Experiment set1S203 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv3102c		-5.3	-4.9	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv1411c		-4.9	-3.4	Conserved lipoprotein LprG
Rv1159		-4.8	-3.8	Mannosyltransferase PimE
Rv2869c		-4.6	-3.2	Membrane bound metalloprotease
Rv2989		-4.4	-1.3	Probable transcriptional regulatory protein
Rv0676c		-3.7	-15.3	Probable conserved transmembrane transport protein MmpL5
Rv3101c		-3.6	-2.0	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv1410c		-3.4	-8.3	Aminoglycosides/tetracycline-transport integral membrane protein
Rv1621c		-3.1	-2.7	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv0929		-3.1	-3.3	Phosphate-transport integral membrane ABC transporter PstC2
Rv0642c		-3.0	-4.3	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv0757		-3.0	-2.5	Possible two component system response transcriptional positive regulator PhoP
Rv3822		-3.0	-15.9	Conserved hypothetical protein
Rv0820		-2.8	-3.4	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv1620c		-2.8	-4.5	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv0472c		-2.7	-3.9	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0930		-2.7	-6.3	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv2001		-2.7	-1.1	Conserved hypothetical protein
Rv1791		-2.6	-3.0	PE family protein PE19
Rv3810		-2.6	-2.0	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv0361		-2.6	-2.1	Probable conserved membrane protein
Rv1836c		-2.5	-4.0	Conserved protein
Rv2224c		-2.4	-13.9	Probable carboxylesterase CaeA
Rv0177		-2.4	-2.1	Probable conserved Mce associated protein
Rv0007		-2.4	-1.0	Possible conserved membrane protein
Rv2696c		-2.4	-3.2	Conserved alanine and glycine and valine rich protein
Rv0819		-2.3	-2.7	GCN5-related N-acetyltransferase, MshD
Rv1184c		-2.3	-11.5	Possible exported protein
Rv0928		-2.3	-4.0	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2630		-2.2	-1.1	Hypothetical protein
Rv3267		-2.2	-6.1	Conserved protein (CPSA-related protein)
Rv3717		-2.1	-4.3	Conserved hypothetical protein
Rv1013		-2.1	-10.2	Putative polyketide synthase Pks16
Rv2553c		-2.0	-1.1	Probable conserved membrane protein
Rv0199		-1.9	-4.7	Probable conserved membrane protein
Rv0367c		-1.9	-1.0	Hypothetical protein
Rv0876c		-1.9	-3.1	Possible conserved transmembrane protein
Rv2044c		-1.8	-0.8	Conserved hypothetical protein
Rv2476c		-1.8	-5.5	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv3005c		-1.8	-10.3	Conserved hypothetical protein
Rv3803c		-1.8	-8.1	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C)
Rv1986		-1.7	-1.7	Probable conserved integral membrane protein
Rv0758		-1.7	-3.2	Possible two component system response sensor kinase membrane associated PhoR
Rv3136		-1.7	-6.5	PPE family protein PPE51
Rv1273c		-1.7	-6.6	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv2171		-1.7	-2.7	Probable conserved lipoprotein LppM
Rv1908c		-1.7	-3.1	Catalase-peroxidase-peroxynitritase T KatG
Rv1823		-1.6	-6.0	Conserved protein
Rv0242c		-1.6	-2.7	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv3303c		-1.6	-4.5	NAD(P)H quinone reductase LpdA
Rv0176		-1.6	-5.9	Probable conserved Mce associated transmembrane protein
Rv0174		-1.6	-6.2	Mce-family protein Mce1F
Rv0200		-1.6	-2.8	Possible conserved transmembrane protein
Rv1821		-1.5	-3.3	Possible preprotein translocase ATPase SecA2
Rv0994		-1.5	-6.9	Probable molybdopterin biosynthesis protein MoeA1
Rv1565c		-1.5	-6.3	Conserved hypothetical membrane protein
Rv0012		-1.5	-6.6	Probable conserved membrane protein
Rv1421		-1.5	-2.6	Conserved protein
Rv1825		-1.4	-3.2	Conserved protein
Rv1272c		-1.4	-5.6	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv1062		-1.4	-0.7	Conserved hypothetical protein
Rv0204c		-1.4	-3.1	Probable conserved transmembrane protein
Rv0170		-1.4	-5.0	Mce-family protein Mce1B
Rv1422		-1.4	-1.5	Conserved hypothetical protein
Rv0178		-1.4	-4.0	Probable conserved Mce associated membrane protein
Rv0040c		-1.4	-6.4	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv1698		-1.4	-1.7	Outer membrane protein MctB
Rv2581c		-1.3	-1.3	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv0173		-1.3	-4.4	Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E)
Rv3311		-1.2	-4.6	Conserved protein
Rv1851		-1.2	-1.4	Urease accessory protein UreF
Rv0018c		-1.2	-3.3	Phosphoserine/threonine phosphatase PstP
Rv2091c		-1.2	-5.3	Probable membrane protein
Rv0169		-1.2	-5.1	Mce-family protein Mce1A
Rv1072		-1.2	-1.4	Probable conserved transmembrane protein
Rv1282c		-1.2	-3.4	Probable oligopeptide-transport integral membrane protein ABC transporter OppC
Rv1946c		-1.2	-2.9	Possible lipoprotein
Rv3850		-1.2	-1.5	Conserved protein
Rv0677c		-1.1	-0.9	Possible conserved membrane protein MmpS5
Rv0171		-1.1	-6.8	Mce-family protein Mce1C
Rv3366		-1.1	-2.2	Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase)
Rv3208A		-1.1	-1.5	Conserved protein TB9.4
Rv2277c		-1.1	-1.5	Possible glycerolphosphodiesterase
Rv0655		-1.1	-2.3	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv3135		-1.1	-2.7	PPE family protein PPE50
Rv1331		-1.1	-3.5	Conserved hypothetical protein
Rv1640c		-1.1	-5.9	Lysyl-tRNA synthetase 2 LysX
Rv1690		-1.1	-2.3	Probable lipoprotein LprJ
Rv2009		-1.1	-1.2	Antitoxin VapB15
Rv0172		-1.1	-5.7	Mce-family protein Mce1D
Rv3140		-1.1	-3.5	Probable acyl-CoA dehydrogenase FadE23
Rv0744c		-1.1	-3.3	Possible transcriptional regulatory protein
Rv3204		-1.1	-0.7	Possible DNA-methyltransferase (modification methylase)
Rv0452		-1.1	-4.6	Possible transcriptional regulatory protein
Rv2680		-1.1	-2.0	Conserved protein
Rv3220c		-1.1	-2.7	Probable two component sensor kinase
Rv3045		-1.1	-3.3	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv3445c		-1.0	-1.6	ESAT-6 like protein EsxU
Rv0580c		-1.0	-0.8	Conserved protein
Rv0825c		-1.0	-1.9	Conserved protein
Rv1283c		-1.0	-1.9	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv0168		-1.0	-2.2	Conserved integral membrane protein YrbE1B
Rv2583c		-1.0	-2.3	Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Rv0680c		-1.0	-1.7	Probable conserved transmembrane protein
Rv0100		-1.0	-1.2	Conserved hypothetical protein
Rv2170		-1.0	-1.3	GCN5-related N-acetyltransferase
Rv1400c		-1.0	-0.9	Probable lipase LipH
Rv3538		-1.0	-1.0	Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.
Rv1679		-1.0	-0.6	Possible acyl-CoA dehydrogenase FadE16
Rv0999		-1.0	-2.3	Unknown protein
Rv0954		-1.0	-2.9	Probable conserved transmembrane protein
Rv1775		-1.0	-3.0	Conserved hypothetical protein
Rv2190c		-1.0	-2.7	Conserved hypothetical protein
Rv3631		-0.9	-0.7	Possible transferase (possibly glycosyltransferase)
Rv0504c		-0.9	-1.4	Conserved protein
Rv1131		-0.9	-2.0	Probable methylcitrate synthase PrpC
Rv3897c		-0.9	-0.8	Conserved hypothetical protein
Rv1925		-0.9	-5.7	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)
Rv0309		-0.8	-2.4	Possible conserved exported protein
Rv2301		-0.8	-3.9	Probable cutinase Cut2
Rv1824		-0.8	-1.4	Conserved hypothetical membrane protein
Rv2544		-0.8	-1.5	Probable conserved lipoprotein LppB
Rv0949		-0.8	-0.5	Probable ATP-dependent DNA helicase II UvrD1
Rv0241c		-0.8	-1.6	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv3768		-0.8	-1.4	Unknown protein
Rv0154c		-0.8	-2.7	Probable acyl-CoA dehydrogenase FadE2
Rv3188		-0.8	-1.1	Conserved hypothetical protein
Rv2321c		-0.8	-0.9	Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase)
Rv2154c		-0.8	-1.6	FtsW-like protein FtsW
Rv0675		-0.8	-0.6	Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv1096		-0.8	-0.7	Possible glycosyl hydrolase
Rv2609c		-0.8	-1.9	Probable conserved membrane protein
Rv2973c		-0.8	-2.8	Probable ATP-dependent DNA helicase RecG
Rv0017c		-0.8	-2.4	Probable cell division protein RodA
Rv3513c		-0.8	-0.7	Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv2745c		-0.8	-1.0	Transcriptional regulatory protein ClgR
Rv3514		-0.8	-2.2	PE-PGRS family protein PE_PGRS57
Rv1128c		-0.8	-1.4	Conserved hypothetical protein
Rv3420c		-0.8	-2.7	Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
Rv0646c		-0.8	-1.8	Probable lipase/esterase LipG
Rv0990c		-0.8	-0.6	Hypothetical protein
Rv1693		-0.7	-1.2	Conserved hypothetical protein
Rv3139		-0.7	-2.4	Probable acyl-CoA dehydrogenase FadE24
Rv0955		-0.7	-1.0	Probable conserved integral membrane protein
Rv3306c		-0.7	-0.6	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv0746		-0.7	-2.8	PE-PGRS family protein PE_PGRS9
Rv3010c		-0.7	-2.5	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)
Rv0740		-0.7	-2.0	Conserved hypothetical protein
Rv0531		-0.7	-0.9	Possible conserved membrane protein
Rv1276c		-0.7	-1.8	Conserved hypothetical protein
Rv1906c		-0.7	-2.7	Conserved protein
Rv2834c		-0.7	-2.7	Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE
Rv3249c		-0.7	-0.8	Possible transcriptional regulatory protein (probably TetR-family)
Rv3632		-0.7	-2.8	Possible conserved membrane protein
Rv0243		-0.7	-3.5	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv2694c		-0.7	-2.0	Conserved protein
Rv1111c		-0.7	-1.3	Conserved hypothetical protein
Rv0940c		-0.7	-0.9	Possible oxidoreductase
Rv0561c		-0.7	-1.0	Possible oxidoreductase
Rv2813		-0.7	-0.9	Conserved hypothetical protein
Rv0084		-0.7	-0.7	Possible formate hydrogenlyase HycD (FHL)
Rv3818		-0.7	-3.1	Unknown protein
Rv1090		-0.7	-4.0	Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase)
Rv2598		-0.7	-1.4	Conserved hypothetical protein
Rv1244		-0.7	-2.2	Probable lipoprotein LpqZ
Rv2739c		-0.7	-1.6	Possible alanine rich transferase
Rv0016c		-0.7	-2.3	Probable penicillin-binding protein PbpA
Rv3098c		-0.7	-1.8	Hypothetical protein
Rv0576		-0.7	-2.5	Probable transcriptional regulatory protein (possibly ArsR-family)
Rv1019		-0.7	-4.6	Probable transcriptional regulatory protein (probably TetR-family)
Rv3196A		-0.7	-1.1	Unknown protein
Rv2173		-0.7	-2.0	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv0773c		-0.7	-1.0	Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT)
Rv3414c		-0.7	-1.5	Probable alternative RNA polymerase sigma-D factor SigD
Rv0818		-0.7	-2.7	Transcriptional regulatory protein
Rv1280c		-0.7	-3.6	Probable periplasmic oligopeptide-binding lipoprotein OppA
Rv1657		-0.7	-1.3	Probable arginine repressor ArgR (AHRC)
Rv2382c		-0.7	-0.6	Polyketide synthetase MbtC (polyketide synthase)
Rv2377c		-0.7	-1.0	Putative conserved protein MbtH
Rv3819		-0.7	-0.4	Unknown protein
Rv1626		-0.7	-2.3	Probable two-component system transcriptional regulator
Rv1006		-0.7	-2.7	Unknown protein
Rv2734		-0.7	-3.6	Conserved hypothetical protein
Rv0679c		-0.7	-1.4	Conserved threonine rich protein
Rv1055		-0.7	-0.6	Possible integrase (fragment)
Rv0279c		-0.7	-3.7	PE-PGRS family protein PE_PGRS4
Rv1281c		-0.7	-2.1	Probable oligopeptide-transport ATP-binding protein ABC transporter OppD
Rv2691		-0.7	-3.1	TRK system potassium uptake protein CeoB
Rv0745		-0.7	-2.1	Conserved hypothetical protein
Rv3477		-0.7	-1.1	PE family protein PE31
Rv1127c		-0.7	-1.0	Probable pyruvate, phosphate dikinase PpdK
Rv0190		-0.7	-1.9	Conserved protein
Rv0436c		-0.7	-1.1	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv0497		-0.6	-1.1	Probable conserved transmembrane protein
Rv1035c		-0.6	-0.8	Probable transposase (fragment)
Rv0959		-0.6	-0.9	Conserved hypothetical protein
Rv2742c		-0.6	-4.1	Conserved hypothetical arginine rich protein
Rv1049		-0.6	-0.9	Probable transcriptional repressor protein
Rv3723		-0.6	-1.8	Probable conserved transmembrane protein
Rv3170		-0.6	-1.6	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)

Specific Phenotypes

For 3 genes in this experiment

For stress Bedaquiline in Mycobacterium tuberculosis H37Rv

For stress Bedaquiline across organisms