Experiment set1S200 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Rifampicin 0.00045 ug/mL

200 most detrimental genes:

  gene name fitness t score description  
Rv0805 +1.6 1.8 Class III cyclic nucleotide phosphodiesterase (cNMP PDE) compare
Rv0867c +1.6 1.0 Possible resuscitation-promoting factor RpfA compare
Rv2758c +1.5 2.9 Possible antitoxin VapB21 compare
Rv3637 +1.3 1.5 Possible transposase compare
Rv0766c +1.3 2.3 Probable cytochrome P450 123 Cyp123 compare
Rv2898c +1.2 1.2 Conserved hypothetical protein compare
Rv2928 +1.1 3.9 Probable thioesterase TesA compare
Rv3230c +1.1 4.9 Hypothetical oxidoreductase compare
Rv2408 +1.1 2.0 Possible PE family-related protein PE24 compare
Rv3198c +1.0 1.3 Probable ATP-dependent DNA helicase II UvrD2 compare
Rv1401 +1.0 1.2 Possible membrane protein compare
Rv1350 +1.0 0.8 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1004c +1.0 1.9 Probable membrane protein compare
Rv0990c +1.0 1.3 Hypothetical protein compare
Rv2474c +0.9 1.8 Conserved hypothetical protein compare
Rv1792 +0.9 1.6 ESAT-6 like protein EsxM compare
Rv2044c +0.9 0.8 Conserved hypothetical protein compare
Rv3374 +0.9 3.1 Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0912 +0.8 1.9 Probable conserved transmembrane protein compare
Rv2932 +0.8 6.7 Phenolpthiocerol synthesis type-I polyketide synthase PpsB compare
Rv3328c +0.8 3.1 Probable alternative RNA polymerase sigma factor (fragment) SigJ compare
Rv3020c +0.8 1.7 ESAT-6 like protein EsxS compare
Rv0858c +0.8 3.6 Probable N-succinyldiaminopimelate aminotransferase DapC (DAP-at) compare
Rv1502 +0.8 1.5 Hypothetical protein compare
Rv3565 +0.8 1.0 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv1581c +0.8 1.4 Probable PhiRv1 phage protein compare
Rv2506 +0.8 2.0 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0470c +0.8 2.8 Mycolic acid synthase PcaA (cyclopropane synthase) compare
Rv1372 +0.8 1.5 Conserved hypothetical protein compare
Rv2930 +0.8 7.4 Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv2939 +0.8 6.5 Possible conserved polyketide synthase associated protein PapA5 compare
Rv0554 +0.8 5.5 Possible peroxidase BpoC (non-haem peroxidase) compare
Rv3176c +0.8 2.7 Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase) compare
Rv2935 +0.8 6.5 Phenolpthiocerol synthesis type-I polyketide synthase PpsE compare
Rv0939 +0.7 1.1 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv2901c +0.7 4.0 Conserved protein compare
Rv2372c +0.7 1.4 Conserved hypothetical protein compare
Rv2762c +0.7 0.8 Conserved hypothetical protein compare
Rv2072c +0.7 0.9 Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL compare
Rv1173 +0.7 2.0 Probable F420 biosynthesis protein FbiC compare
Rv1403c +0.7 1.6 Putative methyltransferase compare
Rv2003c +0.7 1.6 Conserved hypothetical protein compare
Rv2941 +0.7 5.9 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv2829c +0.7 1.8 Possible toxin VapC22 compare
Rv3236c +0.7 2.0 Probable conserved integral membrane transport protein compare
Rv2940c +0.7 6.2 Probable multifunctional mycocerosic acid synthase membrane-associated Mas compare
Rv3427c +0.7 2.1 Possible transposase compare
Rv2931 +0.7 5.9 Phenolpthiocerol synthesis type-I polyketide synthase PpsA compare
Rv3177 +0.7 1.1 Possible peroxidase (non-haem peroxidase) compare
Rv3340 +0.7 2.1 Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase) compare
Rv3431c +0.6 2.5 Possible transposase (fragment) compare
Rv2933 +0.6 5.7 Phenolpthiocerol synthesis type-I polyketide synthase PpsC compare
Rv3368c +0.6 2.5 Possible oxidoreductase compare
Rv1930c +0.6 0.7 Conserved hypothetical protein compare
Rv0991c +0.6 0.9 Conserved serine rich protein compare
Rv1570 +0.6 1.3 Dethiobiotin synthetase BioD compare
Rv1677 +0.6 1.8 Probable conserved lipoprotein DsbF compare
Rv2929 +0.6 2.4 Hypothetical protein compare
Rv2934 +0.6 5.3 Phenolpthiocerol synthesis type-I polyketide synthase PpsD compare
Rv0919 +0.6 1.3 GCN5-related N-acetyltransferase compare
Rv1303 +0.6 0.7 Conserved hypothetical transmembrane protein compare
Rv2976c +0.6 0.8 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv1238 +0.6 1.8 Probable sugar-transport ATP-binding protein ABC transporter SugC compare
Rv2293c +0.6 1.2 Conserved hypothetical protein compare
Rv3065 +0.6 1.5 Multidrugs-transport integral membrane protein Mmr compare
Rv3073c +0.6 1.0 Conserved hypothetical protein compare
Rv0468 +0.6 1.5 3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) compare
Rv3338 +0.6 0.7 Conserved hypothetical protein compare
Rv0356c +0.6 1.3 Conserved protein compare
Rv1116A +0.6 1.0 Conserved hypothetical protein (fragment) compare
Rv1286 +0.6 3.1 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase compare
Rv0085 +0.6 0.9 Possible hydrogenase HycP compare
Rv0544c +0.6 1.0 Possible conserved transmembrane protein compare
Rv2099c +0.6 1.0 PE family protein PE21 compare
Rv1235 +0.6 2.1 Probable sugar-binding lipoprotein LpqY compare
Rv3770B +0.6 1.5 Probable remnant of a transposase compare
Rv0681 +0.6 3.2 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3678A +0.6 1.1 Conserved hypothetical protein compare
Rv2774c +0.6 0.6 Hypothetical protein compare
Rv3486 +0.5 1.6 Conserved protein compare
Rv0686 +0.5 2.2 Probable membrane protein compare
Rv0760c +0.5 1.4 Conserved protein compare
Rv0535 +0.5 1.2 Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) compare
Rv3295 +0.5 4.3 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv2433c +0.5 1.1 Hypothetical protein compare
Rv3716c +0.5 0.4 Conserved protein compare
Rv0069c +0.5 1.0 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) compare
Rv3301c +0.5 1.6 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv0050 +0.5 1.6 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv1538c +0.5 2.9 Probable L-aparaginase AnsA compare
Rv0065 +0.5 1.3 Possible toxin VapC1 compare
Rv2796c +0.5 0.8 Probable conserved lipoprotein LppV compare
Rv0039c +0.5 2.1 Possible conserved transmembrane protein compare
Rv1035c +0.5 1.1 Probable transposase (fragment) compare
Rv1897c +0.5 1.2 Conserved hypothetical protein compare
Rv1956 +0.5 2.0 Possible antitoxin HigA compare
Rv1127c +0.5 1.0 Probable pyruvate, phosphate dikinase PpdK compare
Rv2481c +0.5 1.9 Hypothetical protein compare
Rv3549c +0.5 1.6 Probable short-chain type dehydrogenase/reductase compare
Rv3084 +0.5 2.1 Probable acetyl-hydrolase/esterase LipR compare
Rv1170 +0.5 1.4 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv2086 +0.5 1.0 Conserved hypothetical protein compare
Rv3377c +0.5 1.6 Halimadienyl diphosphate synthase compare
Rv2721c +0.5 3.6 Possible conserved transmembrane alanine and glycine rich protein compare
Rv3779 +0.5 3.4 Probable conserved transmembrane protein alanine and leucine rich compare
Rv2705c +0.5 1.5 Conserved hypothetical protein compare
Rv2337c +0.5 2.3 Hypothetical protein compare
Rv0545c +0.5 1.6 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv0661c +0.5 0.9 Possible toxin VapC7 compare
Rv0383c +0.5 0.6 Possible conserved secreted protein compare
Rv0995 +0.4 1.0 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) compare
Rv2140c +0.4 0.9 Conserved protein TB18.6 compare
Rv1957 +0.4 0.7 Hypothetical protein compare
Rv3254 +0.4 2.0 Conserved hypothetical protein compare
Rv3711c +0.4 1.7 Probable DNA polymerase III (epsilon subunit) DnaQ compare
Rv0643c +0.4 2.4 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) compare
Rv1414 +0.4 0.4 Conserved hypothetical protein compare
Rv3651 +0.4 1.2 Conserved hypothetical protein compare
Rv2159c +0.4 2.0 Conserved protein compare
Rv2772c +0.4 0.7 Probable conserved transmembrane protein compare
Rv0564c +0.4 1.4 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) compare
Rv3395c +0.4 1.2 Conserved hypothetical protein compare
Rv0889c +0.4 1.7 Probable citrate synthase II CitA compare
Rv2662 +0.4 1.2 Hypothetical protein compare
Rv0841 +0.4 0.6 Probable conserved transmembrane protein compare
Rv3196 +0.4 1.9 Conserved hypothetical protein compare
Rv1332 +0.4 0.5 Probable transcriptional regulatory protein compare
Rv2801c +0.4 0.6 Toxin MazF9 compare
Rv1049 +0.4 1.0 Probable transcriptional repressor protein compare
Rv3357 +0.4 2.1 Antitoxin RelJ compare
Rv1218c +0.4 1.4 Probable tetronasin-transport ATP-binding protein ABC transporter compare
Rv2655c +0.4 1.2 Possible PhiRv2 prophage protein compare
Rv0117 +0.4 2.0 Oxidative stress response regulatory protein OxyS compare
Rv0131c +0.4 1.9 Probable acyl-CoA dehydrogenase FadE1 compare
Rv3287c +0.4 0.7 Anti-sigma factor RsbW (sigma negative effector) compare
Rv2789c +0.4 1.8 Probable acyl-CoA dehydrogenase FadE21 compare
Rv2410c +0.4 1.1 Conserved protein compare
Rv3397c +0.4 0.7 Probable phytoene synthase PhyA compare
Rv0255c +0.4 1.7 Probable cobyric acid synthase CobQ1 compare
Rv3312A +0.4 1.9 Secreted protein antigen compare
Rv2660c +0.4 1.4 Hypothetical protein compare
Rv0941c +0.4 1.5 Conserved hypothetical protein compare
Rv3088 +0.4 2.1 Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4 compare
Rv3305c +0.4 0.6 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) compare
Rv0591 +0.4 1.2 Mce-family protein Mce2C compare
Rv2331A +0.4 0.6 Hypothetical protein compare
Rv2626c +0.4 1.3 Hypoxic response protein 1 Hrp1 compare
Rv3839 +0.4 2.7 Conserved hypothetical protein compare
Rv1628c +0.4 1.5 Conserved protein compare
Rv2102 +0.4 1.4 Conserved hypothetical protein compare
Rv0360c +0.4 1.2 Conserved protein compare
Rv2623 +0.4 2.1 Universal stress protein family protein TB31.7 compare
Rv3334 +0.4 1.1 Probable transcriptional regulatory protein (probably MerR-family) compare
Rv3563 +0.4 0.8 Probable acyl-CoA dehydrogenase FadE32 compare
Rv1951c +0.4 1.0 Conserved hypothetical protein compare
Rv3217c +0.4 1.3 Probable conserved integral membrane protein compare
Rv2272 +0.4 0.4 Probable conserved transmembrane protein compare
Rv2849c +0.4 2.2 Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity) compare
Rv2527 +0.4 1.6 Possible toxin VapC17 compare
Rv2416c +0.4 1.6 Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase compare
Rv2336 +0.4 1.9 Hypothetical protein compare
Rv3426 +0.4 1.1 PPE family protein PPE58 compare
Rv0771 +0.4 1.7 Possible 4-carboxymuconolactone decarboxylase (CMD) compare
Rv0370c +0.4 1.5 Possible oxidoreductase compare
Rv2722 +0.4 2.0 Conserved hypothetical protein compare
Rv0294 +0.4 1.5 Probable trans-aconitate methyltransferase Tam compare
Rv3556c +0.4 1.2 Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase) compare
Rv0901 +0.4 2.0 Possible conserved exported or membrane protein compare
Rv0569 +0.4 1.0 Conserved protein compare
Rv3165c +0.4 0.5 Unknown protein compare
Rv0161 +0.4 0.8 Possible oxidoreductase compare
Rv2046 +0.4 1.4 Probable lipoprotein LppI compare
Rv0634A +0.4 1.7 Unknown protein compare
Rv2008c +0.4 1.6 Conserved hypothetical protein compare
Rv2331 +0.4 1.4 Hypothetical protein compare
Rv1001 +0.4 2.0 Probable arginine deiminase ArcA (adi) (ad) (arginine dihydrolase) compare
Rv3454 +0.4 1.5 Probable conserved integral membrane protein compare
Rv2248 +0.4 1.0 Conserved hypothetical protein compare
Rv1446c +0.4 0.5 Putative OXPP cycle protein OpcA compare
Rv1239c +0.4 1.9 Possible magnesium and cobalt transport transmembrane protein CorA compare
Rv3054c +0.4 2.0 Conserved hypothetical protein compare
Rv1751 +0.4 1.0 Probable oxidoreductase compare
Rv3346c +0.4 0.9 Conserved transmembrane protein compare
Rv0621 +0.4 1.0 Possible membrane protein compare
Rv0346c +0.4 2.6 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv3354 +0.4 1.9 Conserved hypothetical protein compare
Rv2478c +0.4 1.6 Conserved hypothetical protein compare
Rv1578c +0.4 0.3 Probable PhiRv1 phage protein compare
Rv0634c +0.4 1.5 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv2578c +0.4 1.7 Conserved hypothetical protein compare
Rv2319c +0.4 1.2 Universal stress protein family protein compare
Rv3076 +0.4 1.3 Conserved hypothetical protein compare
Rv0789c +0.4 0.8 Hypothetical protein compare
Rv0245 +0.4 0.7 Possible oxidoreductase compare
Rv1356c +0.4 2.0 Hypothetical protein compare
Rv3640c +0.4 1.7 Probable transposase compare
Rv0970 +0.4 0.9 Probable conserved integral membrane protein compare
Rv2260 +0.3 0.7 Conserved hypothetical protein compare
Rv0162c +0.3 1.3 Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 compare
Rv0737 +0.3 0.8 Possible transcriptional regulatory protein compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Rifampicin across organisms