Experiment set1S213 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv3102c		-3.6	-4.4	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv2047c		-3.4	-9.4	Conserved hypothetical protein
Rv0202c		-3.2	-12.2	Probable conserved transmembrane transport protein MmpL11
Rv3101c		-3.0	-2.5	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv0676c		-3.0	-15.5	Probable conserved transmembrane transport protein MmpL5
Rv1421		-2.9	-4.5	Conserved protein
Rv1930c		-2.8	-1.2	Conserved hypothetical protein
Rv2048c		-2.8	-11.1	Polyketide synthase Pks12
Rv3717		-2.7	-7.0	Conserved hypothetical protein
Rv0757		-2.7	-2.4	Possible two component system response transcriptional positive regulator PhoP
Rv0472c		-2.5	-4.5	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0504c		-2.4	-2.9	Conserved protein
Rv2224c		-2.3	-13.2	Probable carboxylesterase CaeA
Rv0820		-2.3	-4.7	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv1127c		-2.2	-2.3	Probable pyruvate, phosphate dikinase PpdK
Rv0867c		-2.2	-0.6	Possible resuscitation-promoting factor RpfA
Rv0928		-2.2	-4.6	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv0675		-2.1	-1.1	Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0018c		-2.0	-4.6	Phosphoserine/threonine phosphatase PstP
Rv1578c		-2.0	-1.0	Probable PhiRv1 phage protein
Rv3822		-2.0	-12.4	Conserved hypothetical protein
Rv2691		-1.9	-9.3	TRK system potassium uptake protein CeoB
Rv1291c		-1.9	-2.0	Conserved hypothetical secreted protein
Rv1946c		-1.9	-3.5	Possible lipoprotein
Rv0819		-1.9	-3.9	GCN5-related N-acetyltransferase, MshD
Rv2694c		-1.9	-4.6	Conserved protein
Rv0930		-1.9	-6.5	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1620c		-1.9	-4.3	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv2869c		-1.8	-2.4	Membrane bound metalloprotease
Rv2581c		-1.7	-1.9	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv2989		-1.7	-1.1	Probable transcriptional regulatory protein
Rv1621c		-1.7	-3.4	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv3208A		-1.7	-1.7	Conserved protein TB9.4
Rv2696c		-1.7	-2.9	Conserved alanine and glycine and valine rich protein
Rv2374c		-1.7	-2.6	Probable heat shock protein transcriptional repressor HrcA
Rv1836c		-1.7	-2.9	Conserved protein
Rv1531		-1.7	-1.3	Conserved protein
Rv1159		-1.6	-3.1	Mannosyltransferase PimE
Rv1624c		-1.6	-3.8	Probable conserved membrane protein
Rv3005c		-1.6	-8.7	Conserved hypothetical protein
Rv3897c		-1.6	-1.0	Conserved hypothetical protein
Rv3204		-1.6	-0.9	Possible DNA-methyltransferase (modification methylase)
Rv1512		-1.6	-0.9	Probable nucleotide-sugar epimerase EpiA
Rv0929		-1.6	-2.1	Phosphate-transport integral membrane ABC transporter PstC2
Rv0642c		-1.5	-1.7	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv2014		-1.5	-2.5	Transposase
Rv0680c		-1.5	-2.3	Probable conserved transmembrane protein
Rv1410c		-1.5	-8.4	Aminoglycosides/tetracycline-transport integral membrane protein
Rv1860		-1.5	-3.8	Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen)
Rv1013		-1.5	-8.6	Putative polyketide synthase Pks16
Rv1364c		-1.4	-5.4	Possible sigma factor regulatory protein
Rv3277		-1.4	-1.3	Probable conserved transmembrane protein
Rv3810		-1.4	-1.7	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv1411c		-1.3	-3.3	Conserved lipoprotein LprG
Rv2171		-1.3	-2.4	Probable conserved lipoprotein LppM
Rv3267		-1.3	-3.6	Conserved protein (CPSA-related protein)
Rv2671		-1.3	-3.9	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)
Rv0994		-1.2	-5.3	Probable molybdopterin biosynthesis protein MoeA1
Rv0040c		-1.2	-5.5	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv2553c		-1.2	-1.1	Probable conserved membrane protein
Rv0955		-1.2	-1.6	Probable conserved integral membrane protein
Rv0825c		-1.2	-2.1	Conserved protein
Rv3592		-1.2	-2.6	Possible heme degrading protein MhuD
Rv1272c		-1.2	-5.8	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv1435c		-1.2	-4.1	Probable conserved proline, glycine, valine-rich secreted protein
Rv3366		-1.2	-2.4	Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase)
Rv2154c		-1.1	-1.3	FtsW-like protein FtsW
Rv3715c		-1.1	-2.2	Probable recombination protein RecR
Rv0615		-1.1	-1.4	Probable integral membrane protein
Rv1422		-1.1	-1.3	Conserved hypothetical protein
Rv2170		-1.1	-1.5	GCN5-related N-acetyltransferase
Rv1698		-1.1	-3.2	Outer membrane protein MctB
Rv2382c		-1.1	-0.9	Polyketide synthetase MbtC (polyketide synthase)
Rv2728c		-1.1	-3.2	Conserved alanine rich protein
Rv1657		-1.1	-1.5	Probable arginine repressor ArgR (AHRC)
Rv2702		-1.1	-0.8	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv3200c		-1.1	-2.6	Possible transmembrane cation transporter
Rv2144c		-1.1	-2.4	Probable transmembrane protein
Rv2335		-1.1	-1.4	Probable serine acetyltransferase CysE (sat)
Rv1821		-1.1	-3.3	Possible preprotein translocase ATPase SecA2
Rv3306c		-1.1	-1.3	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv3420c		-1.1	-3.1	Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
Rv1566c		-1.1	-1.6	Possible Inv protein
Rv1433		-1.0	-4.5	Possible conserved exported protein
Rv0200		-1.0	-1.8	Possible conserved transmembrane protein
Rv1565c		-1.0	-4.7	Conserved hypothetical membrane protein
Rv0876c		-1.0	-2.8	Possible conserved transmembrane protein
Rv1244		-1.0	-3.5	Probable lipoprotein LpqZ
Rv3188		-1.0	-1.4	Conserved hypothetical protein
Rv3165c		-1.0	-1.0	Unknown protein
Rv1207		-1.0	-4.3	Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2)
Rv1184c		-1.0	-5.9	Possible exported protein
Rv2190c		-1.0	-3.0	Conserved hypothetical protein
Rv0313		-1.0	-1.5	Conserved protein
Rv3193c		-0.9	-1.2	Probable conserved transmembrane protein
Rv1283c		-0.9	-1.9	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv0204c		-0.9	-3.1	Probable conserved transmembrane protein
Rv2668		-0.9	-3.6	Possible exported alanine and valine rich protein
Rv1273c		-0.9	-3.3	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv2583c		-0.9	-2.7	Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Rv1148c		-0.9	-1.6	Conserved hypothetical protein
Rv3912		-0.9	-2.1	Hypothetical alanine rich protein
Rv3497c		-0.9	-3.0	Mce-family protein Mce4C
Rv0954		-0.9	-2.3	Probable conserved transmembrane protein
Rv3495c		-0.9	-5.4	Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E)
Rv3493c		-0.9	-4.8	Conserved hypothetical Mce associated alanine and valine rich protein
Rv3803c		-0.9	-4.5	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C)
Rv2799		-0.9	-5.4	Probable membrane protein
Rv3910		-0.9	-0.8	Probable conserved transmembrane protein
Rv3492c		-0.9	-1.8	Conserved hypothetical Mce associated protein
Rv0569		-0.9	-1.4	Conserved protein
Rv0309		-0.9	-1.8	Possible conserved exported protein
Rv1908c		-0.9	-2.2	Catalase-peroxidase-peroxynitritase T KatG
Rv1009		-0.8	-4.1	Probable resuscitation-promoting factor RpfB
Rv0017c		-0.8	-2.3	Probable cell division protein RodA
Rv3643		-0.8	-1.5	Hypothetical protein
Rv3610c		-0.8	-1.8	Membrane-bound protease FtsH (cell division protein)
Rv0927c		-0.8	-1.4	Probable short-chain type dehydrogenase/reductase
Rv0863		-0.8	-2.3	Conserved hypothetical protein
Rv1332		-0.8	-0.9	Probable transcriptional regulatory protein
Rv0818		-0.8	-3.6	Transcriptional regulatory protein
Rv1693		-0.8	-1.1	Conserved hypothetical protein
Rv3496c		-0.8	-5.0	Mce-family protein Mce4D
Rv3787c		-0.8	-1.7	Conserved hypothetical protein
Rv3045		-0.8	-2.2	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv3311		-0.8	-2.9	Conserved protein
Rv1824		-0.8	-1.5	Conserved hypothetical membrane protein
Rv0047c		-0.8	-1.9	Conserved protein
Rv0312		-0.8	-2.3	Conserved hypothetical proline and threonine rich protein
Rv2976c		-0.8	-0.8	Probable uracil-DNA glycosylase Ung (UDG)
Rv2693c		-0.8	-3.2	Probable conserved integral membrane alanine and leucine rich protein
Rv3816c		-0.8	-0.7	Possible acyltransferase
Rv2624c		-0.8	-0.8	Universal stress protein family protein
Rv0452		-0.8	-2.1	Possible transcriptional regulatory protein
Rv3500c		-0.8	-5.0	Conserved integral membrane protein YrbE4B. Possible ABC transporter.
Rv2377c		-0.8	-1.8	Putative conserved protein MbtH
Rv0677c		-0.8	-0.7	Possible conserved membrane protein MmpS5
Rv0563		-0.8	-1.1	Probable protease transmembrane protein heat shock protein HtpX
Rv2051c		-0.8	-2.3	Polyprenol-monophosphomannose synthase Ppm1
Rv1131		-0.8	-1.9	Probable methylcitrate synthase PrpC
Rv0744c		-0.7	-1.9	Possible transcriptional regulatory protein
Rv3484		-0.7	-4.4	Possible conserved protein CpsA
Rv3501c		-0.7	-2.7	Conserved integral membrane protein YrbE4A. Possible ABC transporter.
Rv1072		-0.7	-1.0	Probable conserved transmembrane protein
Rv0199		-0.7	-1.6	Probable conserved membrane protein
Rv3498c		-0.7	-4.2	Mce-family protein Mce4B
Rv0432		-0.7	-4.3	Periplasmic superoxide dismutase [Cu-Zn] SodC
Rv0242c		-0.7	-1.8	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv3499c		-0.7	-4.1	Mce-family protein Mce4A
Rv0499		-0.7	-1.4	Conserved hypothetical protein
Rv1944c		-0.7	-1.7	Conserved protein
Rv0208c		-0.7	-2.2	Hypothetical methlytransferase (methylase)
Rv0019c		-0.7	-2.4	Conserved protein with FHA domain, FhaB
Rv1935c		-0.7	-1.5	Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3387		-0.7	-1.3	Possible transposase
Rv3223c		-0.7	-2.9	Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE)
Rv0655		-0.7	-2.0	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv3256c		-0.7	-0.9	Conserved protein
Rv1732c		-0.7	-1.5	Conserved protein
Rv1928c		-0.7	-1.4	Probable short-chain type dehydrogenase/reductase
Rv0734		-0.7	-1.4	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv2270		-0.7	-1.2	Probable lipoprotein LppN
Rv3332		-0.7	-1.6	Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase)
Rv2462c		-0.7	-2.4	Probable trigger factor (TF) protein Tig
Rv2301		-0.7	-2.5	Probable cutinase Cut2
Rv3842c		-0.7	-1.9	Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase)
Rv3140		-0.7	-3.2	Probable acyl-CoA dehydrogenase FadE23
Rv1482c		-0.7	-2.6	Conserved hypothetical protein
Rv0007		-0.7	-0.5	Possible conserved membrane protein
Rv2028c		-0.7	-1.3	Universal stress protein family protein
Rv2444c		-0.7	-1.5	Possible ribonuclease E Rne
Rv2365c		-0.7	-0.5	Conserved hypothetical protein
Rv0885		-0.7	-2.4	Conserved hypothetical protein
Rv2898c		-0.7	-0.4	Conserved hypothetical protein
Rv0188		-0.7	-0.8	Probable conserved transmembrane protein
Rv2855		-0.7	-1.5	NADPH-dependent mycothiol reductase Mtr
Rv2945c		-0.7	-5.0	Probable conserved lipoprotein LppX
Rv1006		-0.7	-2.2	Unknown protein
Rv0037c		-0.6	-4.9	Probable conserved integral membrane protein
Rv1791		-0.6	-1.4	PE family protein PE19
Rv2615c		-0.6	-2.2	PE-PGRS family protein PE_PGRS45
Rv0950c		-0.6	-1.8	Conserved hypothetical protein
Rv1773c		-0.6	-1.1	Probable transcriptional regulatory protein
Rv1046c		-0.6	-1.2	Hypothetical protein
Rv1111c		-0.6	-1.6	Conserved hypothetical protein
Rv1829		-0.6	-3.9	Conserved protein
Rv0353		-0.6	-2.3	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv0323c		-0.6	-1.1	Conserved hypothetical protein
Rv1640c		-0.6	-4.0	Lysyl-tRNA synthetase 2 LysX
Rv1925		-0.6	-4.5	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)
Rv2835c		-0.6	-2.7	Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA
Rv1259		-0.6	-0.9	Probable uracil DNA glycosylase, UdgB
Rv2938		-0.6	-4.6	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv3283		-0.6	-1.5	Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
Rv2272		-0.6	-0.5	Probable conserved transmembrane protein
Rv3891c		-0.6	-3.2	Possible ESAT-6 like protein EsxD
Rv0016c		-0.6	-1.5	Probable penicillin-binding protein PbpA
Rv0344c		-0.6	-1.8	Probable lipoprotein LpqJ
Rv1940		-0.6	-1.6	Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)
Rv1322		-0.6	-0.9	Conserved hypothetical protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Clofazimine across organisms