Experiment set2IT057 for Sinorhizobium meliloti 1021

Compare to:

LB with D-Cycloserine 0.05 mg/ml

200 most detrimental genes:

  gene name fitness t score description  
SMc02659 +8.2 35.7 GTP pyrophosphokinase (ATP:GTP 3'-pyrophosphotransferase) protein compare
SMc00647 +7.0 30.4 ribosomal large subunit pseudouridine synthase compare
SMc03069 +7.0 16.9 6-phosphogluconolactonase compare
SMc00349 +6.7 49.8 GTP-binding protein LepA compare
SMc04003 +6.7 16.6 50S ribosomal protein L36 compare
SMc03826 +6.2 29.0 argininosuccinate synthase compare
SMc02695 +5.9 36.1 GTP-dependent nucleic acid-binding protein EngD compare
SMc02137 +5.9 22.3 ornithine carbamoyltransferase compare
SMc02112 +5.6 35.0 hypothetical protein compare
SMc00565 +5.6 13.8 50S ribosomal protein L9 compare
SMc00566 +5.5 10.6 hypothetical protein compare
SMc00150 +5.3 48.1 hypothetical protein compare
SMc01206 +5.3 14.6 queuine tRNA-ribosyltransferase compare
SMc00711 +5.1 30.1 cyclohexadienyl dehydrogenase compare
SMc00131 +5.0 35.7 transcriptional regulator compare
SMc00427 +4.8 15.4 peptide chain release factor RF-3 protein compare
SMc01124 +4.7 12.9 PII uridylyl-transferase compare
SMc03900 +4.6 38.5 cyclic beta-1,2-glucan ABc transporter compare
SMc01099 +4.5 12.8 tRNA pseudouridine synthase A compare
SMc04382 +4.5 34.1 beta-(1,2)-glucan production associated transmembrane protein compare
SMc03863 +4.2 4.9 50S ribosomal protein L19 compare
SMc01215 +4.1 18.1 carbamoyl phosphate synthase large subunit compare
SMc01275 +4.1 8.7 ribosomal large subunit pseudouridine synthase C protein compare
SMc01569 +4.0 13.7 carbamoyl phosphate synthase small subunit compare
SMc01801 +3.9 7.1 N-acetylglutamylphosphate reductase (EC 1.2.1.38) (from data) compare
SMc00495 +3.8 17.0 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
SMc04454 +3.8 21.0 ABC transporter ATP-binding protein compare
SMc02050 +3.7 13.4 trigger factor compare
SMc02138 +3.7 8.4 acetylornithine transaminase compare
SMc04094 +3.6 11.2 hypothetical protein compare
SMc00458 +3.6 26.7 transcriptional regulator compare
SMc03855 +3.6 6.7 hypothetical protein compare
SMc02367 +3.6 19.9 sensor histidine kinase transmembrane protein compare
SMc02365 +3.5 9.9 protease precursor protein compare
SMc02366 +3.4 28.4 transcriptional regulator compare
SMc02055 +3.4 7.0 phytoene synthase compare
SMc00419 +3.3 13.4 glutathione synthetase compare
SMc00321 +3.3 15.7 tRNA pseudouridine synthase B compare
SMc01726 +3.2 12.3 acetylglutamate kinase compare
SMc02058 +3.2 10.2 YAJC protein compare
SMc00169 +3.2 25.6 malic enzyme compare
SMc02558 +3.1 11.0 hypothetical protein compare
SMc00320 +3.1 6.8 ribosome-binding factor A compare
SMc00482 +3.1 19.6 hypothetical protein compare
SMc02757 +2.9 3.7 hypothetical protein compare
SMc01858 +2.8 3.3 S-adenosyl-methyltransferase MraW compare
SMc01439 +2.7 15.7 hypothetical protein compare
SMc04001 +2.7 4.0 phosphoribosylaminoimidazole carboxylase catalytic subunit protein compare
SMc01207 +2.7 5.5 S-adenosylmethionine--tRNA ribosyltransferase-isomerase compare
SMc03159 +2.6 6.6 ABC transporter ATP-binding protein compare
SMc03930 +2.6 5.2 sarcosine oxidase subunit gamma compare
SM_b20146 +2.6 5.7 pyridoxal phosphate biosynthetic protein compare
SMc00017 +2.6 5.6 homoserine kinase compare
SMc00129 +2.6 14.1 sensor histidine kinase compare
SMc00710 +2.6 6.2 histidinol-phosphate aminotransferase compare
SM_b20613 +2.6 11.1 C4-dicarboxylate transport transcriptional regulator compare
SMc03157 +2.6 11.7 outer membrane lipoprotein transmembrane compare
SMc00761 +2.5 18.1 oxidoreductase compare
SMc02503 +2.5 11.9 hypothetical protein compare
SMc02095 +2.5 9.8 hypothetical protein compare
SMc03933 +2.5 19.0 sarcosine oxidase subunit B protein compare
SMc02166 +2.5 15.4 dihydroorotase compare
SMc04235 +2.5 13.6 tRNA-dihydrouridine synthase A compare
SMc01852 +2.4 15.9 pyrophosphate--fructose-6-phosphate 1-phosphotransferase compare
SMc01613 +2.4 13.1 ribose-5-phosphate isomerase B compare
SMc00727 +2.4 13.2 3-hydroxybutyryl-CoA dehydrogenase compare
SMc03158 +2.3 8.1 ABC transporter permease compare
SMa2020 +2.3 7.7 Transcriptional regulator compare
SMc02245 +2.3 5.4 dihydroorotate dehydrogenase 2 compare
SMc01907 +2.3 17.9 hypothetical protein compare
SMc00403 +2.3 12.2 NOL1/NOP2/SUN family signature protein compare
SMc03932 +2.3 8.9 sarcosine oxidase subunit delta compare
SMc00648 +2.3 12.4 hypothetical protein compare
SMc00522 +2.3 16.1 ATP-dependent RNA helicase compare
SMc04385 +2.3 10.0 L-2-aminoadipate semialdehyde dehydrogenase (EC 1.2.1.31) (from data) compare
SMc00998 +2.3 15.1 signal peptide protein compare
SMc02755 +2.2 8.5 S-adenosyl-L-homocysteine hydrolase compare
SMc00070 +2.2 11.1 signal peptide protein compare
SM_b21397 +2.2 1.9 hypothetical protein compare
SMc03996 +2.2 7.7 thiamine-phosphate pyrophosphorylase compare
SMc03931 +2.2 16.2 sarcosine oxidase subunit alpha compare
SMc01222 +2.1 6.2 lipopolysaccharide core biosynthesis glycosyl transferase compare
SMc04000 +2.1 2.3 hypothetical protein compare
SMc03111 +2.1 10.2 mannose 6-phosphate isomerase (EC 5.3.1.8) (from data) compare
SMc01223 +2.0 2.7 transcriptional regulator compare
SMc02497 +2.0 3.5 hypothetical protein compare
SMc02246 +2.0 3.1 hypothetical protein compare
SMc01120 +2.0 5.9 hypothetical protein compare
SMc02309 +1.9 9.0 arsenate reductase compare
SMc03973 +1.9 6.1 hypothetical protein compare
SM_b20684 +1.9 14.0 hypothetical protein compare
SMc00329 +1.9 7.6 iron response regulator protein compare
SMc00009 +1.8 6.3 cytochrome C oxidase subunit II protein compare
SM_b21192 +1.8 11.4 fructose-1,6-bisphosphate aldolase compare
SMa1921 +1.8 4.9 hypothetical protein compare
SMc00450 +1.8 3.4 protoheme IX farnesyltransferase compare
SMc02714 +1.8 3.3 hypothetical protein compare
SMc01256 +1.7 11.6 L-serine dehydratase compare
SMc01131 +1.7 5.3 hypothetical protein compare
SMc01768 +1.7 11.8 transcriptional regulator compare
SMc01139 +1.6 6.6 RNA polymerase factor sigma-54 compare
SMc00325 +1.6 8.7 hypothetical protein compare
SM_b20131 +1.6 1.2 oxidoreductase compare
SMc00877 +1.6 10.3 transcriptional regulator compare
SMc03792 +1.6 1.4 hypothetical protein compare
SMc00904 +1.5 5.4 hypothetical protein compare
SMc01885 +1.5 8.7 aminopeptidase P protein compare
SMc02713 +1.5 3.8 RNA polymerase sigma-E factor (sigma-24) protein compare
SM_b21266 +1.5 7.0 hypothetical protein compare
SMc02793 +1.4 7.1 hypothetical protein compare
SMc00622 +1.4 7.5 ribonuclease D protein compare
SMc02056 +1.4 2.6 hypothetical protein compare
SM_b20751 +1.4 2.0 3-hydroxyisobutyrate dehydrogenase compare
SMc01193 +1.4 10.4 hypothetical protein compare
SMa0753 +1.4 1.3 hypothetical protein compare
SM_b21265 +1.4 5.8 glycosyltransferase compare
SMc02407 +1.4 4.7 hypothetical protein compare
SMc04383 +1.4 6.3 putative hydrolase, required for lysine catabolism (from data) compare
SMc02640 +1.4 6.2 UDP-glucuronic acid epimerase compare
SMc02766 +1.4 10.4 tryptophan synthase subunit beta compare
SMc02136 +1.3 5.9 Hsp33-like chaperonin compare
SM_b20290 +1.3 3.2 transcriptional regulator compare
SMc01698 +1.3 7.0 oxidoreductase compare
SMc02765 +1.3 8.1 tryptophan synthase subunit alpha compare
SM_b21170 +1.3 6.5 guanylate kinase compare
SMc01834 +1.3 2.5 hypothetical protein compare
SMc01041 +1.3 5.1 NIFR3-like protein compare
SMc01116 +1.3 4.8 acyltransferase transmembrane protein compare
SMc00075 +1.3 3.9 ribosomal-protein-alanine acetyltransferase compare
SMc03880 +1.3 6.4 hypothetical protein compare
SM_b20611 +1.3 8.4 C4-dicarboxylate transporter DctA compare
SM_b21491 +1.2 8.3 hypothetical protein compare
SMc02181 +1.2 8.4 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase compare
SMc00973 +1.2 3.0 hypothetical protein compare
SMc02504 +1.2 5.0 transcriptional regulator compare
SM_b21181 +1.2 7.4 glutaryl-CoA dehydrogenase compare
SM_b21372 +1.2 7.4 LacI family transcriptional regulator compare
SMc03153 +1.2 4.0 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase compare
SMc02853 +1.2 6.1 hypothetical protein compare
SMc00026 +1.2 5.0 hypothetical protein compare
SMc00827 +1.2 7.5 transport transmembrane protein compare
SMc03849 +1.2 0.9 heme exporter C (cytochrome C-type biogenesis protein) transmembrane compare
SMc00650 +1.2 1.0 hypothetical protein compare
SM_b20294 +1.2 1.8 transcriptional regulator NanR compare
SMc02057 +1.2 5.2 preprotein translocase subunit SecD/SecF compare
SMc02577 +1.1 6.9 ATP-dependent protease ATP-binding subunit HslU compare
SMc00064 +1.1 3.9 hypothetical protein compare
SM_b21256 +1.1 7.4 nucleotide sugar oxidase compare
SM_b21253 +1.1 5.2 hypothetical protein compare
SM_b21208 +1.1 2.4 TetR family transcriptional regulator compare
SMa0222 +1.1 1.5 GntR family transcriptional regulator compare
SMc00012 +1.1 1.7 cytochrome C oxidase assembly protein compare
SM_b21374 +1.1 2.9 tagatose kinase (EC 2.7.1.101) (from data) compare
SMc04441 +1.1 1.4 hypothetical protein compare
SMc01987 +1.1 8.1 dehydrogenase compare
SMc00554 +1.1 3.1 amidophosphoribosyltransferase compare
SMc01024 +1.1 1.6 preprotein translocase subunit SecG compare
SMc00302 +1.1 3.8 hypothetical protein compare
SM_b20261 +1.1 1.2 malate dehydrogenase compare
SM_b21286 +1.1 4.8 xanthine dehydrogenase compare
SMc02575 +1.1 5.7 ATP-dependent protease peptidase subunit compare
SMa1171 +1.1 2.5 hypothetical protein compare
SM_b20757 +1.1 5.6 methylmalonyl-CoA mutase compare
SMc01412 +1.1 1.5 hypothetical protein compare
SMc00093 +1.0 7.4 choline dehydrogenase compare
SMa0833 +1.0 1.6 hypothetical protein compare
SMc00788 +1.0 2.6 peptide ABC transporter permease compare
SMc04224 +1.0 1.1 hypothetical protein compare
SMc02478 +1.0 5.2 hypothetical protein compare
SMc00288 +1.0 7.2 signal peptide protein compare
SM_b20218 +1.0 3.0 sensor histidine kinase compare
SM_b20369 +1.0 1.7 hypothetical protein compare
SMc04002 +1.0 3.0 phosphoribosylaminoimidazole carboxylase ATPase subunit compare
SMc02384 +1.0 4.1 glycosyltransferase transmembrane protein compare
SMc00347 +1.0 1.6 nucleoside diphosphate kinase regulator compare
SM_b21428 +1.0 4.2 dTDP-4-dehydrorhamnose 3,5-epimerase compare
SM_b20043 +1.0 6.9 hypothetical protein compare
SM_b20145 +1.0 2.6 hypothetical protein compare
SMa2034 +1.0 1.8 hypothetical protein compare
SMc01930 +1.0 1.7 hypothetical protein compare
SMc01108 +1.0 4.2 tRNA (guanine-N(7)-)-methyltransferase compare
SM_b20815 +1.0 1.2 outer membrane protein assembly protein compare
SMc03839 +1.0 1.6 hypothetical protein compare
SMc04263 +1.0 6.9 amino acid carrier transmembrane protein compare
SMc00576 +1.0 1.6 hypothetical protein compare
SMa0834 +1.0 4.7 FdxB ferredoxin III compare
SMc00709 +0.9 3.7 hypothetical protein compare
SM_b21264 +0.9 6.0 hypothetical protein compare
SMa2253 +0.9 1.3 hypothetical protein compare
SMc00191 +0.9 1.3 hypothetical protein compare
SMc00061 +0.9 2.9 hypothetical protein compare
SMc02383 +0.9 5.7 hypothetical protein compare
SMc01160 +0.9 2.2 hypothetical protein compare
SMc01471 +0.9 2.5 cytochrome C oxidase assembly factor transmembrane protein compare
SMc01107 +0.9 3.9 hypothetical protein compare
SMa0126 +0.9 1.0 CspA8 Cold shock family protein compare
SMc04450 +0.9 7.4 transcription-repair coupling factor compare
SMa5036 +0.9 3.0 hypothetical protein compare
SMc04246 +0.9 1.6 transmembrane signal peptide protein compare
SMc03156 +0.9 4.0 hypothetical protein compare


Specific Phenotypes

For 14 genes in this experiment

For stress D-Cycloserine in Sinorhizobium meliloti 1021

For stress D-Cycloserine across organisms