Experiment set1IT028 for Sinorhizobium meliloti 1021

Compare to:

L-Leucine carbon source

200 most important genes:

  gene name fitness t score description  
SMc02767 -8.5 -8.3 N-(5'-phosphoribosyl)anthranilate isomerase compare
SMc02245 -8.5 -5.9 dihydroorotate dehydrogenase 2 compare
SMc00235 -8.4 -5.8 anthranilate phosphoribosyltransferase compare
SMc00236 -8.3 -5.7 Indole-3-glycerol phosphate synthase compare
SMc00917 -8.2 -5.6 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
SMc00614 -8.2 -5.6 phosphoribosylglycinamide formyltransferase compare
SMc02569 -8.1 -5.6 imidazole glycerol phosphate synthase subunit HisF compare
SMc00495 -8.1 -5.0 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
SMc01801 -8.0 -5.0 N-acetylglutamylphosphate reductase (EC 1.2.1.38) (from data) compare
SMc02766 -7.8 -16.8 tryptophan synthase subunit beta compare
SMc00918 -7.7 -7.5 ATP phosphoribosyltransferase regulatory subunit compare
SMc01726 -7.6 -8.2 acetylglutamate kinase compare
SMc00640 -7.5 -9.0 phosphoserine aminotransferase compare
SMc02137 -7.5 -5.2 ornithine carbamoyltransferase compare
SMc02899 -7.5 -14.4 prephenate dehydratase compare
SMc04002 -7.5 -10.2 phosphoribosylaminoimidazole carboxylase ATPase subunit compare
SMc04045 -7.4 -7.2 dihydroxy-acid dehydratase compare
SMc01431 -7.4 -11.3 acetolactate synthase 3 catalytic subunit compare
SMc02838 -7.3 -8.7 phosphoglyceromutase compare
SMc00768 -7.0 -11.7 isocitrate lyase conserved
SMc01494 -6.9 -9.8 phosphoserine phosphatase compare
SMc00494 -6.9 -2.5 phosphoribosylformylglycinamidine synthase subunit PurS compare
SM_b21125 -6.8 -9.3 Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) (from data) compare
SMc03776 -6.7 -4.7 gamma-glutamyl kinase compare
SMc02765 -6.7 -11.7 tryptophan synthase subunit alpha compare
SMc02725 -6.7 -14.9 anthranilate synthase compare
SMa1635 -6.7 -2.4 hypothetical protein compare
SMc00615 -6.5 -14.1 phosphoribosylaminoimidazole synthetase compare
SMc01004 -6.4 -10.8 phosphoribosyl-AMP cyclohydrolase compare
SMc00493 -6.4 -8.8 phosphoribosylformylglycinamidine synthase I compare
SMc03826 -6.4 -4.4 argininosuccinate synthase compare
SMc00412 -6.2 -6.1 orotidine 5'-phosphate decarboxylase compare
SMc02562 -6.1 -11.0 phosphoenolpyruvate carboxykinase compare
SMc01361 -6.0 -6.7 dihydroorotase compare
SMc00993 -5.9 -13.3 phosphoribosylamine--glycine ligase compare
SMc00711 -5.8 -7.2 cyclohexadienyl dehydrogenase compare
SMc03229 -5.8 -3.6 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase compare
SMc01028 -5.6 -14.9 phosphopyruvate hydratase compare
SMc02165 -5.6 -11.4 orotate phosphoribosyltransferase compare
SMc00488 -5.5 -18.5 phosphoribosylformylglycinamidine synthase II compare
SMc00769 -5.5 -14.6 hypothetical protein compare
SMc03981 -5.5 -4.9 phosphoglycerate kinase compare
SMc03777 -5.4 -11.6 gamma-glutamyl phosphate reductase compare
SMc02570 -5.4 -5.4 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
SMc02572 -5.4 -3.7 imidazole glycerol phosphate synthase subunit HisH compare
SMc03763 -5.3 -3.6 cytosine-specific methyltransferase compare
SMc00554 -5.3 -12.2 amidophosphoribosyltransferase compare
SMc03978 -5.2 -3.6 transketolase compare
SM_b21124 -5.1 -11.5 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) (from data) conserved
SMc00963 -5.1 -6.5 hypothetical protein compare
SMc00293 -5.1 -12.6 homoserine dehydrogenase compare
SMc01360 -5.1 -6.9 aspartate carbamoyltransferase catalytic subunit compare
SMc01215 -5.1 -3.5 carbamoyl phosphate synthase large subunit compare
SMc04088 -5.0 -8.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase compare
SM_b21126 -4.9 -4.1 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18) (from data) compare
SMc01880 -4.7 -4.6 pantoate--beta-alanine ligase compare
SMc04001 -4.7 -1.7 phosphoribosylaminoimidazole carboxylase catalytic subunit protein compare
SM_b21122 -4.7 -14.0 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) (from data) conserved
SM_b20757 -4.7 -7.0 methylmalonyl-CoA mutase compare
SMc02166 -4.6 -9.3 dihydroorotase compare
SMc01770 -4.6 -2.0 serine hydroxymethyltransferase compare
SMc00726 -4.6 -1.7 thiol:disulfide interchange redox-active center transmembrane protein compare
SMc03979 -4.2 -3.7 glyceraldehyde-3-phosphate dehydrogenase compare
SMc01881 -4.2 -6.4 3-methyl-2-oxobutanoate hydroxymethyltransferase compare
SMc00025 -4.2 -8.6 pyruvate phosphate dikinase compare
SMc01930 -4.2 -4.4 hypothetical protein compare
SMc01569 -4.2 -3.0 carbamoyl phosphate synthase small subunit compare
SMc00302 -4.2 -4.7 hypothetical protein compare
SMc02425 -4.1 -6.2 transcriptional regulator compare
SMc02307 -4.1 -10.6 histidinol dehydrogenase compare
SMc03201 -4.0 -13.7 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) (from data) conserved
SMc02217 -4.0 -9.7 O-succinylhomoserine sulfhydrylase compare
SMc04346 -3.9 -4.8 ketol-acid reductoisomerase compare
SMc03203 -3.8 -6.0 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) (from data) conserved
SM_b21121 -3.8 -15.5 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) (from data) conserved
SMc02138 -3.7 -6.3 acetylornithine transaminase compare
SMc00017 -3.7 -2.6 homoserine kinase compare
SM_b21174 -3.7 -8.1 phosphate uptake ABC transporter permease compare
SMc03069 -3.7 -2.7 6-phosphogluconolactonase compare
SMc03202 -3.6 -17.2 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) (from data) conserved
SMc03797 -3.4 -11.7 homoserine O-succinyltransferase compare
SMc00641 -3.4 -4.7 D-3-phosphoglycerate dehydrogenase compare
SMc00131 -3.4 -18.0 transcriptional regulator compare
SM_b21177 -3.3 -11.3 phosphate uptake ABC transporter ATP-binding protein compare
SMc02707 -3.3 -6.7 hypothetical protein compare
SM_b21176 -3.3 -6.7 phosphate uptake ABC transporter substrate-binding protein precursor compare
SMc01843 -3.2 -13.5 5,10-methylenetetrahydrofolate reductase compare
SMc02308 -3.1 -2.8 hypothetical protein compare
SMc02141 -3.1 -4.9 phosphate transporter PhoU compare
SM_b21120 -3.1 -5.5 hypothetical protein compare
SMc01223 -3.0 -6.3 transcriptional regulator compare
SMc00815 -3.0 -3.1 inosine 5'-monophosphate dehydrogenase compare
SMc00774 -3.0 -14.3 Acetoacetate--CoA ligase (EC 6.2.1.16) (from data) compare
SMc02246 -3.0 -1.5 hypothetical protein compare
SM_b21175 -2.9 -4.6 phosphate uptake ABC transporter permease compare
SMc00450 -2.9 -4.1 protoheme IX farnesyltransferase compare
SMc03204 -2.9 -6.9 Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (from data) conserved
SMc01850 -2.8 -3.7 hypothetical protein compare
SMc03112 -2.8 -16.8 B12-dependent methionine synthase compare
SMc02755 -2.7 -7.5 S-adenosyl-L-homocysteine hydrolase compare
SMc02581 -2.5 -11.0 malate synthase G compare
SMc00295 -2.5 -2.2 hypothetical protein compare
SMc00876 -2.5 -7.2 ATP-binding MRP protein compare
SMc02975 -2.4 -8.2 phosphoenolpyruvate carboxykinase regulator transcription regulator protein compare
SMc03974 -2.3 -5.3 hypothetical protein compare
SMc01206 -2.3 -2.8 queuine tRNA-ribosyltransferase compare
SMc00414 -2.2 -13.6 hypothetical protein compare
SMc02833 -2.2 -3.1 penicillin-insensitive murein endopeptidase compare
SMc03880 -2.1 -9.9 hypothetical protein compare
SMc02047 -2.1 -7.9 glycine cleavage system aminomethyltransferase T compare
SMc02640 -2.1 -4.6 UDP-glucuronic acid epimerase compare
SMc04296 -2.1 -2.0 cell division protein FtsZ compare
SMc01124 -1.9 -6.2 PII uridylyl-transferase compare
SMc02753 -1.9 -2.2 PTS system transporter subunit IIA compare
SMc02049 -1.9 -13.8 glycine dehydrogenase compare
SMc02172 -1.8 -7.5 transcriptional regulator compare
SMc02048 -1.8 -9.0 glycine cleavage system protein H compare
SMc02140 -1.8 -2.2 phosphate regulon transcriptional regulatory protein compare
SMc01430 -1.8 -5.0 acetolactate synthase 3 regulatory subunit compare
SMc01845 -1.7 -3.1 transglycosylase transmembrane protein compare
SM_b21123 -1.7 -1.9 translation initiation inhibitor compare
SMc00334 -1.7 -2.9 cytidylate kinase compare
SMc01441 -1.7 -7.6 membrane bound protease compare
SMc02683 -1.7 -2.8 hypothetical protein compare
SMc01153 -1.6 -1.4 enoyl-CoA hydratase compare
SMc02181 -1.6 -11.7 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase conserved
SMc01501 -1.6 -2.1 mannitol 2-dehydrogenase compare
SMc02147 -1.6 -7.2 phosphate regulon sensor histidine kinase transmembrane protein compare
SM_b20752 -1.6 -6.6 3-hydroxyisobutyryl-CoA hydrolase compare
SMc02724 -1.6 -3.7 hypothetical protein compare
SMc00087 -1.6 -8.8 hydrolase compare
SMc02102 -1.6 -4.6 hypothetical protein compare
SMc03100 -1.5 -1.4 hypothetical protein compare
SMc02050 -1.5 -3.9 trigger factor compare
SMc01147 -1.5 -4.6 coproporphyrinogen III oxidase compare
SMc02234 -1.4 -2.4 hypothetical protein compare
SMc00010 -1.4 -2.0 cytochrome C oxidase polypeptide I transmembrane protein compare
SMc02124 -1.4 -10.7 nitrite reductase compare
SMc01438 -1.4 -4.0 protease precursor signal peptide protein compare
SMc01440 -1.3 -5.2 hydrolase serine protease transmembrane protein compare
SMc04000 -1.3 -1.0 hypothetical protein compare
SMa0789 -1.3 -3.7 GntR family transcriptional regulator compare
SMc02641 -1.3 -3.9 UDP-glucose 6-dehydrogenase compare
SMa2020 -1.3 -5.6 Transcriptional regulator compare
SMc00619 -1.3 -1.6 hypothetical protein compare
SMc02227 -1.3 -6.5 fatty oxidation complex enoyl-COA hydratase/3-hydroxyacyl-COA dehydrogenase/3-hydroxybutyryl-COA epimerase compare
SMc01053 -1.2 -4.8 siroheme synthase compare
SMc02123 -1.2 -4.1 required for sulfate utilization, putative electron transport protein for sulfite reductase (from data) compare
SMc02112 -1.2 -3.1 hypothetical protein compare
SMc02115 -1.2 -1.0 hypothetical protein compare
SMc01260 -1.1 -4.5 transcriptional regulator compare
SMc03993 -1.1 -5.5 hypothetical protein compare
SMc03795 -1.1 -1.7 isopropylmalate isomerase small subunit compare
SMc01568 -1.1 -1.6 hypothetical protein compare
SMc01595 -1.1 -4.0 sensor histidine kinase transmembrane protein compare
SMc00294 -1.1 -3.9 aminotransferase compare
SMc01974 -1.0 -3.3 transcriptional regulator compare
SMc02228 -1.0 -5.0 acetyl-CoA acetyltransferase compare
SMc01447 -1.0 -1.3 hypothetical protein compare
SMc00622 -1.0 -4.8 ribonuclease D protein compare
SM_b20143 -1.0 -1.4 oligopeptide ABC transporter permease compare
SMc02229 -1.0 -6.4 acyl-CoA dehydrogenase compare
SMc02574 -1.0 -1.9 imidazoleglycerol-phosphate dehydratase compare
SM_b20595 -1.0 -3.5 cell division protein FtsK compare
SM_b21210 -1.0 -3.0 two-component response regulator protein compare
SMc02435 -1.0 -2.1 methyltransferase compare
SMc01505 -1.0 -1.6 hypothetical protein compare
SMc04085 -1.0 -3.6 hypothetical protein compare
SMc00166 -1.0 -1.9 oxidoreductase NAD protein compare
SMc01950 -1.0 -6.5 high-affinity branched-chain amino acid ABC transporter permease compare
SMc01207 -1.0 -2.0 S-adenosylmethionine--tRNA ribosyltransferase-isomerase compare
SMc03878 -1.0 -2.4 acetoacetyl-CoA reductase compare
SMc02713 -1.0 -2.0 RNA polymerase sigma-E factor (sigma-24) protein compare
SMc04405 -1.0 -4.8 3-isopropylmalate dehydrogenase compare
SM_b20994 -0.9 -3.1 hypothetical protein compare
SMc01948 -0.9 -3.6 high-affinity branched-chain amino acid ABC transporter ATP-binding protein compare
SMc01495 -0.9 -2.7 transcriptional regulator compare
SM_b20148 -0.9 -4.5 transcriptional regulator compare
SMc04260 -0.9 -5.6 transcriptional regulator compare
SMc01842 -0.9 -1.2 methyltransferase transcription regulator protein compare
SMc02659 -0.9 -3.6 GTP pyrophosphokinase (ATP:GTP 3'-pyrophosphotransferase) protein compare
SMc04244 -0.9 -3.0 high-affinity zinc uptake system ATP-binding ABC transporter protein compare
SMc02858 -0.9 -0.7 chaperone protein DnaJ compare
SMc04174 -0.9 -1.7 signal peptide protein compare
SMc00838 -0.9 -4.4 hypothetical protein compare
SMc02521 -0.9 -2.4 glycerol-3-phosphate regulon repressor transcription regulator protein compare
SMc02690 -0.9 -3.5 hypothetical protein compare
SM_b20563 -0.9 -3.2 hypothetical protein compare
SMc00579 -0.9 -4.8 dimethyladenosine transferase compare
SMc01342 -0.9 -3.6 hypothetical protein compare
SMc03823 -0.9 -5.2 isopropylmalate isomerase large subunit compare
SMc02225 -0.9 -4.7 hypothetical protein compare
SM_b20773 -0.9 -3.9 GntR family transcriptional regulator compare
SMc02363 -0.9 -2.1 cytochrome C-type biogenesis transmembrane protein compare
SM_b21598 -0.9 -4.6 transcriptional regulator compare
SMc04243 -0.9 -4.6 high-affinity zinc uptake system membrane ABC transporter protein compare
SMc02983 -0.9 -4.1 ornithine, DAP, or arginine decarboxylase compare
SMc00012 -0.9 -1.3 cytochrome C oxidase assembly protein compare
SMc03140 -0.9 -3.9 transcriptional regulator compare
SMc01164 -0.9 -5.5 hypothetical protein compare


Specific Phenotypes

For 15 genes in this experiment

For carbon source L-Leucine in Sinorhizobium meliloti 1021

For carbon source L-Leucine across organisms