Experiment set1IT048 for Sphingomonas koreensis DSMZ 15582

Compare to:

LB with Choline Lysine 5 mM

200 most detrimental genes:

  gene name fitness t score description  
Ga0059261_3490 +1.2 7.8 Response regulator receiver domain/Sigma-70, region 4 compare
Ga0059261_0208 +1.2 4.6 Response regulator receiver domain compare
Ga0059261_3492 +1.0 6.5 RNA polymerase sigma factor, sigma-70 family compare
Ga0059261_3971 +0.9 2.4 Uncharacterized protein conserved in bacteria compare
Ga0059261_0448 +0.9 2.3 hypothetical protein compare
Ga0059261_3579 +0.8 3.7 hypothetical protein compare
Ga0059261_1181 +0.7 3.0 hypothetical protein compare
Ga0059261_3016 +0.7 2.3 hypothetical protein compare
Ga0059261_3581 +0.7 3.8 Alpha/beta hydrolase family compare
Ga0059261_0931 +0.6 1.5 molybdenum cofactor biosynthesis protein MoaC compare
Ga0059261_3947 +0.6 1.8 type II secretion system protein I (GspI) compare
Ga0059261_1234 +0.6 2.6 Transposase compare
Ga0059261_1762 +0.6 1.0 hypothetical protein compare
Ga0059261_0146 +0.6 1.6 amidohydrolase, PncC family compare
Ga0059261_0357 +0.6 1.5 hypothetical protein compare
Ga0059261_3287 +0.6 4.1 Topoisomerase IB compare
Ga0059261_0921 +0.6 1.4 hypothetical protein compare
Ga0059261_1830 +0.6 1.2 hypothetical protein compare
Ga0059261_1530 +0.6 2.4 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases compare
Ga0059261_0898 +0.5 1.7 Membrane protein implicated in regulation of membrane protease activity compare
Ga0059261_2929 +0.5 1.3 oxygen-dependent methionine synthase, methyltransferase component MesD (from data) compare
Ga0059261_1185 +0.5 2.0 Thiolase, C-terminal domain compare
Ga0059261_3196 +0.5 1.4 Transcriptional regulator compare
Ga0059261_0387 +0.5 1.8 Type IV secretory pathway, TrbD component compare
Ga0059261_4139 +0.5 1.4 hypothetical protein compare
Ga0059261_4222 +0.5 3.6 Enoyl-CoA hydratase/carnithine racemase compare
Ga0059261_2361 +0.5 2.7 Staphylococcal nuclease homologue compare
Ga0059261_3815 +0.5 2.5 hypothetical protein compare
Ga0059261_3877 +0.5 1.3 hypothetical protein compare
Ga0059261_0957 +0.5 0.8 Protein of unknown function (DUF2798) compare
Ga0059261_3144 +0.5 1.6 Transcriptional regulator compare
Ga0059261_4240 +0.5 2.4 hypothetical protein compare
Ga0059261_3027 +0.4 1.4 Predicted transcriptional regulators compare
Ga0059261_1600 +0.4 1.5 Domain of unknown function (DUF4167) compare
Ga0059261_0773 +0.4 1.7 Esterase/lipase compare
Ga0059261_1115 +0.4 0.9 Chemotaxis protein; stimulates methylation of MCP proteins compare
Ga0059261_1396 +0.4 1.6 EF-hand domain pair compare
Ga0059261_2774 +0.4 1.3 Transcription elongation factor compare
Ga0059261_1126 +0.4 2.0 Response regulator compare
Ga0059261_4122 +0.4 1.7 Gluconate 2-dehydrogenase subunit 3 compare
Ga0059261_1587 +0.4 2.3 hypothetical protein compare
Ga0059261_4120 +0.4 0.9 Stress responsive A/B Barrel Domain compare
Ga0059261_2413 +0.4 1.1 hypothetical protein compare
Ga0059261_0685 +0.4 1.0 pyruvate kinase compare
Ga0059261_0035 +0.4 1.2 Uncharacterized protein conserved in bacteria compare
Ga0059261_1862 +0.4 1.5 Transposase compare
Ga0059261_3280 +0.4 1.0 Uncharacterized conserved protein compare
Ga0059261_2934 +0.4 2.2 hypothetical protein compare
Ga0059261_0889 +0.4 0.9 Cold shock proteins compare
Ga0059261_3755 +0.4 1.0 Protein of unknown function (DUF2798) compare
Ga0059261_3194 +0.4 2.7 O-acetylhomoserine sulfhydrylase (EC:2.5.1.49) (from data) compare
Ga0059261_3124 +0.4 1.4 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit compare
Ga0059261_2966 +0.4 1.7 2-deoxy-D-gluconate 3-dehydrogenase compare
Ga0059261_3433 +0.4 2.1 ATPases involved in chromosome partitioning compare
Ga0059261_4143 +0.4 2.1 hypothetical protein compare
Ga0059261_1606 +0.4 2.7 Domain of unknown function (DUF4281) compare
Ga0059261_0473 +0.4 1.6 Predicted Fe-S protein compare
Ga0059261_2684 +0.4 1.3 hypothetical protein compare
Ga0059261_1768 +0.4 0.5 Sigma-70 region 2 compare
Ga0059261_2736 +0.4 2.2 hypothetical protein compare
Ga0059261_1163 +0.4 1.0 Copper chaperone compare
Ga0059261_0650 +0.4 0.8 Negative regulator of beta-lactamase expression compare
Ga0059261_2281 +0.4 2.1 Phytanoyl-CoA dioxygenase (PhyH) compare
Ga0059261_2462 +0.4 1.7 Predicted transcriptional regulators compare
Ga0059261_3009 +0.4 1.8 Acetyltransferase (GNAT) domain compare
Ga0059261_3141 +0.3 1.3 Acetyltransferases compare
Ga0059261_1191 +0.3 1.7 RNA polymerase sigma factor, sigma-70 family compare
Ga0059261_1837 +0.3 1.0 Staphylococcal nuclease homologue compare
Ga0059261_1546 +0.3 2.4 MerC mercury resistance protein compare
Ga0059261_0973 +0.3 1.2 hypothetical protein compare
Ga0059261_2928 +0.3 1.9 oxygen-dependent methionine synthase, putative oxygenase component MesX (from data) compare
Ga0059261_1799 +0.3 1.0 Uncharacterized protein conserved in bacteria (DUF2059) compare
Ga0059261_1904 +0.3 1.1 Asparaginase compare
Ga0059261_1197 +0.3 1.2 hypothetical protein compare
Ga0059261_3210 +0.3 1.1 Organic radical activating enzymes compare
Ga0059261_3371 +0.3 0.9 hypothetical protein compare
Ga0059261_1599 +0.3 2.9 Uncharacterized conserved protein compare
Ga0059261_0334 +0.3 2.1 hypothetical protein compare
Ga0059261_1574 +0.3 0.7 Superfamily II DNA and RNA helicases compare
Ga0059261_3056 +0.3 1.1 Protein of unknown function (DUF2958) compare
Ga0059261_0379 +0.3 0.9 DNA binding domain, excisionase family compare
Ga0059261_2215 +0.3 1.1 Thiamine monophosphate synthase compare
Ga0059261_3507 +0.3 2.7 His Kinase A (phospho-acceptor) domain/Response regulator receiver domain/Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase/CHASE3 domain compare
Ga0059261_0623 +0.3 1.3 ABC-type Fe3+-siderophore transport system, permease component compare
Ga0059261_2471 +0.3 0.6 hypothetical protein compare
Ga0059261_2742 +0.3 1.1 non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family compare
Ga0059261_2088 +0.3 1.1 Flagellar motor component compare
Ga0059261_1811 +0.3 0.7 ATP:cob(I)alamin adenosyltransferase compare
Ga0059261_0869 +0.3 1.7 Acyl-CoA thioesterase compare
Ga0059261_2731 +0.3 1.7 transcriptional regulator, AraC family compare
Ga0059261_3705 +0.3 1.9 Pseudouridylate synthases, 23S RNA-specific compare
Ga0059261_3026 +0.3 1.1 Cation efflux family compare
Ga0059261_0227 +0.3 0.8 hypothetical protein compare
Ga0059261_3491 +0.3 2.0 hypothetical protein compare
Ga0059261_1380 +0.3 2.3 Membrane protease subunits, stomatin/prohibitin homologs compare
Ga0059261_3781 +0.3 1.8 hypothetical protein compare
Ga0059261_1260 +0.3 2.3 cobaltochelatase CobT subunit (EC 6.6.1.2) compare
Ga0059261_0757 +0.3 0.9 Predicted transcriptional regulators compare
Ga0059261_3700 +0.3 1.3 Transcriptional regulator compare
Ga0059261_2068 +0.3 1.4 hypothetical protein compare
Ga0059261_2155 +0.3 1.5 hypothetical protein compare
Ga0059261_2730 +0.3 0.7 Sortase and related acyltransferases compare
Ga0059261_0494 +0.3 0.8 ABC-type antimicrobial peptide transport system, ATPase component compare
Ga0059261_1190 +0.3 1.5 hypothetical protein compare
Ga0059261_1737 +0.3 1.3 hypothetical protein compare
Ga0059261_1114 +0.3 1.2 hypothetical protein compare
Ga0059261_0252 +0.3 0.7 SpoIIAA-like compare
Ga0059261_3772 +0.3 1.3 NIPSNAP compare
Ga0059261_3251 +0.3 0.9 Transcriptional regulator compare
Ga0059261_0199 +0.3 1.5 hypothetical protein compare
Ga0059261_2579 +0.3 2.0 Plasmid replication initiator protein compare
Ga0059261_1424 +0.3 2.0 Acetyltransferases compare
Ga0059261_1588 +0.3 2.0 Methyltransferase domain compare
Ga0059261_1047 +0.3 1.4 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Ga0059261_0754 +0.3 1.6 Glutathione S-transferase compare
Ga0059261_3526 +0.3 1.9 hemimethylated DNA binding domain compare
Ga0059261_1577 +0.3 2.3 L-glutamine and L-histidine transporter (from data) compare
Ga0059261_0024 +0.3 1.6 Predicted membrane protein compare
Ga0059261_2461 +0.3 1.9 hypothetical protein compare
Ga0059261_3627 +0.3 1.6 Rho termination factor, N-terminal domain compare
Ga0059261_0671 +0.3 0.9 Uncharacterized conserved protein compare
Ga0059261_0025 +0.3 2.0 hypothetical protein compare
Ga0059261_2376 +0.3 1.3 phage tail protein, P2 protein I family compare
Ga0059261_4189 +0.3 1.4 hypothetical protein compare
Ga0059261_2612 +0.3 1.3 Uncharacterized secreted protein compare
Ga0059261_3716 +0.3 2.0 hypothetical protein compare
Ga0059261_1752 +0.3 1.8 Methyltransferase domain compare
Ga0059261_3165 +0.3 1.6 PEP phosphonomutase and related enzymes compare
Ga0059261_3396 +0.3 1.4 hypothetical protein compare
Ga0059261_3719 +0.3 2.3 Imidazolonepropionase and related amidohydrolases compare
Ga0059261_2912 +0.3 1.9 P-type conjugative transfer ATPase TrbB compare
Ga0059261_3985 +0.3 1.7 methylmalonyl-CoA epimerase (EC 5.1.99.1) compare
Ga0059261_0556 +0.3 1.2 Signal transduction histidine kinase compare
Ga0059261_1586 +0.3 2.2 Threonine synthase compare
Ga0059261_0867 +0.3 1.5 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) compare
Ga0059261_0121 +0.3 0.5 Sporulation related domain compare
Ga0059261_3257 +0.3 1.5 glycine cleavage system H protein compare
Ga0059261_0268 +0.3 1.1 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily compare
Ga0059261_1423 +0.3 1.9 Trypsin-like peptidase domain compare
Ga0059261_3301 +0.3 1.5 Cyanate permease compare
Ga0059261_2763 +0.3 1.1 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) compare
Ga0059261_0050 +0.3 1.3 Predicted membrane protein compare
Ga0059261_3997 +0.3 1.6 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases compare
Ga0059261_0946 +0.2 1.1 Uncharacterized protein conserved in bacteria compare
Ga0059261_0816 +0.2 0.8 hypothetical protein compare
Ga0059261_2528 +0.2 0.8 Uncharacterized conserved protein compare
Ga0059261_2331 +0.2 1.3 hypothetical protein compare
Ga0059261_4060 +0.2 0.8 Predicted membrane protein compare
Ga0059261_3279 +0.2 1.5 Ubiquinone biosynthesis protein COQ7 compare
Ga0059261_0770 +0.2 0.5 hypothetical protein compare
Ga0059261_2570 +0.2 0.5 Type IV secretory pathway, TrbD component compare
Ga0059261_1049 +0.2 1.3 PEP-CTERM protein-sorting domain compare
Ga0059261_0062 +0.2 1.0 hypothetical protein compare
Ga0059261_0201 +0.2 1.8 Na+/H+-dicarboxylate symporters compare
Ga0059261_1508 +0.2 1.6 Tetratricopeptide repeat compare
Ga0059261_2981 +0.2 2.2 Uncharacterized protein conserved in bacteria compare
Ga0059261_2993 +0.2 1.6 hypothetical protein compare
Ga0059261_0493 +0.2 0.6 hypothetical protein compare
Ga0059261_1117 +0.2 1.6 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain compare
Ga0059261_2856 +0.2 1.2 Acyl-CoA dehydrogenases compare
Ga0059261_0402 +0.2 1.4 Uncharacterized conserved protein compare
Ga0059261_1880 +0.2 1.6 Uncharacterized conserved protein compare
Ga0059261_3697 +0.2 1.7 Predicted transcriptional regulators compare
Ga0059261_1595 +0.2 2.1 Membrane protein involved in the export of O-antigen and teichoic acid compare
Ga0059261_0339 +0.2 1.7 Glutathione peroxidase compare
Ga0059261_3630 +0.2 1.8 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) compare
Ga0059261_1533 +0.2 2.1 conserved hypothetical integral membrane protein compare
Ga0059261_1265 +0.2 1.0 hypothetical protein compare
Ga0059261_2350 +0.2 0.5 hypothetical protein compare
Ga0059261_3639 +0.2 1.6 Uncharacterized protein conserved in bacteria compare
Ga0059261_3840 +0.2 1.5 hypothetical protein compare
Ga0059261_3335 +0.2 0.8 hypothetical protein compare
Ga0059261_0056 +0.2 0.9 Predicted transcriptional regulator compare
Ga0059261_1174 +0.2 0.9 Putative transposase of IS4/5 family (DUF4096) compare
Ga0059261_3031 +0.2 1.2 Polyketide cyclase / dehydrase and lipid transport compare
Ga0059261_3963 +0.2 1.8 Histidine ammonia-lyase (EC 4.3.1.3) (from data) compare
Ga0059261_1147 +0.2 1.5 Bacterial flagellin N-terminal helical region/Bacterial flagellin C-terminal helical region compare
Ga0059261_1557 +0.2 1.1 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase compare
Ga0059261_3249 +0.2 1.7 Amidases related to nicotinamidase compare
Ga0059261_1905 +0.2 1.9 Serine acetyltransferase compare
Ga0059261_3218 +0.2 1.6 Predicted rRNA methylase (SpoU class) compare
Ga0059261_3752 +0.2 0.8 Uncharacterized protein conserved in bacteria compare
Ga0059261_3885 +0.2 0.9 K+-transporting ATPase, C subunit compare
Ga0059261_1506 +0.2 1.6 cytidine deaminase (EC 3.5.4.5) compare
Ga0059261_1122 +0.2 0.5 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) compare
Ga0059261_1410 +0.2 1.2 Fructose-2,6-bisphosphatase compare
Ga0059261_4167 +0.2 1.5 Outer membrane protein and related peptidoglycan-associated (lipo)proteins compare
Ga0059261_0086 +0.2 1.9 hypothetical protein compare
Ga0059261_0592 +0.2 0.9 hypothetical protein compare
Ga0059261_2075 +0.2 1.5 Flagellin and related hook-associated proteins compare
Ga0059261_0760 +0.2 1.5 Uncharacterized protein conserved in bacteria compare
Ga0059261_4220 +0.2 1.7 Uncharacterized protein conserved in bacteria compare
Ga0059261_4145 +0.2 1.5 phage shock protein C (PspC) family protein compare
Ga0059261_3445 +0.2 1.4 PHP domain compare
Ga0059261_3606 +0.2 0.7 Transcription elongation factor compare
Ga0059261_0864 +0.2 0.6 hypothetical protein compare
Ga0059261_1087 +0.2 1.1 hypothetical protein compare
Ga0059261_3572 +0.2 1.4 YCII-related domain compare
Ga0059261_0686 +0.2 1.5 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E compare
Ga0059261_0989 +0.2 1.6 transporter, CPA2 family (TC 2.A.37) compare


Specific Phenotypes

None in this experiment

For Sphingomonas koreensis DSMZ 15582 in stress experiments

For stress Choline Lysine across organisms