Experiment set1IT027 for Sinorhizobium meliloti 1021

Compare to:

L-Proline carbon source

200 most important genes:

  gene name fitness t score description  
SMc02766 -9.1 -8.9 tryptophan synthase subunit beta compare
SMc02838 -9.0 -6.3 phosphoglyceromutase compare
SMc01843 -8.8 -6.1 5,10-methylenetetrahydrofolate reductase compare
SMc04405 -8.5 -5.9 3-isopropylmalate dehydrogenase compare
SMc02899 -8.4 -8.2 prephenate dehydratase compare
SMc02245 -8.4 -5.8 dihydroorotate dehydrogenase 2 compare
SMc02767 -8.4 -8.1 N-(5'-phosphoribosyl)anthranilate isomerase compare
SMc00235 -8.2 -5.7 anthranilate phosphoribosyltransferase compare
SMc00236 -8.1 -5.6 Indole-3-glycerol phosphate synthase compare
SMc00917 -8.1 -5.6 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
SMc03797 -8.0 -9.6 homoserine O-succinyltransferase compare
SMc00993 -8.0 -5.6 phosphoribosylamine--glycine ligase compare
SMc04002 -8.0 -7.8 phosphoribosylaminoimidazole carboxylase ATPase subunit compare
SMc01494 -8.0 -11.0 phosphoserine phosphatase compare
SMc02569 -8.0 -5.5 imidazole glycerol phosphate synthase subunit HisF compare
SMc01801 -7.9 -5.1 N-acetylglutamylphosphate reductase (EC 1.2.1.38) (from data) compare
SMc00918 -7.8 -5.4 ATP phosphoribosyltransferase regulatory subunit compare
SMc00640 -7.8 -7.6 phosphoserine aminotransferase compare
SMc02717 -7.8 -7.6 2-isopropylmalate synthase compare
SMc01028 -7.7 -9.2 phosphopyruvate hydratase compare
SMc04045 -7.7 -5.3 dihydroxy-acid dehydratase compare
SMc01431 -7.7 -5.3 acetolactate synthase 3 catalytic subunit compare
SMc02562 -7.5 -5.2 phosphoenolpyruvate carboxykinase compare
SMc02765 -7.5 -13.4 tryptophan synthase subunit alpha compare
SMc01726 -7.5 -6.1 acetylglutamate kinase compare
SMc00614 -7.4 -7.2 phosphoribosylglycinamide formyltransferase compare
SMc02572 -7.3 -5.3 imidazole glycerol phosphate synthase subunit HisH compare
SMc02725 -7.2 -13.0 anthranilate synthase compare
SMc03823 -7.0 -11.1 isopropylmalate isomerase large subunit compare
SMc00493 -6.8 -6.6 phosphoribosylformylglycinamidine synthase I compare
SMa1635 -6.8 -2.6 hypothetical protein compare
SMc00554 -6.8 -6.6 amidophosphoribosyltransferase compare
SMc02217 -6.8 -6.6 O-succinylhomoserine sulfhydrylase compare
SMc00494 -6.8 -2.6 phosphoribosylformylglycinamidine synthase subunit PurS compare
SMc02425 -6.8 -4.7 transcriptional regulator compare
SMc00488 -6.7 -16.0 phosphoribosylformylglycinamidine synthase II compare
SMc00412 -6.7 -4.6 orotidine 5'-phosphate decarboxylase compare
SMc03112 -6.7 -18.2 B12-dependent methionine synthase compare
SMc00293 -6.6 -11.4 homoserine dehydrogenase compare
SMc02165 -6.6 -6.4 orotate phosphoribosyltransferase compare
SM_b20198 -6.6 -17.1 ribulose bisophosphate carboxylase compare
SMc00495 -6.6 -5.7 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
SMc02123 -6.5 -4.3 required for sulfate utilization, putative electron transport protein for sulfite reductase (from data) compare
SMc02137 -6.5 -6.3 ornithine carbamoyltransferase compare
SMc01360 -6.3 -4.4 aspartate carbamoyltransferase catalytic subunit compare
SMc03826 -6.3 -4.3 argininosuccinate synthase compare
SMc02138 -6.3 -9.9 acetylornithine transaminase compare
SMc00681 -6.3 -8.6 leucine-responsive regulatory protein conserved
SMc00131 -6.3 -16.7 transcriptional regulator compare
SMc02707 -6.2 -6.5 hypothetical protein compare
SMc03974 -6.2 -7.3 hypothetical protein compare
SMc01054 -6.1 -5.0 required for sulfate utilization, putative electron source for sulfite reductase CysI (from data) compare
SMc01004 -5.9 -7.7 phosphoribosyl-AMP cyclohydrolase compare
SMc01881 -5.9 -5.7 3-methyl-2-oxobutanoate hydroxymethyltransferase compare
SMc00711 -5.9 -5.7 cyclohexadienyl dehydrogenase compare
SMc02124 -5.8 -16.5 nitrite reductase compare
SMc04088 -5.8 -8.2 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase compare
SM_b21177 -5.8 -10.5 phosphate uptake ABC transporter ATP-binding protein compare
SMc03069 -5.8 -3.7 6-phosphogluconolactonase compare
SMc00815 -5.7 -3.7 inosine 5'-monophosphate dehydrogenase compare
SMc03229 -5.7 -3.7 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase compare
SMc02181 -5.7 -17.5 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase conserved
SMc02755 -5.7 -6.7 S-adenosyl-L-homocysteine hydrolase compare
SMc04085 -5.6 -3.8 hypothetical protein compare
SMc00615 -5.6 -6.6 phosphoribosylaminoimidazole synthetase compare
SM_b20197 -5.5 -6.2 ribulose-1,5-bisphosphate carboxylase small subunit (EC 4.1.1.39) (from data) compare
SM_b21176 -5.4 -6.5 phosphate uptake ABC transporter substrate-binding protein precursor compare
SMc03979 -5.4 -3.7 glyceraldehyde-3-phosphate dehydrogenase compare
SMc03981 -5.4 -4.1 phosphoglycerate kinase compare
SMc00090 -5.3 -13.6 sulfate adenylyltransferase compare
SMc02166 -5.2 -10.9 dihydroorotase compare
SMc01361 -5.2 -5.3 dihydroorotase compare
SMc03763 -5.2 -3.6 cytosine-specific methyltransferase compare
SMc00092 -5.1 -12.7 phosphoadenosine phosphosulfate reductase compare
SM_b20200 -5.1 -12.6 transketolase compare
SMc03978 -5.1 -3.5 transketolase compare
SMc02570 -5.0 -4.7 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
SMc01215 -4.9 -3.4 carbamoyl phosphate synthase large subunit compare
SMc02307 -4.9 -10.4 histidinol dehydrogenase compare
SM_b20196 -4.9 -14.3 CbbX protein compare
SMc01569 -4.8 -2.5 carbamoyl phosphate synthase small subunit compare
SMc01880 -4.8 -4.7 pantoate--beta-alanine ligase compare
SMc00641 -4.8 -6.9 D-3-phosphoglycerate dehydrogenase compare
SMc02975 -4.6 -9.2 phosphoenolpyruvate carboxykinase regulator transcription regulator protein compare
SMc04001 -4.6 -1.7 phosphoribosylaminoimidazole carboxylase catalytic subunit protein compare
SMc01053 -4.5 -5.2 siroheme synthase compare
SMc01770 -4.5 -2.0 serine hydroxymethyltransferase compare
SM_b21174 -4.4 -5.4 phosphate uptake ABC transporter permease compare
SMc00017 -4.4 -2.3 homoserine kinase compare
SMc00414 -4.4 -9.9 hypothetical protein compare
SMc03795 -4.4 -2.3 isopropylmalate isomerase small subunit compare
SMc03070 -4.3 -10.4 glucose-6-phosphate 1-dehydrogenase compare
SM_b21175 -4.3 -5.7 phosphate uptake ABC transporter permease compare
SMc02048 -4.3 -9.9 glycine cleavage system protein H compare
SMc02049 -4.2 -21.1 glycine dehydrogenase compare
SMc01592 -4.2 -9.9 transcriptional regulator compare
SMc00294 -4.0 -9.5 aminotransferase compare
SMc00091 -4.0 -12.2 sulfate adenylyltransferase compare
SMc02172 -3.9 -13.0 transcriptional regulator compare
SMc01850 -3.8 -5.5 hypothetical protein compare
SMc00876 -3.8 -5.9 ATP-binding MRP protein compare
SMc02047 -3.8 -9.7 glycine cleavage system aminomethyltransferase T compare
SM_b20199 -3.7 -7.1 fructose-1,6-bisphosphate aldolase compare
SMc01430 -3.6 -6.4 acetolactate synthase 3 regulatory subunit compare
SMc04346 -3.5 -4.6 ketol-acid reductoisomerase compare
SMc02812 -3.3 -3.0 hypothetical protein compare
SMc01950 -3.0 -16.1 high-affinity branched-chain amino acid ABC transporter permease conserved
SMc00963 -2.9 -8.4 hypothetical protein compare
SMc00726 -2.9 -1.5 thiol:disulfide interchange redox-active center transmembrane protein compare
SMc01842 -2.8 -2.8 methyltransferase transcription regulator protein compare
SMc01206 -2.8 -3.3 queuine tRNA-ribosyltransferase compare
SMc00682 -2.8 -2.4 hippurate hydrolase compare
SMc02246 -2.8 -1.5 hypothetical protein compare
SMc00302 -2.8 -4.3 hypothetical protein compare
SMc02141 -2.7 -6.1 phosphate transporter PhoU compare
SMc01949 -2.6 -8.0 high-affinity branched-chain amino acid ABC transporter ATP-binding protein conserved
SMc01948 -2.5 -7.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein conserved
SMc01951 -2.5 -9.0 high-affinity branched-chain amino acid ABC transporter permease conserved
SMc02724 -2.5 -5.1 hypothetical protein compare
SMc02574 -2.4 -4.8 imidazoleglycerol-phosphate dehydratase compare
SMc02058 -2.4 -5.4 YAJC protein compare
SMc02753 -2.4 -2.4 PTS system transporter subunit IIA compare
SMc02983 -2.3 -7.7 ornithine, DAP, or arginine decarboxylase compare
SMc01578 -2.2 -8.9 aspartate aminotransferase compare
SMc01126 -2.2 -14.2 malic enzyme compare
SMc00838 -2.2 -5.9 hypothetical protein compare
SMc00295 -2.2 -1.1 hypothetical protein compare
SMc00151 -2.2 -6.3 phosphoglycolate phosphatase compare
SMa2020 -2.1 -6.2 Transcriptional regulator compare
SMc01845 -2.1 -2.4 transglycosylase transmembrane protein compare
SMc01441 -2.0 -5.8 membrane bound protease compare
SMc01495 -2.0 -5.8 transcriptional regulator compare
SMc01505 -1.9 -1.7 hypothetical protein compare
SMc02112 -1.9 -6.9 hypothetical protein compare
SM_b20392 -1.8 -8.1 transcriptional regulator NanR compare
SMc00321 -1.8 -6.9 tRNA pseudouridine synthase B compare
SMc02434 -1.8 -2.4 hypothetical protein compare
SMc02084 -1.8 -1.7 biopolymer transport transmembrane protein compare
SM_b21374 -1.7 -4.4 tagatose kinase (EC 2.7.1.101) (from data) compare
SMc00580 -1.7 -5.8 4-hydroxythreonine-4-phosphate dehydrogenase compare
SMc01947 -1.7 -4.1 hypothetical protein compare
SMc01440 -1.7 -5.3 hydrolase serine protease transmembrane protein compare
SMc01595 -1.7 -4.0 sensor histidine kinase transmembrane protein compare
SMc04260 -1.7 -10.2 transcriptional regulator compare
SMa1442 -1.6 -7.5 GntR family transcriptional regulator compare
SMc01147 -1.6 -4.2 coproporphyrinogen III oxidase compare
SMc03993 -1.6 -4.9 hypothetical protein compare
SMc02435 -1.6 -2.9 methyltransferase compare
SMc00914 -1.5 -5.0 oxidoreductase compare
SMc01368 -1.5 -4.2 transport transmembrane protein compare
SMc02140 -1.5 -2.5 phosphate regulon transcriptional regulatory protein compare
SMc01768 -1.5 -7.7 transcriptional regulator compare
SMc02460 -1.5 -7.9 hypothetical protein compare
SMc01164 -1.5 -7.7 hypothetical protein compare
SMc02232 -1.5 -2.6 hypothetical protein compare
SM_b20773 -1.5 -6.2 GntR family transcriptional regulator compare
SMc01124 -1.5 -5.2 PII uridylyl-transferase compare
SM_b21598 -1.5 -5.0 transcriptional regulator compare
SMc04093 -1.5 -11.1 acetyl-CoA synthetase compare
SMc00514 -1.4 -2.7 monooxygenase compare
SMc02685 -1.4 -2.9 hypothetical protein compare
SMc02121 -1.4 -2.2 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component (from data) compare
SMc01174 -1.4 -8.7 cysteine synthase A compare
SMc00450 -1.4 -1.8 protoheme IX farnesyltransferase compare
SMc02833 -1.4 -2.3 penicillin-insensitive murein endopeptidase compare
SMc02147 -1.4 -6.6 phosphate regulon sensor histidine kinase transmembrane protein compare
SMc03100 -1.3 -1.3 hypothetical protein compare
SM_b21372 -1.3 -7.8 LacI family transcriptional regulator compare
SMc02850 -1.3 -2.3 DNA polymerase I compare
SMc04000 -1.3 -1.0 hypothetical protein compare
SM_b20105 -1.3 -1.7 transcriptional regulator compare
SM_b20509 -1.3 -1.9 transcriptional regulator compare
SMc04243 -1.3 -6.3 high-affinity zinc uptake system membrane ABC transporter protein compare
SMc04262 -1.3 -6.6 6-phosphogluconate dehydrogenase compare
SMc04439 -1.3 -3.6 glycine betaine transport ATP-binding ABC transporter protein compare
SMc01438 -1.3 -3.9 protease precursor signal peptide protein compare
SMc03967 -1.3 -1.3 Holliday junction resolvase compare
SMc02521 -1.2 -4.1 glycerol-3-phosphate regulon repressor transcription regulator protein compare
SMc02777 -1.2 -4.8 transcriptional regulator compare
SMc01501 -1.2 -4.3 mannitol 2-dehydrogenase compare
SMc01207 -1.2 -2.2 S-adenosylmethionine--tRNA ribosyltransferase-isomerase compare
SMc02229 -1.2 -7.9 acyl-CoA dehydrogenase compare
SMc02055 -1.2 -1.9 phytoene synthase compare
SMc02234 -1.2 -2.4 hypothetical protein compare
SMc01852 -1.2 -7.2 pyrophosphate--fructose-6-phosphate 1-phosphotransferase compare
SM_b21035 -1.2 -5.9 hypothetical protein compare
SMc03127 -1.2 -2.6 ABC transporter permease compare
SMc02379 -1.2 -6.5 permease compare
SMc02228 -1.2 -5.9 acetyl-CoA acetyltransferase compare
SMc02227 -1.1 -4.3 fatty oxidation complex enoyl-COA hydratase/3-hydroxyacyl-COA dehydrogenase/3-hydroxybutyryl-COA epimerase compare
SMc02641 -1.1 -3.9 UDP-glucose 6-dehydrogenase compare
SMc02225 -1.1 -5.3 hypothetical protein compare
SMc02897 -1.1 -2.7 cytochrome C transmembrane protein compare
SMc02102 -1.1 -3.7 hypothetical protein compare
SMc03184 -1.1 -1.4 PH adaptation potassium efflux system G transmembrane protein compare
SMc01858 -1.1 -1.7 S-adenosyl-methyltransferase MraW compare
SMc00132 -1.1 -1.6 hypothetical protein compare
SMc02853 -1.1 -4.5 hypothetical protein compare
SMc00513 -1.1 -4.8 amino acid-binding periplasmic protein compare
SMc00013 -1.0 -1.2 cytochrome C oxidase subunit III transmembrane protein compare


Specific Phenotypes

For 18 genes in this experiment

For carbon source L-Proline in Sinorhizobium meliloti 1021

For carbon source L-Proline across organisms