Experiment set1S226 for Mycobacterium tuberculosis H37Rv

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D-Glucose carbon source

200 most important genes:

  gene name fitness t score description  
Rv3331 -3.5 -9.7 Probable sugar-transport integral membrane protein SugI compare
Rv1798 -3.0 -2.1 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv0436c -2.9 -2.6 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv3010c -2.7 -5.4 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) compare
Rv0437c -2.5 -1.3 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv3102c -2.4 -4.6 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv1410c -2.4 -10.1 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv0504c -2.3 -3.0 Conserved protein compare
Rv1127c -2.3 -2.6 Probable pyruvate, phosphate dikinase PpdK compare
Rv0247c -2.2 -1.4 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv2982c -2.2 -6.8 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv3810 -2.2 -3.1 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv1272c -2.1 -10.5 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv2476c -2.1 -6.8 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv0758 -2.1 -4.0 Possible two component system response sensor kinase membrane associated PhoR compare
Rv1159 -2.0 -3.6 Mannosyltransferase PimE compare
Rv3267 -2.0 -5.3 Conserved protein (CPSA-related protein) compare
Rv3816c -2.0 -1.6 Possible acyltransferase compare
Rv0472c -2.0 -4.0 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0361 -1.9 -2.1 Probable conserved membrane protein compare
Rv0955 -1.9 -1.7 Probable conserved integral membrane protein compare
Rv2047c -1.9 -7.9 Conserved hypothetical protein compare
Rv2869c -1.9 -1.8 Membrane bound metalloprotease compare
Rv2277c -1.8 -3.7 Possible glycerolphosphodiesterase compare
Rv1590 -1.8 -5.9 Conserved hypothetical protein compare
Rv0642c -1.8 -3.7 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv1411c -1.8 -5.0 Conserved lipoprotein LprG compare
Rv1049 -1.7 -2.9 Probable transcriptional repressor protein compare
Rv1569 -1.7 -5.4 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv3140 -1.7 -5.3 Probable acyl-CoA dehydrogenase FadE23 compare
Rv0241c -1.7 -3.7 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv2048c -1.6 -5.8 Polyketide synthase Pks12 compare
Rv3321c -1.6 -1.6 Possible antitoxin VapB44 compare
Rv2224c -1.6 -11.0 Probable carboxylesterase CaeA compare
Rv1589 -1.6 -7.1 Probable biotin synthetase BioB compare
Rv0929 -1.6 -3.7 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv3139 -1.5 -6.3 Probable acyl-CoA dehydrogenase FadE24 compare
Rv1273c -1.5 -3.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0871 -1.4 -2.7 Probable cold shock-like protein B CspB compare
Rv1836c -1.4 -3.2 Conserved protein compare
Rv1538c -1.4 -6.1 Probable L-aparaginase AnsA compare
Rv1568 -1.4 -9.0 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv3230c -1.4 -4.6 Hypothetical oxidoreductase compare
Rv3803c -1.4 -8.3 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv0249c -1.3 -4.2 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv0007 -1.3 -1.3 Possible conserved membrane protein compare
Rv0497 -1.3 -2.0 Probable conserved transmembrane protein compare
Rv1829 -1.3 -6.1 Conserved protein compare
Rv0242c -1.3 -4.4 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv0379 -1.3 -1.0 Possible protein transport protein SecE2 compare
Rv1013 -1.3 -8.1 Putative polyketide synthase Pks16 compare
Rv1821 -1.3 -4.0 Possible preprotein translocase ATPase SecA2 compare
Rv3101c -1.3 -3.3 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0202c -1.3 -7.1 Probable conserved transmembrane transport protein MmpL11 compare
Rv0675 -1.2 -1.0 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0930 -1.2 -6.0 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv1974 -1.2 -2.6 Probable conserved membrane protein compare
Rv2606c -1.2 -4.1 Possible pyridoxine biosynthesis protein SnzP compare
Rv1421 -1.2 -3.3 Conserved protein compare
Rv0994 -1.2 -7.5 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv0043c -1.2 -1.4 Probable transcriptional regulatory protein (probably GntR-family) compare
Rv1570 -1.2 -2.5 Dethiobiotin synthetase BioD compare
Rv2170 -1.2 -2.1 GCN5-related N-acetyltransferase compare
Rv2702 -1.1 -0.7 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv2302 -1.1 -1.3 Conserved protein compare
Rv3262 -1.1 -2.2 Probable F420 biosynthesis protein FbiB compare
Rv0892 -1.1 -1.9 Probable monooxygenase compare
Rv0012 -1.1 -4.6 Probable conserved membrane protein compare
Rv3066 -1.1 -4.1 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv1701 -1.1 -4.2 Probable integrase/recombinase compare
Rv1791 -1.1 -2.0 PE family protein PE19 compare
Rv0928 -1.1 -3.3 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0949 -1.0 -1.1 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv2583c -1.0 -2.7 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv0954 -1.0 -3.6 Probable conserved transmembrane protein compare
Rv0248c -1.0 -4.0 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv0204c -1.0 -3.7 Probable conserved transmembrane protein compare
Rv2374c -1.0 -2.5 Probable heat shock protein transcriptional repressor HrcA compare
Rv2793c -1.0 -1.4 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv1291c -1.0 -2.5 Conserved hypothetical secreted protein compare
Rv0129c -1.0 -6.1 Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) compare
Rv0037c -1.0 -7.4 Probable conserved integral membrane protein compare
Rv3338 -1.0 -1.2 Conserved hypothetical protein compare
Rv0676c -1.0 -7.7 Probable conserved transmembrane transport protein MmpL5 compare
Rv0885 -0.9 -3.4 Conserved hypothetical protein compare
Rv2171 -0.9 -2.2 Probable conserved lipoprotein LppM compare
Rv0876c -0.9 -2.9 Possible conserved transmembrane protein compare
Rv3229c -0.9 -2.2 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv0040c -0.9 -6.3 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv1823 -0.9 -3.3 Conserved protein compare
Rv2736c -0.9 -2.0 Regulatory protein RecX compare
Rv3542c -0.9 -2.1 Conserved hypothetical protein compare
Rv0243 -0.9 -5.5 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv3770B -0.9 -1.5 Probable remnant of a transposase compare
Rv0016c -0.9 -3.6 Probable penicillin-binding protein PbpA compare
Rv3005c -0.9 -6.8 Conserved hypothetical protein compare
Rv0017c -0.9 -4.1 Probable cell division protein RodA compare
Rv3419c -0.9 -1.2 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv1717 -0.9 -1.1 Conserved hypothetical protein compare
Rv0610c -0.8 -0.7 Hypothetical protein compare
Rv1003 -0.8 -0.9 Conserved protein compare
Rv0757 -0.8 -1.3 Possible two component system response transcriptional positive regulator PhoP compare
Rv0050 -0.8 -1.6 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv1420 -0.8 -1.4 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv2817c -0.8 -1.7 Conserved hypothetical protein compare
Rv0643c -0.8 -4.2 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) compare
Rv2252 -0.8 -0.8 Diacylglycerol kinase compare
Rv2553c -0.8 -0.9 Probable conserved membrane protein compare
Rv0825c -0.8 -1.3 Conserved protein compare
Rv1657 -0.8 -2.6 Probable arginine repressor ArgR (AHRC) compare
Rv0820 -0.8 -3.0 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv0018c -0.8 -3.2 Phosphoserine/threonine phosphatase PstP compare
Rv3768 -0.8 -1.7 Unknown protein compare
Rv3717 -0.8 -2.2 Conserved hypothetical protein compare
Rv1890c -0.8 -1.5 Hypothetical protein compare
Rv0346c -0.8 -5.2 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv2879c -0.8 -1.3 Conserved hypothetical protein compare
Rv0098 -0.8 -2.0 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv1400c -0.8 -0.9 Probable lipase LipH compare
Rv2989 -0.8 -0.7 Probable transcriptional regulatory protein compare
Rv2173 -0.8 -3.2 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv0632c -0.8 -1.2 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0868c -0.8 -1.5 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv2672 -0.8 -4.8 Possible secreted protease compare
Rv0157 -0.7 -3.0 Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta) compare
Rv3586 -0.7 -3.2 Conserved hypothetical protein compare
Rv0738 -0.7 -0.8 Conserved protein compare
Rv3363c -0.7 -2.3 Conserved hypothetical protein compare
Rv3819 -0.7 -0.7 Unknown protein compare
Rv2003c -0.7 -1.1 Conserved hypothetical protein compare
Rv1332 -0.7 -0.9 Probable transcriptional regulatory protein compare
Rv1679 -0.7 -1.3 Possible acyl-CoA dehydrogenase FadE16 compare
Rv2091c -0.7 -2.9 Probable membrane protein compare
Rv0677c -0.7 -1.3 Possible conserved membrane protein MmpS5 compare
Rv3867 -0.7 -3.7 ESX-1 secretion-associated protein EspH compare
Rv0999 -0.7 -1.7 Unknown protein compare
Rv0766c -0.7 -1.7 Probable cytochrome P450 123 Cyp123 compare
Rv3147 -0.7 -2.4 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) compare
Rv1824 -0.7 -1.6 Conserved hypothetical membrane protein compare
Rv3433c -0.7 -2.0 Conserved protein compare
Rv3868 -0.7 -5.0 ESX conserved component EccA1. ESX-1 type VII secretion system protein. compare
Rv0939 -0.7 -0.9 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv3685c -0.7 -5.0 Probable cytochrome P450 137 Cyp137 compare
Rv0161 -0.7 -2.8 Possible oxidoreductase compare
Rv1566c -0.7 -2.8 Possible Inv protein compare
Rv1620c -0.7 -1.8 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv3249c -0.7 -1.1 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2618 -0.7 -3.5 Conserved hypothetical protein compare
Rv3045 -0.7 -2.4 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv2206 -0.7 -3.7 Probable conserved transmembrane protein compare
Rv0280 -0.7 -5.1 PPE family protein PPE3 compare
Rv2276 -0.7 -1.0 Cytochrome P450 121 Cyp121 compare
Rv1282c -0.7 -2.2 Probable oligopeptide-transport integral membrane protein ABC transporter OppC compare
Rv0886 -0.7 -4.2 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) compare
Rv1825 -0.7 -1.9 Conserved protein compare
Rv2624c -0.7 -1.0 Universal stress protein family protein compare
Rv0563 -0.7 -1.3 Probable protease transmembrane protein heat shock protein HtpX compare
Rv1006 -0.7 -3.4 Unknown protein compare
Rv2154c -0.7 -2.0 FtsW-like protein FtsW compare
Rv3256c -0.7 -1.4 Conserved protein compare
Rv1747 -0.7 -5.2 Probable conserved transmembrane ATP-binding protein ABC transporter compare
Rv0391 -0.7 -3.8 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv0912 -0.7 -1.7 Probable conserved transmembrane protein compare
Rv3850 -0.6 -1.1 Conserved protein compare
Rv3148 -0.6 -3.9 Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) compare
Rv0984 -0.6 -1.6 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) compare
Rv2707 -0.6 -4.9 Probable conserved transmembrane alanine and leucine rich protein compare
Rv1022 -0.6 -3.4 Probable conserved lipoprotein LpqU compare
Rv0250c -0.6 -3.0 Conserved protein compare
Rv2973c -0.6 -3.0 Probable ATP-dependent DNA helicase RecG compare
Rv2801c -0.6 -0.6 Toxin MazF9 compare
Rv3306c -0.6 -1.4 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv2687c -0.6 -2.3 Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter compare
Rv2462c -0.6 -3.3 Probable trigger factor (TF) protein Tig compare
Rv2581c -0.6 -0.8 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv0450c -0.6 -4.1 Probable conserved transmembrane transport protein MmpL4 compare
Rv0444c -0.6 -2.8 Anti-sigma factor RskA (regulator of sigma K) compare
Rv3600c -0.6 -1.4 Conserved protein compare
Rv2268c -0.6 -2.0 Probable cytochrome P450 128 Cyp128 compare
Rv1324 -0.6 -0.7 Possible thioredoxin compare
Rv3719 -0.6 -2.6 Conserved protein compare
Rv1565c -0.6 -3.2 Conserved hypothetical membrane protein compare
Rv3610c -0.6 -1.4 Membrane-bound protease FtsH (cell division protein) compare
Rv0190 -0.6 -3.1 Conserved protein compare
Rv3755c -0.6 -2.6 Conserved protein compare
Rv1509 -0.6 -2.3 Hypothetical protein compare
Rv0200 -0.6 -1.0 Possible conserved transmembrane protein compare
Rv1364c -0.6 -2.2 Possible sigma factor regulatory protein compare
Rv0819 -0.6 -1.9 GCN5-related N-acetyltransferase, MshD compare
Rv0229c -0.6 -2.4 Possible conserved membrane protein with PIN domain compare
Rv3261 -0.6 -2.2 Probable F420 biosynthesis protein FbiA compare
Rv1259 -0.6 -0.6 Probable uracil DNA glycosylase, UdgB compare
Rv2791c -0.6 -1.4 Probable transposase compare
Rv2782c -0.5 -1.8 Probable zinc protease PepR compare
Rv3316 -0.5 -1.5 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv3687c -0.5 -0.6 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv0100 -0.5 -1.5 Conserved hypothetical protein compare
Rv3787c -0.5 -1.2 Conserved hypothetical protein compare
Rv2230c -0.5 -0.9 Conserved protein compare
Rv3136 -0.5 -2.2 PPE family protein PPE51 compare


Specific Phenotypes

For 1 genes in this experiment

For carbon source D-Glucose in Mycobacterium tuberculosis H37Rv

For carbon source D-Glucose across organisms