Experiment set1S234 for Mycobacterium tuberculosis H37Rv

Compare to:

L-Glutamine carbon source

200 most important genes:

  gene name fitness t score description  
Rv0504c -2.4 -3.1 Conserved protein compare
Rv0247c -2.2 -1.4 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv1836c -2.2 -4.0 Conserved protein compare
Rv0497 -2.2 -3.6 Probable conserved transmembrane protein compare
Rv0642c -2.1 -4.8 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv1798 -2.0 -1.9 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv3816c -2.0 -1.6 Possible acyltransferase compare
Rv2982c -2.0 -6.2 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv3066 -1.9 -6.5 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv0472c -1.9 -4.6 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0949 -1.9 -2.1 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0436c -1.9 -2.2 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv1159 -1.8 -5.0 Mannosyltransferase PimE compare
Rv2476c -1.7 -4.7 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv1127c -1.7 -1.9 Probable pyruvate, phosphate dikinase PpdK compare
Rv0758 -1.7 -3.3 Possible two component system response sensor kinase membrane associated PhoR compare
Rv0346c -1.7 -10.0 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv1272c -1.6 -7.3 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1590 -1.6 -6.6 Conserved hypothetical protein compare
Rv0675 -1.6 -1.2 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0241c -1.6 -4.9 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0929 -1.6 -3.6 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1589 -1.6 -7.0 Probable biotin synthetase BioB compare
Rv3513c -1.5 -1.7 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0242c -1.5 -3.0 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2224c -1.5 -10.1 Probable carboxylesterase CaeA compare
Rv2048c -1.4 -6.9 Polyketide synthase Pks12 compare
Rv2553c -1.4 -1.3 Probable conserved membrane protein compare
Rv0344c -1.4 -4.5 Probable lipoprotein LpqJ compare
Rv1512 -1.4 -1.2 Probable nucleotide-sugar epimerase EpiA compare
Rv1410c -1.4 -7.1 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3102c -1.4 -2.0 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0177 -1.4 -2.3 Probable conserved Mce associated protein compare
Rv3428c -1.3 -1.1 Possible transposase compare
Rv0819 -1.3 -3.3 GCN5-related N-acetyltransferase, MshD compare
Rv0955 -1.3 -1.1 Probable conserved integral membrane protein compare
Rv2647 -1.3 -1.8 Hypothetical protein compare
Rv3810 -1.3 -3.3 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv3140 -1.2 -5.2 Probable acyl-CoA dehydrogenase FadE23 compare
Rv1053c -1.2 -1.2 Hypothetical protein compare
Rv3650 -1.2 -0.9 PE family protein PE33 compare
Rv2989 -1.2 -1.5 Probable transcriptional regulatory protein compare
Rv0876c -1.2 -2.9 Possible conserved transmembrane protein compare
Rv2691 -1.2 -8.2 TRK system potassium uptake protein CeoB compare
Rv1538c -1.2 -6.5 Probable L-aparaginase AnsA compare
Rv1003 -1.2 -1.2 Conserved protein compare
Rv2581c -1.1 -1.4 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv2694c -1.1 -4.1 Conserved protein compare
Rv3101c -1.1 -2.8 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0202c -1.1 -5.9 Probable conserved transmembrane transport protein MmpL11 compare
Rv1791 -1.1 -1.9 PE family protein PE19 compare
Rv0017c -1.1 -4.9 Probable cell division protein RodA compare
Rv2869c -1.1 -2.6 Membrane bound metalloprotease compare
Rv0820 -1.1 -3.9 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3321c -1.1 -1.8 Possible antitoxin VapB44 compare
Rv2047c -1.0 -4.7 Conserved hypothetical protein compare
Rv0018c -1.0 -2.2 Phosphoserine/threonine phosphatase PstP compare
Rv2736c -1.0 -2.2 Regulatory protein RecX compare
Rv2171 -1.0 -3.1 Probable conserved lipoprotein LppM compare
Rv3139 -1.0 -5.4 Probable acyl-CoA dehydrogenase FadE24 compare
Rv1400c -1.0 -1.2 Probable lipase LipH compare
Rv2444c -1.0 -2.6 Possible ribonuclease E Rne compare
Rv0383c -1.0 -1.3 Possible conserved secreted protein compare
Rv0655 -1.0 -4.7 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv0361 -1.0 -1.3 Probable conserved membrane protein compare
Rv0243 -1.0 -5.2 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv1411c -1.0 -3.0 Conserved lipoprotein LprG compare
Rv1019 -1.0 -5.4 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv2170 -1.0 -1.7 GCN5-related N-acetyltransferase compare
Rv1890c -1.0 -1.7 Hypothetical protein compare
Rv2606c -1.0 -5.8 Possible pyridoxine biosynthesis protein SnzP compare
Rv0561c -0.9 -1.2 Possible oxidoreductase compare
Rv3200c -0.9 -3.4 Possible transmembrane cation transporter compare
Rv1273c -0.9 -3.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0007 -0.9 -1.0 Possible conserved membrane protein compare
Rv0248c -0.9 -3.4 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv2945c -0.9 -5.8 Probable conserved lipoprotein LppX compare
Rv3803c -0.9 -6.2 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv3919c -0.9 -3.0 Probable glucose-inhibited division protein B Gid compare
Rv0204c -0.9 -2.8 Probable conserved transmembrane protein compare
Rv2428 -0.9 -1.5 Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) compare
Rv0016c -0.9 -2.1 Probable penicillin-binding protein PbpA compare
Rv3631 -0.8 -1.0 Possible transferase (possibly glycosyltransferase) compare
Rv1679 -0.8 -0.9 Possible acyl-CoA dehydrogenase FadE16 compare
Rv0885 -0.8 -3.5 Conserved hypothetical protein compare
Rv3033 -0.8 -0.6 Unknown protein compare
Rv0757 -0.8 -1.3 Possible two component system response transcriptional positive regulator PhoP compare
Rv1010 -0.8 -1.1 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv3229c -0.8 -2.2 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv3868 -0.8 -5.3 ESX conserved component EccA1. ESX-1 type VII secretion system protein. compare
Rv0930 -0.8 -4.1 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0019c -0.8 -4.3 Conserved protein with FHA domain, FhaB compare
Rv3542c -0.8 -2.3 Conserved hypothetical protein compare
Rv0378 -0.8 -1.7 Conserved hypothetical glycine rich protein compare
Rv3856c -0.8 -1.0 Conserved hypothetical protein compare
Rv3400 -0.8 -4.5 Probable hydrolase compare
Rv0738 -0.8 -0.8 Conserved protein compare
Rv2500c -0.8 -1.2 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv1568 -0.8 -5.3 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv2335 -0.8 -2.1 Probable serine acetyltransferase CysE (sat) compare
Rv2462c -0.7 -3.0 Probable trigger factor (TF) protein Tig compare
Rv3249c -0.7 -0.9 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0886 -0.7 -5.1 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) compare
Rv2206 -0.7 -4.1 Probable conserved transmembrane protein compare
Rv2276 -0.7 -0.9 Cytochrome P450 121 Cyp121 compare
Rv2793c -0.7 -1.2 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv2408 -0.7 -0.9 Possible PE family-related protein PE24 compare
Rv2707 -0.7 -5.6 Probable conserved transmembrane alanine and leucine rich protein compare
Rv0676c -0.7 -5.8 Probable conserved transmembrane transport protein MmpL5 compare
Rv0954 -0.7 -2.2 Probable conserved transmembrane protein compare
Rv1013 -0.7 -4.4 Putative polyketide synthase Pks16 compare
Rv2274c -0.7 -2.0 Possible toxin MazF8 compare
Rv3668c -0.7 -2.5 Possible protease compare
Rv1566c -0.7 -3.0 Possible Inv protein compare
Rv3136 -0.7 -3.0 PPE family protein PPE51 compare
Rv1829 -0.7 -3.1 Conserved protein compare
Rv2745c -0.7 -1.5 Transcriptional regulatory protein ClgR compare
Rv2437 -0.7 -2.1 Conserved transmembrane protein compare
Rv1570 -0.7 -1.1 Dethiobiotin synthetase BioD compare
Rv3717 -0.7 -3.0 Conserved hypothetical protein compare
Rv2583c -0.7 -1.7 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv3830c -0.7 -1.9 Transcriptional regulatory protein (probably TetR-family) compare
Rv0928 -0.7 -3.4 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv1332 -0.6 -1.4 Probable transcriptional regulatory protein compare
Rv0444c -0.6 -3.8 Anti-sigma factor RskA (regulator of sigma K) compare
Rv1926c -0.6 -2.0 Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein) compare
Rv2127 -0.6 -4.6 L-asparagine permease AnsP1 compare
Rv3135 -0.6 -2.5 PPE family protein PPE50 compare
Rv3311 -0.6 -3.1 Conserved protein compare
Rv2851c -0.6 -4.2 GCN5-related N-acetyltransferase compare
Rv2496c -0.6 -2.4 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB compare
Rv2898c -0.6 -0.6 Conserved hypothetical protein compare
Rv2369c -0.6 -0.8 Hypothetical protein compare
Rv1824 -0.6 -1.6 Conserved hypothetical membrane protein compare
Rv2367c -0.6 -1.7 Conserved hypothetical protein compare
Rv3098c -0.6 -1.7 Hypothetical protein compare
Rv1569 -0.6 -3.0 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv3222c -0.6 -1.2 Conserved hypothetical protein compare
Rv0020c -0.6 -2.7 Conserved protein with FHA domain, FhaA compare
Rv1745c -0.6 -2.6 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv1450c -0.6 -1.2 PE-PGRS family protein PE_PGRS27 compare
Rv0367c -0.6 -0.7 Hypothetical protein compare
Rv3600c -0.6 -3.3 Conserved protein compare
Rv3723 -0.6 -1.9 Probable conserved transmembrane protein compare
Rv0870c -0.6 -1.3 Possible conserved integral membrane protein compare
Rv1675c -0.6 -0.9 Probable transcriptional regulatory protein Cmr compare
Rv2942 -0.6 -4.7 Conserved transmembrane transport protein MmpL7 compare
Rv0999 -0.6 -1.9 Unknown protein compare
Rv1747 -0.6 -4.0 Probable conserved transmembrane ATP-binding protein ABC transporter compare
Rv0391 -0.6 -3.2 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv1331 -0.6 -1.8 Conserved hypothetical protein compare
Rv3867 -0.6 -3.0 ESX-1 secretion-associated protein EspH compare
Rv1565c -0.6 -2.8 Conserved hypothetical membrane protein compare
Rv1581c -0.6 -1.3 Probable PhiRv1 phage protein compare
Rv2497c -0.6 -4.1 Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA compare
Rv0563 -0.6 -1.8 Probable protease transmembrane protein heat shock protein HtpX compare
Rv3823c -0.6 -4.3 Conserved integral membrane transport protein MmpL8 compare
Rv0065 -0.6 -1.6 Possible toxin VapC1 compare
Rv1336 -0.6 -3.5 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) compare
Rv0996 -0.6 -2.9 Probable conserved transmembrane protein compare
Rv1578c -0.6 -0.6 Probable PhiRv1 phage protein compare
Rv1062 -0.6 -0.8 Conserved hypothetical protein compare
Rv1691 -0.6 -1.8 Conserved hypothetical protein compare
Rv1421 -0.6 -1.7 Conserved protein compare
Rv2137c -0.5 -2.2 Conserved hypothetical protein compare
Rv3314c -0.5 -0.7 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv2912c -0.5 -1.7 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0523c -0.5 -1.0 Conserved protein compare
Rv3230c -0.5 -2.0 Hypothetical oxidoreductase compare
Rv1244 -0.5 -2.2 Probable lipoprotein LpqZ compare
Rv3843c -0.5 -1.1 Probable conserved transmembrane protein compare
Rv0376c -0.5 -2.0 Conserved hypothetical protein compare
Rv2302 -0.5 -0.7 Conserved protein compare
Rv1908c -0.5 -1.0 Catalase-peroxidase-peroxynitritase T KatG compare
Rv2040c -0.5 -1.3 Probable sugar-transport integral membrane protein ABC transporter compare
Rv2055c -0.5 -0.8 30S ribosomal protein S18 RpsR2 compare
Rv3544c -0.5 -2.3 Probable acyl-CoA dehydrogenase FadE28 compare
Rv1620c -0.5 -1.4 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv1006 -0.5 -2.4 Unknown protein compare
Rv0130 -0.5 -0.9 Probable 3-hydroxyl-thioester dehydratase compare
Rv2382c -0.5 -0.8 Polyketide synthetase MbtC (polyketide synthase) compare
Rv2791c -0.5 -2.1 Probable transposase compare
Rv1944c -0.5 -1.3 Conserved protein compare
Rv3405c -0.5 -1.0 Possible transcriptional regulatory protein compare
Rv1324 -0.5 -0.9 Possible thioredoxin compare
Rv0734 -0.5 -1.5 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv3920c -0.5 -0.9 Conserved protein similar to jag protein compare
Rv1030 -0.5 -1.3 Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B) compare
Rv0085 -0.5 -1.0 Possible hydrogenase HycP compare
Rv1049 -0.5 -1.2 Probable transcriptional repressor protein compare
Rv1351 -0.5 -0.8 Hypothetical protein compare
Rv3162c -0.5 -0.8 Possible integral membrane protein compare
Rv2696c -0.5 -1.5 Conserved alanine and glycine and valine rich protein compare
Rv3147 -0.5 -2.2 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) compare
Rv2051c -0.5 -1.4 Polyprenol-monophosphomannose synthase Ppm1 compare
Rv3584 -0.5 -1.6 Possible conserved lipoprotein LpqE compare
Rv3073c -0.5 -0.7 Conserved hypothetical protein compare
Rv0989c -0.5 -3.2 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv0634A -0.5 -3.1 Unknown protein compare
Rv3270 -0.5 -1.0 Probable metal cation-transporting P-type ATPase C CtpC compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in carbon source experiments

For carbon source L-Glutamine across organisms