Experiment set1S226 for Mycobacterium tuberculosis H37Rv

Compare to:

D-Glucose carbon source

200 most detrimental genes:

  gene name fitness t score description  
Rv0991c +1.5 4.0 Conserved serine rich protein compare
Rv0609 +1.5 2.1 Possible toxin VapC28. Contains PIN domain. compare
Rv3046c +1.4 1.5 Conserved protein compare
Rv2292c +1.2 1.9 Hypothetical protein compare
Rv3678A +1.0 1.6 Conserved hypothetical protein compare
Rv3512 +1.0 3.5 PE-PGRS family protein PE_PGRS56 compare
Rv2382c +0.9 1.5 Polyketide synthetase MbtC (polyketide synthase) compare
Rv2867c +0.8 4.9 GCN5-related N-acetyltransferase compare
Rv1112 +0.8 1.8 Probable GTP binding protein compare
Rv0615 +0.8 1.4 Probable integral membrane protein compare
Rv2506 +0.8 4.4 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0470c +0.7 3.2 Mycolic acid synthase PcaA (cyclopropane synthase) compare
Rv1055 +0.7 1.1 Possible integrase (fragment) compare
Rv3751 +0.7 1.3 Probable integrase (fragment) compare
Rv2026c +0.7 1.2 Universal stress protein family protein compare
Rv2731 +0.7 4.5 Conserved alanine and arginine rich protein compare
Rv1751 +0.6 1.4 Probable oxidoreductase compare
Rv2500c +0.6 1.4 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv1303 +0.6 1.0 Conserved hypothetical transmembrane protein compare
Rv1180 +0.6 2.9 Probable polyketide beta-ketoacyl synthase Pks3 compare
Rv2613c +0.6 2.2 Conserved protein compare
Rv3182 +0.6 0.7 Conserved hypothetical protein compare
Rv0674 +0.6 0.6 Conserved hypothetical protein compare
Rv2850c +0.6 1.4 Possible magnesium chelatase compare
Rv2898c +0.6 0.7 Conserved hypothetical protein compare
Rv3826 +0.6 3.2 Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv0203 +0.6 2.3 Possible exported protein compare
Rv1366A +0.6 0.7 Conserved protein compare
Rv3920c +0.6 1.3 Conserved protein similar to jag protein compare
Rv0295c +0.6 2.6 Conserved protein compare
Rv3220c +0.6 1.3 Probable two component sensor kinase compare
Rv1170 +0.6 1.8 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv1401 +0.6 1.2 Possible membrane protein compare
Rv2040c +0.6 2.0 Probable sugar-transport integral membrane protein ABC transporter compare
Rv1715 +0.6 1.8 Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) compare
Rv1792 +0.5 0.9 ESAT-6 like protein EsxM compare
Rv3050c +0.5 2.2 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv3655c +0.5 1.6 Conserved hypothetical protein compare
Rv1934c +0.5 1.3 Probable acyl-CoA dehydrogenase FadE17 compare
Rv3484 +0.5 3.5 Possible conserved protein CpsA compare
Rv1850 +0.5 1.2 Urease alpha subunit UreC (urea amidohydrolase) compare
Rv1474c +0.5 1.8 Probable transcriptional regulatory protein compare
Rv0465c +0.5 4.2 Probable transcriptional regulatory protein compare
Rv3133c +0.5 2.1 Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) compare
Rv1290A +0.5 0.7 Hypothetical protein compare
Rv1414 +0.5 0.5 Conserved hypothetical protein compare
Rv0608 +0.5 1.1 Possible antitoxin VapB28 compare
Rv3387 +0.5 1.4 Possible transposase compare
Rv2887 +0.5 0.5 Probable transcriptional regulatory protein compare
Rv0537c +0.5 2.7 Probable integral membrane protein compare
Rv2055c +0.5 1.3 30S ribosomal protein S18 RpsR2 compare
Rv0577 +0.5 3.0 Conserved protein TB27.3 compare
Rv1444c +0.5 1.4 Unknown protein compare
Rv2858c +0.5 1.8 Probable aldehyde dehydrogenase AldC compare
Rv3726 +0.5 1.1 Possible dehydrogenase compare
Rv0093c +0.5 0.7 Probable conserved membrane protein compare
Rv1982c +0.5 1.6 Possible toxin VapC36. Contains PIN domain. compare
Rv0554 +0.5 2.6 Possible peroxidase BpoC (non-haem peroxidase) compare
Rv3114 +0.5 0.9 Conserved hypothetical protein compare
Rv0030 +0.5 1.1 Conserved hypothetical protein compare
Rv2274c +0.5 1.6 Possible toxin MazF8 compare
Rv0590 +0.5 1.4 Mce-family protein Mce2B compare
Rv0742 +0.5 1.2 PE-PGRS family protein PE_PGRS8 compare
Rv1579c +0.5 1.3 Probable PhiRv1 phage protein compare
Rv0460 +0.4 1.5 Conserved hydrophobic protein compare
Rv1672c +0.4 1.4 Probable conserved integral membrane transport protein compare
Rv0395 +0.4 1.4 Hypothetical protein compare
Rv0786c +0.4 1.3 Conserved protein compare
Rv0360c +0.4 1.8 Conserved protein compare
Rv2416c +0.4 2.1 Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase compare
Rv0234c +0.4 1.6 Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 compare
Rv3527 +0.4 0.9 Hypothetical protein compare
Rv0673 +0.4 1.9 Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2826c +0.4 1.9 Hypothetical protein compare
Rv0889c +0.4 1.4 Probable citrate synthase II CitA compare
Rv3825c +0.4 3.9 Polyketide synthase Pks2 compare
Rv3820c +0.4 3.6 Possible conserved polyketide synthase associated protein PapA2 compare
Rv2739c +0.4 1.2 Possible alanine rich transferase compare
Rv0168 +0.4 1.6 Conserved integral membrane protein YrbE1B compare
Rv2939 +0.4 3.1 Possible conserved polyketide synthase associated protein PapA5 compare
Rv2251 +0.4 1.2 Possible flavoprotein compare
Rv0899 +0.4 1.1 Outer membrane protein A OmpA compare
Rv2137c +0.4 1.4 Conserved hypothetical protein compare
Rv1502 +0.4 1.1 Hypothetical protein compare
Rv2307D +0.4 1.7 Hypothetical protein compare
Rv2821c +0.4 0.9 Conserved hypothetical protein compare
Rv3065 +0.4 1.4 Multidrugs-transport integral membrane protein Mmr compare
Rv2941 +0.4 3.5 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv1262c +0.4 1.0 Hypothetical hit-like protein compare
Rv1513 +0.4 0.8 Conserved protein compare
Rv0572c +0.4 2.5 Hypothetical protein compare
Rv0426c +0.4 1.3 Possible transmembrane protein compare
Rv2621c +0.4 0.8 Possible transcriptional regulatory protein compare
Rv1087 +0.4 2.9 PE-PGRS family protein PE_PGRS21 compare
Rv1070c +0.4 2.8 Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2929 +0.4 2.4 Hypothetical protein compare
Rv2629 +0.4 1.0 Conserved protein compare
Rv3167c +0.4 1.0 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1372 +0.4 1.0 Conserved hypothetical protein compare
Rv1087A +0.4 1.8 Conserved hypothetical protein compare
Rv2558 +0.4 1.1 Conserved protein compare
Rv0877 +0.4 2.5 Conserved hypothetical protein compare
Rv3824c +0.4 2.4 Conserved polyketide synthase associated protein PapA1 compare
Rv0580c +0.4 0.7 Conserved protein compare
Rv0499 +0.4 1.4 Conserved hypothetical protein compare
Rv3777 +0.4 2.0 Probable oxidoreductase compare
Rv1071c +0.4 1.9 Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3737 +0.4 2.0 Probable conserved transmembrane protein compare
Rv0586 +0.4 1.3 Probable transcriptional regulatory protein Mce2R (GntR-family) compare
Rv2774c +0.4 0.6 Hypothetical protein compare
Rv1780 +0.4 1.3 Conserved protein compare
Rv3394c +0.4 0.7 Conserved hypothetical protein compare
Rv3104c +0.4 1.2 Possible conserved transmembrane protein compare
Rv0968 +0.4 1.3 Conserved protein compare
Rv0530A +0.4 2.2 Conserved protein compare
Rv0089 +0.4 1.7 Possible methyltransferase/methylase compare
Rv0745 +0.4 1.6 Conserved hypothetical protein compare
Rv3165c +0.4 0.7 Unknown protein compare
Rv2319c +0.4 1.2 Universal stress protein family protein compare
Rv2571c +0.4 1.6 Probable transmembrane alanine and valine and leucine rich protein compare
Rv3565 +0.4 1.1 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv2227 +0.4 1.6 Conserved hypothetical protein compare
Rv0245 +0.4 1.2 Possible oxidoreductase compare
Rv2396 +0.4 2.2 PE-PGRS family protein PE_PGRS41 compare
Rv3163c +0.4 1.3 Possible conserved secreted protein compare
Rv3022A +0.4 1.5 PE family protein PE29 compare
Rv3197 +0.4 2.0 Probable conserved ATP-binding protein ABC transporter compare
Rv2931 +0.4 3.3 Phenolpthiocerol synthesis type-I polyketide synthase PpsA compare
Rv1399c +0.4 2.0 Probable non lipolytic carboxylesterase NlhH compare
Rv2331A +0.4 0.6 Hypothetical protein compare
Rv0942 +0.4 1.8 Hypothetical protein compare
Rv0260c +0.4 1.5 Possible transcriptional regulatory protein compare
Rv1033c +0.4 2.3 Two component transcriptional regulator TrcR compare
Rv1506c +0.4 1.1 Hypothetical protein compare
Rv2010 +0.4 1.2 Toxin VapC15 compare
Rv3723 +0.4 1.0 Probable conserved transmembrane protein compare
Rv2473 +0.4 2.1 Possible alanine and proline rich membrane protein compare
Rv2800 +0.4 2.5 Possible hydrolase compare
Rv2742c +0.4 2.2 Conserved hypothetical arginine rich protein compare
Rv0279c +0.4 2.5 PE-PGRS family protein PE_PGRS4 compare
Rv1190 +0.4 2.1 Conserved hypothetical protein compare
Rv3637 +0.3 0.7 Possible transposase compare
Rv3298c +0.3 2.1 Possible esterase lipoprotein LpqC compare
Rv3364c +0.3 1.4 Conserved protein compare
Rv2175c +0.3 0.8 Conserved regulatory protein compare
Rv0270 +0.3 1.9 Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv3817 +0.3 1.2 Possible phosphotransferase compare
Rv3766 +0.3 1.2 Hypothetical protein compare
Rv1181 +0.3 1.9 Probable polyketide beta-ketoacyl synthase Pks4 compare
Rv2655c +0.3 1.4 Possible PhiRv2 prophage protein compare
Rv0251c +0.3 1.1 Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A) compare
Rv0170 +0.3 1.5 Mce-family protein Mce1B compare
Rv1182 +0.3 2.0 Probable conserved polyketide synthase associated protein PapA3 compare
Rv1359 +0.3 1.1 Probable transcriptional regulatory protein compare
Rv1896c +0.3 1.8 Conserved hypothetical protein compare
Rv2930 +0.3 3.0 Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv2231A +0.3 1.6 Possible toxin VapC16 compare
Rv2551c +0.3 0.7 Conserved hypothetical protein compare
Rv3377c +0.3 2.0 Halimadienyl diphosphate synthase compare
Rv2365c +0.3 0.4 Conserved hypothetical protein compare
Rv2626c +0.3 1.8 Hypoxic response protein 1 Hrp1 compare
Rv2940c +0.3 2.9 Probable multifunctional mycocerosic acid synthase membrane-associated Mas compare
Rv2070c +0.3 1.2 Precorrin-6X reductase CobK compare
Rv3589 +0.3 1.1 Probable adenine glycosylase MutY compare
Rv3533c +0.3 2.4 PPE family protein PPE62 compare
Rv0258c +0.3 1.2 Conserved hypothetical protein compare
Rv3507 +0.3 2.4 PE-PGRS family protein PE_PGRS53 compare
Rv2932 +0.3 2.6 Phenolpthiocerol synthesis type-I polyketide synthase PpsB compare
Rv3643 +0.3 0.8 Hypothetical protein compare
Rv2637 +0.3 1.0 Possible transmembrane protein DedA compare
Rv2087 +0.3 0.8 Conserved hypothetical protein compare
Rv3427c +0.3 1.0 Possible transposase compare
Rv2321c +0.3 0.6 Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) compare
Rv2933 +0.3 2.6 Phenolpthiocerol synthesis type-I polyketide synthase PpsC compare
Rv2622 +0.3 1.5 Possible methyltransferase (methylase) compare
Rv1088 +0.3 1.3 PE family protein PE9 compare
Rv0281 +0.3 2.0 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv1227c +0.3 1.1 Probable transmembrane protein compare
Rv0169 +0.3 2.1 Mce-family protein Mce1A compare
Rv3208A +0.3 0.9 Conserved protein TB9.4 compare
Rv1350 +0.3 0.4 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv3508 +0.3 1.3 PE-PGRS family protein PE_PGRS54 compare
Rv1091 +0.3 2.2 PE-PGRS family protein PE_PGRS22 compare
Rv1871c +0.3 1.5 Conserved protein compare
Rv1473A +0.3 0.4 Possible transcriptional regulatory protein compare
Rv1394c +0.3 1.6 Probable cytochrome P450 132 Cyp132 compare
Rv0581 +0.3 1.4 Possible antitoxin VapB26 compare
Rv0549c +0.3 1.0 Possible toxin VapC3 compare
Rv0488 +0.3 1.8 Probable conserved integral membrane protein compare
Rv0057 +0.3 1.2 Hypothetical protein compare
Rv3758c +0.3 0.9 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV compare
Rv2935 +0.3 2.5 Phenolpthiocerol synthesis type-I polyketide synthase PpsE compare
Rv2213 +0.3 1.0 Probable aminopeptidase PepB compare
Rv1497 +0.3 1.4 Probable esterase LipL compare
Rv1128c +0.3 0.8 Conserved hypothetical protein compare
Rv2410c +0.3 1.5 Conserved protein compare
Rv0173 +0.3 1.7 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) compare
Rv3863 +0.3 1.3 Unknown alanine rich protein compare
Rv0783c +0.3 1.9 Possible multidrug resistance integral membrane efflux protein EmrB compare
Rv2236c +0.3 0.9 Probable cobalamin biosynthesis transmembrane protein CobD compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in carbon source experiments

For carbon source D-Glucose across organisms