0.4	0.7	Antitoxin VapB15
Rv2625c		+0.4	1.4	Probable conserved transmembrane alanine and leucine rich protein
Rv0321		+0.4	1.0	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Rv0865		+0.4	1.8	Probable molybdopterin biosynthesis Mog protein
Rv0580c		+0.4	0.4	Conserved protein
Rv0578c		+0.4	1.8	PE-PGRS family protein PE_PGRS7
Rv2867c		+0.4	1.5	GCN5-related N-acetyltransferase
Rv1815		+0.4	1.9	Conserved protein
Rv1528c		+0.4	1.2	Probable conserved polyketide synthase associated protein PapA4
Rv1767		+0.4	1.4	Conserved protein
Rv0158		+0.4	2.7	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0033		+0.4	1.5	Probable acyl carrier protein AcpA (ACP)

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Sulfaquinoxaline across organisms