Experiment set1S231 for Mycobacterium tuberculosis H37Rv

Compare to:

L-Aspartic Acid carbon source

200 most important genes:

  gene name fitness t score description  
Rv0504c -3.3 -3.5 Conserved protein compare
Rv0436c -3.2 -3.1 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv1127c -3.1 -2.9 Probable pyruvate, phosphate dikinase PpdK compare
Rv1798 -3.0 -2.3 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv3816c -2.4 -1.8 Possible acyltransferase compare
Rv0675 -2.1 -1.4 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0201c -2.1 -2.2 Conserved protein compare
Rv2047c -1.9 -9.5 Conserved hypothetical protein compare
Rv0642c -1.9 -3.8 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv0346c -1.8 -10.5 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv0247c -1.8 -1.3 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv1890c -1.8 -2.5 Hypothetical protein compare
Rv0007 -1.8 -1.6 Possible conserved membrane protein compare
Rv0018c -1.8 -3.9 Phosphoserine/threonine phosphatase PstP compare
Rv1159 -1.7 -3.0 Mannosyltransferase PimE compare
Rv1512 -1.7 -1.4 Probable nucleotide-sugar epimerase EpiA compare
Rv3140 -1.7 -5.1 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2048c -1.7 -8.6 Polyketide synthase Pks12 compare
Rv2801c -1.7 -1.8 Toxin MazF9 compare
Rv2302 -1.7 -1.8 Conserved protein compare
Rv1272c -1.7 -7.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1824 -1.6 -2.7 Conserved hypothetical membrane protein compare
Rv2476c -1.6 -6.0 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv0757 -1.6 -2.3 Possible two component system response transcriptional positive regulator PhoP compare
Rv3066 -1.6 -5.2 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv1590 -1.6 -6.4 Conserved hypothetical protein compare
Rv2982c -1.6 -5.9 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv2127 -1.5 -8.9 L-asparagine permease AnsP1 compare
Rv2374c -1.5 -3.5 Probable heat shock protein transcriptional repressor HrcA compare
Rv1538c -1.5 -5.5 Probable L-aparaginase AnsA compare
Rv3102c -1.5 -4.7 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv3428c -1.4 -1.1 Possible transposase compare
Rv2224c -1.4 -10.2 Probable carboxylesterase CaeA compare
Rv0012 -1.4 -5.6 Probable conserved membrane protein compare
Rv0472c -1.4 -4.1 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv1410c -1.4 -7.3 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv1273c -1.3 -5.2 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1829 -1.3 -7.5 Conserved protein compare
Rv1025 -1.3 -1.3 Conserved protein compare
Rv2140c -1.3 -2.3 Conserved protein TB18.6 compare
Rv3803c -1.3 -9.0 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv2869c -1.3 -1.9 Membrane bound metalloprotease compare
Rv1821 -1.2 -4.2 Possible preprotein translocase ATPase SecA2 compare
Rv2650c -1.2 -1.0 Possible PhiRv2 prophage protein compare
Rv0009 -1.2 -1.3 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv2001 -1.2 -1.4 Conserved hypothetical protein compare
Rv3139 -1.2 -4.4 Probable acyl-CoA dehydrogenase FadE24 compare
Rv2736c -1.2 -2.6 Regulatory protein RecX compare
Rv0202c -1.2 -6.2 Probable conserved transmembrane transport protein MmpL11 compare
Rv2171 -1.2 -3.0 Probable conserved lipoprotein LppM compare
Rv1679 -1.2 -1.9 Possible acyl-CoA dehydrogenase FadE16 compare
Rv3810 -1.2 -3.7 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv3101c -1.1 -3.3 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0361 -1.1 -1.2 Probable conserved membrane protein compare
Rv3720 -1.1 -6.2 Possible fatty acid synthase compare
Rv0241c -1.1 -2.1 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0563 -1.1 -1.5 Probable protease transmembrane protein heat shock protein HtpX compare
Rv1569 -1.1 -3.7 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv1411c -1.1 -3.3 Conserved lipoprotein LprG compare
Rv2606c -1.1 -6.2 Possible pyridoxine biosynthesis protein SnzP compare
Rv0758 -1.0 -1.7 Possible two component system response sensor kinase membrane associated PhoR compare
Rv1570 -1.0 -2.4 Dethiobiotin synthetase BioD compare
Rv2206 -1.0 -3.2 Probable conserved transmembrane protein compare
Rv3400 -1.0 -5.4 Probable hydrolase compare
Rv1577c -1.0 -1.3 Probable PhiRv1 phage protein compare
Rv3230c -1.0 -2.9 Hypothetical oxidoreductase compare
Rv1013 -1.0 -6.5 Putative polyketide synthase Pks16 compare
Rv0243 -1.0 -5.8 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv3136 -1.0 -4.9 PPE family protein PPE51 compare
Rv1825 -0.9 -3.0 Conserved protein compare
Rv1239c -0.9 -5.4 Possible magnesium and cobalt transport transmembrane protein CorA compare
Rv0676c -0.9 -7.5 Probable conserved transmembrane transport protein MmpL5 compare
Rv3685c -0.9 -5.7 Probable cytochrome P450 137 Cyp137 compare
Rv1791 -0.9 -1.9 PE family protein PE19 compare
Rv2553c -0.9 -0.9 Probable conserved membrane protein compare
Rv2989 -0.9 -1.0 Probable transcriptional regulatory protein compare
Rv3045 -0.8 -3.5 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv1244 -0.8 -4.2 Probable lipoprotein LpqZ compare
Rv0248c -0.8 -4.0 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv2792c -0.8 -3.2 Possible resolvase compare
Rv2185c -0.8 -2.6 Conserved protein TB16.3 compare
Rv3719 -0.8 -3.8 Conserved protein compare
Rv0954 -0.8 -3.2 Probable conserved transmembrane protein compare
Rv2707 -0.8 -6.7 Probable conserved transmembrane alanine and leucine rich protein compare
Rv3600c -0.8 -3.5 Conserved protein compare
Rv0204c -0.8 -2.8 Probable conserved transmembrane protein compare
Rv0070c -0.8 -1.1 Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) compare
Rv0886 -0.8 -5.8 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) compare
Rv0177 -0.8 -1.2 Probable conserved Mce associated protein compare
Rv1710 -0.8 -1.9 Possible segregation and condensation protein ScpB compare
Rv0444c -0.8 -4.7 Anti-sigma factor RskA (regulator of sigma K) compare
Rv0738 -0.8 -0.8 Conserved protein compare
Rv1589 -0.8 -2.9 Probable biotin synthetase BioB compare
Rv2091c -0.8 -3.7 Probable membrane protein compare
Rv0050 -0.8 -1.7 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv1657 -0.8 -2.1 Probable arginine repressor ArgR (AHRC) compare
Rv2973c -0.8 -2.7 Probable ATP-dependent DNA helicase RecG compare
Rv0391 -0.8 -3.6 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv0994 -0.8 -4.7 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv2276 -0.8 -0.9 Cytochrome P450 121 Cyp121 compare
Rv2691 -0.8 -5.4 TRK system potassium uptake protein CeoB compare
Rv0242c -0.7 -2.0 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv3222c -0.7 -0.9 Conserved hypothetical protein compare
Rv2635 -0.7 -0.7 Hypothetical protein compare
Rv1291c -0.7 -2.1 Conserved hypothetical secreted protein compare
Rv1046c -0.7 -1.7 Hypothetical protein compare
Rv3748 -0.7 -1.2 Conserved hypothetical protein compare
Rv3513c -0.7 -0.7 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0037c -0.7 -6.1 Probable conserved integral membrane protein compare
Rv1072 -0.7 -1.4 Probable conserved transmembrane protein compare
Rv0949 -0.7 -1.2 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0311 -0.7 -1.2 Unknown protein compare
Rv1851 -0.7 -0.8 Urease accessory protein UreF compare
Rv1528c -0.7 -2.2 Probable conserved polyketide synthase associated protein PapA4 compare
Rv0868c -0.7 -1.2 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv0966c -0.7 -1.9 Conserved protein compare
Rv1290A -0.7 -0.7 Hypothetical protein compare
Rv0016c -0.7 -2.3 Probable penicillin-binding protein PbpA compare
Rv0825c -0.7 -1.1 Conserved protein compare
Rv1332 -0.7 -1.3 Probable transcriptional regulatory protein compare
Rv0885 -0.7 -1.9 Conserved hypothetical protein compare
Rv0820 -0.7 -2.8 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2922c -0.7 -2.6 Probable chromosome partition protein Smc compare
Rv0930 -0.7 -4.0 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0876c -0.7 -1.6 Possible conserved transmembrane protein compare
Rv2462c -0.7 -3.4 Probable trigger factor (TF) protein Tig compare
Rv0049 -0.7 -2.0 Conserved hypothetical protein compare
Rv3005c -0.6 -4.3 Conserved hypothetical protein compare
Rv2618 -0.6 -3.8 Conserved hypothetical protein compare
Rv3321c -0.6 -1.5 Possible antitoxin VapB44 compare
Rv1620c -0.6 -1.8 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv3433c -0.6 -1.9 Conserved protein compare
Rv3162c -0.6 -1.5 Possible integral membrane protein compare
Rv3542c -0.6 -1.3 Conserved hypothetical protein compare
Rv3366 -0.6 -1.7 Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) compare
Rv3823c -0.6 -4.2 Conserved integral membrane transport protein MmpL8 compare
Rv1085c -0.6 -3.3 Possible hemolysin-like protein compare
Rv2037c -0.6 -1.4 Conserved transmembrane protein compare
Rv1836c -0.6 -1.3 Conserved protein compare
Rv1568 -0.6 -4.0 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv0871 -0.6 -1.8 Probable cold shock-like protein B CspB compare
Rv2945c -0.6 -4.6 Probable conserved lipoprotein LppX compare
Rv2772c -0.6 -1.1 Probable conserved transmembrane protein compare
Rv0929 -0.6 -1.6 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0691c -0.6 -2.5 Probable transcriptional regulatory protein compare
Rv1049 -0.6 -1.2 Probable transcriptional repressor protein compare
Rv1259 -0.6 -0.7 Probable uracil DNA glycosylase, UdgB compare
Rv1578c -0.6 -0.6 Probable PhiRv1 phage protein compare
Rv3543c -0.6 -2.1 Probable acyl-CoA dehydrogenase FadE29 compare
Rv2737c -0.6 -2.6 RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. compare
Rv0017c -0.6 -2.2 Probable cell division protein RodA compare
Rv0476 -0.6 -3.1 Possible conserved transmembrane protein compare
Rv1010 -0.6 -0.9 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv3910 -0.6 -1.7 Probable conserved transmembrane protein compare
Rv2583c -0.6 -1.4 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv0740 -0.6 -1.5 Conserved hypothetical protein compare
Rv3413c -0.6 -1.1 Unknown alanine and proline rich protein compare
Rv1281c -0.6 -3.5 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD compare
Rv1351 -0.6 -0.6 Hypothetical protein compare
Rv3229c -0.6 -1.4 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv1160 -0.6 -0.9 Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) compare
Rv3267 -0.6 -1.4 Conserved protein (CPSA-related protein) compare
Rv0692 -0.6 -2.1 Conserved hypothetical protein compare
Rv3706c -0.6 -2.3 Conserved hypothetical proline rich protein compare
Rv3342 -0.5 -2.2 Possible methyltransferase (methylase) compare
Rv2672 -0.5 -3.0 Possible secreted protease compare
Rv3256c -0.5 -1.1 Conserved protein compare
Rv3358 -0.5 -1.6 Toxin RelK compare
Rv0086 -0.5 -2.0 Possible hydrogenase HycQ compare
Rv0344c -0.5 -1.2 Probable lipoprotein LpqJ compare
Rv3098c -0.5 -1.5 Hypothetical protein compare
Rv2732c -0.5 -1.9 Probable conserved transmembrane protein compare
Rv1234 -0.5 -1.3 Probable transmembrane protein compare
Rv1823 -0.5 -2.9 Conserved protein compare
Rv2709 -0.5 -3.6 Probable conserved transmembrane protein compare
Rv2369c -0.5 -0.7 Hypothetical protein compare
Rv1490 -0.5 -2.2 Probable membrane protein compare
Rv2679 -0.5 -2.7 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3715c -0.5 -0.9 Probable recombination protein RecR compare
Rv2936 -0.5 -4.1 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv2468A -0.5 -2.1 Conserved protein compare
Rv3843c -0.5 -1.2 Probable conserved transmembrane protein compare
Rv2365c -0.5 -0.5 Conserved hypothetical protein compare
Rv0960 -0.5 -1.9 Possible toxin VapC9 compare
Rv0161 -0.5 -1.7 Possible oxidoreductase compare
Rv0674 -0.5 -0.4 Conserved hypothetical protein compare
Rv2170 -0.5 -1.0 GCN5-related N-acetyltransferase compare
Rv1004c -0.5 -0.9 Probable membrane protein compare
Rv2942 -0.5 -4.1 Conserved transmembrane transport protein MmpL7 compare
Rv2203 -0.5 -2.6 Possible conserved membrane protein compare
Rv1414 -0.5 -0.5 Conserved hypothetical protein compare
Rv3200c -0.5 -2.0 Possible transmembrane cation transporter compare
Rv3716c -0.5 -0.6 Conserved protein compare
Rv2231c -0.5 -1.2 Possible aminotransferase CobC compare
Rv3180c -0.5 -1.6 Hypothetical alanine rich protein compare
Rv2403c -0.5 -1.3 Probable conserved lipoprotein LppR compare
Rv2474c -0.5 -1.0 Conserved hypothetical protein compare
Rv1282c -0.5 -1.4 Probable oligopeptide-transport integral membrane protein ABC transporter OppC compare
Rv1717 -0.5 -1.1 Conserved hypothetical protein compare
Rv1928c -0.5 -2.0 Probable short-chain type dehydrogenase/reductase compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in carbon source experiments

For carbon source L-Aspartic Acid across organisms