Experiment set1S201 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv1957		+2.5	5.8	Hypothetical protein
Rv2292c		+2.1	2.8	Hypothetical protein
Rv0470c		+1.8	5.0	Mycolic acid synthase PcaA (cyclopropane synthase)
Rv3419c		+1.8	3.2	Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
Rv2140c		+1.7	4.3	Conserved protein TB18.6
Rv2044c		+1.6	1.3	Conserved hypothetical protein
Rv2506		+1.5	6.3	Probable transcriptional regulatory protein (probably TetR-family)
Rv2721c		+1.4	10.8	Possible conserved transmembrane alanine and glycine rich protein
Rv1792		+1.3	2.2	ESAT-6 like protein EsxM
Rv2722		+1.3	4.8	Conserved hypothetical protein
Rv1112		+1.3	2.9	Probable GTP binding protein
Rv3198c		+1.2	1.5	Probable ATP-dependent DNA helicase II UvrD2
Rv1577c		+1.2	1.4	Probable PhiRv1 phage protein
Rv3338		+1.2	1.5	Conserved hypothetical protein
Rv0643c		+1.2	5.8	Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase)
Rv1366A		+1.2	1.3	Conserved protein
Rv2072c		+1.2	1.5	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv2782c		+1.1	3.0	Probable zinc protease PepR
Rv3484		+1.1	7.5	Possible conserved protein CpsA
Rv2985		+1.1	1.3	Possible hydrolase MutT1
Rv0617		+1.1	1.5	Possible toxin VapC29. Contains PIN domain.
Rv3848		+1.1	2.5	Probable conserved transmembrane protein
Rv2709		+1.1	7.0	Probable conserved transmembrane protein
Rv0177		+1.1	2.1	Probable conserved Mce associated protein
Rv0766c		+1.1	1.7	Probable cytochrome P450 123 Cyp123
Rv0135c		+1.1	5.3	Possible transcriptional regulatory protein
Rv1691		+1.0	3.9	Conserved hypothetical protein
Rv2404c		+1.0	6.0	Probable GTP-binding protein LepA (GTP-binding elongation factor)
Rv2408		+1.0	1.6	Possible PE family-related protein PE24
Rv0056		+1.0	2.7	50S ribosomal protein L9 RplI
Rv1100		+1.0	4.8	Conserved protein
Rv0346c		+1.0	7.8	Possible L-asparagine permease AnsP2 (L-asparagine transport protein)
Rv2989		+1.0	1.4	Probable transcriptional regulatory protein
Rv3230c		+1.0	3.7	Hypothetical oxidoreductase
Rv0939		+1.0	1.5	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv2774c		+1.0	1.1	Hypothetical protein
Rv2348c		+1.0	0.7	Hypothetical protein
Rv2657c		+1.0	1.0	Probable PhiRv2 prophage protein
Rv1578c		+1.0	0.9	Probable PhiRv1 phage protein
Rv3374		+0.9	1.6	Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2949c		+0.9	2.5	Chorismate pyruvate lyase
Rv2976c		+0.9	1.2	Probable uracil-DNA glycosylase Ung (UDG)
Rv2248		+0.9	2.8	Conserved hypothetical protein
Rv2901c		+0.9	2.8	Conserved protein
Rv3751		+0.9	1.5	Probable integrase (fragment)
Rv1963c		+0.9	2.1	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv1170		+0.9	2.7	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)
Rv3631		+0.9	1.0	Possible transferase (possibly glycosyltransferase)
Rv3331		+0.9	3.5	Probable sugar-transport integral membrane protein SugI
Rv2905		+0.8	4.8	Probable conserved alanine rich lipoprotein LppW
Rv1286		+0.8	3.7	Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase
Rv1502		+0.8	1.5	Hypothetical protein
Rv0549c		+0.8	1.2	Possible toxin VapC3
Rv2307A		+0.8	1.3	Hypothetical glycine rich protein
Rv0919		+0.8	2.1	GCN5-related N-acetyltransferase
Rv2758c		+0.8	1.2	Possible antitoxin VapB21
Rv0554		+0.8	4.2	Possible peroxidase BpoC (non-haem peroxidase)
Rv1615		+0.8	3.7	Probable membrane protein
Rv2733c		+0.8	2.5	Conserved hypothetical alanine, arginine-rich protein
Rv3664c		+0.8	3.3	Probable dipeptide-transport integral membrane protein ABC transporter DppC
Rv2752c		+0.8	2.8	Conserved hypothetical protein
Rv2898c		+0.8	0.6	Conserved hypothetical protein
Rv0889c		+0.8	2.2	Probable citrate synthase II CitA
Rv2661c		+0.8	0.9	Hypothetical protein
Rv3176c		+0.7	2.3	Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase)
Rv0234c		+0.7	2.6	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1
Rv0991c		+0.7	1.0	Conserved serine rich protein
Rv0877		+0.7	4.5	Conserved hypothetical protein
Rv2055c		+0.7	1.1	30S ribosomal protein S18 RpsR2
Rv0760c		+0.7	2.0	Conserved protein
Rv1350		+0.7	0.6	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)
Rv3222c		+0.7	1.0	Conserved hypothetical protein
Rv2850c		+0.7	1.1	Possible magnesium chelatase
Rv2681		+0.7	3.7	Conserved hypothetical alanine rich protein
Rv2788		+0.7	1.3	Probable transcriptional repressor SirR
Rv3431c		+0.7	3.3	Possible transposase (fragment)
Rv3167c		+0.7	1.6	Probable transcriptional regulatory protein (probably TetR-family)
Rv0468		+0.7	2.0	3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Rv1677		+0.7	1.3	Probable conserved lipoprotein DsbF
Rv3000		+0.7	1.8	Possible conserved transmembrane protein
Rv1754c		+0.7	5.2	Conserved protein
Rv0251c		+0.7	1.5	Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A)
Rv2372c		+0.7	1.1	Conserved hypothetical protein
Rv0789c		+0.7	3.0	Hypothetical protein
Rv2216		+0.7	2.5	Conserved protein
Rv0590		+0.7	2.5	Mce-family protein Mce2B
Rv3220c		+0.7	1.8	Probable two component sensor kinase
Rv2707		+0.7	5.3	Probable conserved transmembrane alanine and leucine rich protein
Rv0173		+0.7	2.8	Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E)
Rv0295c		+0.7	2.7	Conserved protein
Rv2367c		+0.7	1.3	Conserved hypothetical protein
Rv3768		+0.7	0.8	Unknown protein
Rv3779		+0.7	4.7	Probable conserved transmembrane protein alanine and leucine rich
Rv0916c		+0.6	1.3	PE family protein PE7
Rv1178		+0.6	1.3	Probable aminotransferase
Rv2237A		+0.6	0.8	Conserved protein
Rv3334		+0.6	2.2	Probable transcriptional regulatory protein (probably MerR-family)
Rv3256c		+0.6	1.1	Conserved protein
Rv0092		+0.6	3.1	Cation transporter P-type ATPase a CtpA
Rv2867c		+0.6	2.4	GCN5-related N-acetyltransferase
Rv0245		+0.6	1.1	Possible oxidoreductase
Rv2360c		+0.6	1.8	Unknown protein
Rv3716c		+0.6	0.4	Conserved protein
Rv0588		+0.6	1.9	Conserved hypothetical integral membrane protein YrbE2B
Rv2474c		+0.6	1.0	Conserved hypothetical protein
Rv3328c		+0.6	2.6	Probable alternative RNA polymerase sigma factor (fragment) SigJ
Rv0813c		+0.6	2.9	Conserved protein
Rv1372		+0.6	0.8	Conserved hypothetical protein
Rv3340		+0.6	1.2	Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase)
Rv2930		+0.6	5.3	Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Rv3820c		+0.6	4.4	Possible conserved polyketide synthase associated protein PapA2
Rv0168		+0.6	2.1	Conserved integral membrane protein YrbE1B
Rv0686		+0.6	2.1	Probable membrane protein
Rv2316		+0.6	2.0	Probable sugar-transport integral membrane protein ABC transporter UspA
Rv0756c		+0.6	1.5	Unknown protein
Rv0367c		+0.6	0.5	Hypothetical protein
Rv1049		+0.6	0.7	Probable transcriptional repressor protein
Rv1694		+0.6	0.8	2'-O-methyltransferase TlyA
Rv0315		+0.6	3.1	Possible beta-1,3-glucanase precursor
Rv2369c		+0.6	1.0	Hypothetical protein
Rv2298		+0.6	2.7	Conserved protein
Rv2175c		+0.6	1.7	Conserved regulatory protein
Rv1616		+0.6	1.7	Conserved membrane protein
Rv0199		+0.6	1.7	Probable conserved membrane protein
Rv0973c		+0.6	1.5	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Rv3154		+0.6	2.9	Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J)
Rv0085		+0.6	1.0	Possible hydrogenase HycP
Rv0737		+0.6	1.7	Possible transcriptional regulatory protein
Rv2451		+0.6	1.8	Hypothetical proline and serine rich protein
Rv0043c		+0.6	1.1	Probable transcriptional regulatory protein (probably GntR-family)
Rv1672c		+0.6	2.3	Probable conserved integral membrane transport protein
Rv2259		+0.5	1.5	S-nitrosomycothiol reductase MscR
Rv0306		+0.5	1.6	Putative oxidoreductase
Rv3755c		+0.5	2.1	Conserved protein
Rv0581		+0.5	2.4	Possible antitoxin VapB26
Rv0082		+0.5	2.8	Probable oxidoreductase
Rv0545c		+0.5	2.4	Probable low-affinity inorganic phosphate transporter integral membrane protein PitA
Rv2009		+0.5	0.9	Antitoxin VapB15
Rv2335		+0.5	0.8	Probable serine acetyltransferase CysE (sat)
Rv2633c		+0.5	2.0	Hypothetical protein
Rv0613c		+0.5	2.6	Unknown protein
Rv1626		+0.5	2.4	Probable two-component system transcriptional regulator
Rv3135		+0.5	1.8	PPE family protein PPE50
Rv0544c		+0.5	1.3	Possible conserved transmembrane protein
Rv2234		+0.5	1.6	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
Rv1956		+0.5	2.9	Possible antitoxin HigA
Rv2772c		+0.5	0.9	Probable conserved transmembrane protein
Rv3229c		+0.5	1.7	Possible linoleoyl-CoA desaturase (delta(6)-desaturase)
Rv1212c		+0.5	2.2	Putative glycosyl transferase GlgA
Rv3007c		+0.5	1.6	Possible oxidoreductase
Rv3171c		+0.5	0.4	Possible non-heme haloperoxidase Hpx
Rv2933		+0.5	4.3	Phenolpthiocerol synthesis type-I polyketide synthase PpsC
Rv0871		+0.5	1.5	Probable cold shock-like protein B CspB
Rv1116A		+0.5	0.7	Conserved hypothetical protein (fragment)
Rv0010c		+0.5	2.3	Probable conserved membrane protein
Rv3111		+0.5	1.4	Probable molybdenum cofactor biosynthesis protein C MoaC1
Rv1506c		+0.5	1.3	Hypothetical protein
Rv3262		+0.5	1.3	Probable F420 biosynthesis protein FbiB
Rv3690		+0.5	2.1	Probable conserved membrane protein
Rv2939		+0.5	3.9	Possible conserved polyketide synthase associated protein PapA5
Rv1239c		+0.5	3.0	Possible magnesium and cobalt transport transmembrane protein CorA
Rv0841		+0.5	0.7	Probable conserved transmembrane protein
Rv2706c		+0.5	0.8	Hypothetical protein
Rv0974c		+0.5	1.6	Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2
Rv2021c		+0.5	0.9	Transcriptional regulatory protein
Rv1751		+0.5	1.1	Probable oxidoreductase
Rv0356c		+0.5	1.5	Conserved protein
Rv0725c		+0.5	1.2	Conserved hypothetical protein
Rv2862A		+0.5	1.7	Possible antitoxin VapB23
Rv1579c		+0.5	1.9	Probable PhiRv1 phage protein
Rv1730c		+0.5	1.7	Possible penicillin-binding protein
Rv1916		+0.5	2.0	Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)
Rv1398c		+0.5	0.7	Possible antitoxin VapB10
Rv1171		+0.5	1.4	Conserved hypothetical protein
Rv3375		+0.5	2.0	Probable amidase AmiD (acylamidase) (acylase)
Rv3193c		+0.5	0.7	Probable conserved transmembrane protein
Rv3397c		+0.5	1.3	Probable phytoene synthase PhyA
Rv2025c		+0.5	1.2	Conserved membrane protein
Rv2849c		+0.5	1.7	Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity)
Rv3777		+0.5	1.2	Probable oxidoreductase
Rv3158		+0.5	2.8	Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N)
Rv2437		+0.5	1.2	Conserved transmembrane protein
Rv3157		+0.5	2.6	Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
Rv3076		+0.5	1.3	Conserved hypothetical protein
Rv1219c		+0.5	1.4	Probable transcriptional regulatory protein
Rv2478c		+0.5	1.5	Conserved hypothetical protein
Rv1538c		+0.5	2.7	Probable L-aparaginase AnsA
Rv0936		+0.5	1.3	Phosphate-transport integral membrane ABC transporter PstA2
Rv2433c		+0.5	1.4	Hypothetical protein
Rv2029c		+0.5	1.6	6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase)
Rv3151		+0.5	2.0	Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G)
Rv2307B		+0.5	2.7	Hypothetical glycine rich protein
Rv0734		+0.5	1.5	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv2331		+0.5	1.7	Hypothetical protein
Rv0476		+0.5	1.9	Possible conserved transmembrane protein
Rv2975c		+0.5	0.5	Conserved hypothetical protein
Rv1403c		+0.5	1.9	Putative methyltransferase
Rv0045c		+0.5	1.3	Possible hydrolase
Rv2368c		+0.5	2.6	Probable PHOH-like protein PhoH1 (phosphate starvation-inducible protein PSIH)
Rv2931		+0.5	3.9	Phenolpthiocerol synthesis type-I polyketide synthase PpsA

Specific Phenotypes

For 5 genes in this experiment

For stress Rifampicin in Mycobacterium tuberculosis H37Rv

For stress Rifampicin across organisms