Experiment set14IT053 for Bacteroides thetaiotaomicron VPI-5482

Compare to:

BHIS with Trimethoprim 15 uM

200 most detrimental genes:

  gene name fitness t score description  
BT1222 +3.3 10.3 6-phosphogluconate dehydrogenase,decarboxylating (NCBI ptt file) compare
BT1220 +3.3 9.7 6-phosphogluconolactonase (NCBI ptt file) compare
BT1747 +2.9 12.8 pyruvate-flavodoxin oxidoreductase (NCBI ptt file) compare
BT4698 +2.8 2.8 conserved hypothetical protein (NCBI ptt file) compare
BT3928 +2.6 13.2 hypothetical protein (NCBI ptt file) compare
BT3253 +2.5 6.8 phosphoribosylamine--glycine ligase (NCBI ptt file) compare
BT4531 +2.4 12.2 conserved hypothetical protein (NCBI ptt file) compare
BT1733 +2.3 12.2 putative phosphoribosylformylglycinamidine synthase (NCBI ptt file) compare
BT4533 +2.3 13.3 conserved hypothetical protein (NCBI ptt file) compare
BT0696 +2.3 8.3 putative membrane protein (NCBI ptt file) compare
BT1576 +2.3 2.4 conserved hypothetical protein, with a conserved domain (NCBI ptt file) compare
BT3980 +2.3 4.0 hypothetical protein (NCBI ptt file) compare
BT1844 +2.1 7.4 transcriptional regulator, putative iron uptake regulation protein (NCBI ptt file) compare
BT4532 +2.1 7.0 hypothetical protein (NCBI ptt file) compare
BT2027 +2.1 3.3 N-acetylmuramoyl-L-alanine amidase (NCBI ptt file) compare
BT0173 +2.1 2.9 conserved hypothetical protein (NCBI ptt file) compare
BT4191 +2.1 15.4 hypothetical protein (NCBI ptt file) compare
BT1221 +2.0 5.3 glucose-6-phosphate 1-dehydrogenase (NCBI ptt file) compare
BT0878 +2.0 2.1 ABC transporter, ATP-binding protein (NCBI ptt file) compare
BT4529 +1.9 4.3 hypothetical protein (NCBI ptt file) compare
BT0911 +1.9 8.3 putative integration host factor IHF alpha subunit (NCBI ptt file) compare
BT0067 +1.9 2.6 hypothetical protein (NCBI ptt file) compare
BT2272 +1.8 4.0 conserved hypothetical protein (NCBI ptt file) compare
BT0582 +1.8 2.2 conserved hypothetical protein (NCBI ptt file) compare
BT4530 +1.8 8.4 ATP-dependent DNA helicase recG (NCBI ptt file) compare
BT2646 +1.8 3.7 conserved hypothetical protein (NCBI ptt file) compare
BT2853 +1.8 2.2 hypothetical protein (NCBI ptt file) compare
BT2417 +1.7 2.1 conserved hypothetical protein (NCBI ptt file) compare
BT1380 +1.6 3.1 imidazole glycerol phosphate synthase subunit hisH (NCBI ptt file) compare
BT2006 +1.5 2.5 hypothetical protein (NCBI ptt file) compare
BT4466 +1.5 2.8 hypothetical protein (NCBI ptt file) compare
BT0674 +1.5 3.3 carboxynorspermidine decarboxylase (NCBI ptt file) compare
BT1195 +1.5 3.2 monofunctional biosynthetic peptidoglycan transglycosylase (NCBI ptt file) compare
BT0892 +1.5 1.7 dihydroorotate dehydrogenase (NCBI ptt file) compare
BT0647 +1.5 3.4 thiamine phosphate pyrophosphorylase (NCBI ptt file) compare
BT0178 +1.5 3.1 hypothetical protein (NCBI ptt file) compare
BT3209 +1.4 5.2 conserved hypothetical protein (NCBI ptt file) compare
BT0187 +1.4 2.2 conserved hypothetical protein (NCBI ptt file) compare
BT0077 +1.4 3.2 conserved hypothetical protein (NCBI ptt file) compare
BT4339 +1.4 2.6 glutamine synthetase (NCBI ptt file) compare
BT4442 +1.4 2.3 hypothetical protein (NCBI ptt file) compare
BT3843 +1.4 3.5 ATP-dependent Clp protease ATP-binding subunit (NCBI ptt file) compare
BT4206 +1.4 2.2 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (NCBI ptt file) compare
BT4503 +1.3 2.3 conserved hypothetical protein (NCBI ptt file) compare
BT4582 +1.3 7.2 amidophosphoribosyltransferase precursor (NCBI ptt file) compare
BT3926 +1.3 3.9 putative peptidase (NCBI ptt file) compare
BT4211 +1.3 4.1 putative phosphoribosylformylglycinamidine cyclo-ligase (NCBI ptt file) compare
BT4569 +1.3 2.8 hypothetical protein (NCBI ptt file) compare
BT3320 +1.2 6.6 dihydrodipicolinate reductase (NCBI ptt file) compare
BT3730 +1.2 1.7 putative regulatory protein (NCBI ptt file) compare
BT2274 +1.2 4.6 hypothetical protein (NCBI ptt file) compare
BT3213 +1.2 2.2 tRNA pseudouridine synthase B (NCBI ptt file) compare
BT1561 +1.2 1.0 hypothetical protein (NCBI ptt file) compare
BT1112 +1.2 1.5 transposase (NCBI ptt file) compare
BT0028 +1.2 2.2 alkaline phosphatase (NCBI ptt file) compare
BT0723 +1.2 1.9 hypothetical protein (NCBI ptt file) compare
BT0313 +1.2 1.6 flavodoxin (NCBI ptt file) compare
BT0777 +1.2 2.1 hypothetical protein (NCBI ptt file) compare
BT1018 +1.1 3.6 polygalacturonase (Pectinase) (NCBI ptt file) compare
BT4453 +1.1 1.4 6-pyruvoyl-tetrahydropterin synthase (NCBI ptt file) compare
BT4068 +1.1 3.9 hypothetical protein (NCBI ptt file) compare
BT1470 +1.1 1.8 putative two-component system sensor histidine kinase (NCBI ptt file) compare
BT3264 +1.1 2.9 conserved hypothetical protein (NCBI ptt file) compare
BT1526 +1.1 2.8 myo-inositol-1-phosphate synthase (NCBI ptt file) compare
BT0314 +1.1 2.2 ribosomal protein L11 methyltransferase (NCBI ptt file) compare
p5482_04 +1.1 7.0 hypothetical protein (NCBI) compare
BT3441 +1.1 2.7 hypothetical protein (NCBI ptt file) compare
BT3840 +1.1 3.3 putative RNA-binding protein rbpA (NCBI ptt file) compare
BT0961 +1.1 2.4 conserved hypothetical protein (NCBI ptt file) compare
BT3925 +1.0 5.0 nucleoside diphosphate kinase (NCBI ptt file) compare
BT0327 +1.0 2.4 glutamine ABC transporter, periplasmic glutamine-binding protein (glnH) (NCBI ptt file) compare
BT4753 +1.0 0.9 hypothetical protein (NCBI ptt file) compare
BT2449 +1.0 1.9 hypothetical protein (NCBI ptt file) compare
BT0619 +1.0 1.4 Na+-transporting NADH:ubiquinone oxidoreductase, Electron transport complex protein rnfD (NCBI ptt file) compare
BT3210 +1.0 2.5 cell division protein FtsX (NCBI ptt file) compare
BT1154 +1.0 1.9 ATP-independent RNA helicase (NCBI ptt file) compare
BT0060 +1.0 2.4 putative polysaccharide export protein (NCBI ptt file) compare
BT0704 +1.0 0.8 phosphoribosylglycinamide formyltransferase 2 (NCBI ptt file) compare
BT4451 +1.0 1.7 putative MTA/SAH nucleosidase (NCBI ptt file) compare
BT0462 +1.0 2.0 putative transcriptional regulator (NCBI ptt file) compare
BT3075 +1.0 5.1 NAD-dependent epimerase/dehydratase family protein (NCBI ptt file) compare
BT3363 +1.0 1.7 lipopolysaccharide core biosynthesis protein LpsA (NCBI ptt file) compare
BT1055 +1.0 2.0 pyruvate formate-lyase activating enzyme (NCBI ptt file) compare
BT0756 +1.0 2.0 iduronate 2-sulfatase precursor (NCBI ptt file) compare
BT1098 +1.0 2.5 methylglyoxal synthase (NCBI ptt file) compare
BT4766 +1.0 3.3 hypothetical protein (NCBI ptt file) compare
BT3218 +1.0 3.4 hypothetical protein (NCBI ptt file) compare
BT1252 +1.0 2.3 hypothetical protein (NCBI ptt file) compare
BT0699 +1.0 1.8 putative sugar transporter (NCBI ptt file) compare
BT0302 +1.0 2.6 hypothetical protein (NCBI ptt file) compare
BT1817 +1.0 2.4 RNA polymerase ECF-type sigma factor (NCBI ptt file) compare
BT0891 +0.9 1.5 dihydroorotate dehydrogenase electron transfer subunit (NCBI ptt file) compare
BT0428 +0.9 4.2 phenylacetate-coenzyme A ligase (NCBI ptt file) compare
BT3250 +0.9 5.9 conserved hypothetical protein (NCBI ptt file) compare
BT0581 +0.9 1.7 putative acetyltransferase, GNAT family (NCBI ptt file) compare
BT3318 +0.9 3.9 signal peptidase I (NCBI ptt file) compare
BT2059 +0.9 0.9 TonB (NCBI ptt file) compare
BT4770 +0.9 3.8 conserved protein found in conjugate transposon (NCBI ptt file) compare
BT0778 +0.9 2.1 conserved hypothetical protein (NCBI ptt file) compare
BT1070 +0.9 2.7 conserved hypothetical protein (NCBI ptt file) compare
BT4098 +0.9 1.2 Trk system K+ uptake protein trkA (NCBI ptt file) compare
BT1981 +0.9 1.7 hypothetical protein (NCBI ptt file) compare
BT4527 +0.9 2.7 hypothetical protein (NCBI ptt file) compare
BT3866 +0.9 6.2 ammonium-dependent carbamoyl phosphate synthetase CarB2 (EC 6.3.4.16) (from data) compare
BT4455 +0.9 1.4 oxidoreductase, putative glycolate oxidase (NCBI ptt file) compare
BT3690 +0.9 2.3 putative membrane protein (NCBI ptt file) compare
BT0395 +0.9 2.0 hypothetical protein (NCBI ptt file) compare
BT4720 +0.9 2.8 putative RNA polymerase ECF-type sigma factor (NCBI ptt file) compare
BT3894 +0.9 2.2 putative methyltransferase (NCBI ptt file) compare
BT0827 +0.9 2.5 hypothetical protein (NCBI ptt file) compare
BT0913 +0.9 2.2 putative Fe-S oxidoreductase (NCBI ptt file) compare
BT0543 +0.9 2.7 glutamine synthetase (NCBI ptt file) compare
BT1148 +0.9 1.5 putative NADH dehydrogenase/NAD(P)H nitroreductase (NCBI ptt file) compare
BT2677 +0.9 2.5 hypothetical protein (NCBI ptt file) compare
BT0635 +0.9 1.3 putative transcriptional regulator (NCBI ptt file) compare
BT1558 +0.9 2.9 hypothetical protein (NCBI ptt file) compare
BT1557 +0.9 1.5 hypothetical protein (NCBI ptt file) compare
BT1843 +0.9 4.2 adenylosuccinate synthetase (NCBI ptt file) compare
BT1835 +0.8 2.5 biotin synthase (NCBI ptt file) compare
BT1367 +0.8 2.0 hydrolase, metal-dependent (NCBI ptt file) compare
BT0940 +0.8 2.6 hypothetical protein (NCBI ptt file) compare
BT4223 +0.8 2.3 hypothetical protein (NCBI ptt file) compare
BT0930 +0.8 1.9 hypothetical protein (NCBI ptt file) compare
BT3361 +0.8 3.4 erythronate-4-phosphate dehydrogenase (NCBI ptt file) compare
BT0427 +0.8 0.7 xanthine phosphoribosyltransferase (NCBI ptt file) compare
BT4351 +0.8 3.5 hypothetical protein (NCBI ptt file) compare
BT1107 +0.8 1.7 ferritin A (NCBI ptt file) compare
BT2471 +0.8 2.3 hypothetical protein (NCBI ptt file) compare
BT0923 +0.8 1.3 putative periplasmic protein (NCBI ptt file) compare
BT1058 +0.8 4.5 two-component system sensor histidine kinase (NCBI ptt file) compare
BT0848 +0.8 1.4 hypothetical protein (NCBI ptt file) compare
BT0016 +0.8 1.6 hypothetical protein (NCBI ptt file) compare
BT4773 +0.8 1.0 conserved protein found in conjugate transposon (NCBI ptt file) compare
BT1496 +0.8 1.6 hemolysin-related protein, containing CBS domain (NCBI ptt file) compare
BT2221 +0.8 3.3 hypothetical protein (NCBI ptt file) compare
BT0352 +0.8 1.4 conserved hypothetical protein (NCBI ptt file) compare
BT2979 +0.8 2.6 conserved hypothetical protein, putative membrane protein (NCBI ptt file) compare
BT1994 +0.8 1.7 hypothetical protein (NCBI ptt file) compare
BT4064 +0.8 2.7 NADH dehydrogenase I, chain H (NCBI ptt file) compare
BT3911 +0.8 2.3 malate dehydrogenase (NCBI ptt file) compare
BT3907 +0.8 2.6 conserved hypothetical protein (NCBI ptt file) compare
BT4063 +0.8 1.9 NADH dehydrogenase I, chain I (NCBI ptt file) compare
BT1217 +0.8 1.7 two-component system response regulator (NCBI ptt file) compare
BT0951 +0.8 1.9 hypothetical protein (NCBI ptt file) compare
BT1203 +0.8 1.6 putative UDP-N-acetylglucosamine 2-epimerase (NCBI ptt file) compare
BT4343 +0.8 3.5 conserved hypothetical protein (NCBI ptt file) compare
BT2046 +0.8 0.9 putative cardiolipin synthetase (NCBI ptt file) compare
BT1388 +0.8 1.5 integral membrane protein (NCBI ptt file) compare
BT0701 +0.8 4.5 hypothetical protein (NCBI ptt file) compare
BT3839 +0.8 1.3 ABC transporter ATP-binding protein (NCBI ptt file) compare
BT0877 +0.8 1.1 ferredoxin domain containing protein (NCBI ptt file) compare
BT2284 +0.8 1.6 hypothetical protein (NCBI ptt file) compare
BT0405 +0.8 0.9 hypothetical protein (NCBI ptt file) compare
BT0024 +0.8 2.3 transposase (NCBI ptt file) compare
BT0736 +0.8 1.7 putative transport protein (NCBI ptt file) compare
BT2206 +0.8 2.4 Zinc ABC transporter, permease (NCBI ptt file) compare
BT1466 +0.8 1.7 ABC transporter ATP-binding protein (NCBI ptt file) compare
BT3737 +0.8 0.7 hypothetical protein (NCBI ptt file) compare
BT2281 +0.8 1.1 hypothetical protein (NCBI ptt file) compare
BT0860 +0.8 1.0 putative ABC transporter ATP-binding protein (NCBI ptt file) compare
BT4454 +0.8 1.9 conserved hypothetical protein (NCBI ptt file) compare
BT4027 +0.8 1.2 hypothetical protein (NCBI ptt file) compare
BT3343 +0.8 2.0 putative phenylacetic acid degradation protein (NCBI ptt file) compare
BT0006 +0.8 2.4 hypothetical protein (NCBI ptt file) compare
BT1979 +0.7 2.3 Meso-diaminopimelate D-dehydrogenase (NCBI ptt file) compare
BT1746 +0.7 0.6 conserved hypothetical protein (NCBI ptt file) compare
BT0897 +0.7 3.3 chaperone protein htpG (heat shock protein htpG) (NCBI ptt file) compare
BT4571 +0.7 1.1 RNA polymerase ECF-type sigma factor (NCBI ptt file) compare
BT0411 +0.7 1.9 CysQ, sulfite synthesis pathway protein (NCBI ptt file) compare
BT0782 +0.7 1.1 hypothetical protein (NCBI ptt file) compare
BT1216 +0.7 2.3 putative two-component system sensor protein, without kinase domain (NCBI ptt file) compare
BT0232 +0.7 2.1 putative protein involved in transposition (NCBI ptt file) compare
BT2598 +0.7 1.9 conserved protein found in conjugate transposon (NCBI ptt file) compare
BT0091 +0.7 1.6 conserved protein found in conjugate transposon (NCBI ptt file) compare
BT2287 +0.7 1.8 conserved protein found in conjugate transposon (NCBI ptt file) compare
BT1740 +0.7 2.0 hypothetical protein (NCBI ptt file) compare
BT0154 +0.7 2.7 putative periplasmic protease (NCBI ptt file) compare
BT1578 +0.7 2.6 putative metal dependent hydrolase (NCBI ptt file) compare
BT3164 +0.7 2.1 quinolinate synthetase A (NCBI ptt file) compare
BT1609 +0.7 1.3 conserved hypothetical protein (NCBI ptt file) compare
BT3438 +0.7 2.1 hypothetical protein (NCBI ptt file) compare
BT1299 +0.7 2.6 V-type ATP synthase subunit A (NCBI ptt file) compare
BT0056 +0.7 2.8 putative glycosyltransferase (NCBI ptt file) compare
BT2189 +0.7 3.2 aminopeptidase (NCBI ptt file) compare
BT1612 +0.7 1.9 hypothetical protein (NCBI ptt file) compare
BT4067 +0.7 2.0 NADH dehydrogenase I, chain A (NCBI ptt file) compare
BT0692 +0.7 1.1 putative calcineurin superfamily phosphohydrolase (NCBI ptt file) compare
BT1276 +0.7 1.5 L-fucose mutarotase FucU (EC 5.1.3.29) (from data) compare
BT0491 +0.7 1.1 conserved hypothetical protein (NCBI ptt file) compare
BT2490 +0.7 1.2 hypothetical protein (NCBI ptt file) compare
BT0733 +0.7 2.4 two-component system sensor histidine kinase (NCBI ptt file) compare
BT3004 +0.7 3.2 conserved hypothetical protein (NCBI ptt file) compare
BT0015 +0.7 1.5 rteB, two-component system response regulator (NCBI ptt file) compare
BT3464 +0.7 2.5 putative peptidase (NCBI ptt file) compare
BT3255 +0.7 2.9 putative N6-adenine-specific DNA methylase (NCBI ptt file) compare
BT4102 +0.7 1.1 putative Sec-independent protein translocase (NCBI ptt file) compare
BT1727 +0.7 2.7 putative transmembrane sensor (NCBI ptt file) compare
BT3719 +0.7 2.1 glutamate 5-kinase (EC 2.7.2.11) (from data) compare
BT2514 +0.7 1.7 hypothetical protein (NCBI ptt file) compare
BT1684 +0.7 2.8 conserved hypothetical protein (NCBI ptt file) compare


Specific Phenotypes

For 8 genes in this experiment

For stress Trimethoprim in Bacteroides thetaiotaomicron VPI-5482

For stress Trimethoprim across organisms