Experiment set2S586 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv3428c		+2.2	3.3	Possible transposase
Rv3143		+1.8	1.9	Probable response regulator
Rv0983		+1.6	11.2	Probable serine protease PepD (serine proteinase) (MTB32B)
Rv1675c		+1.5	3.1	Probable transcriptional regulatory protein Cmr
Rv0545c		+1.5	2.6	Probable low-affinity inorganic phosphate transporter integral membrane protein PitA
Rv3295		+1.5	12.6	Probable transcriptional regulatory protein (probably TetR-family)
Rv2752c		+1.5	10.0	Conserved hypothetical protein
Rv1234		+1.3	2.2	Probable transmembrane protein
Rv3220c		+1.2	4.2	Probable two component sensor kinase
Rv3314c		+1.2	2.2	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)
Rv2989		+1.2	1.8	Probable transcriptional regulatory protein
Rv3193c		+1.2	2.1	Probable conserved transmembrane protein
Rv1626		+1.1	5.5	Probable two-component system transcriptional regulator
Rv3819		+1.1	0.8	Unknown protein
Rv2633c		+1.1	5.7	Hypothetical protein
Rv3328c		+1.1	3.8	Probable alternative RNA polymerase sigma factor (fragment) SigJ
Rv2781c		+1.1	5.8	Possible alanine rich oxidoreductase
Rv0674		+1.1	1.5	Conserved hypothetical protein
Rv2072c		+1.0	1.5	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv0468		+1.0	4.0	3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Rv2758c		+1.0	1.8	Possible antitoxin VapB21
Rv2292c		+1.0	1.6	Hypothetical protein
Rv1798		+1.0	1.2	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv0561c		+1.0	2.0	Possible oxidoreductase
Rv2897c		+1.0	2.0	Conserved hypothetical protein
Rv1792		+1.0	1.8	ESAT-6 like protein EsxM
Rv0758		+1.0	1.9	Possible two component system response sensor kinase membrane associated PhoR
Rv2382c		+1.0	1.4	Polyketide synthetase MbtC (polyketide synthase)
Rv1963c		+1.0	1.3	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv1401		+1.0	1.4	Possible membrane protein
Rv1303		+0.9	1.3	Conserved hypothetical transmembrane protein
Rv2681		+0.9	4.2	Conserved hypothetical alanine rich protein
Rv2586c		+0.9	1.7	Probable protein-export membrane protein SecF
Rv0098		+0.9	1.3	Probable fatty acyl CoA thioesterase type III FcoT
Rv2867c		+0.9	5.4	GCN5-related N-acetyltransferase
Rv3085		+0.9	1.2	Probable short-chain type dehydrogenase/reductase
Rv3135		+0.9	3.8	PPE family protein PPE50
Rv0084		+0.9	1.1	Possible formate hydrogenlyase HycD (FHL)
Rv2657c		+0.9	0.8	Probable PhiRv2 prophage protein
Rv0113		+0.9	1.1	Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase)
Rv2140c		+0.8	1.9	Conserved protein TB18.6
Rv0841		+0.8	1.4	Probable conserved transmembrane protein
Rv0451c		+0.8	1.1	Probable conserved membrane protein MmpS4
Rv2432c		+0.8	0.9	Hypothetical protein
Rv3230c		+0.8	3.9	Hypothetical oxidoreductase
Rv2091c		+0.8	3.6	Probable membrane protein
Rv3538		+0.8	1.4	Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.
Rv0540		+0.8	1.2	Conserved hypothetical protein
Rv0554		+0.8	5.4	Possible peroxidase BpoC (non-haem peroxidase)
Rv3069		+0.8	2.4	Probable conserved transmembrane protein
Rv0085		+0.8	0.9	Possible hydrogenase HycP
Rv3331		+0.8	2.9	Probable sugar-transport integral membrane protein SugI
Rv3651		+0.7	1.3	Conserved hypothetical protein
Rv1140		+0.7	2.3	Probable integral membrane protein
Rv0496		+0.7	1.4	Conserved hypothetical protein
Rv3716c		+0.7	0.8	Conserved protein
Rv1929c		+0.7	1.9	Conserved hypothetical protein
Rv0955		+0.7	0.8	Probable conserved integral membrane protein
Rv1691		+0.7	1.8	Conserved hypothetical protein
Rv3893c		+0.7	1.9	PE family protein PE36
Rv2801c		+0.7	0.8	Toxin MazF9
Rv3136		+0.7	3.9	PPE family protein PPE51
Rv3136A		+0.7	4.9	Conserved protein
Rv1468c		+0.7	1.7	PE-PGRS family protein PE_PGRS29
Rv0985c		+0.7	2.5	Possible large-conductance ion mechanosensitive channel MscL
Rv2782c		+0.7	2.3	Probable zinc protease PepR
Rv1046c		+0.7	1.4	Hypothetical protein
Rv1276c		+0.7	1.5	Conserved hypothetical protein
Rv2506		+0.7	2.8	Probable transcriptional regulatory protein (probably TetR-family)
Rv1193		+0.7	2.4	Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv0323c		+0.7	0.9	Conserved hypothetical protein
Rv3073c		+0.7	1.0	Conserved hypothetical protein
Rv2474c		+0.6	1.2	Conserved hypothetical protein
Rv1919c		+0.6	2.7	Conserved protein
Rv3207c		+0.6	1.5	Conserved protein
Rv3161c		+0.6	2.3	Possible dioxygenase
Rv3663c		+0.6	2.2	Probable dipeptide-transport ATP-binding protein ABC transporter DppD
Rv2383c		+0.6	1.6	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)
Rv3394c		+0.6	2.0	Conserved hypothetical protein
Rv2873		+0.6	2.4	Cell surface lipoprotein Mpt83 (lipoprotein P23)
Rv3389c		+0.6	1.8	Probable 3-hydroxyacyl-thioester dehydratase HtdY
Rv0275c		+0.6	1.7	Possible transcriptional regulatory protein (possibly TetR-family)
Rv2237A		+0.6	0.7	Conserved protein
Rv3166c		+0.6	1.5	Conserved hypothetical protein
Rv0270		+0.6	4.0	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv2683		+0.6	0.7	Conserved protein
Rv2901c		+0.6	2.3	Conserved protein
Rv0737		+0.6	1.4	Possible transcriptional regulatory protein
Rv0901		+0.6	2.1	Possible conserved exported or membrane protein
Rv0995		+0.6	1.2	Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5)
Rv3321c		+0.6	2.1	Possible antitoxin VapB44
Rv2798c		+0.6	0.9	Conserved hypothetical protein
Rv3532		+0.6	1.8	PPE family protein PPE61
Rv2378c		+0.6	1.6	Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)
Rv0043c		+0.6	1.2	Probable transcriptional regulatory protein (probably GntR-family)
Rv3286c		+0.6	0.9	Alternative RNA polymerase sigma factor SigF
Rv3664c		+0.6	1.7	Probable dipeptide-transport integral membrane protein ABC transporter DppC
Rv0974c		+0.6	1.5	Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2
Rv0182c		+0.6	2.3	Probable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor)
Rv0934		+0.6	2.1	Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1)
Rv2522c		+0.6	1.7	Conserved hypothetical protein
Rv3058c		+0.6	3.2	Possible transcriptional regulatory protein (probably TetR-family)
Rv1192		+0.6	1.7	Unknown protein
Rv1147		+0.6	2.2	Conserved protein
Rv2575		+0.6	1.8	Possible conserved membrane glycine rich protein
Rv1788		+0.6	2.8	PE family protein PE18
Rv0905		+0.6	0.9	Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3032A		+0.6	1.4	Conserved protein
Rv0681		+0.5	2.5	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0564c		+0.5	1.5	Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase)
Rv1444c		+0.5	0.8	Unknown protein
Rv3885c		+0.5	1.4	ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein.
Rv0319		+0.5	2.4	Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase)
Rv2275		+0.5	0.9	Conserved hypothetical protein
Rv0642c		+0.5	0.7	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv0587		+0.5	1.7	Conserved hypothetical integral membrane protein YrbE2A
Rv2558		+0.5	1.8	Conserved protein
Rv2042c		+0.5	1.7	Conserved protein
Rv2647		+0.5	0.8	Hypothetical protein
Rv1169c		+0.5	1.3	PE family protein. Possible lipase LipX.
Rv2434c		+0.5	2.2	Probable conserved transmembrane protein
Rv0660c		+0.5	2.8	Possible antitoxin MazE2
Rv2414c		+0.5	1.8	Conserved hypothetical protein
Rv1470		+0.5	2.8	Probable thioredoxin TrxA
Rv3177		+0.5	1.1	Possible peroxidase (non-haem peroxidase)
Rv1181		+0.5	3.1	Probable polyketide beta-ketoacyl synthase Pks4
Rv0868c		+0.5	1.2	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv2026c		+0.5	0.7	Universal stress protein family protein
Rv2599		+0.5	2.3	Probable conserved membrane protein
Rv2767c		+0.5	2.0	Possible membrane protein
Rv1054		+0.5	1.9	Probable integrase (fragment)
Rv3178		+0.5	1.9	Conserved hypothetical protein
Rv2259		+0.5	1.0	S-nitrosomycothiol reductase MscR
Rv1526c		+0.5	2.2	Probable glycosyltransferase
Rv0370c		+0.5	0.8	Possible oxidoreductase
Rv2427c		+0.5	1.6	Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase)
Rv0984		+0.5	1.6	Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD)
Rv1956		+0.5	3.9	Possible antitoxin HigA
Rv0310c		+0.5	1.3	Conserved protein
Rv0029		+0.5	1.9	Conserved hypothetical protein
Rv2437		+0.5	1.4	Conserved transmembrane protein
Rv1171		+0.5	1.7	Conserved hypothetical protein
Rv3647c		+0.5	0.6	Conserved hypothetical protein
Rv2033c		+0.5	1.8	Conserved hypothetical protein
Rv1616		+0.5	1.3	Conserved membrane protein
Rv1159A		+0.5	1.1	Unknown protein
Rv1608c		+0.5	1.9	Probable peroxidoxin BcpB
Rv1353c		+0.5	0.7	Probable transcriptional regulatory protein
Rv3431c		+0.5	2.7	Possible transposase (fragment)
Rv0918		+0.5	1.2	Conserved protein
Rv3229c		+0.5	1.2	Possible linoleoyl-CoA desaturase (delta(6)-desaturase)
Rv0250c		+0.5	1.4	Conserved protein
Rv1528c		+0.5	1.7	Probable conserved polyketide synthase associated protein PapA4
Rv0068		+0.5	1.9	Probable oxidoreductase
Rv2623		+0.5	1.4	Universal stress protein family protein TB31.7
Rv0964c		+0.5	0.8	Hypothetical protein
Rv3560c		+0.5	0.9	Probable acyl-CoA dehydrogenase FadE30
Rv3098c		+0.5	0.9	Hypothetical protein
Rv3820c		+0.5	3.8	Possible conserved polyketide synthase associated protein PapA2
Rv3692		+0.5	2.0	Probable methanol dehydrogenase transcriptional regulatory protein MoxR2
Rv1662		+0.5	1.7	Probable polyketide synthase Pks8
Rv1533		+0.5	1.6	Conserved protein
Rv2331		+0.5	1.5	Hypothetical protein
Rv0940c		+0.5	1.0	Possible oxidoreductase
Rv0249c		+0.5	1.3	Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase)
Rv3196		+0.5	1.5	Conserved hypothetical protein
Rv0578c		+0.5	2.3	PE-PGRS family protein PE_PGRS7
Rv3446c		+0.5	1.7	Hypothetical alanine and valine rich protein
Rv3416		+0.5	1.0	Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster.
Rv2277c		+0.5	0.6	Possible glycerolphosphodiesterase
Rv0474		+0.4	2.6	Probable transcriptional regulatory protein
Rv1930c		+0.4	0.5	Conserved hypothetical protein
Rv0590A		+0.4	1.2	Mce-family related protein
Rv2208		+0.4	1.0	Probable cobalamin 5'-phosphate synthase CobS
Rv0449c		+0.4	2.8	Conserved hypothetical protein
Rv3435c		+0.4	0.9	Probable conserved transmembrane protein
Rv2621c		+0.4	0.9	Possible transcriptional regulatory protein
Rv2929		+0.4	2.3	Hypothetical protein
Rv1957		+0.4	0.6	Hypothetical protein
Rv0450c		+0.4	2.9	Probable conserved transmembrane transport protein MmpL4
Rv2422		+0.4	1.7	Hypothetical protein
Rv3853		+0.4	2.1	Regulator of RNase E activity a RraA
Rv0356c		+0.4	1.0	Conserved protein
Rv1789		+0.4	3.0	PPE family protein PPE26
Rv3565		+0.4	0.8	Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase)
Rv1235		+0.4	1.4	Probable sugar-binding lipoprotein LpqY
Rv2622		+0.4	1.9	Possible methyltransferase (methylase)
Rv2858c		+0.4	2.4	Probable aldehyde dehydrogenase AldC
Rv0045c		+0.4	1.4	Possible hydrolase
Rv0762c		+0.4	1.4	Conserved hypothetical protein
Rv3413c		+0.4	0.6	Unknown alanine and proline rich protein
Rv2576c		+0.4	1.0	Possible conserved membrane protein
Rv0426c		+0.4	1.1	Possible transmembrane protein
Rv3912		+0.4	0.9	Hypothetical alanine rich protein
Rv2384		+0.4	1.2	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
Rv3829c		+0.4	2.7	Probable dehydrogenase
Rv3826		+0.4	2.2	Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Rv1372		+0.4	1.0	Conserved hypothetical protein
Rv1120c		+0.4	1.5	Conserved hypothetical protein
Rv1967		+0.4	1.4	Mce-family protein Mce3B

Specific Phenotypes

For 7 genes in this experiment

For stress Meropenem in Mycobacterium tuberculosis H37Rv

For stress Meropenem across organisms