Experiment set1S221 for Mycobacterium tuberculosis H37Rv

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Sodium propionate carbon source

200 most important genes:

  gene name fitness t score description  
Rv1129c -3.9 -8.5 Probable transcriptional regulator protein compare
Rv1538c -3.9 -9.4 Probable L-aparaginase AnsA compare
Rv3400 -3.3 -11.1 Probable hydrolase compare
Rv3848 -3.2 -3.2 Probable conserved transmembrane protein compare
Rv1131 -3.1 -3.4 Probable methylcitrate synthase PrpC compare
Rv3810 -3.1 -3.2 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv3150 -3.0 -6.3 Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) compare
Rv3148 -2.9 -7.1 Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) compare
Rv1130 -2.8 -6.5 Possible methylcitrate dehydratase PrpD compare
Rv1798 -2.7 -1.6 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv0249c -2.7 -7.2 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv0018c -2.7 -4.9 Phosphoserine/threonine phosphatase PstP compare
Rv3149 -2.6 -7.9 Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E) compare
Rv3154 -2.6 -6.1 Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J) compare
Rv3156 -2.6 -11.5 Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L) compare
Rv3152 -2.6 -9.9 Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) compare
Rv2982c -2.5 -5.1 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv3145 -2.4 -10.7 Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) compare
Rv2606c -2.4 -4.0 Possible pyridoxine biosynthesis protein SnzP compare
Rv3147 -2.4 -5.1 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) compare
Rv2365c -2.3 -1.0 Conserved hypothetical protein compare
Rv3146 -2.3 -6.9 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) compare
Rv1193 -2.3 -5.4 Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2476c -2.3 -5.2 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv3229c -2.2 -2.8 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv3158 -2.2 -10.4 Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) compare
Rv2292c -2.2 -1.1 Hypothetical protein compare
Rv3153 -2.2 -6.7 Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I) compare
Rv3157 -2.2 -5.5 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) compare
Rv0248c -2.1 -6.1 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv0758 -2.0 -2.9 Possible two component system response sensor kinase membrane associated PhoR compare
Rv0247c -2.0 -1.0 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3143 -2.0 -2.0 Probable response regulator compare
Rv0472c -2.0 -4.4 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0757 -2.0 -2.2 Possible two component system response transcriptional positive regulator PhoP compare
Rv1085c -2.0 -5.6 Possible hemolysin-like protein compare
Rv1291c -1.9 -2.8 Conserved hypothetical secreted protein compare
Rv2583c -1.9 -2.8 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv0642c -1.9 -3.4 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv3066 -1.9 -5.7 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv1272c -1.9 -9.2 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0871 -1.8 -2.4 Probable cold shock-like protein B CspB compare
Rv1890c -1.8 -1.7 Hypothetical protein compare
Rv3151 -1.8 -4.1 Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G) compare
Rv1512 -1.8 -1.0 Probable nucleotide-sugar epimerase EpiA compare
Rv0408 -1.8 -5.8 Probable phosphate acetyltransferase Pta (phosphotransacetylase) conserved
Rv0280 -1.8 -10.5 PPE family protein PPE3 compare
Rv1410c -1.8 -9.8 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3102c -1.7 -3.1 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv1578c -1.7 -1.0 Probable PhiRv1 phage protein compare
Rv1590 -1.7 -4.2 Conserved hypothetical protein compare
Rv0056 -1.7 -2.2 50S ribosomal protein L9 RplI compare
Rv0190 -1.6 -4.8 Conserved protein compare
Rv3321c -1.6 -1.5 Possible antitoxin VapB44 compare
Rv1569 -1.6 -3.9 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv1127c -1.6 -1.5 Probable pyruvate, phosphate dikinase PpdK compare
Rv2869c -1.6 -2.5 Membrane bound metalloprotease compare
Rv1568 -1.6 -8.0 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv1159 -1.6 -3.7 Mannosyltransferase PimE compare
Rv1836c -1.5 -2.3 Conserved protein compare
Rv1565c -1.5 -6.6 Conserved hypothetical membrane protein compare
Rv3816c -1.5 -1.0 Possible acyltransferase compare
Rv3610c -1.5 -2.2 Membrane-bound protease FtsH (cell division protein) compare
Rv1273c -1.4 -3.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1058 -1.4 -5.9 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0346c -1.4 -9.1 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv0437c -1.4 -0.7 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv1364c -1.4 -5.2 Possible sigma factor regulatory protein compare
Rv2224c -1.4 -8.9 Probable carboxylesterase CaeA compare
Rv1898 -1.4 -2.2 Conserved hypothetical protein compare
Rv3230c -1.4 -3.2 Hypothetical oxidoreductase compare
Rv1626 -1.4 -3.4 Probable two-component system transcriptional regulator compare
Rv0409 -1.4 -3.8 Probable acetate kinase AckA (acetokinase) compare
Rv3267 -1.4 -3.2 Conserved protein (CPSA-related protein) compare
Rv2374c -1.3 -2.8 Probable heat shock protein transcriptional repressor HrcA compare
Rv0995 -1.3 -1.3 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) compare
Rv2170 -1.3 -1.7 GCN5-related N-acetyltransferase compare
Rv0391 -1.3 -5.7 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv1821 -1.3 -3.3 Possible preprotein translocase ATPase SecA2 compare
Rv0990c -1.3 -0.7 Hypothetical protein compare
Rv2444c -1.3 -2.7 Possible ribonuclease E Rne compare
Rv1570 -1.3 -1.9 Dethiobiotin synthetase BioD compare
Rv0741 -1.3 -2.1 Probable transposase (fragment) compare
Rv2048c -1.3 -6.1 Polyketide synthase Pks12 compare
Rv2635 -1.3 -0.7 Hypothetical protein compare
Rv2047c -1.3 -5.3 Conserved hypothetical protein compare
Rv0275c -1.3 -2.0 Possible transcriptional regulatory protein (possibly TetR-family) compare
Rv2862A -1.3 -2.7 Possible antitoxin VapB23 compare
Rv0407 -1.2 -4.0 F420-dependent glucose-6-phosphate dehydrogenase Fgd1 compare
Rv1589 -1.2 -3.3 Probable biotin synthetase BioB compare
Rv0876c -1.2 -2.0 Possible conserved transmembrane protein compare
Rv0321 -1.2 -1.8 Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) compare
Rv3575c -1.2 -5.4 Transcriptional regulatory protein (probably LacI-family) compare
Rv3101c -1.2 -2.4 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv2788 -1.2 -2.3 Probable transcriptional repressor SirR compare
Rv3823c -1.2 -7.6 Conserved integral membrane transport protein MmpL8 compare
Rv0436c -1.2 -1.7 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv3193c -1.2 -1.5 Probable conserved transmembrane protein compare
Rv3478 -1.2 -2.4 PE family protein PPE60 compare
Rv3513c -1.2 -0.9 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2506 -1.1 -2.1 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1013 -1.1 -6.7 Putative polyketide synthase Pks16 compare
Rv0016c -1.1 -2.4 Probable penicillin-binding protein PbpA compare
Rv2745c -1.1 -1.8 Transcriptional regulatory protein ClgR compare
Rv0504c -1.1 -1.6 Conserved protein compare
Rv3136 -1.1 -4.3 PPE family protein PPE51 compare
Rv0955 -1.1 -1.0 Probable conserved integral membrane protein compare
Rv0390 -1.1 -3.0 Conserved protein compare
Rv2588c -1.1 -1.7 Probable conserved membrane protein secretion factor YajC compare
Rv3033 -1.0 -0.5 Unknown protein compare
Rv3650 -1.0 -0.6 PE family protein PE33 compare
Rv1531 -1.0 -1.6 Conserved protein compare
Rv1946c -1.0 -1.9 Possible lipoprotein compare
Rv3085 -1.0 -0.5 Probable short-chain type dehydrogenase/reductase compare
Rv0204c -1.0 -2.8 Probable conserved transmembrane protein compare
Rv0200 -1.0 -1.8 Possible conserved transmembrane protein compare
Rv3140 -1.0 -4.1 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2417c -1.0 -2.1 Conserved protein compare
Rv0043c -1.0 -1.4 Probable transcriptional regulatory protein (probably GntR-family) compare
Rv2657c -1.0 -1.0 Probable PhiRv2 prophage protein compare
Rv0545c -1.0 -2.9 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv1183 -1.0 -4.3 Probable conserved transmembrane transport protein MmpL10 compare
Rv1072 -1.0 -1.1 Probable conserved transmembrane protein compare
Rv2154c -1.0 -1.6 FtsW-like protein FtsW compare
Rv0400c -1.0 -2.2 Acyl-CoA dehydrogenase FadE7 compare
Rv0161 -1.0 -2.3 Possible oxidoreductase compare
Rv3358 -1.0 -1.8 Toxin RelK compare
Rv1332 -1.0 -1.4 Probable transcriptional regulatory protein compare
Rv0344c -1.0 -2.3 Probable lipoprotein LpqJ compare
Rv3139 -1.0 -4.2 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3249c -1.0 -0.8 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3420c -0.9 -2.2 Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18) compare
Rv2736c -0.9 -1.6 Regulatory protein RecX compare
Rv0017c -0.9 -3.0 Probable cell division protein RodA compare
Rv3803c -0.9 -4.4 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv3868 -0.9 -5.9 ESX conserved component EccA1. ESX-1 type VII secretion system protein. compare
Rv0989c -0.9 -4.3 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2384 -0.9 -2.1 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv1640c -0.9 -4.7 Lysyl-tRNA synthetase 2 LysX compare
Rv1286 -0.9 -2.2 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase compare
Rv2605c -0.9 -2.2 Probable acyl-CoA thioesterase II TesB2 (TEII) compare
Rv1053c -0.9 -0.7 Hypothetical protein compare
Rv0819 -0.9 -2.4 GCN5-related N-acetyltransferase, MshD compare
Rv2064 -0.9 -2.8 Precorrin-3B synthase CobG compare
Rv3374 -0.9 -1.5 Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2429 -0.9 -1.0 Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) compare
Rv2550c -0.9 -2.0 Possible antitoxin VapB20 compare
Rv0655 -0.9 -2.7 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv1411c -0.9 -2.2 Conserved lipoprotein LprG compare
Rv2774c -0.9 -0.8 Hypothetical protein compare
Rv3416 -0.8 -1.1 Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster. compare
Rv1791 -0.8 -1.1 PE family protein PE19 compare
Rv2694c -0.8 -3.4 Conserved protein compare
Rv3200c -0.8 -2.2 Possible transmembrane cation transporter compare
Rv3477 -0.8 -1.2 PE family protein PE31 compare
Rv2029c -0.8 -1.3 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) compare
Rv2691 -0.8 -3.7 TRK system potassium uptake protein CeoB compare
Rv1940 -0.8 -2.1 Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II) compare
Rv0019c -0.8 -2.7 Conserved protein with FHA domain, FhaB compare
Rv2707 -0.8 -5.1 Probable conserved transmembrane alanine and leucine rich protein compare
Rv2661c -0.8 -1.4 Hypothetical protein compare
Rv0825c -0.8 -1.3 Conserved protein compare
Rv0744c -0.8 -2.5 Possible transcriptional regulatory protein compare
Rv3306c -0.8 -1.0 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv1096 -0.8 -0.8 Possible glycosyl hydrolase compare
Rv0135c -0.8 -2.8 Possible transcriptional regulatory protein compare
Rv0202c -0.8 -5.1 Probable conserved transmembrane transport protein MmpL11 compare
Rv0328 -0.8 -0.9 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) compare
Rv1276c -0.8 -2.1 Conserved hypothetical protein compare
Rv0820 -0.8 -3.4 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv1097c -0.8 -1.5 Probable membrane glycine and proline rich protein compare
Rv1025 -0.8 -0.6 Conserved protein compare
Rv2427c -0.8 -2.4 Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase) compare
Rv1895 -0.8 -1.6 Possible dehydrogenase compare
Rv2722 -0.8 -3.3 Conserved hypothetical protein compare
Rv3045 -0.8 -2.8 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv1620c -0.8 -1.5 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0497 -0.8 -1.2 Probable conserved transmembrane protein compare
Rv2553c -0.8 -0.7 Probable conserved membrane protein compare
Rv1829 -0.8 -3.9 Conserved protein compare
Rv1160 -0.7 -1.4 Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) compare
Rv0413 -0.7 -3.5 Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) compare
Rv3919c -0.7 -1.8 Probable glucose-inhibited division protein B Gid compare
Rv2462c -0.7 -3.7 Probable trigger factor (TF) protein Tig compare
Rv2252 -0.7 -0.5 Diacylglycerol kinase compare
Rv0930 -0.7 -4.4 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv3050c -0.7 -2.6 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv0113 -0.7 -1.0 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv3433c -0.7 -1.5 Conserved protein compare
Rv1694 -0.7 -1.0 2'-O-methyltransferase TlyA compare
Rv1657 -0.7 -0.9 Probable arginine repressor ArgR (AHRC) compare
Rv3723 -0.7 -2.6 Probable conserved transmembrane protein compare
Rv3543c -0.7 -2.4 Probable acyl-CoA dehydrogenase FadE29 compare
Rv0452 -0.7 -2.5 Possible transcriptional regulatory protein compare
Rv2696c -0.7 -1.7 Conserved alanine and glycine and valine rich protein compare
Rv3540c -0.7 -1.9 Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2 compare
Rv2502c -0.7 -3.7 Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1 compare
Rv2205c -0.7 -2.7 Conserved hypothetical protein compare
Rv0877 -0.7 -4.6 Conserved hypothetical protein compare
Rv3833 -0.7 -1.5 Transcriptional regulatory protein (probably AraC-family) compare


Specific Phenotypes

For 16 genes in this experiment

For carbon source Sodium propionate in Mycobacterium tuberculosis H37Rv

For carbon source Sodium propionate across organisms