Experiment set2S591 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv1420		-2.1	-3.5	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv1421		-2.0	-5.2	Conserved protein
Rv0392c		-1.8	-1.7	Probable membrane NADH dehydrogenase NdhA
Rv3033		-1.8	-1.1	Unknown protein
Rv0819		-1.8	-4.0	GCN5-related N-acetyltransferase, MshD
Rv3610c		-1.8	-3.3	Membrane-bound protease FtsH (cell division protein)
Rv3715c		-1.6	-2.5	Probable recombination protein RecR
Rv0437c		-1.6	-1.1	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv3277		-1.3	-1.2	Probable conserved transmembrane protein
Rv0990c		-1.2	-0.9	Hypothetical protein
Rv2680		-1.2	-2.2	Conserved protein
Rv3214		-1.2	-1.6	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)
Rv0436c		-1.2	-1.9	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv2671		-1.1	-3.4	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)
Rv1003		-1.1	-0.9	Conserved protein
Rv3389c		-1.1	-2.4	Probable 3-hydroxyacyl-thioester dehydratase HtdY
Rv1324		-1.1	-1.0	Possible thioredoxin
Rv3591c		-1.1	-2.4	Possible hydrolase
Rv0113		-1.1	-1.3	Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase)
Rv0929		-1.1	-2.0	Phosphate-transport integral membrane ABC transporter PstC2
Rv2758c		-1.1	-1.2	Possible antitoxin VapB21
Rv3358		-1.1	-1.5	Toxin RelK
Rv2702		-1.1	-0.8	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv2173		-1.0	-4.0	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv0949		-1.0	-1.0	Probable ATP-dependent DNA helicase II UvrD1
Rv2850c		-1.0	-1.0	Possible magnesium chelatase
Rv3196A		-0.9	-1.7	Unknown protein
Rv1512		-0.9	-0.6	Probable nucleotide-sugar epimerase EpiA
Rv3311		-0.9	-4.3	Conserved protein
Rv0930		-0.9	-3.8	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv2976c		-0.9	-0.6	Probable uracil-DNA glycosylase Ung (UDG)
Rv2619c		-0.9	-1.7	Conserved protein
Rv3642c		-0.9	-1.4	Hypothetical protein
Rv2745c		-0.9	-1.2	Transcriptional regulatory protein ClgR
Rv3114		-0.9	-0.9	Conserved hypothetical protein
Rv3073c		-0.9	-1.0	Conserved hypothetical protein
Rv0820		-0.9	-3.3	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv3672c		-0.9	-1.0	Conserved hypothetical protein
Rv1621c		-0.8	-2.0	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv1290A		-0.8	-0.9	Hypothetical protein
Rv0610c		-0.8	-1.0	Hypothetical protein
Rv0177		-0.8	-1.5	Probable conserved Mce associated protein
Rv0928		-0.8	-3.1	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2817c		-0.8	-2.0	Conserved hypothetical protein
Rv2945c		-0.8	-5.0	Probable conserved lipoprotein LppX
Rv2588c		-0.7	-1.2	Probable conserved membrane protein secretion factor YajC
Rv0018c		-0.7	-2.4	Phosphoserine/threonine phosphatase PstP
Rv1031		-0.7	-2.3	Probable potassium-transporting ATPase C chain KdpC (potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (potassium binding and translocating subunit C)
Rv3287c		-0.7	-0.8	Anti-sigma factor RsbW (sigma negative effector)
Rv3813c		-0.7	-1.7	Conserved protein
Rv1025		-0.7	-0.7	Conserved protein
Rv1131		-0.7	-1.8	Probable methylcitrate synthase PrpC
Rv1745c		-0.7	-2.4	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv1364c		-0.7	-2.6	Possible sigma factor regulatory protein
Rv0084		-0.7	-0.9	Possible formate hydrogenlyase HycD (FHL)
Rv0441c		-0.7	-3.1	Hypothetical protein
Rv1102c		-0.7	-1.1	Toxin MazF3
Rv2046		-0.7	-1.1	Probable lipoprotein LppI
Rv0531		-0.7	-1.0	Possible conserved membrane protein
Rv0870c		-0.7	-1.1	Possible conserved integral membrane protein
Rv0617		-0.7	-1.6	Possible toxin VapC29. Contains PIN domain.
Rv1398c		-0.7	-1.4	Possible antitoxin VapB10
Rv2691		-0.7	-3.6	TRK system potassium uptake protein CeoB
Rv3085		-0.7	-0.6	Probable short-chain type dehydrogenase/reductase
Rv0786c		-0.7	-1.7	Conserved protein
Rv0019c		-0.7	-2.8	Conserved protein with FHA domain, FhaB
Rv1620c		-0.7	-2.2	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv3200c		-0.7	-1.9	Possible transmembrane cation transporter
Rv1720c		-0.7	-2.6	Possible toxin VapC12
Rv1946c		-0.7	-1.4	Possible lipoprotein
Rv1410c		-0.7	-4.5	Aminoglycosides/tetracycline-transport integral membrane protein
Rv1291c		-0.7	-1.0	Conserved hypothetical secreted protein
Rv1407		-0.6	-4.3	Probable Fmu protein (sun protein)
Rv1740		-0.6	-1.2	Possible antitoxin VapB34
Rv0782		-0.6	-1.1	Probable protease II PtrBb [second part] (oligopeptidase B)
Rv0939		-0.6	-0.7	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv1120c		-0.6	-1.7	Conserved hypothetical protein
Rv1270c		-0.6	-2.1	Possible lipoprotein LprA
Rv3527		-0.6	-1.1	Hypothetical protein
Rv0085		-0.6	-0.8	Possible hydrogenase HycP
Rv0468		-0.6	-1.6	3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Rv1473A		-0.6	-0.6	Possible transcriptional regulatory protein
Rv3309c		-0.6	-1.7	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Rv2695		-0.6	-2.1	Conserved hypothetical alanine rich protein
Rv3304		-0.6	-2.9	Conserved protein
Rv0921		-0.6	-1.4	Possible resolvase
Rv0975c		-0.6	-3.1	Probable acyl-CoA dehydrogenase FadE13
Rv3483c		-0.6	-3.0	Possible exported protein
Rv1698		-0.6	-2.4	Outer membrane protein MctB
Rv2879c		-0.6	-0.7	Conserved hypothetical protein
Rv0199		-0.6	-1.3	Probable conserved membrane protein
Rv1751		-0.6	-1.3	Probable oxidoreductase
Rv2427A		-0.6	-1.5	'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11
Rv0078		-0.6	-1.5	Probable transcriptional regulatory protein
Rv3481c		-0.6	-1.0	Probable integral membrane protein
Rv3400		-0.6	-4.0	Probable hydrolase
Rv2812		-0.6	-1.4	Probable transposase
Rv0394c		-0.6	-1.8	Possible secreted protein
Rv1145		-0.6	-2.6	Probable conserved transmembrane transport protein MmpL13a
Rv2376c		-0.6	-0.7	Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Rv3830c		-0.6	-1.8	Transcriptional regulatory protein (probably TetR-family)
Rv2378c		-0.6	-1.0	Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)
Rv1035c		-0.6	-0.8	Probable transposase (fragment)
Rv2635		-0.6	-0.6	Hypothetical protein
Rv3328c		-0.6	-1.1	Probable alternative RNA polymerase sigma factor (fragment) SigJ
Rv1710		-0.6	-0.8	Possible segregation and condensation protein ScpB
Rv0713		-0.5	-3.8	Probable conserved transmembrane protein
Rv3284		-0.5	-1.4	Conserved hypothetical protein
Rv3237c		-0.5	-2.1	Conserved protein
Rv1195		-0.5	-2.3	PE family protein PE13
Rv1278		-0.5	-1.7	Hypothetical protein
Rv3592		-0.5	-1.6	Possible heme degrading protein MhuD
Rv2942		-0.5	-4.3	Conserved transmembrane transport protein MmpL7
Rv0444c		-0.5	-2.1	Anti-sigma factor RskA (regulator of sigma K)
Rv1441c		-0.5	-1.6	PE-PGRS family protein PE_PGRS26
Rv2923c		-0.5	-0.5	Conserved protein
Rv0098		-0.5	-0.8	Probable fatty acyl CoA thioesterase type III FcoT
Rv2938		-0.5	-4.3	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv1019		-0.5	-2.4	Probable transcriptional regulatory protein (probably TetR-family)
Rv0185		-0.5	-2.1	Conserved hypothetical protein
Rv3363c		-0.5	-0.9	Conserved hypothetical protein
Rv1170		-0.5	-1.1	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)
Rv2606c		-0.5	-1.7	Possible pyridoxine biosynthesis protein SnzP
Rv1450c		-0.5	-1.0	PE-PGRS family protein PE_PGRS27
Rv1836c		-0.5	-1.1	Conserved protein
Rv1082		-0.5	-1.9	Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase)
Rv3102c		-0.5	-1.3	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv2154c		-0.5	-1.0	FtsW-like protein FtsW
Rv2668		-0.5	-2.8	Possible exported alanine and valine rich protein
Rv0089		-0.5	-1.4	Possible methyltransferase/methylase
Rv2252		-0.5	-0.6	Diacylglycerol kinase
Rv3165c		-0.5	-0.6	Unknown protein
Rv2937		-0.5	-3.7	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv1422		-0.5	-0.5	Conserved hypothetical protein
Rv2190c		-0.5	-2.6	Conserved hypothetical protein
Rv1244		-0.5	-1.8	Probable lipoprotein LpqZ
Rv2736c		-0.5	-0.7	Regulatory protein RecX
Rv1912c		-0.5	-1.2	Possible oxidoreductase FadB5
Rv3292		-0.5	-2.0	Conserved hypothetical protein
Rv0426c		-0.5	-1.2	Possible transmembrane protein
Rv3133c		-0.5	-1.6	Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family)
Rv2739c		-0.5	-1.2	Possible alanine rich transferase
Rv3538		-0.5	-0.7	Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.
Rv0403c		-0.5	-1.5	Probable conserved membrane protein MmpS1
Rv0862c		-0.5	-1.4	Conserved protein
Rv0181c		-0.4	-3.0	Conserved hypothetical protein
Rv0050		-0.4	-1.0	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv3814c		-0.4	-2.2	Possible acyltransferase
Rv0313		-0.4	-0.9	Conserved protein
Rv2231c		-0.4	-0.9	Possible aminotransferase CobC
Rv3643		-0.4	-1.0	Hypothetical protein
Rv3213c		-0.4	-1.4	Possible SOJ/para-related protein
Rv2302		-0.4	-0.4	Conserved protein
Rv1159		-0.4	-1.1	Mannosyltransferase PimE
Rv1940		-0.4	-1.5	Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)
Rv3725		-0.4	-1.6	Possible oxidoreductase
Rv3045		-0.4	-1.3	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv1256c		-0.4	-1.6	Probable cytochrome P450 130 Cyp130
Rv0452		-0.4	-1.0	Possible transcriptional regulatory protein
Rv1062		-0.4	-0.6	Conserved hypothetical protein
Rv2941		-0.4	-3.6	Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Rv0381c		-0.4	-2.1	Hypothetical protein
Rv2089c		-0.4	-0.6	Dipeptidase PepE
Rv1773c		-0.4	-0.9	Probable transcriptional regulatory protein
Rv0086		-0.4	-1.6	Possible hydrogenase HycQ
Rv2792c		-0.4	-1.0	Possible resolvase
Rv2721c		-0.4	-2.7	Possible conserved transmembrane alanine and glycine rich protein
Rv2116		-0.4	-1.4	Conserved lipoprotein LppK
Rv3850		-0.4	-0.7	Conserved protein
Rv0725c		-0.4	-1.5	Conserved hypothetical protein
Rv1112		-0.4	-0.5	Probable GTP binding protein
Rv2367c		-0.4	-0.5	Conserved hypothetical protein
Rv3167c		-0.4	-1.4	Probable transcriptional regulatory protein (probably TetR-family)
Rv0370c		-0.4	-1.1	Possible oxidoreductase
Rv3346c		-0.4	-1.1	Conserved transmembrane protein
Rv1490		-0.4	-1.5	Probable membrane protein
Rv2855		-0.4	-1.4	NADPH-dependent mycothiol reductase Mtr
Rv2365c		-0.4	-0.3	Conserved hypothetical protein
Rv2403c		-0.4	-1.0	Probable conserved lipoprotein LppR
Rv2936		-0.4	-3.4	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv3758c		-0.4	-1.6	Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV
Rv3482c		-0.4	-2.4	Probable conserved membrane protein
Rv0679c		-0.4	-0.5	Conserved threonine rich protein
Rv1401		-0.4	-0.6	Possible membrane protein
Rv2344c		-0.4	-1.6	Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase)
Rv0989c		-0.4	-2.5	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv0243		-0.4	-2.3	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv0566c		-0.4	-2.1	Conserved protein
Rv0494		-0.4	-1.8	Probable transcriptional regulatory protein (probably GntR-family)
Rv2322c		-0.4	-0.6	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)
Rv3905c		-0.4	-1.6	Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13)
Rv0028		-0.4	-1.5	Conserved hypothetical protein
Rv3472		-0.4	-2.2	Conserved protein
Rv2756c		-0.4	-1.3	Possible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase)
Rv2821c		-0.4	-0.6	Conserved hypothetical protein
Rv3267		-0.4	-0.8	Conserved protein (CPSA-related protein)
Rv3189		-0.4	-0.9	Conserved hypothetical protein
Rv2503c		-0.4	-1.1	Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase)
Rv0130		-0.4	-0.7	Probable 3-hydroxyl-thioester dehydratase
Rv0125		-0.4	-1.8	Probable serine protease PepA (serine proteinase) (MTB32A)

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Sulfamethizole across organisms