Experiment set1IT017 for Pseudomonas fluorescens FW300-N1B4

Compare to:

Sodium L-Lactate carbon source

200 most important genes:

  gene name fitness t score description  
Pf1N1B4_5666 -4.1 -2.8 Oxidoreductase probably involved in sulfite reduction compare
Pf1N1B4_2880 -3.8 -11.4 Ketol-acid reductoisomerase (EC 1.1.1.86) compare
Pf1N1B4_6 -3.7 -5.0 Phosphoribosylanthranilate isomerase (EC 5.3.1.24) compare
Pf1N1B4_1067 -3.6 -6.8 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
Pf1N1B4_1307 -3.6 -2.5 3-dehydroquinate dehydratase II (EC 4.2.1.10) compare
Pf1N1B4_1188 -3.5 -8.8 Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF conserved
Pf1N1B4_2548 -3.5 -7.1 Anthranilate phosphoribosyltransferase (EC 2.4.2.18) compare
Pf1N1B4_2486 -3.5 -3.3 hypothetical protein compare
Pf1N1B4_1624 -3.4 -8.8 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Pf1N1B4_2272 -3.4 -3.3 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) compare
Pf1N1B4_5665 -3.4 -6.0 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) compare
Pf1N1B4_2303 -3.4 -14.4 Dihydroxy-acid dehydratase (EC 4.2.1.9) compare
Pf1N1B4_1625 -3.3 -5.5 FIG00956267: hypothetical protein compare
Pf1N1B4_1534 -3.3 -17.2 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) compare
Pf1N1B4_2879 -3.2 -7.2 Acetolactate synthase small subunit (EC 2.2.1.6) compare
Pf1N1B4_1626 -3.2 -7.2 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) compare
Pf1N1B4_1535 -3.2 -3.8 hypothetical protein compare
Pf1N1B4_2338 -3.2 -7.6 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf1N1B4_742 -3.2 -7.6 Argininosuccinate synthase (EC 6.3.4.5) compare
Pf1N1B4_2549 -3.2 -9.7 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) compare
Pf1N1B4_2545 -3.2 -13.4 Anthranilate synthase, aminase component (EC 4.1.3.27) compare
Pf1N1B4_1831 -3.1 -11.9 Tryptophan synthase beta chain (EC 4.2.1.20) compare
Pf1N1B4_2547 -3.1 -3.0 Anthranilate synthase, amidotransferase component (EC 4.1.3.27) @ Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) compare
Pf1N1B4_1533 -3.1 -8.4 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) compare
Pf1N1B4_1627 -3.0 -5.4 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) compare
Pf1N1B4_15 -3.0 -4.5 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) compare
Pf1N1B4_1830 -3.0 -8.4 Tryptophan synthase alpha chain (EC 4.2.1.20) compare
Pf1N1B4_12 -3.0 -7.7 3-isopropylmalate dehydrogenase (EC 1.1.1.85) compare
Pf1N1B4_2858 -2.9 -10.7 Two-component sensor CbrB: intrcellular carbon:nitrogen balance compare
Pf1N1B4_3697 -2.9 -8.9 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) compare
Pf1N1B4_2010 -2.9 -5.7 Pyruvate carboxyl transferase subunit A (EC 6.4.1.1) compare
Pf1N1B4_847 -2.8 -9.8 2-isopropylmalate synthase (EC 2.3.3.13) compare
Pf1N1B4_1565 -2.7 -4.5 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) compare
Pf1N1B4_2878 -2.7 -8.1 Acetolactate synthase large subunit (EC 2.2.1.6) compare
Pf1N1B4_1408 -2.7 -3.5 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) compare
Pf1N1B4_1186 -2.7 -9.2 L-lactate permease conserved
Pf1N1B4_1434 -2.6 -7.5 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf1N1B4_1189 -2.6 -5.4 Predicted L-lactate dehydrogenase, hypothetical protein subunit YkgG compare
Pf1N1B4_2384 -2.6 -9.6 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) compare
Pf1N1B4_2011 -2.5 -8.9 Pyruvate carboxyl transferase subunit B (EC 6.4.1.1) compare
Pf1N1B4_1617 -2.4 -7.6 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) compare
Pf1N1B4_2009 -2.4 -5.1 LysR family transcriptional regulator PA5437 compare
Pf1N1B4_1315 -2.4 -8.3 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) compare
Pf1N1B4_762 -2.4 -6.3 Ornithine carbamoyltransferase (EC 2.1.3.3) compare
Pf1N1B4_2282 -2.4 -8.7 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf1N1B4_3506 -2.4 -8.0 Cysteine synthase B (EC 2.5.1.47) compare
Pf1N1B4_3917 -2.3 -4.9 NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.13) compare
Pf1N1B4_6041 -2.2 -2.9 Carbon storage regulator compare
Pf1N1B4_350 -2.2 -7.0 Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51) compare
Pf1N1B4_1187 -2.1 -6.7 Predicted L-lactate dehydrogenase, Fe-S oxidoreductase subunit YkgE conserved
Pf1N1B4_2337 -2.0 -5.0 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf1N1B4_2112 -2.0 -12.1 Bona fide RidA/YjgF/TdcF/RutC subgroup compare
Pf1N1B4_4065 -2.0 -6.4 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
Pf1N1B4_3812 -2.0 -7.5 Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10) compare
Pf1N1B4_3518 -1.9 -3.3 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) compare
Pf1N1B4_1566 -1.9 -6.9 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
Pf1N1B4_2859 -1.8 -11.7 Two-component sensor CbrA: intrcellular carbon:nitrogen balance compare
Pf1N1B4_1057 -1.8 -3.0 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25) compare
Pf1N1B4_1906 -1.7 -3.6 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) compare
Pf1N1B4_652 -1.7 -8.0 Sensory box histidine kinase compare
Pf1N1B4_5659 -1.7 -9.3 NfuA Fe-S protein maturation compare
Pf1N1B4_407 -1.6 -2.4 ADP-ribosylglycohydrolase YegU (EC 3.2.-.-) compare
Pf1N1B4_27 -1.6 -4.4 Biosynthetic Aromatic amino acid aminotransferase alpha (EC 2.6.1.57) @ Aromatic-amino-acid aminotransferase (EC 2.6.1.57) compare
Pf1N1B4_2280 -1.6 -7.1 Threonine dehydratase biosynthetic (EC 4.3.1.19) compare
Pf1N1B4_1317 -1.5 -2.8 Sensor histidine kinase/response regulator compare
Pf1N1B4_1180 -1.5 -2.4 Outer membrane lipoprotein SmpA, a component of the essential YaeT outer-membrane protein assembly complex compare
Pf1N1B4_3081 -1.5 -12.5 [Protein-PII] uridylyltransferase (EC 2.7.7.59) compare
Pf1N1B4_688 -1.5 -2.2 FIG00955483: hypothetical protein compare
Pf1N1B4_2683 -1.5 -4.2 LrgA-associated membrane protein LrgB compare
Pf1N1B4_2958 -1.4 -2.2 Medium-chain-fatty-acid--CoA ligase (EC 6.2.1.-) compare
Pf1N1B4_1 -1.4 -1.7 Colicin V production protein compare
Pf1N1B4_4596 -1.4 -2.6 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) compare
Pf1N1B4_2487 -1.4 -6.8 Biotin synthase (EC 2.8.1.6) compare
Pf1N1B4_4486 -1.4 -2.9 Outer membrane protein (porin) compare
Pf1N1B4_2791 -1.4 -2.5 Putative inner membrane protein (Fragment) compare
Pf1N1B4_365 -1.4 -4.7 Cell division protein BolA compare
Pf1N1B4_412 -1.3 -2.6 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) (from data) compare
Pf1N1B4_197 -1.3 -2.4 FIG139991: Putative thiamine pyrophosphate-requiring enzyme compare
Pf1N1B4_4824 -1.3 -2.4 Gamma-glutamyl-putrescine oxidase (EC1.4.3.-) compare
Pf1N1B4_1653 -1.3 -5.3 Branched-chain amino acid transport protein AzlC compare
Pf1N1B4_3605 -1.3 -1.6 Flagellar motor switch protein FliG compare
Pf1N1B4_2491 -1.3 -3.2 Dethiobiotin synthetase (EC 6.3.3.3) compare
Pf1N1B4_5365 -1.2 -1.8 hypothetical protein compare
Pf1N1B4_814 -1.2 -1.7 Transcriptional regulator, PadR family compare
Pf1N1B4_4103 -1.2 -2.3 Flagellar synthesis regulator FleN compare
Pf1N1B4_644 -1.2 -1.7 Cold shock protein CspC compare
Pf1N1B4_257 -1.2 -4.7 sensor histidine kinase/response regulator compare
Pf1N1B4_886 -1.2 -1.9 FIG137478: Hypothetical protein compare
Pf1N1B4_2682 -1.2 -2.0 Antiholin-like protein LrgA compare
Pf1N1B4_381 -1.2 -2.0 hypothetical protein compare
Pf1N1B4_5498 -1.2 -1.4 hypothetical protein compare
Pf1N1B4_2488 -1.2 -5.4 8-amino-7-oxononanoate synthase (EC 2.3.1.47) compare
Pf1N1B4_4446 -1.2 -2.0 DNA topoisomerase III (EC 5.99.1.2) compare
Pf1N1B4_3191 -1.2 -1.9 FIG00953505: hypothetical protein compare
Pf1N1B4_3751 -1.1 -1.9 FIG00953060: hypothetical protein compare
Pf1N1B4_5255 -1.1 -1.8 hypothetical protein compare
Pf1N1B4_4336 -1.1 -2.6 FMN-dependent NADH-azoreductase compare
Pf1N1B4_4212 -1.1 -1.8 Gfa-like protein compare
Pf1N1B4_1115 -1.1 -6.2 Dna binding response regulator PrrA (RegA) compare
Pf1N1B4_751 -1.1 -1.7 hypothetical protein compare
Pf1N1B4_5334 -1.1 -2.2 hypothetical protein compare
Pf1N1B4_2105 -1.1 -1.9 ATP-dependent DNA helicase RecG (EC 3.6.1.-) compare
Pf1N1B4_4839 -1.1 -1.8 lipoprotein compare
Pf1N1B4_131 -1.1 -2.3 hypothetical protein compare
Pf1N1B4_5899 -1.0 -1.6 FIG00954746: hypothetical protein compare
Pf1N1B4_2377 -1.0 -4.5 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) compare
Pf1N1B4_4627 -1.0 -2.1 FIG00957600: hypothetical protein compare
Pf1N1B4_2171 -1.0 -2.6 Tyrosine recombinase XerC compare
Pf1N1B4_2552 -1.0 -2.5 OsmC/Ohr family protein compare
Pf1N1B4_1993 -1.0 -1.4 C4-type zinc finger protein, DksA/TraR family compare
Pf1N1B4_1348 -1.0 -2.2 Urease accessory protein UreD compare
Pf1N1B4_2225 -1.0 -6.3 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) compare
Pf1N1B4_3468 -1.0 -1.5 Negative regulator of flagellin synthesis FlgM compare
Pf1N1B4_1113 -1.0 -3.8 Predicted D-glucarate or D-galactorate regulator, GntR family compare
Pf1N1B4_2568 -1.0 -2.3 Translation elongation factor Tu compare
Pf1N1B4_3445 -1.0 -2.6 Succinylarginine dihydrolase (EC 3.5.3.23) compare
Pf1N1B4_2695 -1.0 -1.4 Rare lipoprotein A precursor compare
Pf1N1B4_1069 -1.0 -3.8 YrbA protein compare
Pf1N1B4_1668 -1.0 -3.5 3'(2'),5'-bisphosphate nucleotidase (EC 3.1.3.7) compare
Pf1N1B4_3325 -1.0 -1.2 Sigma factor RpoE negative regulatory protein RseB precursor compare
Pf1N1B4_2853 -0.9 -1.4 Pantoate--beta-alanine ligase (EC 6.3.2.1) compare
Pf1N1B4_5509 -0.9 -1.7 hypothetical protein compare
Pf1N1B4_578 -0.9 -1.7 enoyl-CoA hydratase, R-specific compare
Pf1N1B4_5483 -0.9 -1.2 hypothetical protein compare
Pf1N1B4_1279 -0.9 -1.9 Flp pilus assembly protein TadB compare
Pf1N1B4_3508 -0.9 -2.9 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) compare
Pf1N1B4_4569 -0.9 -1.4 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) compare
Pf1N1B4_4273 -0.9 -3.1 Predicted transcriptional regulator of the myo-inositol catabolic operon compare
Pf1N1B4_5560 -0.9 -1.3 hypothetical protein compare
Pf1N1B4_5447 -0.9 -1.5 hypothetical protein compare
Pf1N1B4_2048 -0.9 -1.0 hypothetical protein compare
Pf1N1B4_3413 -0.9 -0.9 Transcriptional regulator, LysR family compare
Pf1N1B4_3713 -0.9 -1.3 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) compare
Pf1N1B4_5920 -0.9 -2.1 Transcriptional regulator, AraC family compare
Pf1N1B4_1975 -0.9 -1.1 Transcriptional regulator, AsnC family compare
Pf1N1B4_2026 -0.9 -2.0 Transcriptional regulator compare
Pf1N1B4_3909 -0.8 -1.8 Cell division inhibitor-related protein compare
Pf1N1B4_2526 -0.8 -6.7 Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41) compare
Pf1N1B4_2209 -0.8 -4.6 Exopolyphosphatase (EC 3.6.1.11) compare
Pf1N1B4_1042 -0.8 -2.5 Dihydroneopterin triphosphate epimerase compare
Pf1N1B4_3044 -0.8 -2.4 Putative lipoprotein, specific for Pseudomonas, in cluster with COG2110 compare
Pf1N1B4_3017 -0.8 -2.8 NAD(FAD)-utilizing enzyme possibly involved in translation compare
Pf1N1B4_4835 -0.8 -1.7 Carbon starvation protein A compare
Pf1N1B4_4648 -0.8 -1.8 transcriptional regulator, MerR family compare
Pf1N1B4_239 -0.8 -2.3 Similar to ribosomal large subunit pseudouridine synthase A compare
Pf1N1B4_4053 -0.8 -2.9 Cold shock protein CspD compare
Pf1N1B4_3334 -0.8 -2.3 Metal-dependent hydrolases of the beta-lactamase superfamily I compare
Pf1N1B4_2352 -0.8 -3.5 Glutathione synthetase (EC 6.3.2.3) compare
Pf1N1B4_6031 -0.8 -2.0 Ribokinase (EC 2.7.1.15) (from data) compare
Pf1N1B4_13 -0.8 -1.9 SAM-dependent methyltransferase YafE (UbiE paralog) compare
Pf1N1B4_5283 -0.8 -1.4 hypothetical protein compare
Pf1N1B4_2854 -0.8 -2.3 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) compare
Pf1N1B4_56 -0.8 -1.8 Tryptophan synthase beta chain like (EC 4.2.1.20) compare
Pf1N1B4_609 -0.8 -1.7 FIG039061: hypothetical protein related to heme utilization compare
Pf1N1B4_2407 -0.8 -2.7 FIG00953367: hypothetical protein compare
Pf1N1B4_5302 -0.8 -1.7 hypothetical protein compare
Pf1N1B4_35 -0.8 -1.6 hypothetical protein compare
Pf1N1B4_4043 -0.7 -1.8 Type II and III secretion system family protein compare
Pf1N1B4_327 -0.7 -1.4 hypothetical protein compare
Pf1N1B4_3001 -0.7 -2.1 hypothetical protein compare
Pf1N1B4_175 -0.7 -1.1 sigma-54 dependent transcriptional regulator compare
Pf1N1B4_4857 -0.7 -3.1 Chemotaxis protein methyltransferase CheR (EC 2.1.1.80) compare
Pf1N1B4_438 -0.7 -2.6 hypothetical protein compare
Pf1N1B4_49 -0.7 -1.8 hypothetical protein compare
Pf1N1B4_5972 -0.7 -1.7 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) compare
Pf1N1B4_4028 -0.7 -1.5 NADH-ubiquinone oxidoreductase chain N (EC 1.6.5.3) compare
Pf1N1B4_716 -0.7 -2.0 Probable thiol oxidoreductase with 2 cytochrome c heme-binding sites compare
Pf1N1B4_4190 -0.7 -3.6 transcriptional regulator, AraC family compare
Pf1N1B4_228 -0.7 -2.1 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 compare
Pf1N1B4_4368 -0.7 -1.8 Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) compare
Pf1N1B4_4765 -0.7 -1.6 2-ketogluconate kinase (EC 2.7.1.13) compare
Pf1N1B4_3833 -0.7 -3.6 Major porin and structural outer membrane porin OprF compare
Pf1N1B4_2856 -0.7 -2.3 Poly(A) polymerase (EC 2.7.7.19) compare
Pf1N1B4_1065 -0.7 -3.1 Histidinol-phosphate aminotransferase (EC 2.6.1.9) compare
Pf1N1B4_5652 -0.7 -1.6 ChlI component of cobalt chelatase involved in B12 biosynthesis compare
Pf1N1B4_2917 -0.7 -3.9 FIG140336: TPR domain protein compare
Pf1N1B4_6028 -0.7 -2.1 FIG00954052: hypothetical protein compare
Pf1N1B4_1590 -0.7 -2.9 Histidine utilization repressor compare
Pf1N1B4_1785 -0.7 -2.1 Uricase (urate oxidase) (EC 1.7.3.3) compare
Pf1N1B4_1329 -0.7 -2.9 Cobalamin biosynthesis protein CobG compare
Pf1N1B4_2489 -0.7 -2.3 Biotin synthesis protein BioH compare
Pf1N1B4_4587 -0.7 -1.2 probable dioxygenase compare
Pf1N1B4_2783 -0.7 -1.1 Transcription elongation factor GreB-related protein compare
Pf1N1B4_5602 -0.7 -2.2 6-aminohexanoate-dimer hydrolase (EC 3.5.1.46) compare
Pf1N1B4_126 -0.7 -1.2 Pirin compare
Pf1N1B4_5072 -0.7 -1.8 Glycerol-3-phosphate regulon repressor compare
Pf1N1B4_2005 -0.7 -0.9 ATP-dependent DNA helicase UvrD/PcrA compare
Pf1N1B4_3709 -0.7 -1.7 Adenosylcobinamide-phosphate synthase (EC 6.3.1.10) compare
Pf1N1B4_3145 -0.7 -2.1 Decarboxylase family protein compare
Pf1N1B4_2214 -0.7 -2.0 Transcriptional regulator, GntR family compare
Pf1N1B4_3456 -0.7 -2.2 ATP-binding protein PhnN; Guanylate kinase (EC 2.7.4.8) compare
Pf1N1B4_5018 -0.7 -1.6 FIG00962345: hypothetical protein compare
Pf1N1B4_669 -0.7 -2.0 INTEGRAL MEMBRANE PROTEIN (Rhomboid family) compare
Pf1N1B4_4612 -0.7 -1.1 FIG00954117: hypothetical protein compare
Pf1N1B4_2334 -0.7 -1.2 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB compare
Pf1N1B4_967 -0.7 -1.1 hypothetical protein compare
Pf1N1B4_5311 -0.7 -1.3 hypothetical protein compare
Pf1N1B4_1818 -0.7 -2.9 NAD(P) transhydrogenase alpha subunit (EC 1.6.1.2) compare
Pf1N1B4_6036 -0.7 -1.6 FIG00953132: hypothetical protein compare
Pf1N1B4_3152 -0.7 -2.8 LysR family transcriptional regulator PA3398 compare


Specific Phenotypes

For 3 genes in this experiment

For carbon source Sodium L-Lactate in Pseudomonas fluorescens FW300-N1B4

For carbon source Sodium L-Lactate across organisms