Experiment set1S214 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv0642c		-5.3	-3.7	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv0361		-4.7	-2.2	Probable conserved membrane protein
Rv1930c		-4.3	-1.2	Conserved hypothetical protein
Rv2047c		-3.8	-12.8	Conserved hypothetical protein
Rv0757		-3.8	-2.4	Possible two component system response transcriptional positive regulator PhoP
Rv3102c		-3.7	-3.9	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv3810		-3.2	-3.1	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv1127c		-3.0	-2.3	Probable pyruvate, phosphate dikinase PpdK
Rv0676c		-2.9	-14.6	Probable conserved transmembrane transport protein MmpL5
Rv0202c		-2.9	-11.2	Probable conserved transmembrane transport protein MmpL11
Rv2696c		-2.8	-3.5	Conserved alanine and glycine and valine rich protein
Rv2048c		-2.7	-7.5	Polyketide synthase Pks12
Rv1159		-2.5	-2.9	Mannosyltransferase PimE
Rv0007		-2.4	-1.0	Possible conserved membrane protein
Rv0472c		-2.4	-4.4	Probable transcriptional regulatory protein (possibly TetR-family)
Rv3101c		-2.3	-1.7	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv2630		-2.2	-1.0	Hypothetical protein
Rv3897c		-2.2	-1.1	Conserved hypothetical protein
Rv2581c		-2.2	-1.8	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv0820		-2.1	-4.0	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv2224c		-2.0	-11.8	Probable carboxylesterase CaeA
Rv2553c		-1.9	-1.2	Probable conserved membrane protein
Rv2691		-1.8	-9.8	TRK system potassium uptake protein CeoB
Rv1620c		-1.8	-3.8	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv3822		-1.8	-12.6	Conserved hypothetical protein
Rv3193c		-1.7	-1.9	Probable conserved transmembrane protein
Rv1621c		-1.7	-2.9	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv2331A		-1.7	-1.2	Hypothetical protein
Rv1410c		-1.7	-8.0	Aminoglycosides/tetracycline-transport integral membrane protein
Rv0930		-1.6	-5.6	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv0929		-1.6	-2.0	Phosphate-transport integral membrane ABC transporter PstC2
Rv1291c		-1.6	-1.6	Conserved hypothetical secreted protein
Rv2869c		-1.6	-2.2	Membrane bound metalloprotease
Rv0677c		-1.6	-1.2	Possible conserved membrane protein MmpS5
Rv2694c		-1.6	-4.5	Conserved protein
Rv1010		-1.6	-1.2	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv0018c		-1.5	-4.1	Phosphoserine/threonine phosphatase PstP
Rv0994		-1.5	-8.4	Probable molybdopterin biosynthesis protein MoeA1
Rv3717		-1.5	-5.1	Conserved hypothetical protein
Rv3687c		-1.5	-1.0	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv0497		-1.5	-1.9	Probable conserved transmembrane protein
Rv3267		-1.5	-3.3	Conserved protein (CPSA-related protein)
Rv0819		-1.5	-2.9	GCN5-related N-acetyltransferase, MshD
Rv2190c		-1.5	-4.2	Conserved hypothetical protein
Rv1013		-1.4	-6.9	Putative polyketide synthase Pks16
Rv0999		-1.4	-2.2	Unknown protein
Rv0928		-1.4	-2.8	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2624c		-1.4	-1.0	Universal stress protein family protein
Rv3005c		-1.4	-7.2	Conserved hypothetical protein
Rv3208A		-1.3	-1.3	Conserved protein TB9.4
Rv3650		-1.3	-0.7	PE family protein PE33
Rv0955		-1.3	-1.4	Probable conserved integral membrane protein
Rv1364c		-1.2	-4.2	Possible sigma factor regulatory protein
Rv0499		-1.2	-2.1	Conserved hypothetical protein
Rv1421		-1.2	-2.4	Conserved protein
Rv3045		-1.2	-2.9	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv2001		-1.2	-0.7	Conserved hypothetical protein
Rv1332		-1.1	-0.9	Probable transcriptional regulatory protein
Rv1433		-1.1	-4.6	Possible conserved exported protein
Rv2317		-1.1	-0.7	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv2099c		-1.1	-1.6	PE family protein PE21
Rv0040c		-1.1	-5.0	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv0241c		-1.1	-2.8	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv2444c		-1.0	-2.6	Possible ribonuclease E Rne
Rv0504c		-1.0	-1.9	Conserved protein
Rv1062		-1.0	-0.6	Conserved hypothetical protein
Rv2240c		-1.0	-1.1	Unknown protein
Rv3495c		-1.0	-6.3	Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E)
Rv2072c		-1.0	-0.7	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv1207		-1.0	-5.9	Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2)
Rv0204c		-1.0	-2.6	Probable conserved transmembrane protein
Rv3817		-1.0	-1.7	Possible phosphotransferase
Rv2335		-1.0	-1.4	Probable serine acetyltransferase CysE (sat)
Rv2635		-1.0	-0.5	Hypothetical protein
Rv1244		-1.0	-4.2	Probable lipoprotein LpqZ
Rv0950c		-1.0	-3.3	Conserved hypothetical protein
Rv1860		-1.0	-2.5	Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen)
Rv2728c		-0.9	-4.0	Conserved alanine rich protein
Rv3366		-0.9	-1.4	Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase)
Rv3874		-0.9	-1.0	10 kDa culture filtrate antigen EsxB (LHP) (CFP10)
Rv2014		-0.9	-1.6	Transposase
Rv2377c		-0.9	-1.6	Putative conserved protein MbtH
Rv3496c		-0.9	-5.3	Mce-family protein Mce4D
Rv1273c		-0.9	-3.9	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv2548		-0.9	-1.2	Possible toxin VapC19
Rv3338		-0.9	-0.7	Conserved hypothetical protein
Rv0201c		-0.9	-1.5	Conserved protein
Rv3493c		-0.9	-2.4	Conserved hypothetical Mce associated alanine and valine rich protein
Rv1111c		-0.9	-2.5	Conserved hypothetical protein
Rv2989		-0.9	-0.6	Probable transcriptional regulatory protein
Rv1698		-0.9	-2.3	Outer membrane protein MctB
Rv1836c		-0.9	-1.8	Conserved protein
Rv3420c		-0.9	-2.4	Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
Rv1046c		-0.9	-1.6	Hypothetical protein
Rv1272c		-0.9	-3.8	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv3414c		-0.9	-1.8	Probable alternative RNA polymerase sigma-D factor SigD
Rv1184c		-0.9	-6.3	Possible exported protein
Rv2301		-0.9	-3.1	Probable cutinase Cut2
Rv1766		-0.9	-1.7	Conserved protein
Rv0432		-0.9	-4.1	Periplasmic superoxide dismutase [Cu-Zn] SodC
Rv2171		-0.9	-1.7	Probable conserved lipoprotein LppM
Rv3497c		-0.9	-4.2	Mce-family protein Mce4C
Rv3803c		-0.9	-4.6	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C)
Rv3204		-0.8	-0.6	Possible DNA-methyltransferase (modification methylase)
Rv1624c		-0.8	-1.8	Probable conserved membrane protein
Rv3492c		-0.8	-1.6	Conserved hypothetical Mce associated protein
Rv3498c		-0.8	-4.1	Mce-family protein Mce4B
Rv0016c		-0.8	-2.3	Probable penicillin-binding protein PbpA
Rv1009		-0.8	-3.1	Probable resuscitation-promoting factor RpfB
Rv3389c		-0.8	-1.9	Probable 3-hydroxyacyl-thioester dehydratase HtdY
Rv0971c		-0.8	-2.3	Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3387		-0.8	-1.5	Possible transposase
Rv3223c		-0.8	-2.5	Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE)
Rv0892		-0.8	-1.4	Probable monooxygenase
Rv2271		-0.8	-2.1	Conserved hypothetical protein
Rv2365c		-0.8	-0.5	Conserved hypothetical protein
Rv3760		-0.8	-0.9	Possible conserved membrane protein
Rv2237A		-0.8	-0.7	Conserved protein
Rv0199		-0.8	-1.8	Probable conserved membrane protein
Rv1435c		-0.8	-2.6	Probable conserved proline, glycine, valine-rich secreted protein
Rv2144c		-0.8	-2.7	Probable transmembrane protein
Rv0655		-0.8	-2.6	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv1331		-0.8	-2.4	Conserved hypothetical protein
Rv3843c		-0.8	-1.3	Probable conserved transmembrane protein
Rv3494c		-0.8	-3.8	Mce-family protein Mce4F
Rv2693c		-0.8	-1.2	Probable conserved integral membrane alanine and leucine rich protein
Rv1675c		-0.8	-2.0	Probable transcriptional regulatory protein Cmr
Rv1821		-0.8	-1.9	Possible preprotein translocase ATPase SecA2
Rv3592		-0.7	-2.2	Possible heme degrading protein MhuD
Rv1590		-0.7	-2.7	Conserved hypothetical protein
Rv1566c		-0.7	-1.7	Possible Inv protein
Rv3920c		-0.7	-0.9	Conserved protein similar to jag protein
Rv2170		-0.7	-0.7	GCN5-related N-acetyltransferase
Rv0765c		-0.7	-1.2	Probable oxidoreductase
Rv2799		-0.7	-4.5	Probable membrane protein
Rv1137c		-0.7	-2.0	Hypothetical protein
Rv2249c		-0.7	-2.3	Probable glycerol-3-phosphate dehydrogenase GlpD1
Rv3572		-0.7	-3.0	Unknown protein
Rv0556		-0.7	-1.2	Probable conserved transmembrane protein
Rv1657		-0.7	-1.7	Probable arginine repressor ArgR (AHRC)
Rv2979c		-0.7	-2.4	Probable resolvase
Rv2671		-0.7	-1.6	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)
Rv3723		-0.7	-1.9	Probable conserved transmembrane protein
Rv1411c		-0.7	-1.7	Conserved lipoprotein LprG
Rv2321c		-0.7	-0.8	Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase)
Rv0818		-0.7	-2.8	Transcriptional regulatory protein
Rv1693		-0.7	-1.0	Conserved hypothetical protein
Rv2945c		-0.7	-4.1	Probable conserved lipoprotein LppX
Rv3500c		-0.7	-4.0	Conserved integral membrane protein YrbE4B. Possible ABC transporter.
Rv3491		-0.7	-3.4	Unknown protein
Rv3910		-0.7	-0.9	Probable conserved transmembrane protein
Rv2272		-0.7	-0.5	Probable conserved transmembrane protein
Rv1565c		-0.7	-3.5	Conserved hypothetical membrane protein
Rv0309		-0.7	-2.5	Possible conserved exported protein
Rv1946c		-0.7	-1.0	Possible lipoprotein
Rv0485		-0.7	-3.9	Possible transcriptional regulatory protein
Rv3833		-0.7	-1.4	Transcriptional regulatory protein (probably AraC-family)
Rv2568c		-0.7	-2.1	Conserved hypothetical protein
Rv1591		-0.7	-2.6	Probable transmembrane protein
Rv1581c		-0.6	-1.1	Probable PhiRv1 phage protein
Rv1262c		-0.6	-0.9	Hypothetical hit-like protein
Rv2476c		-0.6	-1.8	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv0019c		-0.6	-2.2	Conserved protein with FHA domain, FhaB
Rv1751		-0.6	-1.0	Probable oxidoreductase
Rv2183c		-0.6	-0.9	Conserved protein
Rv3311		-0.6	-2.1	Conserved protein
Rv0887c		-0.6	-0.9	Conserved hypothetical protein
Rv0563		-0.6	-0.8	Probable protease transmembrane protein heat shock protein HtpX
Rv0680c		-0.6	-1.2	Probable conserved transmembrane protein
Rv2668		-0.6	-2.3	Possible exported alanine and valine rich protein
Rv0590A		-0.6	-1.6	Mce-family related protein
Rv0135c		-0.6	-2.4	Possible transcriptional regulatory protein
Rv3303c		-0.6	-1.2	NAD(P)H quinone reductase LpdA
Rv0452		-0.6	-2.0	Possible transcriptional regulatory protein
Rv0157A		-0.6	-1.0	Conserved protein
Rv3848		-0.6	-0.9	Probable conserved transmembrane protein
Rv3499c		-0.6	-3.5	Mce-family protein Mce4A
Rv2374c		-0.6	-1.4	Probable heat shock protein transcriptional repressor HrcA
Rv2028c		-0.6	-1.0	Universal stress protein family protein
Rv1138c		-0.6	-2.7	Possible oxidoreductase
Rv0081		-0.6	-1.0	Probable transcriptional regulatory protein
Rv2788		-0.6	-1.1	Probable transcriptional repressor SirR
Rv1283c		-0.6	-1.2	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv0679c		-0.6	-1.2	Conserved threonine rich protein
Rv2836c		-0.6	-1.3	Possible DNA-damage-inducible protein F DinF
Rv2302		-0.6	-0.3	Conserved protein
Rv1019		-0.6	-2.7	Probable transcriptional regulatory protein (probably TetR-family)
Rv3691		-0.6	-0.7	Conserved protein
Rv1490		-0.6	-1.0	Probable membrane protein
Rv3167c		-0.6	-1.1	Probable transcriptional regulatory protein (probably TetR-family)
Rv3610c		-0.6	-1.4	Membrane-bound protease FtsH (cell division protein)
Rv0494		-0.6	-2.3	Probable transcriptional regulatory protein (probably GntR-family)
Rv0272c		-0.6	-1.9	Unknown protein
Rv1829		-0.6	-2.3	Conserved protein
Rv1939		-0.6	-1.7	Probable oxidoreductase
Rv0037c		-0.6	-4.2	Probable conserved integral membrane protein
Rv3140		-0.6	-2.1	Probable acyl-CoA dehydrogenase FadE23
Rv0323c		-0.5	-1.0	Conserved hypothetical protein
Rv2236c		-0.5	-1.4	Probable cobalamin biosynthesis transmembrane protein CobD
Rv2762c		-0.5	-0.4	Conserved hypothetical protein

Specific Phenotypes

For 1 genes in this experiment

For stress Clofazimine in Mycobacterium tuberculosis H37Rv

For stress Clofazimine across organisms