Experiment set1IT070 for Acidovorax sp. GW101-3H11

Compare to:

Sodium D-Lactate carbon source

200 most important genes:

  gene name fitness t score description  
Ac3H11_4277 -6.6 -16.0 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Ac3H11_4401 -6.4 -8.8 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) compare
Ac3H11_1525 -6.2 -20.2 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) compare
Ac3H11_772 -6.2 -4.3 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) compare
Ac3H11_4276 -6.0 -12.4 Probable transmembrane protein compare
Ac3H11_771 -6.0 -7.1 Anthranilate phosphoribosyltransferase (EC 2.4.2.18) compare
Ac3H11_2452 -6.0 -5.8 O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) (from data) compare
Ac3H11_769 -5.9 -3.9 Anthranilate synthase, amidotransferase component (EC 4.1.3.27) @ Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) compare
Ac3H11_3449 -5.9 -4.1 Shikimate kinase I (EC 2.7.1.71) compare
Ac3H11_4278 -5.7 -12.1 Methionine biosynthesis protein MetW compare
Ac3H11_3400 -5.6 -10.3 Glycolate dehydrogenase (EC 1.1.99.14), FAD-binding subunit GlcE compare
Ac3H11_3045 -5.5 -12.9 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) compare
Ac3H11_3553 -5.4 -19.7 Phosphoenolpyruvate carboxylase (EC 4.1.1.31) compare
Ac3H11_1528 -5.4 -24.2 3-isopropylmalate dehydrogenase (EC 1.1.1.85) compare
Ac3H11_29 -5.3 -11.4 3-dehydroquinate dehydratase II (EC 4.2.1.10) compare
Ac3H11_573 -5.3 -6.3 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) compare
Ac3H11_206 -5.3 -17.1 Phosphoenolpyruvate synthase (EC 2.7.9.2) compare
Ac3H11_4483 -5.3 -18.5 Glycolate dehydrogenase (EC 1.1.99.14), subunit GlcD compare
Ac3H11_1535 -5.2 -11.7 Tryptophan synthase alpha chain (EC 4.2.1.20) compare
Ac3H11_2034 -5.2 -3.6 General secretion pathway protein K compare
Ac3H11_1533 -5.2 -12.0 Phosphoribosylanthranilate isomerase (EC 5.3.1.24) compare
Ac3H11_4044 -5.0 -10.2 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) compare
Ac3H11_3341 -4.9 -3.4 Orotate phosphoribosyltransferase (EC 2.4.2.10) compare
Ac3H11_767 -4.9 -15.2 Anthranilate synthase, aminase component (EC 4.1.3.27) compare
Ac3H11_1534 -4.8 -17.2 Tryptophan synthase beta chain (EC 4.2.1.20) compare
Ac3H11_1527 -4.8 -7.1 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) compare
Ac3H11_4034 -4.7 -11.0 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I alpha (EC 2.5.1.54) compare
Ac3H11_2574 -4.7 -10.9 Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51) compare
Ac3H11_2345 -4.6 -17.8 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) compare
Ac3H11_2960 -4.6 -1.7 Nicotinamide-nucleotide adenylyltransferase, NadM family (EC 2.7.7.1) / ADP-ribose pyrophosphatase (EC 3.6.1.13) compare
Ac3H11_3860 -4.6 -8.6 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) compare
Ac3H11_2395 -4.6 -4.4 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) compare
Ac3H11_4711 -4.5 -5.3 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) compare
Ac3H11_4771 -4.4 -10.3 Glutamate 5-kinase (EC 2.7.2.11) compare
Ac3H11_3398 -4.3 -10.3 Glycolate dehydrogenase (EC 1.1.99.14), iron-sulfur subunit GlcF compare
Ac3H11_3241 -4.3 -5.0 Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
Ac3H11_574 -4.2 -9.6 Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) compare
Ac3H11_4092 -4.1 -2.8 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) compare
Ac3H11_4093 -4.0 -18.5 Pyruvate dehydrogenase E1 component (EC 1.2.4.1) compare
Ac3H11_4710 -4.0 -22.8 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) compare
Ac3H11_2035 -3.9 -2.0 General secretion pathway protein J compare
Ac3H11_2970 -3.9 -8.1 Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) compare
Ac3H11_2403 -3.8 -6.9 Alkanesulfonate utilization operon LysR-family regulator CbI compare
Ac3H11_3567 -3.8 -15.0 TRAP transporter solute receptor, unknown substrate 6 compare
Ac3H11_4484 -3.7 -8.3 Glycine cleavage system transcriptional activator GcvA compare
Ac3H11_467 -3.7 -7.0 Thioredoxin compare
Ac3H11_2036 -3.7 -1.9 General secretion pathway protein I compare
Ac3H11_577 -3.7 -9.9 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) compare
Ac3H11_2925 -3.7 -8.5 Chorismate synthase (EC 4.2.3.5) compare
Ac3H11_4705 -3.6 -10.8 3-dehydroquinate synthase (EC 4.2.3.4) compare
Ac3H11_525 -3.6 -11.6 Acetolactate synthase large subunit (EC 2.2.1.6) compare
Ac3H11_2027 -3.4 -15.6 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) compare
Ac3H11_2344 -3.4 -6.1 Transcriptional activator MetR compare
Ac3H11_952 -3.4 -1.8 Cytochrome c551/c552 compare
Ac3H11_1908 -3.3 -12.0 Response regulator receiver:Transcriptional regulatory protein, C- terminal compare
Ac3H11_2575 -3.3 -4.6 Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43) compare
Ac3H11_2029 -3.2 -5.7 General secretion pathway protein E / Type II secretion cytoplasmic ATP binding protein (PulE, ATPase) compare
Ac3H11_1909 -3.2 -8.2 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal compare
Ac3H11_2608 -3.2 -4.7 Amidophosphoribosyltransferase (EC 2.4.2.14) compare
Ac3H11_4473 -3.1 -10.4 Twitching motility protein PilT compare
Ac3H11_4828 -3.0 -3.6 Ferredoxin compare
Ac3H11_3568 -3.0 -8.9 TRAP dicarboxylate transporter, DctM subunit, unknown substrate 6 compare
Ac3H11_376 -3.0 -1.6 DNA-binding protein HU-beta compare
Ac3H11_4091 -2.9 -5.9 Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex (EC 1.8.1.4) compare
Ac3H11_575 -2.8 -5.1 Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) compare
Ac3H11_526 -2.8 -5.0 Acetolactate synthase small subunit (EC 2.2.1.6) compare
Ac3H11_4054 -2.8 -7.8 General secretion pathway protein F / Type II secretory pathway, component PulF compare
Ac3H11_4095 -2.7 -6.6 Nitrogen regulation protein NR(I) compare
Ac3H11_4669 -2.7 -4.0 AMP nucleosidase (EC 3.2.2.4) compare
Ac3H11_3269 -2.7 -2.1 Putative translation initiation inhibitor, yjgF family compare
Ac3H11_3882 -2.6 -2.6 Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone compare
Ac3H11_2571 -2.5 -5.1 Outer membrane protein A precursor compare
Ac3H11_2038 -2.5 -3.1 General secretion pathway protein G compare
Ac3H11_3839 -2.5 -7.1 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) compare
Ac3H11_3502 -2.5 -1.3 hypothetical protein compare
Ac3H11_3380 -2.4 -1.3 transcriptional regulator, MarR family compare
Ac3H11_1122 -2.4 -1.6 Pyrrolidone-carboxylate peptidase (EC 3.4.19.3) compare
Ac3H11_1650 -2.4 -2.1 FIG00537534: hypothetical protein compare
Ac3H11_2302 -2.4 -3.5 Acetoacetyl-CoA reductase (EC 1.1.1.36) compare
Ac3H11_3266 -2.3 -1.6 3-demethylubiquinone-9 3-methyltransferase compare
Ac3H11_2030 -2.3 -6.3 General secretion pathway protein D / Type II secretion outermembrane pore forming protein (PulD) compare
Ac3H11_2171 -2.2 -2.6 ABC-type transport system involved in resistance to organic solvents, permease component USSDB6A compare
Ac3H11_955 -2.2 -10.5 Dihydroxy-acid dehydratase (EC 4.2.1.9) compare
Ac3H11_110 -2.2 -2.8 FIG01198471: hypothetical protein compare
Ac3H11_3630 -2.1 -2.4 Undecaprenyl-diphosphatase (EC 3.6.1.27) compare
Ac3H11_3569 -2.1 -2.6 TRAP dicarboxylate transporter, DctQ subunit, unknown substrate 6 compare
Ac3H11_3240 -2.0 -2.0 Anthranilate phosphoribosyltransferase like (EC 2.4.2.18) compare
Ac3H11_456 -1.9 -1.7 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) compare
Ac3H11_1689 -1.9 -4.7 Probable low-affinity inorganic phosphate transporter compare
Ac3H11_2059 -1.9 -6.2 Transaldolase (EC 2.2.1.2) compare
Ac3H11_576 -1.8 -3.3 required for sulfate utilization, putative electron transport protein for sulfite reductase (from data) compare
Ac3H11_3838 -1.8 -6.4 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) compare
Ac3H11_2285 -1.8 -1.4 Transcriptional regulator, AsnC family compare
Ac3H11_578 -1.8 -2.9 Putative sulfate permease compare
Ac3H11_1453 -1.7 -2.7 Preprotein translocase subunit SecG (TC 3.A.5.1.1) compare
Ac3H11_412 -1.7 -4.9 3'-to-5' exoribonuclease RNase R compare
Ac3H11_3464 -1.7 -1.9 hypothetical protein compare
Ac3H11_3707 -1.7 -3.1 Membrane-associated phospholipid phosphatase (EC 3.1.3.27) compare
Ac3H11_3399 -1.6 -3.1 Probable transmembrane protein compare
Ac3H11_770 -1.6 -2.5 Lysine exporter protein (LYSE/YGGA) compare
Ac3H11_2042 -1.6 -9.8 Threonine dehydratase biosynthetic (EC 4.3.1.19) compare
Ac3H11_568 -1.6 -1.5 tRNA-Leu-CAG compare
Ac3H11_3837 -1.6 -7.2 Quinolinate synthetase (EC 2.5.1.72) compare
Ac3H11_4024 -1.6 -6.8 Sugar kinases, ribokinase family compare
Ac3H11_3765 -1.6 -1.5 Transcriptional regulator, IclR family compare
Ac3H11_3459 -1.6 -8.5 Hypothetical ATP-binding protein UPF0042, contains P-loop compare
Ac3H11_4925 -1.6 -3.7 Isocitrate dehydrogenase [NADP] (EC 1.1.1.42); Monomeric isocitrate dehydrogenase [NADP] (EC 1.1.1.42) compare
Ac3H11_2272 -1.6 -7.4 Biotin synthase (EC 2.8.1.6) compare
Ac3H11_1955 -1.5 -4.2 Glutamate Aspartate periplasmic binding protein precursor GltI (TC 3.A.1.3.4) compare
Ac3H11_3926 -1.5 -2.8 putative membrane protein compare
Ac3H11_362 -1.5 -7.2 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I compare
Ac3H11_3080 -1.5 -2.0 Flagellar motor protein compare
Ac3H11_220 -1.5 -1.7 hypothetical protein compare
Ac3H11_4449 -1.5 -3.1 RND efflux system, membrane fusion protein CmeA compare
Ac3H11_2032 -1.5 -1.5 General secretion pathway protein M compare
Ac3H11_2033 -1.5 -3.0 General secretion pathway protein L compare
Ac3H11_1339 -1.4 -1.3 Mobile element protein compare
Ac3H11_4264 -1.4 -3.5 GTPase and tRNA-U34 5-formylation enzyme TrmE compare
Ac3H11_1000 -1.4 -1.7 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) compare
Ac3H11_4956 -1.4 -4.7 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA compare
Ac3H11_977 -1.4 -1.8 Heavy-metal-associated domain (N-terminus) and membrane-bounded cytochrome biogenesis cycZ-like domain, possible membrane copper tolerance protein compare
Ac3H11_3907 -1.4 -1.6 hypothetical protein compare
Ac3H11_2382 -1.3 -3.6 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) compare
Ac3H11_4676 -1.3 -1.1 Cobalt-zinc-cadmium resistance protein compare
Ac3H11_781 -1.3 -2.0 ATP-dependent DNA helicase RecG (EC 3.6.1.-) compare
Ac3H11_3246 -1.3 -1.6 hypothetical protein compare
Ac3H11_926 -1.3 -2.7 Phytoene desaturase, pro-zeta-carotene producing (EC 1.-.-.-) compare
Ac3H11_2600 -1.3 -8.4 Probable transmembrane protein compare
Ac3H11_2076 -1.3 -3.9 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) compare
Ac3H11_4450 -1.3 -1.0 Transcription repressor of multidrug efflux pump acrAB operon, TetR (AcrR) family compare
Ac3H11_3827 -1.3 -3.9 Aspartate 1-decarboxylase (EC 4.1.1.11) compare
Ac3H11_4709 -1.2 -7.3 Transposase and inactivated derivatives compare
Ac3H11_1755 -1.2 -1.3 FIG004556: membrane metalloprotease compare
Ac3H11_1681 -1.2 -3.0 Similar to cobalamin biosynthesis protein CbiB compare
Ac3H11_2170 -1.2 -1.1 Methionine ABC transporter ATP-binding protein compare
Ac3H11_973 -1.2 -2.3 Putative analog of CcoH, COG3198 compare
Ac3H11_3647 -1.1 -1.5 Serine acetyltransferase (EC 2.3.1.30) compare
Ac3H11_2805 -1.1 -1.2 IncF plasmid conjugative transfer pilus assembly protein TraK compare
Ac3H11_2464 -1.1 -3.9 ATPase component BioM of energizing module of biotin ECF transporter compare
Ac3H11_2745 -1.1 -1.8 Transcriptional regulator, TetR family compare
Ac3H11_4114 -1.1 -3.3 Excinuclease ABC subunit B compare
Ac3H11_4864 -1.1 -1.1 hypothetical protein compare
Ac3H11_1569 -1.1 -4.6 Translation elongation factor LepA compare
Ac3H11_867 -1.1 -1.8 hypothetical protein compare
Ac3H11_4101 -1.1 -2.1 hypothetical protein compare
Ac3H11_768 -1.0 -1.5 Chorismate mutase compare
Ac3H11_36 -1.0 -2.1 hypothetical protein compare
Ac3H11_2661 -1.0 -1.0 hypothetical protein compare
Ac3H11_4539 -1.0 -1.3 Protein RcsF compare
Ac3H11_3101 -1.0 -0.8 protein of unknown function DUF1234 compare
Ac3H11_2615 -1.0 -1.8 FIG074102: hypothetical protein compare
Ac3H11_3833 -1.0 -1.5 probable membrane protein YPO2051 compare
Ac3H11_3859 -1.0 -2.5 Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) compare
Ac3H11_1995 -1.0 -1.6 Tyrosine recombinase XerC compare
Ac3H11_3587 -1.0 -1.1 DNA-binding domain of ModE / Molybdate-binding domain of ModE compare
Ac3H11_4448 -1.0 -3.5 RND efflux system, inner membrane transporter CmeB compare
Ac3H11_2169 -1.0 -3.1 ABC-type transport system involved in resistance to organic solvents, periplasmic component compare
Ac3H11_2567 -1.0 -1.4 hypothetical protein compare
Ac3H11_2115 -1.0 -3.7 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) compare
Ac3H11_3824 -1.0 -2.1 L-aspartate oxidase (EC 1.4.3.16) compare
Ac3H11_1044 -1.0 -2.5 tRNA-Leu-TAG compare
Ac3H11_3585 -1.0 -1.1 Permeases of the major facilitator superfamily compare
Ac3H11_2443 -0.9 -1.4 heat shock protein DnaJ domain protein compare
Ac3H11_3884 -0.9 -3.2 Heme A synthase, cytochrome oxidase biogenesis protein Cox15-CtaA compare
Ac3H11_1873 -0.9 -0.8 hypothetical protein compare
Ac3H11_3233 -0.9 -1.3 hypothetical protein compare
Ac3H11_3079 -0.9 -1.0 FIG01210206: hypothetical protein compare
Ac3H11_2438 -0.9 -1.4 hypothetical protein compare
Ac3H11_1319 -0.9 -5.4 membrane protein, putative compare
Ac3H11_3550 -0.9 -2.4 Homolog of E. coli HemX protein compare
Ac3H11_2320 -0.9 -4.2 Transcriptional regulator, XRE family compare
Ac3H11_3763 -0.9 -3.0 Phage transposase compare
Ac3H11_4004 -0.9 -6.5 Thiol:disulfide interchange protein DsbC compare
Ac3H11_3673 -0.9 -1.4 putative exported protein compare
Ac3H11_2145 -0.9 -3.2 Probable transmembrane protein compare
Ac3H11_42 -0.9 -2.6 Peptidyl-prolyl cis-trans isomerase PpiA precursor (EC 5.2.1.8) compare
Ac3H11_4232 -0.9 -1.2 Outer membrane protein romA compare
Ac3H11_1142 -0.9 -1.3 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) compare
Ac3H11_3155 -0.9 -3.0 Putative alkanesulfonate metabolism utilization regulator compare
Ac3H11_841 -0.9 -0.7 hypothetical protein compare
Ac3H11_4320 -0.9 -2.9 Acyl-CoA dehydrogenase (EC 1.3.8.7) compare
Ac3H11_4031 -0.9 -4.0 Predicted nucleotidyltransferase compare
Ac3H11_3605 -0.8 -1.4 FIG00349159: hypothetical protein compare
Ac3H11_1690 -0.8 -2.6 Phosphate transport regulator (distant homolog of PhoU) compare
Ac3H11_1869 -0.8 -0.8 D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (EC 3.1.1.-); Histidinol-phosphatase (EC 3.1.3.15) compare
Ac3H11_2456 -0.8 -5.1 ATP-dependent Clp protease ATP-binding subunit ClpA compare
Ac3H11_4202 -0.8 -0.9 hypothetical protein compare
Ac3H11_727 -0.8 -4.4 RNA polymerase sigma-54 factor RpoN compare
Ac3H11_3794 -0.8 -2.6 Hemoglobin-like protein HbO compare
Ac3H11_2531 -0.8 -2.2 transcriptional regulator, Crp/Fnr family compare
Ac3H11_1556 -0.8 -2.9 HpcH/HpaI aldolase compare
Ac3H11_4271 -0.8 -2.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (EC 3.1.3.45) compare
Ac3H11_132 -0.8 -6.0 Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5) compare
Ac3H11_3435 -0.8 -2.5 Mll4877 protein compare
Ac3H11_1956 -0.8 -2.4 Glutamate Aspartate transport system permease protein GltJ (TC 3.A.1.3.4) compare
Ac3H11_4852 -0.8 -2.3 Protein of unknown function DUF218 compare
Ac3H11_4604 -0.8 -3.0 hypothetical protein compare
Ac3H11_861 -0.8 -3.8 tRNA-guanine transglycosylase (EC 2.4.2.29) compare
Ac3H11_2483 -0.8 -1.3 TPR repeat containing exported protein; Putative periplasmic protein contains a protein prenylyltransferase domain compare
Ac3H11_3886 -0.8 -2.3 Cytochrome oxidase biogenesis protein Surf1, facilitates heme A insertion compare


Specific Phenotypes

None in this experiment

For Acidovorax sp. GW101-3H11 in carbon source experiments

For carbon source Sodium D-Lactate across organisms