Experiment set2S592 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv1957		+2.5	4.9	Hypothetical protein
Rv3193c		+2.2	5.1	Probable conserved transmembrane protein
Rv0758		+1.8	6.6	Possible two component system response sensor kinase membrane associated PhoR
Rv3716c		+1.7	2.5	Conserved protein
Rv0983		+1.7	8.4	Probable serine protease PepD (serine proteinase) (MTB32B)
Rv1798		+1.6	2.6	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv1626		+1.3	6.8	Probable two-component system transcriptional regulator
Rv1284		+1.3	1.2	Beta-carbonic anhydrase
Rv1531		+1.3	1.9	Conserved protein
Rv3843c		+1.3	2.9	Probable conserved transmembrane protein
Rv3220c		+1.3	4.6	Probable two component sensor kinase
Rv2583c		+1.3	2.8	Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Rv2876		+1.2	1.1	Possible conserved transmembrane protein
Rv3419c		+1.2	2.6	Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
Rv0757		+1.2	2.0	Possible two component system response transcriptional positive regulator PhoP
Rv2348c		+1.1	1.4	Hypothetical protein
Rv3256c		+1.1	3.0	Conserved protein
Rv3136		+1.1	5.4	PPE family protein PPE51
Rv2752c		+1.1	5.4	Conserved hypothetical protein
Rv1422		+1.1	1.9	Conserved hypothetical protein
Rv0995		+1.1	2.6	Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5)
Rv0451c		+1.1	2.3	Probable conserved membrane protein MmpS4
Rv2091c		+1.1	8.0	Probable membrane protein
Rv3058c		+1.0	3.8	Possible transcriptional regulatory protein (probably TetR-family)
Rv1096		+1.0	2.0	Possible glycosyl hydrolase
Rv3477		+1.0	2.4	PE family protein PE31
Rv3920c		+1.0	1.2	Conserved protein similar to jag protein
Rv3295		+1.0	8.0	Probable transcriptional regulatory protein (probably TetR-family)
Rv0642c		+1.0	1.9	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv1694		+0.9	2.9	2'-O-methyltransferase TlyA
Rv1303		+0.9	1.5	Conserved hypothetical transmembrane protein
Rv0275c		+0.9	1.6	Possible transcriptional regulatory protein (possibly TetR-family)
Rv3230c		+0.9	3.7	Hypothetical oxidoreductase
Rv1112		+0.9	1.0	Probable GTP binding protein
Rv0964c		+0.9	2.1	Hypothetical protein
Rv3706c		+0.9	1.9	Conserved hypothetical proline rich protein
Rv3647c		+0.9	1.3	Conserved hypothetical protein
Rv1986		+0.8	1.4	Probable conserved integral membrane protein
Rv2414c		+0.8	1.7	Conserved hypothetical protein
Rv0085		+0.8	1.4	Possible hydrogenase HycP
Rv2408		+0.8	2.0	Possible PE family-related protein PE24
Rv3478		+0.8	3.4	PE family protein PPE60
Rv2374c		+0.8	2.2	Probable heat shock protein transcriptional repressor HrcA
Rv1271c		+0.8	2.0	Conserved hypothetical secreted protein
Rv2026c		+0.8	1.0	Universal stress protein family protein
Rv1239c		+0.8	4.5	Possible magnesium and cobalt transport transmembrane protein CorA
Rv3842c		+0.8	3.7	Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase)
Rv0919		+0.8	1.8	GCN5-related N-acetyltransferase
Rv0677c		+0.7	2.6	Possible conserved membrane protein MmpS5
Rv2436		+0.7	2.4	Ribokinase RbsK
Rv1565c		+0.7	4.3	Conserved hypothetical membrane protein
Rv0563		+0.7	3.2	Probable protease transmembrane protein heat shock protein HtpX
Rv3420c		+0.7	2.4	Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
Rv3366		+0.7	1.2	Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase)
Rv1823		+0.7	2.8	Conserved protein
Rv1707		+0.7	2.9	Probable conserved transmembrane protein
Rv0893c		+0.7	2.2	Possible S-adenosylmethionine-dependent methyltransferase
Rv3559c		+0.7	0.7	Probable oxidoreductase
Rv1792		+0.7	1.3	ESAT-6 like protein EsxM
Rv3413c		+0.7	0.6	Unknown alanine and proline rich protein
Rv2736c		+0.7	1.3	Regulatory protein RecX
Rv2781c		+0.7	4.8	Possible alanine rich oxidoreductase
Rv3135		+0.7	2.3	PPE family protein PPE50
Rv0295c		+0.7	2.2	Conserved protein
Rv1035c		+0.7	1.2	Probable transposase (fragment)
Rv0043c		+0.7	1.1	Probable transcriptional regulatory protein (probably GntR-family)
Rv2384		+0.6	1.7	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
Rv2731		+0.6	4.5	Conserved alanine and arginine rich protein
Rv1207		+0.6	4.4	Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2)
Rv3263		+0.6	4.1	Probable DNA methylase (modification methylase) (methyltransferase)
Rv2051c		+0.6	2.7	Polyprenol-monophosphomannose synthase Ppm1
Rv1351		+0.6	1.8	Hypothetical protein
Rv3182		+0.6	0.6	Conserved hypothetical protein
Rv1901		+0.6	3.6	Probable CinA-like protein CinA
Rv3885c		+0.6	1.4	ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein.
Rv0012		+0.6	3.1	Probable conserved membrane protein
Rv0545c		+0.6	1.7	Probable low-affinity inorganic phosphate transporter integral membrane protein PitA
Rv0450c		+0.6	3.9	Probable conserved transmembrane transport protein MmpL4
Rv2633c		+0.6	3.4	Hypothetical protein
Rv1824		+0.6	2.0	Conserved hypothetical membrane protein
Rv2851c		+0.6	1.5	GCN5-related N-acetyltransferase
Rv1053c		+0.6	0.8	Hypothetical protein
Rv3377c		+0.6	2.8	Halimadienyl diphosphate synthase
Rv3848		+0.6	1.3	Probable conserved transmembrane protein
Rv2553c		+0.6	0.5	Probable conserved membrane protein
Rv0974c		+0.6	1.3	Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2
Rv0868c		+0.6	1.6	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv2586c		+0.6	1.1	Probable protein-export membrane protein SecF
Rv3136A		+0.6	3.8	Conserved protein
Rv0523c		+0.6	1.1	Conserved protein
Rv3631		+0.6	0.5	Possible transferase (possibly glycosyltransferase)
Rv3018c		+0.6	1.9	PPE family protein PPE46
Rv0190		+0.6	1.7	Conserved protein
Rv1963c		+0.6	1.5	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv0158		+0.6	3.6	Probable transcriptional regulatory protein (possibly TetR-family)
Rv2307A		+0.6	0.8	Hypothetical glycine rich protein
Rv0877		+0.6	3.9	Conserved hypothetical protein
Rv1825		+0.6	2.2	Conserved protein
Rv2993c		+0.6	0.9	Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase)
Rv0726c		+0.6	1.9	Possible S-adenosylmethionine-dependent methyltransferase
Rv0178		+0.6	2.4	Probable conserved Mce associated membrane protein
Rv0693		+0.5	2.1	Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III)
Rv2009		+0.5	1.3	Antitoxin VapB15
Rv2558		+0.5	1.6	Conserved protein
Rv2901c		+0.5	2.1	Conserved protein
Rv2989		+0.5	0.6	Probable transcriptional regulatory protein
Rv0362		+0.5	3.2	Possible Mg2+ transport transmembrane protein MgtE
Rv3835		+0.5	1.2	Conserved membrane protein
Rv2028c		+0.5	1.0	Universal stress protein family protein
Rv2185c		+0.5	1.6	Conserved protein TB16.3
Rv2011c		+0.5	1.6	Conserved hypothetical protein, probable transcription repressor.
Rv0112		+0.5	2.0	Possible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase)
Rv3553		+0.5	1.4	Possible oxidoreductase
Rv3836		+0.5	2.6	Conserved hypothetical protein
Rv0009		+0.5	0.7	Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A)
Rv3417c		+0.5	1.9	60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1)
Rv3259		+0.5	1.8	Conserved hypothetical protein
Rv2044c		+0.5	0.5	Conserved hypothetical protein
Rv1948c		+0.5	1.6	Hypothetical protein
Rv0916c		+0.5	2.4	PE family protein PE7
Rv0328		+0.5	1.1	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv2506		+0.5	2.1	Probable transcriptional regulatory protein (probably TetR-family)
Rv3664c		+0.5	1.7	Probable dipeptide-transport integral membrane protein ABC transporter DppC
Rv1468c		+0.5	1.4	PE-PGRS family protein PE_PGRS29
Rv0470c		+0.5	1.5	Mycolic acid synthase PcaA (cyclopropane synthase)
Rv3556c		+0.5	1.3	Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase)
Rv2598		+0.5	2.2	Conserved hypothetical protein
Rv0501		+0.5	1.6	Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
Rv2862c		+0.5	3.3	Conserved hypothetical protein
Rv1486c		+0.5	2.5	Conserved hypothetical protein
Rv1791		+0.5	0.6	PE family protein PE19
Rv1691		+0.5	1.7	Conserved hypothetical protein
Rv1234		+0.5	0.9	Probable transmembrane protein
Rv0204c		+0.5	1.5	Probable conserved transmembrane protein
Rv2003c		+0.5	0.3	Conserved hypothetical protein
Rv2240c		+0.5	1.1	Unknown protein
Rv0901		+0.5	2.2	Possible conserved exported or membrane protein
Rv3695		+0.5	1.8	Possible conserved membrane protein
Rv0813c		+0.5	2.6	Conserved protein
Rv3779		+0.5	3.7	Probable conserved transmembrane protein alanine and leucine rich
Rv3632		+0.5	1.7	Possible conserved membrane protein
Rv1580c		+0.5	1.2	Probable PhiRv1 phage protein
Rv2360c		+0.5	1.9	Unknown protein
Rv2132		+0.5	2.3	Conserved hypothetical protein
Rv0907		+0.5	2.5	Conserved protein
Rv0306		+0.5	1.6	Putative oxidoreductase
Rv2281		+0.5	1.8	Putative phosphate-transport permease PitB
Rv0033		+0.5	1.4	Probable acyl carrier protein AcpA (ACP)
Rv0249c		+0.5	1.8	Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase)
Rv0092		+0.5	2.3	Cation transporter P-type ATPase a CtpA
Rv3824c		+0.5	2.1	Conserved polyketide synthase associated protein PapA1
Rv0749		+0.5	1.5	Possible toxin VapC31. Contains PIN domain.
Rv2723		+0.5	2.5	Probable conserved integral membrane protein
Rv3446c		+0.4	2.0	Hypothetical alanine and valine rich protein
Rv1448c		+0.4	1.7	Probable transaldolase Tal
Rv3236c		+0.4	1.0	Probable conserved integral membrane transport protein
Rv3850		+0.4	0.5	Conserved protein
Rv3771c		+0.4	1.4	Conserved hypothetical protein
Rv2774c		+0.4	0.5	Hypothetical protein
Rv1556		+0.4	0.8	Possible regulatory protein
Rv1577c		+0.4	0.5	Probable PhiRv1 phage protein
Rv0972c		+0.4	2.1	Acyl-CoA dehydrogenase FadE12
Rv0773c		+0.4	1.6	Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT)
Rv3910		+0.4	0.6	Probable conserved transmembrane protein
Rv3820c		+0.4	3.4	Possible conserved polyketide synthase associated protein PapA2
Rv1640c		+0.4	3.3	Lysyl-tRNA synthetase 2 LysX
Rv0321		+0.4	0.9	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Rv0939		+0.4	0.5	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv1181		+0.4	3.1	Probable polyketide beta-ketoacyl synthase Pks4
Rv1164		+0.4	2.2	Probable respiratory nitrate reductase (gamma chain) NarI
Rv0407		+0.4	2.1	F420-dependent glucose-6-phosphate dehydrogenase Fgd1
Rv2251		+0.4	1.6	Possible flavoprotein
Rv2107		+0.4	1.2	PE family protein PE22
Rv3316		+0.4	0.7	Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Rv3893c		+0.4	1.7	PE family protein PE36
Rv2831		+0.4	2.0	Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0748		+0.4	1.4	Possible antitoxin VapB31
Rv3825c		+0.4	3.7	Polyketide synthase Pks2
Rv0420c		+0.4	1.4	Possible transmembrane protein
Rv0889c		+0.4	1.8	Probable citrate synthase II CitA
Rv2404c		+0.4	2.6	Probable GTP-binding protein LepA (GTP-binding elongation factor)
Rv0302		+0.4	2.1	Probable transcriptional regulatory protein (probably TetR/AcrR-family)
Rv2949c		+0.4	0.8	Chorismate pyruvate lyase
Rv2148c		+0.4	1.4	Conserved protein
Rv3166c		+0.4	1.1	Conserved hypothetical protein
Rv3523		+0.4	1.9	Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3
Rv0135c		+0.4	1.1	Possible transcriptional regulatory protein
Rv3098c		+0.4	1.4	Hypothetical protein
Rv3314c		+0.4	0.7	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)
Rv2331		+0.4	1.7	Hypothetical protein
Rv3641c		+0.4	1.9	Possible cell filamentation protein Fic
Rv0688		+0.4	2.2	Putative ferredoxin reductase
Rv2271		+0.4	1.7	Conserved hypothetical protein
Rv3649		+0.4	1.0	Probable helicase
Rv0580c		+0.4	0.5	Conserved protein
Rv0177		+0.4	0.8	Probable conserved Mce associated protein
Rv3618		+0.4	1.4	Possible monooxygenase
Rv1144		+0.4	1.8	Probable short-chain type dehydrogenase/reductase
Rv3081		+0.4	0.6	Conserved hypothetical protein
Rv0832		+0.4	1.7	PE-PGRS family protein PE_PGRS12

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Sulfamethizole across organisms