Experiment set2IT019 for Pseudomonas fluorescens FW300-N2E2

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D-Sorbitol carbon source

200 most important genes:

  gene name fitness t score description  
Pf6N2E2_5006 -7.1 -4.9 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) compare
Pf6N2E2_3842 -7.0 -4.8 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) compare
Pf6N2E2_3782 -6.4 -4.4 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) compare
Pf6N2E2_4597 -6.4 -8.8 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf6N2E2_4826 -6.4 -7.6 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) compare
Pf6N2E2_3783 -6.3 -6.1 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
Pf6N2E2_77 -6.3 -6.1 O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) compare
Pf6N2E2_64 -6.2 -4.3 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) compare
Pf6N2E2_4825 -6.2 -9.4 Anthranilate phosphoribosyltransferase (EC 2.4.2.18) compare
Pf6N2E2_3839 -5.9 -5.7 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Pf6N2E2_71 -5.7 -7.8 Phosphoribosylanthranilate isomerase (EC 5.3.1.24) compare
Pf6N2E2_3610 -5.6 -7.4 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) compare
Pf6N2E2_4596 -5.5 -12.7 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf6N2E2_5175 -5.3 -19.1 Acetolactate synthase large subunit (EC 2.2.1.6) compare
Pf6N2E2_3751 -5.1 -17.0 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) compare
Pf6N2E2_4564 -5.1 -13.0 Dihydroxy-acid dehydratase (EC 4.2.1.9) compare
Pf6N2E2_5014 -5.1 -2.1 Apolipoprotein N-acyltransferase (EC 2.3.1.-) / Copper homeostasis protein CutE compare
Pf6N2E2_3253 -5.0 -8.3 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
Pf6N2E2_4048 -5.0 -10.5 Tryptophan synthase beta chain (EC 4.2.1.20) compare
Pf6N2E2_4047 -4.9 -8.9 Tryptophan synthase alpha chain (EC 4.2.1.20) compare
Pf6N2E2_5176 -4.9 -13.0 Acetolactate synthase small subunit (EC 2.2.1.6) compare
Pf6N2E2_1959 -4.8 -6.5 D-sorbitol dehydrogenase (EC 1.1.1.14) (from data) compare
Pf6N2E2_3630 -4.7 -9.0 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf6N2E2_2885 -4.7 -9.9 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) compare
Pf6N2E2_3752 -4.6 -22.2 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) compare
Pf6N2E2_1961 -4.5 -11.9 ABC transporter for D-sorbitol, permease component 2 (from data) conserved
Pf6N2E2_1963 -4.5 -12.9 ABC transporter for D-sorbitol, periplasmic substrate-binding component (from data) conserved
Pf6N2E2_5150 -4.4 -8.4 Glucose-6-phosphate isomerase (EC 5.3.1.9) compare
Pf6N2E2_5177 -4.3 -11.3 Ketol-acid reductoisomerase (EC 1.1.1.86) compare
Pf6N2E2_2753 -4.2 -5.6 HtrA protease/chaperone protein compare
Pf6N2E2_3252 -4.1 -11.1 Histidinol dehydrogenase (EC 1.1.1.23) compare
Pf6N2E2_2073 -4.0 -10.5 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) compare
Pf6N2E2_3841 -4.0 -8.8 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) compare
Pf6N2E2_4279 -4.0 -16.4 Pyruvate carboxyl transferase subunit B (EC 6.4.1.1) compare
Pf6N2E2_5156 -3.9 -3.8 Two-component sensor CbrB: intrcellular carbon:nitrogen balance compare
Pf6N2E2_66 -3.9 -8.3 3-isopropylmalate dehydrogenase (EC 1.1.1.85) compare
Pf6N2E2_1960 -3.9 -7.5 ABC transporter for D-sorbitol, ATPase component (from data) conserved
Pf6N2E2_50 -3.9 -11.1 Biosynthetic Aromatic amino acid aminotransferase alpha (EC 2.6.1.57) @ Aromatic-amino-acid aminotransferase (EC 2.6.1.57) compare
Pf6N2E2_1965 -3.8 -12.1 Fructokinase (EC 2.7.1.4) (from data) conserved
Pf6N2E2_3940 -3.7 -10.6 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf6N2E2_4418 -3.7 -1.5 Diaminopimelate epimerase (EC 5.1.1.7) compare
Pf6N2E2_3248 -3.7 -6.6 Probable transmembrane protein compare
Pf6N2E2_4071 -3.6 -6.5 Phosphate transport system regulatory protein PhoU compare
Pf6N2E2_2217 -3.6 -8.4 ATP-dependent Clp protease ATP-binding subunit ClpX compare
Pf6N2E2_5527 -3.5 -4.6 Cold shock protein CspC compare
Pf6N2E2_2074 -3.5 -2.7 required for sulfate utilization, putative electron transport protein for sulfite reductase (from data) compare
Pf6N2E2_4278 -3.5 -12.5 Pyruvate carboxyl transferase subunit A (EC 6.4.1.1) compare
Pf6N2E2_4762 -3.5 -4.2 Biotin synthesis protein BioH compare
Pf6N2E2_302 -3.4 -6.8 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
Pf6N2E2_5780 -3.4 -12.5 Periplasmic protease compare
Pf6N2E2_4759 -3.3 -15.1 Biotin synthase (EC 2.8.1.6) compare
Pf6N2E2_5160 -3.3 -2.7 C4-type zinc finger protein, DksA/TraR family compare
Pf6N2E2_3932 -3.1 -7.0 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) compare
Pf6N2E2_5728 -3.1 -6.6 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) compare
Pf6N2E2_4764 -2.9 -6.2 Dethiobiotin synthetase (EC 6.3.3.3) compare
Pf6N2E2_63 -2.9 -4.0 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) compare
Pf6N2E2_4277 -2.9 -10.1 LysR family transcriptional regulator PA5437 compare
Pf6N2E2_2258 -2.8 -12.6 Transaldolase (EC 2.2.1.2) compare
Pf6N2E2_4761 -2.8 -11.9 8-amino-7-oxononanoate synthase (EC 2.3.1.47) compare
Pf6N2E2_5252 -2.7 -3.7 FIG00956396: hypothetical protein compare
Pf6N2E2_3170 -2.7 -7.0 2-isopropylmalate synthase (EC 2.3.3.13) compare
Pf6N2E2_3251 -2.6 -10.6 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
Pf6N2E2_2588 -2.6 -3.5 Anti-sigma F factor antagonist (spoIIAA-2); Anti-sigma B factor antagonist RsbV compare
Pf6N2E2_2899 -2.5 -6.7 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) compare
Pf6N2E2_4638 -2.5 -5.3 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) compare
Pf6N2E2_3346 -2.5 -8.3 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) compare
Pf6N2E2_4187 -2.5 -5.6 Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) compare
Pf6N2E2_1381 -2.5 -6.5 Aldehyde dehydrogenase (EC 1.2.1.3) compare
Pf6N2E2_2465 -2.4 -5.3 Cys regulon transcriptional activator CysB compare
Pf6N2E2_4372 -2.4 -6.7 FIG00460773: hypothetical protein compare
Pf6N2E2_2218 -2.4 -6.4 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) compare
Pf6N2E2_4763 -2.3 -11.1 Biotin synthesis protein BioC compare
Pf6N2E2_3349 -2.3 -4.0 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) compare
Pf6N2E2_3240 -2.3 -2.4 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) compare
Pf6N2E2_5553 -2.3 -7.1 Quinolinate synthetase (EC 2.5.1.72) compare
Pf6N2E2_5579 -2.3 -5.2 Ornithine carbamoyltransferase (EC 2.1.3.3) compare
Pf6N2E2_1932 -2.3 -7.4 Transcriptional regulator, IclR family compare
Pf6N2E2_3060 -2.2 -5.2 Outer membrane protein H precursor compare
Pf6N2E2_4077 -2.1 -2.9 cytosolic long-chain acyl-CoA thioester hydrolase family protein compare
Pf6N2E2_2514 -2.1 -4.7 regulator of length of O-antigen component of lipopolysaccharide chains compare
Pf6N2E2_4631 -2.1 -7.2 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) compare
Pf6N2E2_4803 -2.1 -1.9 Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41) compare
Pf6N2E2_2473 -2.0 -1.9 Major outer membrane lipoprotein I compare
Pf6N2E2_3461 -2.0 -2.5 Exodeoxyribonuclease V gamma chain (EC 3.1.11.5) compare
Pf6N2E2_5316 -2.0 -1.9 Periplasmic thiol:disulfide oxidoreductase DsbB, required for DsbA reoxidation compare
Pf6N2E2_3260 -1.9 -6.4 Uncharacterized ABC transporter, ATP-binding protein YrbF compare
Pf6N2E2_2574 -1.8 -3.4 Flagellar synthesis regulator FleN compare
Pf6N2E2_3941 -1.8 -4.8 Adenosine (5')-pentaphospho-(5'')-adenosine pyrophosphohydrolase (EC 3.6.1.-) compare
Pf6N2E2_3984 -1.8 -9.5 T1SS associated transglutaminase-like cysteine proteinase LapP compare
Pf6N2E2_1400 -1.8 -11.2 Sensory box histidine kinase/response regulator compare
Pf6N2E2_3074 -1.7 -2.8 FIG00960973: hypothetical protein compare
Pf6N2E2_5676 -1.7 -5.6 Aspartokinase (EC 2.7.2.4) compare
Pf6N2E2_3661 -1.7 -5.0 hypothetical protein compare
Pf6N2E2_3271 -1.6 -2.8 Phosphocarrier protein, nitrogen regulation associated compare
Pf6N2E2_3942 -1.6 -9.4 FIG001592: Phosphocarrier protein kinase/phosphorylase, nitrogen regulation associated compare
Pf6N2E2_5723 -1.6 -9.8 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) compare
Pf6N2E2_2274 -1.6 -5.1 Soluble pyridine nucleotide transhydrogenase (EC 1.6.1.1) compare
Pf6N2E2_5219 -1.6 -8.1 FIG140336: TPR domain protein compare
Pf6N2E2_2756 -1.6 -6.4 RNA polymerase sigma-H factor AlgT compare
Pf6N2E2_5943 -1.6 -2.2 hypothetical protein compare
Pf6N2E2_2261 -1.5 -7.1 VacJ-like lipoprotein precursor compare
Pf6N2E2_4009 -1.5 -7.9 GGDEF domain protein compare
Pf6N2E2_2312 -1.5 -2.7 Cytochrome c oxidase subunit CcoQ (EC 1.9.3.1) compare
Pf6N2E2_3938 -1.5 -10.4 Threonine dehydratase biosynthetic (EC 4.3.1.19) compare
Pf6N2E2_4204 -1.5 -2.3 rRNA small subunit 7-methylguanosine (m7G) methyltransferase GidB compare
Pf6N2E2_4417 -1.5 -4.5 Protein of unknown function DUF484 compare
Pf6N2E2_6140 -1.4 -1.4 Large Subunit Ribosomal RNA; lsuRNA; LSU rRNA compare
Pf6N2E2_1402 -1.4 -6.7 hypothetical protein compare
Pf6N2E2_4416 -1.4 -2.7 Tyrosine recombinase XerC compare
Pf6N2E2_4162 -1.4 -3.6 DNA polymerase I (EC 2.7.7.7) compare
Pf6N2E2_3835 -1.4 -3.7 Carboxyl-terminal protease (EC 3.4.21.102) compare
Pf6N2E2_2282 -1.4 -4.2 Predicted transcriptional regulator for fatty acid degradation FadQ, TetR family compare
Pf6N2E2_5666 -1.4 -7.0 Arginine N-succinyltransferase, alpha subunit (EC 2.3.1.109) compare
Pf6N2E2_3062 -1.4 -4.9 Membrane-associated zinc metalloprotease compare
Pf6N2E2_2758 -1.3 -9.3 L-aspartate oxidase (EC 1.4.3.16) compare
Pf6N2E2_5494 -1.3 -4.8 Pyruvate kinase (EC 2.7.1.40) compare
Pf6N2E2_3257 -1.3 -4.0 Uncharacterized ABC transporter, auxiliary component YrbC compare
Pf6N2E2_4453 -1.3 -10.3 Polyphosphate kinase (EC 2.7.4.1) compare
Pf6N2E2_5027 -1.3 -8.5 AMP nucleosidase (EC 3.2.2.4) compare
Pf6N2E2_248 -1.2 -6.8 hypothetical protein compare
Pf6N2E2_2010 -1.2 -2.2 hypothetical protein compare
Pf6N2E2_5391 -1.2 -6.3 Predicted ATPase related to phosphate starvation-inducible protein PhoH compare
Pf6N2E2_3300 -1.2 -3.3 Predicted D-glucarate or D-galactorate regulator, GntR family compare
Pf6N2E2_2752 -1.2 -6.5 Exported zinc metalloprotease YfgC precursor compare
Pf6N2E2_2693 -1.1 -1.8 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII (EC 2.3.1.180) compare
Pf6N2E2_2013 -1.1 -1.5 hypothetical protein compare
Pf6N2E2_1412 -1.1 -3.1 hypothetical protein compare
Pf6N2E2_4352 -1.1 -2.5 ATP-dependent DNA helicase RecG (EC 3.6.1.-) compare
Pf6N2E2_4678 -1.1 -1.1 hypothetical protein compare
Pf6N2E2_4362 -1.1 -3.2 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) compare
Pf6N2E2_3833 -1.1 -4.6 hypothetical protein compare
Pf6N2E2_289 -1.1 -7.4 Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) compare
Pf6N2E2_1186 -1.1 -5.0 Permease of the drug/metabolite transporter (DMT) superfamily compare
Pf6N2E2_3258 -1.1 -4.5 Uncharacterized ABC transporter, periplasmic component YrbD compare
Pf6N2E2_5536 -1.1 -1.2 Holliday junction DNA helicase RuvA compare
Pf6N2E2_595 -1.1 -2.9 Arsenical resistance operon repressor compare
Pf6N2E2_5001 -1.1 -1.7 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) compare
Pf6N2E2_4059 -1.1 -1.3 DNA-binding protein HU-alpha compare
Pf6N2E2_4049 -1.1 -6.5 Glycine cleavage system transcriptional activator compare
Pf6N2E2_3505 -1.0 -1.6 Translation initiation factor SUI1-related protein compare
Pf6N2E2_1315 -1.0 -1.7 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) compare
Pf6N2E2_2864 -1.0 -2.3 Gluconokinase (EC 2.7.1.12) compare
Pf6N2E2_3826 -1.0 -4.5 Nitrogen regulation protein NR(I) compare
Pf6N2E2_3665 -1.0 -1.1 serine/threonine protein kinase compare
Pf6N2E2_2340 -1.0 -3.1 Transcriptional regulator, GntR family compare
Pf6N2E2_3666 -1.0 -3.7 InaA protein compare
Pf6N2E2_3825 -1.0 -3.4 Nitrogen regulation protein NtrB (EC 2.7.13.3) compare
Pf6N2E2_434 -1.0 -3.1 hypothetical protein compare
Pf6N2E2_2938 -1.0 -3.1 Outer membrane lipoprotein compare
Pf6N2E2_4205 -1.0 -3.0 Chromosome (plasmid) partitioning protein ParA compare
Pf6N2E2_3264 -1.0 -1.9 Uncharacterized protein YrbK clustered with lipopolysaccharide transporters compare
Pf6N2E2_5667 -1.0 -5.0 Arginine N-succinyltransferase (EC 2.3.1.109) compare
Pf6N2E2_2852 -0.9 -6.1 GGDEF domain/EAL domain protein compare
Pf6N2E2_5255 -0.9 -6.5 Outer membrane stress sensor protease DegS compare
Pf6N2E2_544 -0.9 -3.4 Short-chain dehydrogenase/reductase SDR compare
Pf6N2E2_4414 -0.9 -3.1 FIG00953808: hypothetical protein compare
Pf6N2E2_5103 -0.9 -0.7 Glutamate 5-kinase (EC 2.7.2.11) / RNA-binding C-terminal domain PUA compare
Pf6N2E2_2681 -0.9 -3.3 3-phosphoglycerate kinase compare
Pf6N2E2_2746 -0.9 -3.9 Outer membrane protein NlpB, lipoprotein component of the protein assembly complex (forms a complex with YaeT, YfiO, and YfgL); Lipoprotein-34 precursor compare
Pf6N2E2_807 -0.9 -4.8 Various polyols ABC transporter, ATP-binding component compare
Pf6N2E2_809 -0.9 -3.6 Various polyols ABC transporter, permease component 1 compare
Pf6N2E2_1288 -0.9 -2.8 Protein containing transglutaminase-like domain, putative cysteine protease compare
Pf6N2E2_5190 -0.9 -5.6 Carbonic anhydrase (EC 4.2.1.1) compare
Pf6N2E2_3834 -0.9 -4.5 Lipoprotein NlpD compare
Pf6N2E2_4160 -0.9 -1.4 Cytochrome c5 compare
Pf6N2E2_2526 -0.9 -3.3 Similar to phosphoglycolate phosphatase, clustered with ubiquinone biosynthesis SAM-dependent O-methyltransferase compare
Pf6N2E2_3351 -0.9 -3.1 tRNA pseudouridine synthase B (EC 4.2.1.70) compare
Pf6N2E2_2467 -0.9 -2.7 5'-nucleotidase (EC 3.1.3.5) compare
Pf6N2E2_1501 -0.9 -3.0 Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (EC 3.6.1.17) compare
Pf6N2E2_51 -0.9 -3.2 hypothetical protein compare
Pf6N2E2_3201 -0.9 -3.6 Transcriptional regulator, MerR family compare
Pf6N2E2_1964 -0.9 -3.2 Transcriptional regulator of various polyols utilization, AraC family compare
Pf6N2E2_4476 -0.9 -5.2 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) compare
Pf6N2E2_2518 -0.8 -1.7 Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43) / 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) compare
Pf6N2E2_5111 -0.8 -2.7 FKBP-type peptidyl-prolyl cis-trans isomerase SlpA (EC 5.2.1.8) compare
Pf6N2E2_1717 -0.8 -5.4 Anthranilate synthase, aminase component (EC 4.1.3.27) compare
Pf6N2E2_178 -0.8 -0.9 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) compare
Pf6N2E2_1469 -0.8 -3.6 NAD-dependent formate dehydrogenase gamma subunit compare
Pf6N2E2_3480 -0.8 -1.3 Transcriptional regulator, ArsR family compare
Pf6N2E2_3072 -0.8 -5.8 [Protein-PII] uridylyltransferase (EC 2.7.7.59) compare
Pf6N2E2_2219 -0.8 -1.6 Cell division trigger factor (EC 5.2.1.8) compare
Pf6N2E2_4276 -0.8 -2.9 Phosphogluconate repressor HexR, RpiR family compare
Pf6N2E2_579 -0.8 -1.9 FIG00962753: hypothetical protein compare
Pf6N2E2_5524 -0.8 -5.8 Outer membrane porin, OprD family compare
Pf6N2E2_3460 -0.8 -1.5 Exodeoxyribonuclease V beta chain (EC 3.1.11.5) compare
Pf6N2E2_5766 -0.8 -1.6 Quaternary ammonium compound-resistance protein SugE compare
Pf6N2E2_65 -0.8 -2.8 SAM-dependent methyltransferase YafE (UbiE paralog) compare
Pf6N2E2_3534 -0.8 -2.3 Cobalamin biosynthesis protein CobG compare
Pf6N2E2_5328 -0.8 -3.7 FIG00958649: hypothetical protein compare
Pf6N2E2_504 -0.8 -2.4 DNA-binding response regulator compare
Pf6N2E2_2586 -0.8 -1.3 Hpt domain protein compare
Pf6N2E2_2706 -0.8 -2.6 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) compare
Pf6N2E2_70 -0.8 -3.1 tRNA pseudouridine synthase A (EC 4.2.1.70) compare
Pf6N2E2_5646 -0.8 -1.3 PROBABLE MEMBRANE PROTEIN compare
Pf6N2E2_3039 -0.8 -3.1 Protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77) compare
Pf6N2E2_309 -0.8 -1.6 FIG00957702: hypothetical protein compare
Pf6N2E2_660 -0.8 -2.7 hypothetical protein compare
Pf6N2E2_2186 -0.8 -3.5 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) compare
Pf6N2E2_4800 -0.8 -6.1 yeaH component of nitrogen-related signalling system yeaH (of yeaGH-ycgB) (from data) compare
Pf6N2E2_3906 -0.8 -5.4 Transcription accessory protein (S1 RNA-binding domain) compare


Specific Phenotypes

For 7 genes in this experiment

For carbon source D-Sorbitol in Pseudomonas fluorescens FW300-N2E2

For carbon source D-Sorbitol across organisms