Experiment set2H25 for Pseudomonas stutzeri RCH2

Compare to:

L-Isoleucine nitrogen source

200 most important genes:

  gene name fitness t score description  
Psest_2590 -5.3 -2.0 3-isopropylmalate dehydratase, small subunit compare
Psest_2591 -5.1 -5.0 3-isopropylmalate dehydratase, large subunit compare
Psest_0153 -4.7 -15.4 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit compare
Psest_2584 -4.6 -9.2 Phosphoribosylanthranilate isomerase compare
Psest_3650 -4.5 -12.6 anthranilate synthase component I, non-proteobacterial lineages compare
Psest_0155 -4.5 -8.0 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Psest_0450 -4.4 -11.7 Branched-chain amino acid aminotransferase (EC 2.6.1.42) (from data) conserved
Psest_2579 -4.3 -8.7 amidophosphoribosyltransferase compare
Psest_0489 -4.3 -2.9 phosphoserine phosphatase SerB compare
Psest_3648 -4.2 -9.8 anthranilate phosphoribosyltransferase compare
Psest_3647 -4.2 -7.5 Indole-3-glycerol phosphate synthase compare
Psest_3932 -4.2 -4.1 nitrogen regulation protein NR(I) compare
Psest_3931 -4.2 -6.3 Signal transduction histidine kinase, nitrogen specific compare
Psest_3298 -4.2 -13.0 histidinol dehydrogenase compare
Psest_0279 -4.0 -6.5 methionine biosynthesis protein MetW compare
Psest_0062 -3.8 -11.0 tryptophan synthase, alpha subunit compare
Psest_3649 -3.7 -10.7 glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase compare
Psest_1474 -3.7 -7.1 phosphoribosylaminoimidazole synthetase compare
Psest_3299 -3.6 -12.9 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
Psest_0325 -3.6 -18.7 Putative threonine efflux protein compare
Psest_0152 -3.5 -6.5 Imidazoleglycerol-phosphate dehydratase compare
Psest_0687 -3.5 -12.1 ATP phosphoribosyltransferase, regulatory subunit compare
Psest_3862 -3.4 -14.5 phosphoenolpyruvate-protein phosphotransferase compare
Psest_3864 -3.4 -16.2 Histidinol-phosphatase (EC:3.1.3.15) (from data) compare
Psest_0280 -3.3 -17.1 homoserine O-acetyltransferase compare
Psest_2589 -3.3 -11.5 3-isopropylmalate dehydrogenase compare
Psest_0326 -3.3 -12.9 Taurine catabolism dioxygenase TauD, TfdA family. compare
Psest_1013 -3.2 -4.8 phosphoribosylamine--glycine ligase compare
Psest_0063 -3.2 -9.4 tryptophan synthase, beta subunit compare
Psest_2578 -3.0 -13.2 O-succinylhomoserine sulfhydrylase compare
Psest_3766 -2.7 -3.6 Uncharacterized protein conserved in bacteria compare
Psest_0313 -2.7 -5.9 5,10-methylenetetrahydrofolate reductase, prokaryotic form compare
Psest_1452 -2.7 -12.0 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase compare
Psest_3159 -2.6 -8.4 phosphoribosylformylglycinamidine synthase, single chain form compare
Psest_0508 -2.6 -9.3 gamma-glutamyl phosphate reductase compare
Psest_3123 -2.6 -5.2 dihydroorotase, homodimeric type compare
Psest_3317 -2.6 -5.8 Phosphotransferase System HPr (HPr) Family compare
Psest_0999 -2.5 -4.9 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains compare
Psest_3810 -2.4 -4.1 orotate phosphoribosyltransferase compare
Psest_3384 -2.3 -9.1 glutamate 5-kinase compare
Psest_2845 -2.3 -10.7 [Protein-PII] uridylyltransferase compare
Psest_1870 -2.2 -2.5 Transcriptional regulators compare
Psest_3129 -2.2 -2.3 tyrosine recombinase XerD compare
Psest_0919 -2.1 -3.7 Permeases of the drug/metabolite transporter (DMT) superfamily compare
Psest_0259 -2.0 -2.3 cell division ATP-binding protein FtsE compare
Psest_0920 -2.0 -10.3 Transcriptional regulators conserved
Psest_0212 -2.0 -1.3 exodeoxyribonuclease V, gamma subunit compare
Psest_1037 -1.9 -2.8 acetolactate synthase, small subunit compare
Psest_0327 -1.7 -5.1 Transcriptional regulator compare
Psest_3816 -1.7 -1.4 DNA-directed RNA polymerase, omega subunit compare
Psest_2088 -1.6 -2.2 Uncharacterized protein conserved in bacteria compare
Psest_1947 -1.6 -2.8 dihydroorotate dehydrogenase, subfamily 2 compare
Psest_0243 -1.6 -0.8 hypothetical protein compare
Psest_3226 -1.6 -1.4 Predicted membrane protein compare
Psest_1640 -1.6 -9.5 (p)ppGpp synthetase, RelA/SpoT family compare
Psest_2027 -1.6 -11.3 ATP-dependent Clp protease ATP-binding subunit clpA compare
Psest_1496 -1.5 -2.1 Holliday junction DNA helicase, RuvA subunit compare
Psest_1505 -1.5 -2.8 Organic radical activating enzymes compare
Psest_1313 -1.5 -2.0 Uncharacterized conserved small protein compare
Psest_1473 -1.5 -7.5 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent compare
Psest_3943 -1.5 -2.6 Phosphoribosyl-AMP cyclohydrolase compare
Psest_3161 -1.4 -6.8 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family conserved
Psest_4049 -1.4 -1.6 hypothetical protein compare
Psest_1704 -1.4 -1.5 Dehydrogenases (flavoproteins) compare
Psest_1814 -1.4 -9.9 pseudaminic acid biosynthesis N-acetyl transferase compare
Psest_1506 -1.4 -5.2 queuosine biosynthesis protein QueC compare
Psest_2850 -1.3 -1.7 Multisubunit Na+/H+ antiporter, MnhC subunit compare
Psest_1082 -1.3 -2.2 Enoyl-CoA hydratase/carnithine racemase compare
Psest_0411 -1.3 -7.7 biotin synthetase compare
Psest_3177 -1.3 -2.1 hypothetical protein compare
Psest_3162 -1.3 -6.3 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family conserved
Psest_2714 -1.3 -2.4 7-cyano-7-deazaguanine reductase compare
Psest_1813 -1.3 -9.3 pseudaminic acid biosynthesis-associated protein PseG compare
Psest_1241 -1.3 -6.0 S-adenosylmethionine:tRNA ribosyltransferase-isomerase compare
Psest_3338 -1.3 -2.1 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain compare
Psest_1679 -1.3 -1.7 ribonuclease, Rne/Rng family compare
Psest_3478 -1.2 -1.2 Cytochrome B561 compare
Psest_0170 -1.2 -4.9 5,10-methenyltetrahydrofolate synthetase compare
Psest_3910 -1.2 -1.4 Uncharacterized protein conserved in bacteria compare
Psest_3163 -1.2 -6.4 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain compare
Psest_2899 -1.1 -1.4 hypothetical protein compare
Psest_0281 -1.1 -6.1 Dynamin family. compare
Psest_3496 -1.1 -1.4 Predicted metal-binding protein compare
Psest_4191 -1.1 -2.6 Transcriptional regulator compare
Psest_3998 -1.1 -4.0 glutamate--cysteine ligase compare
Psest_4154 -1.1 -3.8 flagella basal body P-ring formation protein FlgA compare
Psest_0510 -1.1 -4.0 iojap-like ribosome-associated protein compare
Psest_1486 -1.1 -3.1 hypothetical protein compare
Psest_1295 -1.1 -5.5 Aspartate/tyrosine/aromatic aminotransferase compare
Psest_3573 -1.1 -3.5 dTDP-4-dehydrorhamnose reductase compare
Psest_3178 -1.1 -2.9 formyltetrahydrofolate deformylase compare
Psest_2809 -1.1 -2.9 protein-L-isoaspartate(D-aspartate) O-methyltransferase compare
Psest_2360 -1.0 -2.3 Uncharacterized protein, putative amidase compare
Psest_0722 -1.0 -6.3 Predicted ATPase compare
Psest_1750 -1.0 -2.9 Protein of unknown function (DUF2802). compare
Psest_3749 -1.0 -7.4 Response regulator of the LytR/AlgR family compare
Psest_1881 -1.0 -2.5 Nitroreductase compare
Psest_4044 -1.0 -5.4 type I site-specific deoxyribonuclease, HsdR family compare
Psest_1311 -1.0 -5.7 Branched-chain amino acid ABC-type transport system, permease components conserved
Psest_3377 -1.0 -0.8 FKBP-type peptidyl-prolyl cis-trans isomerases 2 compare
Psest_0831 -1.0 -1.1 hypothetical protein compare
Psest_1424 -0.9 -1.5 Lipoate-protein ligase A compare
Psest_2719 -0.9 -2.6 acetylornithine and succinylornithine aminotransferases/succinylornithine transaminase family compare
Psest_0154 -0.9 -4.0 Uncharacterized conserved protein compare
Psest_1772 -0.9 -3.0 Aspartate/tyrosine/aromatic aminotransferase compare
Psest_0297 -0.9 -3.0 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain compare
Psest_1815 -0.9 -6.3 pseudaminic acid synthase compare
Psest_1310 -0.9 -4.5 ABC-type branched-chain amino acid transport system, permease component conserved
Psest_0031 -0.9 -0.9 Uncharacterized conserved protein compare
Psest_4363 -0.9 -5.1 ATPases involved in chromosome partitioning compare
Psest_1792 -0.9 -3.1 RND family efflux transporter, MFP subunit compare
Psest_3767 -0.9 -2.9 tyrosine recombinase XerC compare
Psest_0719 -0.9 -3.7 Uncharacterized protein conserved in bacteria compare
Psest_3517 -0.9 -6.5 branched-chain ketoacid ferredoxin reductase (EC 1.2.7.7) active on 4-methyl-2-oxopentanoate, (S)-3-methyl-2-oxopentanoate, or 3-methyl-2-oxobutanoate (from data) compare
Psest_3545 -0.9 -2.7 clan AA aspartic protease, TIGR02281 family compare
Psest_4287 -0.9 -3.4 Predicted glutamine amidotransferases compare
Psest_4396 -0.9 -4.6 Site-specific recombinases, DNA invertase Pin homologs compare
Psest_1078 -0.9 -2.7 acetyl-CoA:acetoacetate CoA transferase, A subunit (EC 2.8.3.8) (from data) compare
Psest_0691 -0.9 -5.7 ribonuclease R compare
Psest_0139 -0.9 -3.9 ABC-type histidine transport system, ATPase component compare
Psest_0161 -0.8 -1.7 Membrane-bound metallopeptidase compare
Psest_3827 -0.8 -2.2 Transcriptional regulator compare
Psest_3884 -0.8 -0.6 Signal transduction histidine kinase compare
Psest_1439 -0.8 -4.2 Transcriptional regulator compare
Psest_2744 -0.8 -1.3 Uncharacterized conserved protein compare
Psest_3348 -0.8 -3.7 Uncharacterized iron-regulated protein compare
Psest_4247 -0.8 -2.5 Serine/threonine protein phosphatase compare
Psest_2119 -0.8 -1.8 Glycine/D-amino acid oxidases (deaminating) compare
Psest_3449 -0.8 -1.2 DJ-1 family protein compare
Psest_3042 -0.8 -1.1 Nitrate reductase cytochrome c-type subunit compare
Psest_3850 -0.8 -0.9 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains compare
Psest_0182 -0.8 -2.8 glycine cleavage system H protein compare
Psest_1167 -0.8 -0.8 hypothetical protein compare
Psest_2646 -0.8 -1.9 SOS regulatory protein LexA compare
Psest_4316 -0.8 -2.2 ABC-type metal ion transport system, periplasmic component/surface antigen compare
Psest_4391 -0.8 -5.7 ATPases involved in chromosome partitioning compare
Psest_2067 -0.8 -0.9 ABC-type oligopeptide transport system, periplasmic component compare
Psest_0024 -0.8 -4.7 LysM domain. compare
Psest_2907 -0.8 -1.3 Protein of unknown function (DUF3618). compare
Psest_1308 -0.8 -3.3 ABC-type branched-chain amino acid transport systems, ATPase component compare
Psest_3375 -0.8 -4.6 prepilin-type N-terminal cleavage/methylation domain compare
Psest_2158 -0.8 -6.0 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase compare
Psest_1235 -0.8 -4.6 Leucyl aminopeptidase compare
Psest_1242 -0.8 -1.7 tRNA-guanine transglycosylase, queuosine-34-forming compare
Psest_1149 -0.8 -2.0 Protein affecting phage T7 exclusion by the F plasmid compare
Psest_1277 -0.8 -5.5 2-isopropylmalate synthase, yeast type compare
Psest_2405 -0.8 -1.4 NAD-dependent protein deacetylases, SIR2 family compare
Psest_3944 -0.8 -1.1 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
Psest_3297 -0.7 -4.4 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
Psest_1879 -0.7 -2.0 Trk-type K+ transport systems, membrane components compare
Psest_0203 -0.7 -3.5 Signal transduction histidine kinase compare
Psest_3721 -0.7 -4.0 Malic enzyme compare
Psest_4315 -0.7 -1.5 ABC-type metal ion transport system, permease component compare
Psest_0445 -0.7 -5.3 PAS domain S-box/diguanylate cyclase (GGDEF) domain compare
Psest_2581 -0.7 -1.9 Uncharacterized protein conserved in bacteria compare
Psest_3395 -0.7 -1.2 hypothetical protein compare
Psest_2557 -0.7 -1.4 Protein of unknown function (DUF2474). compare
Psest_1551 -0.7 -2.0 Integral membrane protein, interacts with FtsH compare
Psest_0952 -0.7 -1.7 Uncharacterized conserved protein compare
Psest_1527 -0.7 -5.0 Na+/proline symporter compare
Psest_2531 -0.7 -5.4 cytochrome c oxidase accessory protein FixG compare
Psest_3322 -0.7 -5.7 TIGR02099 family protein compare
Psest_1309 -0.7 -3.0 ABC-type branched-chain amino acid transport systems, ATPase component conserved
Psest_3532 -0.7 -4.4 Peptidase propeptide and YPEB domain. compare
Psest_4005 -0.7 -2.7 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB compare
Psest_1185 -0.7 -1.7 heavy metal response regulator compare
Psest_4163 -0.7 -1.6 hypothetical protein compare
Psest_2946 -0.7 -2.5 septum site-determining protein MinD compare
Psest_0409 -0.7 -1.7 Putative homoserine kinase type II (protein kinase fold) compare
Psest_3306 -0.7 -1.8 conserved hypothetical integral membrane protein compare
Psest_0057 -0.7 -2.2 Predicted transcriptional regulators compare
Psest_0491 -0.7 -4.3 PAS domain S-box/diguanylate cyclase (GGDEF) domain compare
Psest_0285 -0.7 -3.9 pilus retraction protein PilT compare
Psest_2874 -0.7 -4.0 Predicted acyltransferases compare
Psest_3113 -0.7 -1.2 electron transport complex, RnfABCDGE type, B subunit compare
Psest_2265 -0.7 -1.6 Outer membrane protein compare
Psest_1249 -0.7 -3.5 serine O-acetyltransferase compare
Psest_3155 -0.6 -2.7 hypothetical protein compare
Psest_0814 -0.6 -1.7 MoxR-like ATPases compare
Psest_0954 -0.6 -3.6 Fe-S oxidoreductase compare
Psest_2369 -0.6 -1.8 Transcriptional regulator compare
Psest_2885 -0.6 -1.4 Acyl carrier protein compare
Psest_1366 -0.6 -0.7 hypothetical protein compare
Psest_0193 -0.6 -0.7 conserved hypothetical protein compare
Psest_1030 -0.6 -2.5 Methylase involved in ubiquinone/menaquinone biosynthesis compare
Psest_1176 -0.6 -2.1 Urea transporter compare
Psest_0367 -0.6 -0.8 Predicted branched-chain amino acid permease (azaleucine resistance) compare
Psest_1139 -0.6 -2.1 PAS domain S-box compare
Psest_2359 -0.6 -1.6 Predicted permeases compare
Psest_0294 -0.6 -2.3 Putative transcriptional regulator compare
Psest_1920 -0.6 -0.6 Uncharacterized protein conserved in bacteria compare
Psest_0442 -0.6 -3.1 ATPases of the AAA+ class compare
Psest_4297 -0.6 -3.9 PAS domain S-box compare
Psest_0136 -0.6 -4.2 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family compare
Psest_3878 -0.6 -1.5 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain compare
Psest_3626 -0.6 -2.1 hypothetical protein compare
Psest_1643 -0.6 -1.0 hypothetical protein compare
Psest_3750 -0.6 -3.1 Predicted signal transduction protein with a C-terminal ATPase domain compare
Psest_2618 -0.6 -2.3 Flp pilus assembly protein TadB compare
Psest_4084 -0.6 -4.5 oxaloacetate decarboxylase alpha subunit compare


Specific Phenotypes

For 7 genes in this experiment

For nitrogen source L-Isoleucine in Pseudomonas stutzeri RCH2

For nitrogen source L-Isoleucine across organisms