Experiment set2S584 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Dimethyl Sulfoxide 1 vol%

200 most important genes:

  gene name fitness t score description  
Rv2335 -2.7 -2.2 Probable serine acetyltransferase CysE (sat) compare
Rv2331A -2.7 -1.4 Hypothetical protein compare
Rv0825c -2.0 -2.5 Conserved protein compare
Rv3249c -1.9 -1.5 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1420 -1.8 -3.4 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv1620c -1.8 -3.6 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv1159 -1.7 -2.2 Mannosyltransferase PimE compare
Rv1621c -1.6 -3.0 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv2694c -1.6 -2.8 Conserved protein compare
Rv0392c -1.5 -1.7 Probable membrane NADH dehydrogenase NdhA compare
Rv0452 -1.4 -2.9 Possible transcriptional regulatory protein compare
Rv0990c -1.4 -0.8 Hypothetical protein compare
Rv3222c -1.4 -1.5 Conserved hypothetical protein compare
Rv1745c -1.4 -5.5 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv1473A -1.4 -1.0 Possible transcriptional regulatory protein compare
Rv2912c -1.4 -2.6 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0949 -1.3 -0.8 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0200 -1.3 -2.2 Possible conserved transmembrane protein compare
Rv3655c -1.3 -1.7 Conserved hypothetical protein compare
Rv0328 -1.3 -2.2 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) compare
Rv2206 -1.3 -4.2 Probable conserved transmembrane protein compare
Rv3046c -1.2 -0.8 Conserved protein compare
Rv0379 -1.2 -0.9 Possible protein transport protein SecE2 compare
Rv2553c -1.2 -0.8 Probable conserved membrane protein compare
Rv1003 -1.2 -0.8 Conserved protein compare
Rv1798 -1.2 -1.0 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv2444c -1.2 -2.5 Possible ribonuclease E Rne compare
Rv0820 -1.2 -3.7 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3513c -1.2 -1.1 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0019c -1.2 -3.8 Conserved protein with FHA domain, FhaB compare
Rv2709 -1.2 -5.5 Probable conserved transmembrane protein compare
Rv1013 -1.2 -6.3 Putative polyketide synthase Pks16 compare
Rv0989c -1.2 -5.3 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv1421 -1.1 -3.0 Conserved protein compare
Rv0924c -1.1 -3.8 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv0093c -1.1 -1.3 Probable conserved membrane protein compare
Rv3335c -1.1 -2.4 Probable conserved integral membrane protein compare
Rv0018c -1.1 -2.5 Phosphoserine/threonine phosphatase PstP compare
Rv2222c -1.1 -2.3 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv1332 -1.1 -1.1 Probable transcriptional regulatory protein compare
Rv2581c -1.1 -1.0 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv2850c -1.1 -1.0 Possible magnesium chelatase compare
Rv0130 -1.1 -1.3 Probable 3-hydroxyl-thioester dehydratase compare
Rv3114 -1.1 -0.9 Conserved hypothetical protein compare
Rv3855 -1.0 -4.0 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv1414 -1.0 -0.7 Conserved hypothetical protein compare
Rv3102c -1.0 -2.1 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv2736c -1.0 -1.1 Regulatory protein RecX compare
Rv0930 -1.0 -4.1 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv2018 -1.0 -2.6 Conserved protein compare
Rv1010 -1.0 -1.4 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv2190c -1.0 -2.7 Conserved hypothetical protein compare
Rv3311 -1.0 -1.9 Conserved protein compare
Rv0184 -1.0 -3.2 Conserved hypothetical protein compare
Rv1450c -1.0 -1.5 PE-PGRS family protein PE_PGRS27 compare
Rv3050c -0.9 -2.3 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv2707 -0.9 -6.9 Probable conserved transmembrane alanine and leucine rich protein compare
Rv3542c -0.9 -1.7 Conserved hypothetical protein compare
Rv0655 -0.9 -2.5 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv3498c -0.9 -4.0 Mce-family protein Mce4B compare
Rv1259 -0.9 -0.9 Probable uracil DNA glycosylase, UdgB compare
Rv2732c -0.9 -2.1 Probable conserved transmembrane protein compare
Rv0734 -0.9 -2.3 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv3920c -0.9 -0.9 Conserved protein similar to jag protein compare
Rv3850 -0.9 -1.1 Conserved protein compare
Rv2812 -0.9 -1.7 Probable transposase compare
Rv3386 -0.9 -0.8 Possible transposase compare
Rv1897c -0.9 -1.6 Conserved hypothetical protein compare
Rv0928 -0.9 -2.4 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0344c -0.8 -2.0 Probable lipoprotein LpqJ compare
Rv3494c -0.8 -4.2 Mce-family protein Mce4F compare
Rv3405c -0.8 -1.0 Possible transcriptional regulatory protein compare
Rv1171 -0.8 -2.1 Conserved hypothetical protein compare
Rv3650 -0.8 -0.7 PE family protein PE33 compare
Rv2618 -0.8 -3.4 Conserved hypothetical protein compare
Rv1366A -0.8 -0.7 Conserved protein compare
Rv1364c -0.8 -3.8 Possible sigma factor regulatory protein compare
Rv3591c -0.8 -2.0 Possible hydrolase compare
Rv2317 -0.8 -0.7 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv0892 -0.8 -1.3 Probable monooxygenase compare
Rv0819 -0.8 -2.1 GCN5-related N-acetyltransferase, MshD compare
Rv3033 -0.8 -0.6 Unknown protein compare
Rv3496c -0.8 -5.3 Mce-family protein Mce4D compare
Rv3214 -0.8 -1.1 Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) compare
Rv0857 -0.8 -1.3 Conserved hypothetical protein compare
Rv3237c -0.8 -2.3 Conserved protein compare
Rv0563 -0.8 -1.8 Probable protease transmembrane protein heat shock protein HtpX compare
Rv3527 -0.8 -1.2 Hypothetical protein compare
Rv3693 -0.8 -1.4 Possible conserved membrane protein compare
Rv3818 -0.8 -2.6 Unknown protein compare
Rv1836c -0.8 -1.2 Conserved protein compare
Rv0549c -0.8 -0.8 Possible toxin VapC3 compare
Rv0760c -0.8 -1.2 Conserved protein compare
Rv1127c -0.8 -1.0 Probable pyruvate, phosphate dikinase PpdK compare
Rv2691 -0.8 -3.6 TRK system potassium uptake protein CeoB compare
Rv2668 -0.7 -1.9 Possible exported alanine and valine rich protein compare
Rv3204 -0.7 -0.6 Possible DNA-methyltransferase (modification methylase) compare
Rv0472c -0.7 -2.4 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0017c -0.7 -2.4 Probable cell division protein RodA compare
Rv3123 -0.7 -2.1 Hypothetical protein compare
Rv1112 -0.7 -0.9 Probable GTP binding protein compare
Rv1701 -0.7 -2.0 Probable integrase/recombinase compare
Rv0398c -0.7 -1.0 Possible secreted protein compare
Rv2588c -0.7 -1.3 Probable conserved membrane protein secretion factor YajC compare
Rv0078 -0.7 -1.2 Probable transcriptional regulatory protein compare
Rv2989 -0.7 -0.4 Probable transcriptional regulatory protein compare
Rv0056 -0.7 -1.6 50S ribosomal protein L9 RplI compare
Rv3600c -0.7 -2.5 Conserved protein compare
Rv2745c -0.7 -0.6 Transcriptional regulatory protein ClgR compare
Rv2302 -0.7 -0.5 Conserved protein compare
Rv2733c -0.7 -1.2 Conserved hypothetical alanine, arginine-rich protein compare
Rv0135c -0.7 -1.8 Possible transcriptional regulatory protein compare
Rv3140 -0.7 -1.8 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2799 -0.7 -3.8 Probable membrane protein compare
Rv3499c -0.7 -2.7 Mce-family protein Mce4A compare
Rv2272 -0.7 -0.4 Probable conserved transmembrane protein compare
Rv3817 -0.7 -1.1 Possible phosphotransferase compare
Rv1411c -0.7 -2.2 Conserved lipoprotein LprG compare
Rv3500c -0.7 -3.7 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv2696c -0.6 -1.2 Conserved alanine and glycine and valine rich protein compare
Rv0929 -0.6 -1.4 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv3304 -0.6 -1.9 Conserved protein compare
Rv3200c -0.6 -1.5 Possible transmembrane cation transporter compare
Rv0204c -0.6 -1.9 Probable conserved transmembrane protein compare
Rv1203c -0.6 -1.4 Hypothetical protein compare
Rv2500c -0.6 -0.8 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv3188 -0.6 -1.0 Conserved hypothetical protein compare
Rv3637 -0.6 -1.0 Possible transposase compare
Rv1691 -0.6 -1.2 Conserved hypothetical protein compare
Rv2132 -0.6 -1.3 Conserved hypothetical protein compare
Rv2374c -0.6 -1.4 Probable heat shock protein transcriptional repressor HrcA compare
Rv2662 -0.6 -1.7 Hypothetical protein compare
Rv3331 -0.6 -2.0 Probable sugar-transport integral membrane protein SugI compare
Rv3492c -0.6 -1.4 Conserved hypothetical Mce associated protein compare
Rv2809 -0.6 -1.6 Hypothetical protein compare
Rv3101c -0.6 -0.8 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0591 -0.6 -1.4 Mce-family protein Mce2C compare
Rv3497c -0.6 -3.3 Mce-family protein Mce4C compare
Rv0203 -0.6 -2.1 Possible exported protein compare
Rv0991c -0.6 -0.7 Conserved serine rich protein compare
Rv0586 -0.6 -1.4 Probable transcriptional regulatory protein Mce2R (GntR-family) compare
Rv3493c -0.6 -3.5 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv3340 -0.6 -2.1 Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase) compare
Rv3610c -0.6 -2.1 Membrane-bound protease FtsH (cell division protein) compare
Rv0531 -0.6 -0.8 Possible conserved membrane protein compare
Rv0381c -0.6 -3.6 Hypothetical protein compare
Rv2046 -0.6 -1.5 Probable lipoprotein LppI compare
Rv1950c -0.6 -1.3 Conserved hypothetical protein compare
Rv0954 -0.6 -3.0 Probable conserved transmembrane protein compare
Rv2468A -0.6 -1.9 Conserved protein compare
Rv2793c -0.6 -0.5 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv2344c -0.6 -2.3 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv2544 -0.6 -1.5 Probable conserved lipoprotein LppB compare
Rv2498c -0.6 -2.3 Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) compare
Rv3481c -0.6 -0.9 Probable integral membrane protein compare
Rv3289c -0.6 -2.4 Possible transmembrane protein compare
Rv1616 -0.6 -1.0 Conserved membrane protein compare
Rv0661c -0.6 -1.2 Possible toxin VapC7 compare
Rv2650c -0.6 -0.5 Possible PhiRv2 prophage protein compare
Rv0523c -0.6 -0.8 Conserved protein compare
Rv1244 -0.6 -2.3 Probable lipoprotein LpqZ compare
Rv0188 -0.6 -0.9 Probable conserved transmembrane protein compare
Rv0051 -0.6 -3.5 Probable conserved transmembrane protein compare
Rv1107c -0.6 -0.8 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv1072 -0.6 -0.7 Probable conserved transmembrane protein compare
Rv1528c -0.6 -2.3 Probable conserved polyketide synthase associated protein PapA4 compare
Rv2037c -0.6 -2.0 Conserved transmembrane protein compare
Rv2801c -0.6 -0.4 Toxin MazF9 compare
Rv0078B -0.6 -2.0 Conserved protein compare
Rv2154c -0.6 -1.2 FtsW-like protein FtsW compare
Rv1624c -0.6 -1.8 Probable conserved membrane protein compare
Rv2240c -0.6 -1.0 Unknown protein compare
Rv0612 -0.6 -1.2 Conserved hypothetical protein compare
Rv0852 -0.5 -2.0 Possible fatty-acid-CoA ligase FadD16 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv3516 -0.5 -1.4 Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1495 -0.5 -0.6 Possible toxin MazF4 compare
Rv0202c -0.5 -3.0 Probable conserved transmembrane transport protein MmpL11 compare
Rv0912 -0.5 -0.9 Probable conserved transmembrane protein compare
Rv1335 -0.5 -2.8 Sulfur carrier protein CysO compare
Rv1068c -0.5 -1.7 PE-PGRS family protein PE_PGRS20 compare
Rv3016 -0.5 -2.5 Probable lipoprotein LpqA compare
Rv1537 -0.5 -1.6 Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) compare
Rv3167c -0.5 -1.3 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv2173 -0.5 -1.3 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv0749 -0.5 -1.5 Possible toxin VapC31. Contains PIN domain. compare
Rv2429 -0.5 -1.0 Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) compare
Rv1911c -0.5 -1.6 Probable lipoprotein LppC compare
Rv1004c -0.5 -1.0 Probable membrane protein compare
Rv0273c -0.5 -1.8 Possible transcriptional regulatory protein compare
Rv2492 -0.5 -1.1 Hypothetical protein compare
Rv0309 -0.5 -2.2 Possible conserved exported protein compare
Rv0966c -0.5 -1.5 Conserved protein compare
Rv0689c -0.5 -1.2 Hypothetical protein compare
Rv3748 -0.5 -0.8 Conserved hypothetical protein compare
Rv3146 -0.5 -2.5 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) compare
Rv0394c -0.5 -2.1 Possible secreted protein compare
Rv3093c -0.5 -1.8 Hypothetical oxidoreductase compare
Rv3395A -0.5 -2.9 Probable membrane protein compare
Rv2680 -0.5 -0.6 Conserved protein compare
Rv0470c -0.5 -1.2 Mycolic acid synthase PcaA (cyclopropane synthase) compare


Specific Phenotypes

For 1 genes in this experiment

For stress Dimethyl Sulfoxide in Mycobacterium tuberculosis H37Rv

For stress Dimethyl Sulfoxide across organisms