Experiment set1S203 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv3256c		+1.7	4.1	Conserved protein
Rv1414		+1.5	1.6	Conserved hypothetical protein
Rv2372c		+1.4	2.7	Conserved hypothetical protein
Rv2657c		+1.4	1.6	Probable PhiRv2 prophage protein
Rv0328		+1.3	1.8	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv2252		+1.3	1.7	Diacylglycerol kinase
Rv1350		+1.2	1.7	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)
Rv0678		+1.2	5.9	Conserved protein
Rv3165c		+1.1	1.8	Unknown protein
Rv1290A		+1.1	1.3	Hypothetical protein
Rv2758c		+1.1	1.8	Possible antitoxin VapB21
Rv0295c		+1.0	5.8	Conserved protein
Rv3481c		+1.0	1.8	Probable integral membrane protein
Rv3658c		+1.0	1.4	Probable conserved transmembrane protein
Rv0310c		+1.0	2.2	Conserved protein
Rv2829c		+1.0	1.9	Possible toxin VapC22
Rv1107c		+0.9	1.0	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)
Rv2428		+0.9	0.8	Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C)
Rv0991c		+0.9	1.3	Conserved serine rich protein
Rv2260		+0.8	1.8	Conserved hypothetical protein
Rv2635		+0.8	0.7	Hypothetical protein
Rv0034		+0.8	1.5	Conserved hypothetical protein
Rv0867c		+0.8	0.4	Possible resuscitation-promoting factor RpfA
Rv3198c		+0.8	0.9	Probable ATP-dependent DNA helicase II UvrD2
Rv0766c		+0.8	1.1	Probable cytochrome P450 123 Cyp123
Rv3309c		+0.7	1.6	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Rv3230c		+0.7	2.4	Hypothetical oxidoreductase
Rv0085		+0.7	1.3	Possible hydrogenase HycP
Rv3716c		+0.7	0.6	Conserved protein
Rv0760c		+0.7	2.2	Conserved protein
Rv1897c		+0.7	1.8	Conserved hypothetical protein
Rv1121		+0.7	1.6	Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD)
Rv0632c		+0.7	1.9	Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv1053c		+0.7	0.8	Hypothetical protein
Rv3693		+0.7	1.3	Possible conserved membrane protein
Rv2817c		+0.7	0.9	Conserved hypothetical protein
Rv0805		+0.7	0.8	Class III cyclic nucleotide phosphodiesterase (cNMP PDE)
Rv1366A		+0.7	0.9	Conserved protein
Rv1717		+0.7	0.7	Conserved hypothetical protein
Rv3104c		+0.7	2.0	Possible conserved transmembrane protein
Rv3550		+0.7	2.5	Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2774c		+0.7	0.8	Hypothetical protein
Rv2331		+0.7	3.8	Hypothetical protein
Rv3004		+0.7	1.4	Low molecular weight protein antigen 6 (CFP-6)
Rv1444c		+0.7	2.2	Unknown protein
Rv2976c		+0.6	0.9	Probable uracil-DNA glycosylase Ung (UDG)
Rv1677		+0.6	1.4	Probable conserved lipoprotein DsbF
Rv3282		+0.6	0.8	Conserved hypothetical protein
Rv2782c		+0.6	1.6	Probable zinc protease PepR
Rv3835		+0.6	1.3	Conserved membrane protein
Rv2850c		+0.6	0.8	Possible magnesium chelatase
Rv0460		+0.6	1.2	Conserved hydrophobic protein
Rv2088		+0.6	0.7	Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J)
Rv0789c		+0.6	1.5	Hypothetical protein
Rv0912		+0.6	0.9	Probable conserved transmembrane protein
Rv0056		+0.6	1.4	50S ribosomal protein L9 RplI
Rv3363c		+0.6	2.0	Conserved hypothetical protein
Rv3364c		+0.6	0.9	Conserved protein
Rv0761c		+0.6	2.5	Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB
Rv1171		+0.6	1.8	Conserved hypothetical protein
Rv3446c		+0.6	2.1	Hypothetical alanine and valine rich protein
Rv3312A		+0.6	3.3	Secreted protein antigen
Rv2055c		+0.5	0.7	30S ribosomal protein S18 RpsR2
Rv1021		+0.5	1.3	Conserved protein
Rv3167c		+0.5	1.2	Probable transcriptional regulatory protein (probably TetR-family)
Rv0088		+0.5	0.6	Possible polyketide cyclase/dehydrase
Rv3073c		+0.5	0.8	Conserved hypothetical protein
Rv0612		+0.5	1.7	Conserved hypothetical protein
Rv2714		+0.5	2.1	Conserved alanine and leucine rich protein
Rv1538c		+0.5	2.4	Probable L-aparaginase AnsA
Rv3820c		+0.5	3.9	Possible conserved polyketide synthase associated protein PapA2
Rv0893c		+0.5	1.1	Possible S-adenosylmethionine-dependent methyltransferase
Rv3413c		+0.5	0.4	Unknown alanine and proline rich protein
Rv1289		+0.5	2.2	Unknown protein
Rv1577c		+0.5	0.6	Probable PhiRv1 phage protein
Rv0260c		+0.5	1.9	Possible transcriptional regulatory protein
Rv2571c		+0.5	1.4	Probable transmembrane alanine and valine and leucine rich protein
Rv1884c		+0.5	1.3	Probable resuscitation-promoting factor RpfC
Rv3107c		+0.5	1.7	Possible alkyldihydroxyacetonephosphate synthase AgpS (alkyl-DHAP synthase) (alkylglycerone-phosphate synthase)
Rv2137c		+0.5	1.3	Conserved hypothetical protein
Rv3438		+0.5	1.6	Conserved protein
Rv1533		+0.5	1.4	Conserved protein
Rv3196		+0.5	2.4	Conserved hypothetical protein
Rv3340		+0.5	2.0	Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase)
Rv3229c		+0.5	1.2	Possible linoleoyl-CoA desaturase (delta(6)-desaturase)
Rv0695		+0.5	2.4	Conserved hypothetical protein
Rv0212c		+0.5	1.8	Possible transcriptional regulatory protein NadR (probably AsnC-family)
Rv3826		+0.5	2.8	Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Rv0887c		+0.5	0.8	Conserved hypothetical protein
Rv2272		+0.5	0.5	Probable conserved transmembrane protein
Rv0665		+0.5	1.2	Possible toxin VapC8
Rv2072c		+0.5	0.5	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv0413		+0.5	1.4	Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase)
Rv3777		+0.5	1.8	Probable oxidoreductase
Rv2484c		+0.5	2.8	Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Rv1524		+0.5	1.3	Probable glycosyltransferase
Rv3338		+0.5	0.5	Conserved hypothetical protein
Rv0737		+0.5	0.8	Possible transcriptional regulatory protein
Rv2762c		+0.5	0.5	Conserved hypothetical protein
Rv0394c		+0.5	1.8	Possible secreted protein
Rv3825c		+0.5	4.0	Polyketide synthase Pks2
Rv0321		+0.5	1.5	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Rv2376c		+0.5	0.8	Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Rv3690		+0.5	1.2	Probable conserved membrane protein
Rv2660c		+0.4	1.8	Hypothetical protein
Rv0090		+0.4	2.1	Possible membrane protein
Rv3305c		+0.4	1.0	Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase)
Rv2750		+0.4	1.2	Probable dehydrogenase
Rv0487		+0.4	2.3	Conserved hypothetical protein
Rv1270c		+0.4	2.1	Possible lipoprotein LprA
Rv1112		+0.4	0.8	Probable GTP binding protein
Rv0076c		+0.4	2.3	Probable membrane protein
Rv3567c		+0.4	1.0	Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase.
Rv0426c		+0.4	1.1	Possible transmembrane protein
Rv3594		+0.4	1.9	Conserved hypothetical protein
Rv1403c		+0.4	1.9	Putative methyltransferase
Rv1052		+0.4	2.5	Hypothetical protein
Rv0130		+0.4	0.6	Probable 3-hydroxyl-thioester dehydratase
Rv3863		+0.4	1.1	Unknown alanine rich protein
Rv1235		+0.4	1.5	Probable sugar-binding lipoprotein LpqY
Rv0294		+0.4	1.3	Probable trans-aconitate methyltransferase Tam
Rv1593c		+0.4	1.8	Conserved protein
Rv3360		+0.4	1.9	Conserved hypothetical protein
Rv2706c		+0.4	0.7	Hypothetical protein
Rv2570		+0.4	0.8	Conserved hypothetical protein
Rv3824c		+0.4	2.1	Conserved polyketide synthase associated protein PapA1
Rv3428c		+0.4	0.7	Possible transposase
Rv3540c		+0.4	1.3	Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2
Rv1518		+0.4	1.8	Conserved hypothetical protein
Rv3328c		+0.4	1.6	Probable alternative RNA polymerase sigma factor (fragment) SigJ
Rv0251c		+0.4	1.5	Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A)
Rv0273c		+0.4	2.1	Possible transcriptional regulatory protein
Rv2849c		+0.4	1.6	Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity)
Rv3395c		+0.4	1.0	Conserved hypothetical protein
Rv1956		+0.4	2.0	Possible antitoxin HigA
Rv1029		+0.4	2.1	Probable potassium-transporting ATPase a chain KdpA (potassium-translocating ATPase a chain) (ATP phosphohydrolase [potassium-transporting] a chain) (potassium binding and translocating subunit A)
Rv1637c		+0.4	1.2	Conserved protein
Rv3856c		+0.4	0.8	Conserved hypothetical protein
Rv3298c		+0.4	1.8	Possible esterase lipoprotein LpqC
Rv2214c		+0.4	2.3	Possible short-chain dehydrogenase EphD
Rv3751		+0.4	0.6	Probable integrase (fragment)
Rv2234		+0.4	1.4	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
Rv0862c		+0.4	1.0	Conserved protein
Rv3469c		+0.4	1.7	Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA)
Rv1895		+0.4	1.3	Possible dehydrogenase
Rv2991		+0.4	1.8	Conserved protein
Rv1152		+0.4	1.4	Probable transcriptional regulatory protein
Rv2026c		+0.4	0.7	Universal stress protein family protein
Rv3663c		+0.4	0.8	Probable dipeptide-transport ATP-binding protein ABC transporter DppD
Rv1912c		+0.4	1.3	Possible oxidoreductase FadB5
Rv3643		+0.4	0.8	Hypothetical protein
Rv2792c		+0.4	1.0	Possible resolvase
Rv0564c		+0.4	1.1	Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase)
Rv0738		+0.4	0.6	Conserved protein
Rv1238		+0.4	1.2	Probable sugar-transport ATP-binding protein ABC transporter SugC
Rv0454		+0.4	2.5	Conserved hypothetical protein
Rv0748		+0.4	0.7	Possible antitoxin VapB31
Rv2307D		+0.4	0.9	Hypothetical protein
Rv2148c		+0.4	1.0	Conserved protein
Rv0545c		+0.4	1.0	Probable low-affinity inorganic phosphate transporter integral membrane protein PitA
Rv2010		+0.4	0.7	Toxin VapC15
Rv2450c		+0.4	1.8	Probable resuscitation-promoting factor RpfE
Rv3147		+0.4	1.7	Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C)
Rv3334		+0.4	1.4	Probable transcriptional regulatory protein (probably MerR-family)
Rv3128c		+0.4	1.4	Conserved hypothetical protein
Rv1188		+0.4	0.9	Probable proline dehydrogenase
Rv3771c		+0.4	0.8	Conserved hypothetical protein
Rv3020c		+0.4	1.0	ESAT-6 like protein EsxS
Rv3151		+0.4	1.9	Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G)
Rv0832		+0.4	0.9	PE-PGRS family protein PE_PGRS12
Rv2912c		+0.4	0.9	Probable transcriptional regulatory protein (probably TetR-family)
Rv3209		+0.4	1.4	Conserved hypothetical threonine and proline rich protein
Rv3667		+0.4	2.7	Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase)
Rv0234c		+0.4	1.4	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1
Rv1473A		+0.4	0.6	Possible transcriptional regulatory protein
Rv0673		+0.4	0.7	Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0588		+0.4	0.9	Conserved hypothetical integral membrane protein YrbE2B
Rv1569		+0.4	1.7	Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase)
Rv3486		+0.4	1.0	Conserved protein
Rv0571c		+0.4	1.0	Conserved protein
Rv1378c		+0.4	2.0	Conserved hypothetical protein
Rv2360c		+0.4	0.7	Unknown protein
Rv0771		+0.4	2.4	Possible 4-carboxymuconolactone decarboxylase (CMD)
Rv1788		+0.4	1.8	PE family protein PE18
Rv3748		+0.4	0.4	Conserved hypothetical protein
Rv3554		+0.4	2.0	Possible electron transfer protein FdxB
Rv2801c		+0.4	0.5	Toxin MazF9
Rv3146		+0.4	1.9	Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B)
Rv0490		+0.4	1.2	Putative two component sensor histidine kinase SenX3
Rv3416		+0.4	1.1	Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster.
Rv2038c		+0.4	1.4	Probable sugar-transport ATP-binding protein ABC transporter
Rv1352		+0.4	1.3	Conserved protein
Rv1542c		+0.4	1.5	Hemoglobin GlbN
Rv1500		+0.4	2.2	Probable glycosyltransferase
Rv1182		+0.4	2.1	Probable conserved polyketide synthase associated protein PapA3
Rv0554		+0.4	2.5	Possible peroxidase BpoC (non-haem peroxidase)
Rv3691		+0.4	0.6	Conserved protein
Rv1581c		+0.4	0.5	Probable PhiRv1 phage protein
Rv3719		+0.3	1.8	Conserved protein
Rv1720c		+0.3	1.1	Possible toxin VapC12

Specific Phenotypes

For 1 genes in this experiment

For stress Bedaquiline in Mycobacterium tuberculosis H37Rv

For stress Bedaquiline across organisms