Experiment set1S202 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv2869c		-4.8	-3.0	Membrane bound metalloprotease
Rv0007		-4.1	-1.1	Possible conserved membrane protein
Rv3810		-3.4	-2.7	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv0929		-3.0	-3.1	Phosphate-transport integral membrane ABC transporter PstC2
Rv0930		-3.0	-7.8	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1512		-2.8	-1.1	Probable nucleotide-sugar epimerase EpiA
Rv1421		-2.8	-2.7	Conserved protein
Rv3717		-2.8	-4.4	Conserved hypothetical protein
Rv0820		-2.7	-4.1	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv0757		-2.7	-2.2	Possible two component system response transcriptional positive regulator PhoP
Rv3005c		-2.6	-11.8	Conserved hypothetical protein
Rv2581c		-2.6	-1.9	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv1620c		-2.6	-4.2	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv3101c		-2.5	-2.3	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv0928		-2.5	-3.5	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv3102c		-2.5	-2.4	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv2224c		-2.5	-13.1	Probable carboxylesterase CaeA
Rv0472c		-2.4	-4.2	Probable transcriptional regulatory protein (possibly TetR-family)
Rv1621c		-2.4	-3.2	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv0361		-2.4	-1.8	Probable conserved membrane protein
Rv1836c		-2.2	-3.5	Conserved protein
Rv3267		-2.1	-4.3	Conserved protein (CPSA-related protein)
Rv1010		-2.1	-1.5	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv2553c		-2.1	-1.7	Probable conserved membrane protein
Rv3822		-2.0	-10.8	Conserved hypothetical protein
Rv0994		-2.0	-6.1	Probable molybdopterin biosynthesis protein MoeA1
Rv1244		-2.0	-5.5	Probable lipoprotein LpqZ
Rv2938		-1.9	-11.6	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv1433		-1.8	-8.8	Possible conserved exported protein
Rv0742		-1.8	-1.8	PE-PGRS family protein PE_PGRS8
Rv1860		-1.8	-5.2	Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen)
Rv0819		-1.8	-2.4	GCN5-related N-acetyltransferase, MshD
Rv3414c		-1.7	-4.4	Probable alternative RNA polymerase sigma-D factor SigD
Rv2170		-1.7	-1.7	GCN5-related N-acetyltransferase
Rv1013		-1.7	-8.4	Putative polyketide synthase Pks16
Rv2525c		-1.7	-9.9	Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system.
Rv1459c		-1.6	-1.3	Possible conserved integral membrane protein
Rv2945c		-1.6	-6.2	Probable conserved lipoprotein LppX
Rv0040c		-1.6	-6.5	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv1657		-1.6	-3.1	Probable arginine repressor ArgR (AHRC)
Rv2091c		-1.6	-6.4	Probable membrane protein
Rv1821		-1.6	-3.9	Possible preprotein translocase ATPase SecA2
Rv1410c		-1.5	-6.8	Aminoglycosides/tetracycline-transport integral membrane protein
Rv2365c		-1.5	-0.8	Conserved hypothetical protein
Rv2302		-1.5	-0.8	Conserved protein
Rv0309		-1.5	-3.8	Possible conserved exported protein
Rv1272c		-1.5	-4.2	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv2476c		-1.4	-3.9	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv2942		-1.4	-10.8	Conserved transmembrane transport protein MmpL7
Rv2672		-1.4	-7.3	Possible secreted protease
Rv2937		-1.4	-8.5	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv1280c		-1.4	-6.8	Probable periplasmic oligopeptide-binding lipoprotein OppA
Rv0050		-1.4	-2.1	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv3726		-1.4	-1.4	Possible dehydrogenase
Rv1006		-1.4	-3.3	Unknown protein
Rv2936		-1.4	-8.7	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv2801c		-1.4	-1.1	Toxin MazF9
Rv0241c		-1.3	-2.2	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv1332		-1.3	-0.9	Probable transcriptional regulatory protein
Rv3162c		-1.3	-1.4	Possible integral membrane protein
Rv1291c		-1.3	-1.4	Conserved hypothetical secreted protein
Rv1281c		-1.3	-5.0	Probable oligopeptide-transport ATP-binding protein ABC transporter OppD
Rv0955		-1.3	-1.3	Probable conserved integral membrane protein
Rv2044c		-1.3	-0.6	Conserved hypothetical protein
Rv0504c		-1.3	-2.3	Conserved protein
Rv1220c		-1.2	-4.6	Probable methyltransferase
Rv0084		-1.2	-1.1	Possible formate hydrogenlyase HycD (FHL)
Rv1698		-1.2	-2.6	Outer membrane protein MctB
Rv2154c		-1.2	-2.0	FtsW-like protein FtsW
Rv0561c		-1.2	-1.2	Possible oxidoreductase
Rv0312		-1.2	-3.7	Conserved hypothetical proline and threonine rich protein
Rv3897c		-1.2	-0.8	Conserved hypothetical protein
Rv1273c		-1.2	-4.3	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv2171		-1.2	-2.3	Probable conserved lipoprotein LppM
Rv2762c		-1.2	-0.7	Conserved hypothetical protein
Rv3413c		-1.1	-0.5	Unknown alanine and proline rich protein
Rv0444c		-1.1	-4.3	Anti-sigma factor RskA (regulator of sigma K)
Rv3819		-1.1	-0.6	Unknown protein
Rv3196A		-1.1	-1.5	Unknown protein
Rv2197c		-1.1	-4.2	Probable conserved transmembrane protein
Rv2812		-1.1	-1.6	Probable transposase
Rv0531		-1.1	-1.1	Possible conserved membrane protein
Rv1411c		-1.1	-2.4	Conserved lipoprotein LprG
Rv3687c		-1.1	-0.8	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv1435c		-1.1	-3.0	Probable conserved proline, glycine, valine-rich secreted protein
Rv0204c		-1.1	-2.1	Probable conserved transmembrane protein
Rv0037c		-1.1	-7.6	Probable conserved integral membrane protein
Rv1283c		-1.1	-1.8	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv0018c		-1.0	-2.2	Phosphoserine/threonine phosphatase PstP
Rv0954		-1.0	-2.2	Probable conserved transmembrane protein
Rv0012		-1.0	-4.8	Probable conserved membrane protein
Rv2190c		-1.0	-2.7	Conserved hypothetical protein
Rv2444c		-1.0	-2.2	Possible ribonuclease E Rne
Rv3843c		-1.0	-1.6	Probable conserved transmembrane protein
Rv2644c		-1.0	-2.2	Hypothetical protein
Rv0615		-1.0	-1.2	Probable integral membrane protein
Rv2693c		-1.0	-2.8	Probable conserved integral membrane alanine and leucine rich protein
Rv1640c		-1.0	-4.5	Lysyl-tRNA synthetase 2 LysX
Rv0825c		-1.0	-1.3	Conserved protein
Rv2452c		-1.0	-3.0	Hypothetical protein
Rv0093c		-1.0	-1.4	Probable conserved membrane protein
Rv0427c		-1.0	-3.2	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)
Rv3668c		-1.0	-4.5	Possible protease
Rv1747		-1.0	-5.5	Probable conserved transmembrane ATP-binding protein ABC transporter
Rv0983		-0.9	-3.5	Probable serine protease PepD (serine proteinase) (MTB32B)
Rv1159		-0.9	-1.9	Mannosyltransferase PimE
Rv3304		-0.9	-2.0	Conserved protein
Rv2551c		-0.9	-1.3	Conserved hypothetical protein
Rv2694c		-0.9	-1.4	Conserved protein
Rv0154c		-0.9	-1.7	Probable acyl-CoA dehydrogenase FadE2
Rv3910		-0.9	-1.1	Probable conserved transmembrane protein
Rv1887		-0.9	-5.3	Hypothetical protein
Rv0497		-0.9	-0.9	Probable conserved transmembrane protein
Rv0179c		-0.9	-6.5	Possible lipoprotein LprO
Rv3085		-0.9	-0.7	Probable short-chain type dehydrogenase/reductase
Rv0646c		-0.9	-2.6	Probable lipase/esterase LipG
Rv0642c		-0.9	-1.7	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv3445c		-0.8	-0.9	ESAT-6 like protein EsxU
Rv1062		-0.8	-0.4	Conserved hypothetical protein
Rv1823		-0.8	-2.6	Conserved protein
Rv0999		-0.8	-1.9	Unknown protein
Rv2366c		-0.8	-2.2	Probable conserved transmembrane protein
Rv3311		-0.8	-2.8	Conserved protein
Rv2736c		-0.8	-1.0	Regulatory protein RecX
Rv1815		-0.8	-2.4	Conserved protein
Rv0374c		-0.8	-2.1	Probable carbon monoxyde dehydrogenase (small chain)
Rv2650c		-0.8	-1.0	Possible PhiRv2 prophage protein
Rv3316		-0.8	-1.3	Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Rv2272		-0.8	-0.5	Probable conserved transmembrane protein
Rv1128c		-0.8	-1.3	Conserved hypothetical protein
Rv3592		-0.8	-1.8	Possible heme degrading protein MhuD
Rv3394c		-0.8	-2.1	Conserved hypothetical protein
Rv0857		-0.7	-1.0	Conserved hypothetical protein
Rv3335c		-0.7	-2.6	Probable conserved integral membrane protein
Rv2463		-0.7	-3.6	Probable esterase/lipase LipP
Rv0680c		-0.7	-1.3	Probable conserved transmembrane protein
Rv3223c		-0.7	-3.2	Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE)
Rv0675		-0.7	-0.5	Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0108c		-0.7	-3.1	Hypothetical protein
Rv2743c		-0.7	-3.7	Possible conserved transmembrane alanine rich protein
Rv1278		-0.7	-1.8	Hypothetical protein
Rv2132		-0.7	-1.7	Conserved hypothetical protein
Rv1925		-0.7	-4.4	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)
Rv3387		-0.7	-1.4	Possible transposase
Rv2586c		-0.7	-0.7	Probable protein-export membrane protein SecF
Rv0818		-0.7	-2.4	Transcriptional regulatory protein
Rv0950c		-0.7	-3.0	Conserved hypothetical protein
Rv1137c		-0.7	-1.5	Hypothetical protein
Rv0078		-0.7	-1.1	Probable transcriptional regulatory protein
Rv0677c		-0.7	-1.0	Possible conserved membrane protein MmpS5
Rv1926c		-0.7	-1.7	Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein)
Rv0377		-0.7	-1.7	Probable transcriptional regulatory protein (probably LysR-family)
Rv3273		-0.7	-3.4	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Rv3366		-0.7	-1.7	Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase)
Rv3643		-0.7	-1.2	Hypothetical protein
Rv2855		-0.7	-1.4	NADPH-dependent mycothiol reductase Mtr
Rv1174c		-0.7	-4.8	Low molecular weight T-cell antigen TB8.4
Rv3018c		-0.7	-2.2	PPE family protein PPE46
Rv1468c		-0.7	-1.7	PE-PGRS family protein PE_PGRS29
Rv0436c		-0.7	-0.9	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv3045		-0.7	-1.7	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv0017c		-0.7	-1.7	Probable cell division protein RodA
Rv3817		-0.7	-1.2	Possible phosphotransferase
Rv2923c		-0.7	-1.1	Conserved protein
Rv0851c		-0.7	-0.9	Probable short-chain type dehydrogenase/reductase
Rv2864c		-0.7	-4.4	Possible penicillin-binding lipoprotein
Rv0949		-0.7	-0.5	Probable ATP-dependent DNA helicase II UvrD1
Rv2231c		-0.7	-1.1	Possible aminotransferase CobC
Rv0432		-0.7	-3.8	Periplasmic superoxide dismutase [Cu-Zn] SodC
Rv2851c		-0.7	-2.4	GCN5-related N-acetyltransferase
Rv3136		-0.7	-2.9	PPE family protein PPE51
Rv2107		-0.7	-1.0	PE family protein PE22
Rv1159A		-0.7	-1.3	Unknown protein
Rv0129c		-0.7	-3.9	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)
Rv1282c		-0.6	-1.3	Probable oligopeptide-transport integral membrane protein ABC transporter OppC
Rv1935c		-0.6	-2.3	Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3748		-0.6	-0.6	Conserved hypothetical protein
Rv2328		-0.6	-1.6	PE family protein PE23
Rv2668		-0.6	-2.4	Possible exported alanine and valine rich protein
Rv2691		-0.6	-2.7	TRK system potassium uptake protein CeoB
Rv3707c		-0.6	-3.0	Conserved hypothetical protein
Rv0051		-0.6	-3.1	Probable conserved transmembrane protein
Rv2203		-0.6	-3.2	Possible conserved membrane protein
Rv0916c		-0.6	-1.1	PE family protein PE7
Rv1635c		-0.6	-5.1	Probable mannosyltransferase. Probable conserved transmembrane protein.
Rv0242c		-0.6	-1.5	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv0566c		-0.6	-2.6	Conserved protein
Rv1287		-0.6	-1.9	Conserved hypothetical protein
Rv2548		-0.6	-0.9	Possible toxin VapC19
Rv3700c		-0.6	-1.1	Conserved hypothetical protein
Rv0971c		-0.6	-2.3	Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0569		-0.6	-1.0	Conserved protein
Rv1256c		-0.6	-1.9	Probable cytochrome P450 130 Cyp130
Rv3283		-0.6	-1.9	Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
Rv2048c		-0.6	-3.4	Polyketide synthase Pks12
Rv3330		-0.6	-3.5	Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase)
Rv2876		-0.6	-0.5	Possible conserved transmembrane protein
Rv1919c		-0.6	-1.9	Conserved protein
Rv3912		-0.6	-1.5	Hypothetical alanine rich protein
Rv1107c		-0.6	-0.6	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)

Specific Phenotypes

For 5 genes in this experiment

For stress Rifampicin in Mycobacterium tuberculosis H37Rv

For stress Rifampicin across organisms