Experiment set1IT021 for Pseudomonas fluorescens FW300-N2E2

Compare to:

L-Malic acid disodium salt monohydrate carbon source

200 most important genes:

  gene name fitness t score description  
Pf6N2E2_77 -6.9 -4.8 O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) compare
Pf6N2E2_4597 -6.4 -11.4 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf6N2E2_3842 -6.3 -6.2 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) compare
Pf6N2E2_64 -6.2 -6.0 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) compare
Pf6N2E2_3751 -6.1 -16.6 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) compare
Pf6N2E2_71 -5.7 -8.7 Phosphoribosylanthranilate isomerase (EC 5.3.1.24) compare
Pf6N2E2_4596 -5.7 -13.2 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf6N2E2_4826 -5.6 -9.4 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) compare
Pf6N2E2_5175 -5.4 -18.9 Acetolactate synthase large subunit (EC 2.2.1.6) compare
Pf6N2E2_3783 -5.4 -7.4 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
Pf6N2E2_4825 -5.3 -11.3 Anthranilate phosphoribosyltransferase (EC 2.4.2.18) compare
Pf6N2E2_3610 -5.3 -5.9 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) compare
Pf6N2E2_5176 -5.3 -13.6 Acetolactate synthase small subunit (EC 2.2.1.6) compare
Pf6N2E2_4048 -5.1 -10.8 Tryptophan synthase beta chain (EC 4.2.1.20) compare
Pf6N2E2_3253 -5.1 -9.1 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
Pf6N2E2_4047 -5.0 -7.6 Tryptophan synthase alpha chain (EC 4.2.1.20) compare
Pf6N2E2_5177 -4.8 -10.5 Ketol-acid reductoisomerase (EC 1.1.1.86) compare
Pf6N2E2_3839 -4.8 -7.3 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Pf6N2E2_3752 -4.7 -21.8 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) compare
Pf6N2E2_3940 -4.7 -11.1 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf6N2E2_3782 -4.7 -7.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) compare
Pf6N2E2_3630 -4.5 -6.3 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf6N2E2_3841 -4.4 -8.3 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) compare
Pf6N2E2_3251 -4.4 -13.3 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
Pf6N2E2_4564 -4.4 -8.8 Dihydroxy-acid dehydratase (EC 4.2.1.9) compare
Pf6N2E2_2073 -4.3 -10.4 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) compare
Pf6N2E2_3252 -4.2 -8.2 Histidinol dehydrogenase (EC 1.1.1.23) compare
Pf6N2E2_4638 -4.2 -4.9 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) compare
Pf6N2E2_2277 -4.0 -4.7 NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.13) compare
Pf6N2E2_302 -4.0 -10.4 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
Pf6N2E2_5950 -3.9 -5.5 Phosphate:acyl-ACP acyltransferase PlsX compare
Pf6N2E2_66 -3.7 -7.7 3-isopropylmalate dehydrogenase (EC 1.1.1.85) compare
Pf6N2E2_2465 -3.7 -6.8 Cys regulon transcriptional activator CysB compare
Pf6N2E2_5156 -3.6 -4.9 Two-component sensor CbrB: intrcellular carbon:nitrogen balance compare
Pf6N2E2_3248 -3.4 -5.4 Probable transmembrane protein compare
Pf6N2E2_50 -3.3 -8.4 Biosynthetic Aromatic amino acid aminotransferase alpha (EC 2.6.1.57) @ Aromatic-amino-acid aminotransferase (EC 2.6.1.57) compare
Pf6N2E2_5006 -3.0 -10.3 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) compare
Pf6N2E2_3170 -3.0 -8.0 2-isopropylmalate synthase (EC 2.3.3.13) compare
Pf6N2E2_5579 -3.0 -7.5 Ornithine carbamoyltransferase (EC 2.1.3.3) compare
Pf6N2E2_3932 -2.9 -4.3 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) compare
Pf6N2E2_3461 -2.6 -3.0 Exodeoxyribonuclease V gamma chain (EC 3.1.11.5) compare
Pf6N2E2_5728 -2.6 -4.7 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) compare
Pf6N2E2_2074 -2.5 -2.1 required for sulfate utilization, putative electron transport protein for sulfite reductase (from data) compare
Pf6N2E2_1056 -2.5 -1.5 Quinone oxidoreductase (EC 1.6.5.5) compare
Pf6N2E2_63 -2.5 -4.1 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) compare
Pf6N2E2_4759 -2.5 -13.9 Biotin synthase (EC 2.8.1.6) compare
Pf6N2E2_3346 -2.1 -5.7 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) compare
Pf6N2E2_2217 -2.1 -7.2 ATP-dependent Clp protease ATP-binding subunit ClpX compare
Pf6N2E2_5527 -2.1 -3.1 Cold shock protein CspC compare
Pf6N2E2_2218 -2.1 -6.4 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) compare
Pf6N2E2_2753 -2.0 -3.8 HtrA protease/chaperone protein compare
Pf6N2E2_4764 -2.0 -6.0 Dethiobiotin synthetase (EC 6.3.3.3) compare
Pf6N2E2_2285 -2.0 -2.3 FIG00954079: hypothetical protein compare
Pf6N2E2_3762 -1.9 -8.6 NADP-dependent malic enzyme (EC 1.1.1.40) compare
Pf6N2E2_3826 -1.9 -5.5 Nitrogen regulation protein NR(I) compare
Pf6N2E2_5331 -1.9 -7.1 ATPase, AFG1 family compare
Pf6N2E2_5707 -1.9 -11.2 Aerobic C4-dicarboxylate transporter for fumarate, L-malate, D-malate, succunate conserved
Pf6N2E2_4761 -1.8 -10.1 8-amino-7-oxononanoate synthase (EC 2.3.1.47) compare
Pf6N2E2_3984 -1.8 -10.4 T1SS associated transglutaminase-like cysteine proteinase LapP compare
Pf6N2E2_4763 -1.8 -8.1 Biotin synthesis protein BioC compare
Pf6N2E2_4009 -1.8 -8.7 GGDEF domain protein compare
Pf6N2E2_3763 -1.8 -2.1 hypothetical protein compare
Pf6N2E2_1705 -1.8 -2.5 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) compare
Pf6N2E2_5242 -1.7 -2.2 Malate:quinone oxidoreductase (EC 1.1.5.4) compare
Pf6N2E2_3349 -1.7 -2.5 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) compare
Pf6N2E2_2693 -1.7 -2.3 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII (EC 2.3.1.180) compare
Pf6N2E2_3883 -1.6 -6.9 C4-dicarboxylate transport transcriptional regulatory protein conserved
Pf6N2E2_5258 -1.6 -7.3 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25) compare
Pf6N2E2_3825 -1.6 -4.4 Nitrogen regulation protein NtrB (EC 2.7.13.3) compare
Pf6N2E2_3533 -1.6 -6.3 Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) compare
Pf6N2E2_5666 -1.5 -7.9 Arginine N-succinyltransferase, alpha subunit (EC 2.3.1.109) compare
Pf6N2E2_2286 -1.5 -3.8 FIG00953287: hypothetical protein compare
Pf6N2E2_2514 -1.5 -4.0 regulator of length of O-antigen component of lipopolysaccharide chains compare
Pf6N2E2_2646 -1.5 -1.9 FIG00953416: hypothetical protein compare
Pf6N2E2_5553 -1.5 -7.2 Quinolinate synthetase (EC 2.5.1.72) compare
Pf6N2E2_5252 -1.5 -2.6 FIG00956396: hypothetical protein compare
Pf6N2E2_3882 -1.5 -7.8 Signal transduction histidine kinase regulating C4-dicarboxylate transport system conserved
Pf6N2E2_3899 -1.4 -7.3 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) compare
Pf6N2E2_5667 -1.4 -7.0 Arginine N-succinyltransferase (EC 2.3.1.109) compare
Pf6N2E2_2065 -1.4 -4.3 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) compare
Pf6N2E2_4601 -1.4 -3.3 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC compare
Pf6N2E2_2317 -1.4 -4.8 Putative analog of CcoH, COG3198 compare
Pf6N2E2_5739 -1.4 -2.0 Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family compare
Pf6N2E2_3938 -1.3 -9.3 Threonine dehydratase biosynthetic (EC 4.3.1.19) compare
Pf6N2E2_3534 -1.3 -2.4 Cobalamin biosynthesis protein CobG compare
Pf6N2E2_4631 -1.3 -6.1 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) compare
Pf6N2E2_5257 -1.3 -7.0 Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) compare
Pf6N2E2_5316 -1.3 -1.8 Periplasmic thiol:disulfide oxidoreductase DsbB, required for DsbA reoxidation compare
Pf6N2E2_5676 -1.2 -2.3 Aspartokinase (EC 2.7.2.4) compare
Pf6N2E2_3835 -1.2 -4.5 Carboxyl-terminal protease (EC 3.4.21.102) compare
Pf6N2E2_420 -1.2 -2.1 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY compare
Pf6N2E2_5103 -1.1 -2.0 Glutamate 5-kinase (EC 2.7.2.11) / RNA-binding C-terminal domain PUA compare
Pf6N2E2_2640 -1.1 -2.7 Permease of the drug/metabolite transporter (DMT) superfamily compare
Pf6N2E2_2984 -1.1 -2.1 LysR family transcriptional regulator PA3398 compare
Pf6N2E2_2473 -1.1 -1.5 Major outer membrane lipoprotein I compare
Pf6N2E2_4579 -1.1 -2.8 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) compare
Pf6N2E2_248 -1.1 -5.9 hypothetical protein compare
Pf6N2E2_2320 -1.1 -3.4 Heavy-metal-associated domain (N-terminus) and membrane-bounded cytochrome biogenesis cycZ-like domain, possible membrane copper tolerance protein compare
Pf6N2E2_5219 -1.1 -6.9 FIG140336: TPR domain protein compare
Pf6N2E2_2059 -1.1 -3.5 ChlI component of cobalt chelatase involved in B12 biosynthesis compare
Pf6N2E2_5520 -1.0 -5.6 Sensory box histidine kinase compare
Pf6N2E2_4762 -1.0 -2.5 Biotin synthesis protein BioH compare
Pf6N2E2_51 -1.0 -3.8 hypothetical protein compare
Pf6N2E2_4797 -1.0 -1.4 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) compare
Pf6N2E2_3537 -1.0 -4.1 Cobalt-precorrin-6x reductase (EC 1.3.1.54) compare
Pf6N2E2_4417 -1.0 -3.3 Protein of unknown function DUF484 compare
Pf6N2E2_5160 -1.0 -1.8 C4-type zinc finger protein, DksA/TraR family compare
Pf6N2E2_3277 -1.0 -1.8 FagA protein compare
Pf6N2E2_4454 -1.0 -4.1 Exopolyphosphatase (EC 3.6.1.11) compare
Pf6N2E2_1315 -1.0 -2.2 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) compare
Pf6N2E2_3258 -1.0 -3.8 Uncharacterized ABC transporter, periplasmic component YrbD compare
Pf6N2E2_2318 -1.0 -5.5 Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4) compare
Pf6N2E2_2586 -1.0 -1.9 Hpt domain protein compare
Pf6N2E2_5339 -1.0 -5.2 ubiquinol cytochrome C oxidoreductase, cytochrome C1 subunit compare
Pf6N2E2_127 -1.0 -1.8 AttE component of AttEFGH ABC transport system compare
Pf6N2E2_5001 -1.0 -1.8 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) compare
Pf6N2E2_4372 -0.9 -3.0 FIG00460773: hypothetical protein compare
Pf6N2E2_1718 -0.9 -1.7 Anthranilate synthase, amidotransferase component (EC 4.1.3.27) compare
Pf6N2E2_4416 -0.9 -2.4 Tyrosine recombinase XerC compare
Pf6N2E2_2527 -0.9 -4.0 Oxidoreductase, short chain dehydrogenase/reductase family compare
Pf6N2E2_2264 -0.9 -3.5 NADPH dependent preQ0 reductase (EC 1.7.1.13) compare
Pf6N2E2_3338 -0.9 -2.1 1-phosphofructokinase (EC 2.7.1.56) compare
Pf6N2E2_621 -0.9 -4.7 TPR domain protein in aerotolerance operon compare
Pf6N2E2_4987 -0.8 -1.1 MaoC-like domain protein compare
Pf6N2E2_4205 -0.8 -2.9 Chromosome (plasmid) partitioning protein ParA compare
Pf6N2E2_1281 -0.8 -2.8 ATPase involved in DNA repair compare
Pf6N2E2_3257 -0.8 -2.9 Uncharacterized ABC transporter, auxiliary component YrbC compare
Pf6N2E2_4206 -0.8 -1.1 Chromosome (plasmid) partitioning protein ParB compare
Pf6N2E2_3532 -0.8 -5.0 Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) compare
Pf6N2E2_5738 -0.8 -5.0 Cobyrinic acid A,C-diamide synthase compare
Pf6N2E2_2756 -0.8 -4.4 RNA polymerase sigma-H factor AlgT compare
Pf6N2E2_5338 -0.8 -5.1 Ubiquinol--cytochrome c reductase, cytochrome B subunit (EC 1.10.2.2) compare
Pf6N2E2_5584 -0.8 -1.6 Bacterioferritin-associated ferredoxin compare
Pf6N2E2_2139 -0.8 -2.2 Paraquat-inducible protein A compare
Pf6N2E2_3536 -0.8 -3.9 Cobalt-precorrin-6 synthase, anaerobic compare
Pf6N2E2_5936 -0.8 -1.8 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) compare
Pf6N2E2_469 -0.8 -2.0 lipoprotein, putative compare
Pf6N2E2_3039 -0.8 -4.8 Protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77) compare
Pf6N2E2_5342 -0.8 -1.6 21 kDa hemolysin precursor compare
Pf6N2E2_2068 -0.8 -4.5 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) compare
Pf6N2E2_3820 -0.8 -1.5 hypothetical protein compare
Pf6N2E2_2903 -0.8 -2.6 Heme oxygenase HemO, associated with heme uptake compare
Pf6N2E2_2674 -0.7 -1.0 FIG00953856: hypothetical protein compare
Pf6N2E2_384 -0.7 -2.7 Glycine cleavage system transcriptional activator compare
Pf6N2E2_3183 -0.7 -2.2 Believed to be involved in assembly of Fe-S clusters compare
Pf6N2E2_2088 -0.7 -1.5 SOS-response repressor and protease LexA (EC 3.4.21.88) compare
Pf6N2E2_5505 -0.7 -1.6 hypothetical protein compare
Pf6N2E2_734 -0.7 -2.6 Molybdenum cofactor biosynthesis protein MoaA compare
Pf6N2E2_5742 -0.7 -4.0 Cobyric acid synthase (EC 6.3.5.10) compare
Pf6N2E2_3326 -0.7 -1.4 hypothetical protein compare
Pf6N2E2_4077 -0.7 -1.8 cytosolic long-chain acyl-CoA thioester hydrolase family protein compare
Pf6N2E2_3072 -0.7 -5.1 [Protein-PII] uridylyltransferase (EC 2.7.7.59) compare
Pf6N2E2_2912 -0.7 -1.5 FIG00954094: hypothetical protein compare
Pf6N2E2_3908 -0.7 -3.8 Glutamate--cysteine ligase (EC 6.3.2.2) compare
Pf6N2E2_1652 -0.7 -1.5 Transcriptional regulator, TetR family compare
Pf6N2E2_5741 -0.7 -2.9 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) compare
Pf6N2E2_3040 -0.7 -4.0 5-nucleotidase SurE (EC 3.1.3.5) compare
Pf6N2E2_1932 -0.7 -2.8 Transcriptional regulator, IclR family compare
Pf6N2E2_1870 -0.7 -2.2 hypothetical protein compare
Pf6N2E2_3665 -0.7 -0.7 serine/threonine protein kinase compare
Pf6N2E2_4352 -0.7 -1.7 ATP-dependent DNA helicase RecG (EC 3.6.1.-) compare
Pf6N2E2_689 -0.7 -1.6 FIG00956189: hypothetical protein compare
Pf6N2E2_2309 -0.7 -2.1 hypothetical protein compare
Pf6N2E2_282 -0.7 -1.1 GNAT family acetyltransferase YjcF compare
Pf6N2E2_3770 -0.7 -2.0 ATP-dependent hsl protease ATP-binding subunit HslU compare
Pf6N2E2_3531 -0.7 -3.1 Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase compare
Pf6N2E2_3786 -0.7 -1.6 Twin-arginine translocation protein TatC compare
Pf6N2E2_434 -0.7 -2.0 hypothetical protein compare
Pf6N2E2_2106 -0.7 -1.2 hypothetical protein compare
Pf6N2E2_2060 -0.7 -4.7 CobN component of cobalt chelatase involved in B12 biosynthesis compare
Pf6N2E2_5640 -0.7 -1.5 FIG00955597: hypothetical protein compare
Pf6N2E2_2313 -0.7 -2.0 Cytochrome c oxidase subunit CcoP (EC 1.9.3.1) compare
Pf6N2E2_3535 -0.7 -2.7 Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) compare
Pf6N2E2_1667 -0.7 -2.3 Fumarylacetoacetate hydrolase family protein compare
Pf6N2E2_3875 -0.7 -1.1 FIG00953324: hypothetical protein compare
Pf6N2E2_4640 -0.7 -1.3 hypothetical protein compare
Pf6N2E2_2574 -0.7 -1.9 Flagellar synthesis regulator FleN compare
Pf6N2E2_6029 -0.7 -2.0 hypothetical protein compare
Pf6N2E2_3747 -0.6 -3.4 hypothetical protein compare
Pf6N2E2_5345 -0.6 -4.6 LppC putative lipoprotein compare
Pf6N2E2_1717 -0.6 -4.4 Anthranilate synthase, aminase component (EC 4.1.3.27) compare
Pf6N2E2_5337 -0.6 -3.0 Ubiquinol-cytochrome C reductase iron-sulfur subunit (EC 1.10.2.2) compare
Pf6N2E2_3260 -0.6 -2.6 Uncharacterized ABC transporter, ATP-binding protein YrbF compare
Pf6N2E2_4159 -0.6 -2.2 Cytochrome c4 compare
Pf6N2E2_4364 -0.6 -1.8 Protein YicC compare
Pf6N2E2_4803 -0.6 -1.1 Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41) compare
Pf6N2E2_1113 -0.6 -1.2 Transcriptional regulator, TetR family compare
Pf6N2E2_1611 -0.6 -2.6 Phosphonate ABC transporter permease protein phnE2 (TC 3.A.1.9.1) compare
Pf6N2E2_5190 -0.6 -4.6 Carbonic anhydrase (EC 4.2.1.1) compare
Pf6N2E2_1606 -0.6 -3.2 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) compare
Pf6N2E2_2002 -0.6 -2.7 hypothetical protein compare
Pf6N2E2_3557 -0.6 -1.6 Chaperone-modulator protein CbpM compare
Pf6N2E2_955 -0.6 -2.5 FIG00953508: hypothetical protein compare
Pf6N2E2_3199 -0.6 -3.2 S-adenosylmethionine:tRNA ribosyltransferase-isomerase (EC 5.-.-.-) compare
Pf6N2E2_5745 -0.6 -3.3 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) compare
Pf6N2E2_5188 -0.6 -2.3 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) compare
Pf6N2E2_70 -0.6 -2.4 tRNA pseudouridine synthase A (EC 4.2.1.70) compare
Pf6N2E2_5406 -0.6 -1.8 FIG00958224: hypothetical protein compare
Pf6N2E2_4494 -0.6 -2.1 Adenylate cyclase (EC 4.6.1.1) compare
Pf6N2E2_1470 -0.6 -2.0 Transcriptional regulator, LysR family compare


Specific Phenotypes

For 3 genes in this experiment

For carbon source L-Malic acid disodium salt monohydrate in Pseudomonas fluorescens FW300-N2E2

For carbon source L-Malic acid disodium salt monohydrate across organisms