Experiment set13S628 for Methanococcus maripaludis S2

Compare to:

McCas_formate_complete Rifampicin 0.5 mM

200 most detrimental genes:

  gene name fitness t score description  
MMP_RS01370 +3.3 19.5 acetate--CoA ligase family protein compare
MMP_RS04605 +1.7 5.0 cobalt ECF transporter T component CbiQ compare
MMP_RS07415 +1.5 6.6 molybdopterin-guanine dinucleotide biosynthesis protein MobB compare
MMP_RS06485 +1.5 1.5 zinc ribbon domain-containing protein compare
MMP_RS08360 +1.5 2.7 hypothetical protein compare
MMP_RS04695 +1.5 6.7 selenide water dikinase SelD compare
MMP_RS07725 +1.4 3.6 4Fe-4S dicluster domain-containing protein compare
MMP_RS06555 +1.3 3.6 cupin domain-containing protein compare
MMP_RS04620 +1.3 6.5 cobalt transporter CbiM compare
MMP_RS07705 +1.2 4.8 transcriptional regulator compare
MMP_RS02885 +1.1 8.8 molybdopterin biosynthesis protein compare
MMP_RS08335 +1.1 3.3 NADH-quinone oxidoreductase subunit B family protein compare
MMP_RS06590 +1.1 3.6 GNAT family N-acetyltransferase compare
MMP_RS08355 +1.1 5.4 Na(+)/H(+) antiporter subunit B compare
MMP_RS08340 +1.1 2.9 4Fe-4S binding protein compare
MMP_RS08275 +1.1 6.0 hypothetical protein compare
MMP_RS07095 +1.1 2.2 PspC domain-containing protein compare
MMP_RS08365 +1.0 2.7 energy conserving hydrogenase EhbF compare
MMP_RS05950 +1.0 5.9 nickel-dependent hydrogenase large subunit compare
MMP_RS02790 +1.0 1.2 class III signal peptide-containing protein compare
MMP_RS05315 +0.9 1.9 hypothetical protein compare
MMP_RS08345 +0.9 5.3 4Fe-4S binding protein compare
MMP_RS03320 +0.9 1.7 metal-dependent transcriptional regulator compare
MMP_RS02880 +0.9 4.3 AmmeMemoRadiSam system radical SAM enzyme compare
MMP_RS06535 +0.9 3.7 2-oxoacid:acceptor oxidoreductase family protein compare
MMP_RS05460 +0.9 4.9 YcaO-related McrA-glycine thioamidation protein compare
MMP_RS08320 +0.9 3.2 molybdopterin molybdotransferase MoeA compare
MMP_RS00345 +0.9 3.9 DUF2666 domain-containing protein compare
MMP_RS05720 +0.9 2.7 signal recognition particle subunit SRP19/SEC65 family protein compare
MMP_RS04615 +0.9 1.5 PDGLE domain-containing protein compare
MMP_RS07435 +0.9 1.3 GMP synthase subunit A compare
MMP_RS06705 +0.8 2.3 formate/nitrite transporter family protein compare
MMP_RS06545 +0.8 1.9 ferredoxin family protein compare
MMP_RS00395 +0.8 1.4 MGMT family protein compare
MMP_RS01540 +0.8 2.5 DUF504 domain-containing protein compare
MMP_RS05355 +0.8 0.8 hypothetical protein compare
MMP_RS07815 +0.8 0.9 DUF2120 domain-containing protein compare
MMP_RS08090 +0.7 2.9 hypothetical protein compare
MMP_RS06325 +0.7 1.1 hypothetical protein compare
MMP_RS02780 +0.7 4.3 hypothetical protein compare
MMP_RS00125 +0.7 1.0 DUF2798 domain-containing protein compare
MMP_RS00060 +0.7 0.8 3-dehydroquinate synthase II compare
MMP_RS07955 +0.7 2.2 FumA C-terminus/TtdB family hydratase beta subunit compare
MMP_RS06365 +0.7 1.6 hypothetical protein compare
MMP_RS01095 +0.7 2.1 iron ABC transporter permease compare
MMP_RS00945 +0.7 0.9 PadR family transcriptional regulator compare
MMP_RS08315 +0.7 2.6 S-methyl-5-thioribose-1-phosphate isomerase compare
MMP_RS02300 +0.7 2.9 NAD(P)H-dependent oxidoreductase compare
MMP_RS06165 +0.7 3.0 ABC transporter permease compare
MMP_RS04145 +0.7 1.2 hypothetical protein compare
MMP_RS04945 +0.7 2.1 hypothetical protein compare
MMP_RS05365 +0.7 1.7 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH compare
MMP_RS08380 +0.6 3.0 phosphatase PAP2 family protein compare
MMP_RS01470 +0.6 2.0 ATP-binding cassette domain-containing protein compare
MMP_RS02595 +0.6 0.8 putative zinc-binding protein compare
MMP_RS03270 +0.6 2.2 ADP-ribosylglycohydrolase family protein compare
MMP_RS07540 +0.6 1.4 CBS domain-containing protein compare
MMP_RS00960 +0.6 2.8 iron export ABC transporter permease subunit FetB compare
MMP_RS08785 +0.6 0.6 RNA-protein complex protein Nop10 compare
MMP_RS00670 +0.6 2.0 TIM barrel protein compare
MMP_RS08410 +0.6 1.6 DUF169 domain-containing protein compare
MMP_RS02310 +0.6 1.1 RimK-like ATPgrasp N-terminal domain-containing protein compare
MMP_RS02805 +0.6 0.7 HEPN domain-containing protein compare
MMP_RS06480 +0.6 3.1 ABC transporter substrate-binding protein compare
MMP_RS01620 +0.6 2.3 hypothetical protein compare
MMP_RS05675 +0.6 1.2 phosphate ABC transporter ATP-binding protein PstB compare
MMP_RS06575 +0.6 2.5 fluoride efflux transporter CrcB compare
MMP_RS06860 +0.6 1.0 4Fe-4S binding protein compare
MMP_RS07850 +0.5 1.5 prephenate dehydratase compare
MMP_RS06550 +0.5 3.3 AMP-binding protein compare
MMP_RS07960 +0.5 2.9 sugar phosphate isomerase/epimerase compare
MMP_RS03675 +0.5 3.6 RimK family alpha-L-glutamate ligase compare
MMP_RS06515 +0.5 1.3 UPF0489 family protein compare
MMP_RS05955 +0.5 1.0 CoB--CoM heterodisulfide reductase subunit C compare
MMP_RS01525 +0.5 1.0 nucleoside-diphosphate kinase compare
MMP_RS08930 +0.5 0.8 hypothetical protein compare
MMP_RS05790 +0.5 2.6 HDIG domain-containing protein compare
MMP_RS07890 +0.5 1.0 OB-fold nucleic acid binding domain-containing protein compare
MMP_RS01150 +0.5 0.9 aldo/keto reductase compare
MMP_RS01055 +0.5 2.0 hypothetical protein compare
MMP_RS01420 +0.5 1.0 hypothetical protein compare
MMP_RS06170 +0.5 1.5 ABC transporter ATP-binding protein compare
MMP_RS07125 +0.5 1.7 coenzyme F420-reducing hydrogenase FrhD protein compare
MMP_RS03215 +0.5 2.2 MBL fold metallo-hydrolase compare
MMP_RS01435 +0.5 0.9 DMT family transporter compare
MMP_RS07140 +0.5 3.4 TIGR00341 family protein compare
MMP_RS02405 +0.5 2.1 hypothetical protein compare
MMP_RS00795 +0.5 2.4 formate dehydrogenase H subunit alpha selenocysteine-containing compare
MMP_RS00740 +0.5 1.4 cyclase family protein compare
MMP_RS01320 +0.5 1.9 hypothetical protein compare
MMP_RS05450 +0.4 1.1 CoB--CoM heterodisulfide reductase subunit C compare
MMP_RS02385 +0.4 1.9 ATP-binding protein compare
MMP_RS05435 +0.4 2.2 5'/3'-nucleotidase SurE compare
MMP_RS02480 +0.4 1.0 hypothetical protein compare
MMP_RS08690 +0.4 1.8 RNA-guided pseudouridylation complex pseudouridine synthase subunit Cbf5 compare
MMP_RS06570 +0.4 2.1 DUF190 domain-containing protein compare
MMP_RS06540 +0.4 0.8 3-methyl-2-oxobutanoate dehydrogenase subunit VorB compare
MMP_RS02265 +0.4 1.5 nitroreductase family protein compare
MMP_RS08430 +0.4 1.5 HAD family hydrolase compare
MMP_RS05665 +0.4 1.7 phosphate ABC transporter permease subunit PstC compare
MMP_RS01210 +0.4 2.0 sodium:solute symporter compare
MMP_RS07555 +0.4 0.3 monovalent cation/H+ antiporter subunit E compare
MMP_RS08830 +0.4 2.3 GTP-binding protein compare
MMP_RS06225 +0.4 2.5 DNA double-strand break repair nuclease NurA compare
MMP_RS08390 +0.4 1.3 DUF5400 domain-containing protein compare
MMP_RS04105 +0.4 2.1 MarR family transcriptional regulator compare
MMP_RS06715 +0.4 2.7 cache domain-containing protein compare
MMP_RS02960 +0.4 1.8 class I SAM-dependent methyltransferase family protein compare
MMP_RS00975 +0.4 2.6 HD domain-containing protein compare
MMP_RS07120 +0.4 1.9 coenzyme F420 hydrogenase subunit alpha compare
MMP_RS07915 +0.4 1.9 DUF4870 domain-containing protein compare
MMP_RS07720 +0.4 2.7 4Fe-4S binding protein compare
MMP_RS08000 +0.4 2.9 methyl coenzyme M reductase-arginine methyltransferase Mmp10 compare
MMP_RS02290 +0.4 1.4 MBL fold metallo-hydrolase compare
MMP_RS03150 +0.4 2.4 phosphoglycerate mutase compare
MMP_RS08370 +0.4 0.2 cation:proton antiporter subunit C compare
MMP_RS08235 +0.4 1.9 hypothetical protein compare
MMP_RS08670 +0.4 1.3 metallophosphoesterase compare
MMP_RS07335 +0.4 1.3 tRNA (cytidine(56)-2'-O)-methyltransferase compare
MMP_RS04630 +0.4 1.6 3'-5' exonuclease compare
MMP_RS01855 +0.4 2.2 2-hydroxyacyl-CoA dehydratase family protein compare
MMP_RS00450 +0.4 0.7 4Fe-4S binding protein compare
MMP_RS04960 +0.4 2.4 cytochrome c biogenesis CcdA family protein compare
MMP_RS06190 +0.4 1.9 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO compare
MMP_RS00660 +0.4 2.0 alkaline phosphatase family protein compare
MMP_RS08850 +0.4 3.0 hypothetical protein compare
MMP_RS05780 +0.4 2.4 multidrug resistance efflux transporter family protein compare
MMP_RS01190 +0.4 1.5 cadmium-translocating P-type ATPase compare
MMP_RS06990 +0.4 1.2 CatB-related O-acetyltransferase compare
MMP_RS00845 +0.4 2.0 acetate--CoA ligase compare
MMP_RS06385 +0.4 0.9 hypothetical protein compare
MMP_RS00235 +0.4 1.6 HDIG domain-containing protein compare
MMP_RS07910 +0.4 1.2 NAD(P)H-hydrate dehydratase compare
MMP_RS02785 +0.4 1.8 MarR family transcriptional regulator compare
MMP_RS06075 +0.3 1.3 class I SAM-dependent methyltransferase compare
MMP_RS03755 +0.3 2.3 MarR family transcriptional regulator compare
MMP_RS00655 +0.3 0.7 hypothetical protein compare
MMP_RS07970 +0.3 0.8 hypothetical protein compare
MMP_RS06910 +0.3 1.7 RlmF-related methyltransferase compare
MMP_RS08500 +0.3 1.0 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT compare
MMP_RS07895 +0.3 1.1 cytochrome c compare
MMP_RS01460 +0.3 1.4 hypothetical protein compare
MMP_RS03250 +0.3 0.8 MJ1244 family protein compare
MMP_RS08415 +0.3 0.8 radical SAM protein compare
MMP_RS00100 +0.3 2.3 tRNA pseudouridine(13) synthase TruD compare
MMP_RS01130 +0.3 1.3 flavoprotein compare
MMP_RS01160 +0.3 1.2 DMT family transporter compare
MMP_RS00990 +0.3 1.1 hypothetical protein compare
MMP_RS02645 +0.3 1.4 ArsR family transcriptional regulator compare
MMP_RS07130 +0.3 1.5 coenzyme F420 hydrogenase subunit gamma compare
MMP_RS00085 +0.3 1.8 DNA cytosine methyltransferase compare
MMP_RS04310 +0.3 1.2 hypothetical protein compare
MMP_RS03685 +0.3 1.9 Mrp/NBP35 family ATP-binding protein compare
MMP_RS03395 +0.3 0.8 hypothetical protein compare
MMP_RS00530 +0.3 1.2 tRNA pseudouridine(54/55) synthase Pus10 compare
MMP_RS04415 +0.3 1.7 peptide-methionine (S)-S-oxide reductase MsrA compare
MMP_RS08215 +0.3 0.8 DUF483 domain-containing protein compare
MMP_RS06310 +0.3 0.9 NAD(P)/FAD-dependent oxidoreductase compare
MMP_RS01785 +0.3 1.1 hypothetical protein compare
MMP_RS01200 +0.3 1.1 hypothetical protein compare
MMP_RS02725 +0.3 1.3 molybdate ABC transporter permease subunit compare
MMP_RS04055 +0.3 0.5 hypothetical protein compare
MMP_RS03480 +0.3 1.9 SulP family inorganic anion transporter compare
MMP_RS01605 +0.3 1.4 hypothetical protein compare
MMP_RS00105 +0.3 1.3 hypothetical protein compare
MMP_RS06495 +0.3 0.9 YkgJ family cysteine cluster protein compare
MMP_RS01260 +0.3 0.9 HDIG domain-containing protein compare
MMP_RS00565 +0.3 1.3 CBS domain-containing protein compare
MMP_RS07100 +0.3 1.9 hypothetical protein compare
MMP_RS08395 +0.3 1.3 DsrE family protein compare
MMP_RS07770 +0.3 1.1 alanine racemase compare
MMP_RS03770 +0.3 1.5 hydroxylamine reductase compare
MMP_RS06655 +0.3 1.6 glycoside hydrolase family 15 protein compare
MMP_RS05310 +0.3 1.5 hypothetical protein compare
MMP_RS06525 +0.3 0.3 YciI family protein compare
MMP_RS03750 +0.3 1.4 ACT domain-containing protein compare
MMP_RS00760 +0.3 1.1 branched-chain-amino-acid transaminase compare
MMP_RS08685 +0.3 1.7 hypothetical protein compare
MMP_RS06745 +0.3 1.1 DUF2119 domain-containing protein compare
MMP_RS01765 +0.3 1.0 HIT family protein compare
MMP_RS06610 +0.3 0.9 DUF2334 domain-containing protein compare
MMP_RS01745 +0.3 1.0 AMP phosphorylase compare
MMP_RS04735 +0.3 1.4 tautomerase family protein compare
MMP_RS01165 +0.3 0.9 DUF434 domain-containing protein compare
MMP_RS08175 +0.3 0.9 7-cyano-7-deazaguanine synthase compare
MMP_RS08555 +0.3 0.7 hypothetical protein compare
MMP_RS00645 +0.3 1.4 iron ABC transporter permease compare
MMP_RS00940 +0.3 1.4 daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein compare
MMP_RS03100 +0.3 0.9 hypothetical protein compare
MMP_RS07650 +0.3 1.6 TldD/PmbA family protein compare
MMP_RS08700 +0.3 1.5 hypothetical protein compare
MMP_RS03735 +0.3 1.1 indolepyruvate ferredoxin oxidoreductase subunit alpha compare
MMP_RS08845 +0.3 1.1 archaellum operon transcriptional activator EarA family protein compare
MMP_RS03790 +0.3 1.1 hypothetical protein compare
MMP_RS03910 +0.2 0.6 hypothetical protein compare
MMP_RS04510 +0.2 1.3 ABC transporter permease subunit compare
MMP_RS08350 +0.2 0.2 hypothetical protein compare
MMP_RS02735 +0.2 0.8 MBL fold metallo-hydrolase compare
MMP_RS06585 +0.2 0.4 DMT family protein compare
MMP_RS03670 +0.2 0.8 DUF1890 domain-containing protein compare


Specific Phenotypes

None in this experiment

For Methanococcus maripaludis S2 in stress experiments

For stress Rifampicin across organisms