Experiment set2IT048 for Shewanella loihica PV-4

Compare to:

LB with Polymyxin B sulfate 20 mg/ml

200 most detrimental genes:

  gene name fitness t score description  
Shew_3695 +4.2 6.4 cytidyltransferase-like protein (RefSeq) compare
Shew_1657 sucC +3.4 3.8 succinyl-CoA synthetase subunit beta (RefSeq) compare
Shew_3696 +3.4 11.0 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (RefSeq) compare
Shew_2049 +3.3 7.5 DNA-binding transcriptional regulator HexR (RefSeq) compare
Shew_2895 +3.3 8.7 2-dehydropantoate 2-reductase (RefSeq) compare
Shew_2572 +3.2 12.3 enoyl-CoA hydratase/isomerase (RefSeq) compare
Shew_3432 pdhR +2.9 5.4 transcriptional regulator PdhR (RefSeq) compare
Shew_3377 +2.9 1.1 twin-arginine translocation protein, TatB subunit (RefSeq) compare
Shew_3273 +2.8 10.9 hypothetical protein (RefSeq) compare
Shew_3697 +2.6 13.3 glycosyl transferase family protein (RefSeq) compare
Shew_0570 +2.6 2.0 ubiquinol-cytochrome c reductase, iron-sulfur subunit (RefSeq) compare
Shew_3431 aceE +2.5 14.6 pyruvate dehydrogenase subunit E1 (RefSeq) compare
Shew_1602 +2.4 3.9 malonyl CoA-acyl carrier protein transacylase (RefSeq) compare
Shew_3660 +2.3 18.3 glutathione reductase (RefSeq) compare
Shew_3694 +2.2 11.0 ADP-L-glycero-D-manno-heptose-6-epimerase (RefSeq) compare
Shew_3693 +2.1 11.8 ADP-heptose--lipooligosaccharide heptosyltransferase III (RefSeq) compare
Shew_3430 +2.1 3.4 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase (RefSeq) compare
Shew_1227 +2.1 2.4 glutamate--cysteine ligase (RefSeq) compare
Shew_1224 +2.0 13.4 sodium:dicarboxylate symporter (RefSeq) compare
Shew_2327 +2.0 1.1 hypothetical protein (RefSeq) compare
Shew_1287 +2.0 4.6 hypothetical protein (RefSeq) compare
Shew_2906 +2.0 1.8 hypothetical protein (RefSeq) compare
Shew_0867 +1.9 2.1 malate dehydrogenase (RefSeq) compare
Shew_3295 +1.9 9.4 AFG1 family ATPase (RefSeq) compare
Shew_2642 +1.9 3.5 flavodoxin (RefSeq) compare
Shew_3378 +1.9 1.8 Sec-independent protein translocase, TatC subunit (RefSeq) compare
Shew_2194 +1.9 1.2 hypothetical protein (RefSeq) compare
Shew_1985 +1.7 3.5 cytochrome c oxidase, cbb3-type, subunit I (RefSeq) compare
Shew_1731 +1.7 1.0 histidine triad (HIT) protein (RefSeq) compare
Shew_1341 +1.7 3.5 anti-sigma-28 factor, FlgM (RefSeq) compare
Shew_3388 +1.6 0.9 hypothetical protein (RefSeq) compare
Shew_2573 +1.6 6.0 carbamoyl-phosphate synthase L chain, ATP-binding (RefSeq) compare
Shew_1865 +1.6 4.3 phosphoenolpyruvate-protein phosphotransferase (RefSeq) compare
Shew_0137 +1.6 5.3 DNA-binding transcriptional repressor FabR (RefSeq) compare
Shew_1531 grxA +1.6 3.1 glutaredoxin 1 (RefSeq) compare
Shew_2228 +1.6 7.4 inosine kinase (RefSeq) compare
Shew_1932 cls +1.6 3.9 cardiolipin synthetase (RefSeq) compare
Shew_2907 +1.5 5.0 invasion gene expression up-regulator, SirB (RefSeq) compare
Shew_3786 +1.5 1.4 hypothetical protein (RefSeq) compare
Shew_1987 +1.5 3.5 Cbb3-type cytochrome oxidase component (RefSeq) compare
Shew_3708 +1.4 9.0 TetR family transcriptional regulator (RefSeq) compare
Shew_3500 +1.4 2.5 putative endoribonuclease L-PSP (RefSeq) compare
Shew_1001 +1.4 1.8 putative glycerol-3-phosphate acyltransferase PlsY (RefSeq) compare
Shew_1590 +1.4 0.9 2OG-Fe(II) oxygenase (RefSeq) compare
Shew_2571 +1.4 5.9 propionyl-CoA carboxylase (RefSeq) compare
Shew_3698 +1.4 5.3 glycosyl transferase family protein (RefSeq) compare
Shew_1819 +1.4 2.6 GntR family transcriptional regulator (RefSeq) compare
Shew_1183 +1.4 5.5 putative ABC transporter ATP-binding protein (RefSeq) compare
Shew_2153 +1.3 1.4 LysR family transcriptional regulator (RefSeq) compare
Shew_1992 +1.3 3.1 hypothetical protein (RefSeq) compare
Shew_2646 +1.3 0.9 hypothetical protein (RefSeq) compare
Shew_2406 +1.3 2.0 AraC family transcriptional regulator (RefSeq) compare
Shew_0827 +1.3 1.2 peptidyl-prolyl cis-trans isomerase, cyclophilin type (RefSeq) compare
Shew_3681 +1.3 9.7 integral membrane sensor signal transduction histidine kinase (RefSeq) compare
Shew_3682 +1.3 8.4 two component, sigma54 specific, Fis family transcriptional regulator (RefSeq) compare
Shew_1092 +1.3 4.2 amino acid carrier protein (RefSeq) compare
Shew_0343 +1.3 1.3 hypothetical protein (RefSeq) compare
Shew_0895 +1.3 8.3 integral membrane sensor signal transduction histidine kinase (RefSeq) conserved
Shew_3411 zntR +1.2 5.4 zinc-responsive transcriptional regulator (RefSeq) compare
Shew_0081 +1.2 3.8 two component transcriptional regulator (RefSeq) compare
Shew_3632 +1.2 6.8 sulfatase (RefSeq) conserved
Shew_1011 +1.2 4.7 citrate transporter (RefSeq) compare
Shew_2320 +1.2 4.9 RNA methyltransferase (RefSeq) compare
Shew_1867 +1.2 2.3 hypothetical protein (RefSeq) compare
Shew_0795 +1.2 1.4 hypothetical protein (RefSeq) compare
Shew_3710 tdh +1.2 3.8 L-threonine 3-dehydrogenase (RefSeq) compare
Shew_2458 +1.2 0.9 glutathione S-transferase domain-containing protein (RefSeq) compare
Shew_1397 +1.2 2.0 amino acid/peptide transporter (RefSeq) compare
Shew_0896 +1.2 6.6 two component transcriptional regulator (RefSeq) conserved
Shew_3131 +1.2 4.4 poly(A) polymerase (RefSeq) compare
Shew_0462 +1.2 0.9 hypothetical protein (RefSeq) compare
Shew_1920 +1.2 3.5 alpha/beta hydrolase fold (RefSeq) compare
Shew_3305 +1.1 2.6 CaCA family Na(+)/Ca(+) antiporter (RefSeq) compare
Shew_1769 +1.1 1.3 NapD family protein (RefSeq) compare
Shew_1575 +1.1 4.5 uridine kinase (RefSeq) compare
Shew_3709 +1.1 7.3 2-amino-3-ketobutyrate coenzyme A ligase (RefSeq) compare
Shew_0738 +1.1 0.9 NTPase (RefSeq) compare
Shew_3225 +1.1 3.5 glutathione synthetase (RefSeq) compare
Shew_0722 +1.1 0.9 hypothetical protein (RefSeq) compare
Shew_1202 +1.1 5.3 (p)ppGpp synthetase I, SpoT/RelA (RefSeq) compare
Shew_0728 +1.1 4.5 dihydroorotase (RefSeq) compare
Shew_2584 +1.1 6.8 electron transfer flavoprotein beta-subunit (RefSeq) compare
Shew_2155 +1.1 2.2 4-hydroxyphenylpyruvate dioxygenase (RefSeq) compare
Shew_1510 +1.0 1.7 peptidase M28 (RefSeq) compare
Shew_3064 gcvT +1.0 6.5 glycine cleavage system aminomethyltransferase T (RefSeq) compare
Shew_0763 +1.0 3.8 putative PAS/PAC sensor protein (RefSeq) compare
Shew_3483 dut +1.0 0.8 deoxyuridine 5'-triphosphate nucleotidohydrolase (RefSeq) compare
Shew_2544 +1.0 1.7 phosphoglucomutase/phosphomannomutase alpha/beta/subunit (RefSeq) compare
Shew_3442 +1.0 1.9 hypothetical protein (RefSeq) compare
Shew_3537 +1.0 1.8 hypothetical protein (RefSeq) compare
Shew_0086 +1.0 6.7 electron-transferring-flavoproteindehydrogenase (RefSeq) compare
Shew_1810 +1.0 2.7 dihydroorotate dehydrogenase 2 (RefSeq) compare
Shew_1264 +1.0 1.3 UvrD/REP helicase (RefSeq) compare
Shew_1574 +1.0 3.1 ATP-binding Mrp/Nbp35 family protein (RefSeq) compare
Shew_2569 +0.9 2.6 MerR family transcriptional regulator (RefSeq) compare
Shew_1990 +0.9 1.5 heavy metal translocating P-type ATPase (RefSeq) compare
Shew_1445 +0.9 0.6 dicarboxylate TRAP transporter (succinate, fumarate, L-malate, and alpha-ketoglutarate), small permease component (from data) compare
Shew_0430 +0.9 1.7 histone family protein DNA-binding protein (RefSeq) compare
Shew_0620 +0.9 1.2 ion transport 2 domain-containing protein (RefSeq) compare
Shew_3029 +0.9 1.6 hypothetical protein (RefSeq) compare
Shew_0127 +0.9 2.5 LexA repressor (RefSeq) compare
Shew_0698 +0.9 4.6 Na+/H+ antiporter NhaC (RefSeq) compare
Shew_2884 +0.9 1.6 glycine cleavage system regulatory protein-like protein (RefSeq) compare
Shew_1110 +0.9 2.8 nitrogen regulatory protein P-II (RefSeq) compare
Shew_3262 +0.9 0.7 hypothetical protein (RefSeq) compare
Shew_0860 +0.9 1.4 hypothetical protein (RefSeq) compare
Shew_2444 +0.9 1.1 hypothetical protein (RefSeq) compare
Shew_2644 +0.9 1.8 hypothetical protein (RefSeq) compare
Shew_2367 +0.9 1.1 hypothetical protein (RefSeq) compare
Shew_2278 +0.9 0.9 LysR family transcriptional regulator (RefSeq) compare
Shew_2008 +0.9 1.0 short-chain dehydrogenase/reductase SDR (RefSeq) compare
Shew_2435 +0.9 3.6 sodium/proline symporter (RefSeq) compare
Shew_1137 +0.9 2.0 alanine racemase domain-containing protein (RefSeq) compare
Shew_2175 nhaB +0.9 3.1 sodium/proton antiporter (RefSeq) compare
Shew_0897 +0.8 1.5 hypothetical protein (RefSeq) compare
Shew_3518 +0.8 2.6 thioesterase superfamily protein (RefSeq) compare
Shew_0057 +0.8 1.2 cytoplasmic chaperone TorD family protein (RefSeq) compare
Shew_0583 +0.8 0.9 two component transcriptional regulator (RefSeq) compare
Shew_0647 +0.8 1.2 hypothetical protein (RefSeq) compare
Shew_0500 +0.8 1.8 hypothetical protein (RefSeq) compare
Shew_3820 +0.8 2.2 hypothetical protein (RefSeq) compare
Shew_0775 +0.8 3.5 TetR family transcriptional regulator (RefSeq) compare
Shew_2121 +0.8 1.4 diguanylate cyclase (RefSeq) compare
Shew_1395 +0.8 3.3 VacJ family lipoprotein (RefSeq) compare
Shew_1477 +0.8 2.2 anti-ECFsigma factor, ChrR (RefSeq) compare
Shew_0821 +0.8 1.1 mitomycin resistance protein (RefSeq) compare
Shew_3304 +0.8 1.3 ABC transporter-related protein (RefSeq) compare
Shew_0480 +0.8 0.9 Sel1 domain-containing protein (RefSeq) compare
Shew_0220 +0.8 2.9 phosphoglycolate phosphatase (RefSeq) compare
Shew_3267 +0.8 2.5 sodium/hydrogen exchanger (RefSeq) compare
Shew_0326 +0.8 1.9 HAD family hydrolase (RefSeq) compare
Shew_0226 +0.8 1.7 hypothetical protein (RefSeq) compare
Shew_0788 +0.8 2.2 dienelactone hydrolase (RefSeq) compare
Shew_0055 +0.8 4.7 hypothetical protein (RefSeq) compare
Shew_1732 +0.8 1.7 hypothetical protein (RefSeq) compare
Shew_1432 +0.7 0.9 ferredoxin-type protein NapF (RefSeq) compare
Shew_1186 +0.7 1.4 transcriptional regulator NrdR (RefSeq) compare
Shew_1555 +0.7 1.2 Glu/Leu/Phe/Val dehydrogenase, dimerisation region (RefSeq) compare
Shew_1774 +0.7 1.0 excinuclease ATPase subunit (RefSeq) compare
Shew_0401 +0.7 1.7 MSHA biogenesis protein MshP (RefSeq) compare
Shew_0973 +0.7 2.4 extracellular solute-binding protein (RefSeq) compare
Shew_0340 +0.7 2.0 Ppx/GppA phosphatase (RefSeq) compare
Shew_1951 +0.7 1.2 aromatic amino acid aminotransferase (RefSeq) compare
Shew_3664 +0.7 4.6 alpha-L-glutamate ligase (RefSeq) compare
Shew_3063 +0.7 0.9 glycine cleavage system protein H (RefSeq) compare
Shew_0956 +0.7 2.1 peptidylprolyl isomerase, FKBP-type (RefSeq) compare
Shew_3542 +0.7 2.4 D-tyrosyl-tRNA deacylase (RefSeq) compare
Shew_1782 +0.7 3.9 MarR family transcriptional regulator (RefSeq) compare
Shew_0839 +0.7 1.8 WD-40 repeat-containing protein (RefSeq) compare
Shew_3673 +0.7 2.5 hypothetical protein (RefSeq) compare
Shew_3353 +0.7 2.1 hypothetical protein (RefSeq) compare
Shew_3684 +0.7 3.5 binding-protein-dependent transport systems inner membrane component (RefSeq) compare
Shew_2706 +0.7 1.6 Na(+)-translocating NADH-quinone reductase subunit D (RefSeq) compare
Shew_0718 +0.7 1.7 cob(I)yrinic acid a,c-diamide adenosyltransferase (RefSeq) compare
Shew_R0049 +0.7 3.7 tRNA-Pro (RefSeq) compare
Shew_1820 prpB +0.7 2.2 2-methylisocitrate lyase (RefSeq) compare
Shew_1357 +0.7 2.7 flagellin domain-containing protein (RefSeq) compare
Shew_1518 +0.7 0.6 hypothetical protein (RefSeq) compare
Shew_3302 +0.7 0.6 hypothetical protein (RefSeq) compare
Shew_0833 +0.7 0.6 hypoxanthine-guanine phosphoribosyltransferase (RefSeq) compare
Shew_1133 +0.7 3.1 hypothetical protein (RefSeq) compare
Shew_0410 +0.7 2.2 peptidase U62, modulator of DNA gyrase (RefSeq) compare
Shew_3197 +0.7 1.9 hypothetical protein (RefSeq) compare
Shew_0885 djlA +0.7 0.7 DNA-J like membrane chaperone protein (RefSeq) compare
Shew_2806 +0.7 0.8 GCN5-related N-acetyltransferase (RefSeq) compare
Shew_0856 +0.7 1.8 phosphoglycerate mutase (RefSeq) compare
Shew_1082 +0.7 0.9 hypothetical protein (RefSeq) compare
Shew_3487 pyrE +0.7 1.6 orotate phosphoribosyltransferase (RefSeq) compare
Shew_1571 +0.7 2.4 hypothetical protein (RefSeq) compare
Shew_1230 +0.7 1.9 phosphoribosylaminoimidazole carboxylase, catalytic subunit (RefSeq) compare
Shew_1453 +0.7 2.5 methylated-DNA--protein-cysteinemethyltransferase (RefSeq) compare
Shew_2188 +0.7 2.3 long-chain-fatty-acid--CoA ligase (RefSeq) compare
Shew_2724 +0.7 2.1 indigoidine synthase A family protein (RefSeq) compare
Shew_1811 +0.7 2.8 hypothetical protein (RefSeq) compare
Shew_3517 +0.7 3.7 histidine ammonia-lyase (RefSeq) compare
Shew_2189 +0.7 1.7 alpha/beta hydrolase fold (RefSeq) compare
Shew_1163 +0.7 0.6 RND family efflux transporter MFP subunit (RefSeq) compare
Shew_1023 +0.7 1.1 hypothetical protein (RefSeq) compare
Shew_0274 +0.7 3.2 hypothetical protein (RefSeq) compare
Shew_2498 +0.7 0.5 extracellular solute-binding protein (RefSeq) compare
Shew_2403 +0.7 0.5 arylesterase (RefSeq) compare
Shew_1776 +0.6 1.6 acetolactate synthase 3 catalytic subunit (RefSeq) compare
Shew_0528 +0.6 1.8 Sel1 domain-containing protein (RefSeq) compare
Shew_3685 +0.6 2.4 ABC transporter-related protein (RefSeq) compare
Shew_0261 +0.6 0.4 hypothetical protein (RefSeq) compare
Shew_0888 +0.6 2.3 no description compare
Shew_0468 +0.6 3.5 LysR family transcriptional regulator (RefSeq) compare
Shew_1483 +0.6 1.3 hypothetical protein (RefSeq) compare
Shew_2652 +0.6 1.7 hypothetical protein (RefSeq) compare
Shew_3167 +0.6 1.4 hypothetical protein (RefSeq) compare
Shew_1519 +0.6 1.2 hypothetical protein (RefSeq) compare
Shew_1239 +0.6 2.5 PepSY-associated TM helix domain-containing protein (RefSeq) compare
Shew_1356 +0.6 2.3 flagellin domain-containing protein (RefSeq) compare
Shew_1998 +0.6 1.4 protein of unknown function UPF0052 and CofD (RefSeq) compare
Shew_3121 +0.6 1.0 FMN-binding domain-containing protein (RefSeq) compare
Shew_3188 +0.6 3.0 aromatic amino acid permease (RefSeq) compare
Shew_2199 +0.6 1.4 histidinol-phosphate aminotransferase (RefSeq) compare
Shew_2202 +0.6 0.5 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (RefSeq) compare
Shew_1889 +0.6 2.7 alpha amylase, catalytic region (RefSeq) compare
Shew_2905 +0.6 2.2 hypothetical protein (RefSeq) compare


Specific Phenotypes

For 4 genes in this experiment

For stress Polymyxin B sulfate in Shewanella loihica PV-4

For stress Polymyxin B sulfate across organisms