| Pathway | #Steps | #Present | #Specific |
|---|
| pseudouridine degradation | 2 | 2 | 2 |
| acetate and ATP formation from acetyl-CoA III | 1 | 1 | 1 |
| fatty acid β-oxidation III (unsaturated, odd number) | 1 | 1 | 1 |
| acetate conversion to acetyl-CoA | 1 | 1 | 1 |
| fatty acid β-oxidation I (generic) | 7 | 6 | 5 |
| benzoyl-CoA biosynthesis | 3 | 3 | 2 |
| starch degradation IV | 3 | 2 | 2 |
| fatty acid β-oxidation IV (unsaturated, even number) | 5 | 3 | 3 |
| oleate β-oxidation | 35 | 32 | 19 |
| starch degradation III | 4 | 4 | 2 |
| oleate β-oxidation (thioesterase-dependent, yeast) | 2 | 2 | 1 |
| pyruvate fermentation to butanol II (engineered) | 6 | 4 | 3 |
| pyruvate fermentation to hexanol (engineered) | 11 | 8 | 5 |
| adipate degradation | 5 | 5 | 2 |
| adipate biosynthesis | 5 | 4 | 2 |
| fatty acid β-oxidation II (plant peroxisome) | 5 | 3 | 2 |
| glutaryl-CoA degradation | 5 | 3 | 2 |
| fatty acid β-oxidation V (unsaturated, odd number, di-isomerase-dependent) | 5 | 2 | 2 |
| (8E,10E)-dodeca-8,10-dienol biosynthesis | 11 | 5 | 4 |
| 2-methyl-branched fatty acid β-oxidation | 14 | 9 | 5 |
| superpathway of acetate utilization and formation | 3 | 3 | 1 |
| glycine biosynthesis II | 3 | 3 | 1 |
| ethanol degradation II | 3 | 3 | 1 |
| ethanol degradation IV | 3 | 3 | 1 |
| glycine cleavage | 3 | 3 | 1 |
| fatty acid salvage | 6 | 5 | 2 |
| L-isoleucine degradation I | 6 | 4 | 2 |
| propanoate fermentation to 2-methylbutanoate | 6 | 4 | 2 |
| L-isoleucine biosynthesis V | 3 | 2 | 1 |
| ethanol degradation III | 3 | 2 | 1 |
| valproate β-oxidation | 9 | 5 | 3 |
| methyl ketone biosynthesis (engineered) | 6 | 3 | 2 |
| plastoquinol-9 biosynthesis I | 3 | 1 | 1 |
| oleate β-oxidation (reductase-dependent, yeast) | 3 | 1 | 1 |
| pyruvate fermentation to butanoate | 7 | 4 | 2 |
| benzoyl-CoA degradation I (aerobic) | 7 | 3 | 2 |
| fatty acid β-oxidation VI (mammalian peroxisome) | 7 | 3 | 2 |
| D-arabinose degradation II | 4 | 4 | 1 |
| gallate degradation I | 4 | 4 | 1 |
| L-fucose degradation I | 4 | 4 | 1 |
| allantoin degradation to ureidoglycolate II (ammonia producing) | 4 | 4 | 1 |
| chitin deacetylation | 4 | 3 | 1 |
| L-valine degradation I | 8 | 4 | 2 |
| pyruvate fermentation to butanol I | 8 | 4 | 2 |
| oleate β-oxidation (isomerase-dependent, yeast) | 4 | 1 | 1 |
| phenylacetate degradation I (aerobic) | 9 | 9 | 2 |
| superpathway of Clostridium acetobutylicum acidogenic fermentation | 9 | 6 | 2 |
| benzoate biosynthesis I (CoA-dependent, β-oxidative) | 9 | 4 | 2 |
| allantoin degradation to glyoxylate II | 5 | 5 | 1 |
| allantoin degradation to glyoxylate III | 5 | 5 | 1 |
| (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) | 5 | 4 | 1 |
| enterobacterial common antigen biosynthesis | 5 | 4 | 1 |
| L-tyrosine degradation I | 5 | 4 | 1 |
| gallate degradation II | 5 | 4 | 1 |
| 3-phenylpropanoate degradation | 10 | 6 | 2 |
| L-glutamate degradation V (via hydroxyglutarate) | 10 | 6 | 2 |
| lactate biosynthesis (archaea) | 5 | 3 | 1 |
| 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast) | 10 | 4 | 2 |
| benzoate biosynthesis III (CoA-dependent, non-β-oxidative) | 5 | 2 | 1 |
| superpathway of plastoquinol biosynthesis | 5 | 2 | 1 |
| 2-methylcitrate cycle I | 5 | 2 | 1 |
| 4-hydroxybenzoate biosynthesis III (plants) | 5 | 2 | 1 |
| superpathway of phenylethylamine degradation | 11 | 11 | 2 |
| ppGpp metabolism | 6 | 6 | 1 |
| methylgallate degradation | 6 | 4 | 1 |
| L-isoleucine biosynthesis IV | 6 | 4 | 1 |
| L-glutamate degradation VII (to butanoate) | 12 | 7 | 2 |
| nucleoside and nucleotide degradation (halobacteria) | 6 | 3 | 1 |
| 2-methylcitrate cycle II | 6 | 2 | 1 |
| 6-gingerol analog biosynthesis (engineered) | 6 | 2 | 1 |
| superpathway of bitter acids biosynthesis | 18 | 3 | 3 |
| lupulone and humulone biosynthesis | 6 | 1 | 1 |
| colupulone and cohumulone biosynthesis | 6 | 1 | 1 |
| adlupulone and adhumulone biosynthesis | 6 | 1 | 1 |
| β-alanine biosynthesis II | 6 | 1 | 1 |
| superpathway of Clostridium acetobutylicum solventogenic fermentation | 13 | 7 | 2 |
| 1-butanol autotrophic biosynthesis (engineered) | 27 | 19 | 4 |
| superpathway of glyoxylate cycle and fatty acid degradation | 14 | 11 | 2 |
| vitamin E biosynthesis (tocopherols) | 7 | 1 | 1 |
| Spodoptera littoralis pheromone biosynthesis | 22 | 3 | 3 |
| L-tryptophan degradation III (eukaryotic) | 15 | 4 | 2 |
| partial TCA cycle (obligate autotrophs) | 8 | 7 | 1 |
| superpathway of allantoin degradation in plants | 8 | 7 | 1 |
| glycerol degradation to butanol | 16 | 12 | 2 |
| protocatechuate degradation I (meta-cleavage pathway) | 8 | 6 | 1 |
| 2-methylpropene degradation | 8 | 2 | 1 |
| crotonate fermentation (to acetate and cyclohexane carboxylate) | 16 | 3 | 2 |
| superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation | 17 | 9 | 2 |
| benzoate fermentation (to acetate and cyclohexane carboxylate) | 17 | 3 | 2 |
| allantoin degradation IV (anaerobic) | 9 | 8 | 1 |
| TCA cycle VI (Helicobacter) | 9 | 7 | 1 |
| reductive glycine pathway of autotrophic CO2 fixation | 9 | 6 | 1 |
| TCA cycle VII (acetate-producers) | 9 | 6 | 1 |
| 3-hydroxypropanoate/4-hydroxybutanate cycle | 18 | 10 | 2 |
| L-phenylalanine degradation IV (mammalian, via side chain) | 9 | 5 | 1 |
| toluene degradation VI (anaerobic) | 18 | 3 | 2 |
| cis-geranyl-CoA degradation | 9 | 1 | 1 |
| TCA cycle I (prokaryotic) | 10 | 9 | 1 |
| Rubisco shunt | 10 | 9 | 1 |
| superpathway of enterobacterial common antigen biosynthesis | 10 | 9 | 1 |
| superpathway of vanillin and vanillate degradation | 10 | 7 | 1 |
| superpathway of coenzyme A biosynthesis II (plants) | 10 | 5 | 1 |
| methyl tert-butyl ether degradation | 10 | 2 | 1 |
| gallate degradation III (anaerobic) | 11 | 5 | 1 |
| superpathway of glyoxylate bypass and TCA | 12 | 11 | 1 |
| superpathway of fucose and rhamnose degradation | 12 | 11 | 1 |
| syringate degradation | 12 | 6 | 1 |
| 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast) | 12 | 2 | 1 |
| 10-cis-heptadecenoyl-CoA degradation (yeast) | 12 | 2 | 1 |
| androstenedione degradation I (aerobic) | 25 | 7 | 2 |
| Calvin-Benson-Bassham cycle | 13 | 10 | 1 |
| photosynthetic 3-hydroxybutanoate biosynthesis (engineered) | 26 | 19 | 2 |
| platensimycin biosynthesis | 26 | 6 | 2 |
| (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) | 13 | 2 | 1 |
| androstenedione degradation II (anaerobic) | 27 | 4 | 2 |
| peptidoglycan recycling I | 14 | 14 | 1 |
| superpathway of testosterone and androsterone degradation | 28 | 7 | 2 |
| superpathway of cholesterol degradation I (cholesterol oxidase) | 42 | 9 | 3 |
| docosahexaenoate biosynthesis III (6-desaturase, mammals) | 14 | 2 | 1 |
| superpathway of cholesterol degradation II (cholesterol dehydrogenase) | 47 | 9 | 3 |
| oxygenic photosynthesis | 17 | 11 | 1 |
| cholesterol degradation to androstenedione I (cholesterol oxidase) | 17 | 2 | 1 |
| cholesterol degradation to androstenedione II (cholesterol dehydrogenase) | 22 | 2 | 1 |
| superpathway of cholesterol degradation III (oxidase) | 49 | 4 | 2 |
| ethene biosynthesis V (engineered) | 25 | 18 | 1 |
| superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass | 26 | 25 | 1 |
| superpathway of pentose and pentitol degradation | 42 | 21 | 1 |