Experiment set13S627 for Methanococcus maripaludis S2

Compare to:

McCas_formate_complete Thioridazine hydrochloride 0.05 mM

200 most important genes:

  gene name fitness t score description  
MMP_RS03640 -4.1 -3.6 archaeal proteasome endopeptidase complex subunit beta compare
MMP_RS02900 -4.0 -0.6 imidazoleglycerol-phosphate dehydratase HisB compare
MMP_RS07380 -3.9 -2.3 transcription elongation factor Spt5 compare
MMP_RS00300 -3.8 -0.6 6 7-dimethyl-8-ribityllumazine synthase compare
MMP_RS06230 -3.7 -2.6 helix-turn-helix domain-containing protein compare
MMP_RS06625 -3.6 -1.7 DNA primase compare
MMP_RS06285 -3.4 -1.9 precorrin-6Y C5 15-methyltransferase (decarboxylating) subunit CbiT compare
MMP_RS01225 -3.4 -4.6 DUF5379 domain-containing protein compare
MMP_RS06885 -3.4 -2.7 50S ribosome-binding GTPase compare
MMP_RS08460 -3.3 -2.8 proteasome-activating nucleotidase compare
MMP_RS01610 -3.2 -2.9 hypothetical protein compare
MMP_RS04890 -3.2 -0.7 adenylyltransferase/cytidyltransferase family protein compare
MMP_RS05515 -3.1 -6.8 cyclic pyranopterin monophosphate synthase MoaC compare
MMP_RS06895 -3.1 -1.4 selenocysteine-specific translation elongation factor compare
MMP_RS06350 -3.0 -6.0 HesA/MoeB/ThiF family protein compare
MMP_RS05265 -2.9 -2.4 2-isopropylmalate synthase compare
MMP_RS01020 -2.9 -0.9 3 4-dihydroxy-2-butanone-4-phosphate synthase compare
MMP_RS00110 -2.9 -3.1 hypothetical protein compare
MMP_RS05550 -2.9 -0.6 cation:proton antiporter compare
MMP_RS07635 -2.8 -5.6 MogA/MoaB family molybdenum cofactor biosynthesis protein compare
MMP_RS01175 -2.8 -3.0 triphosphoribosyl-dephospho-CoA synthase compare
MMP_RS06400 -2.7 -1.2 4Fe-4S binding protein compare
MMP_RS03445 -2.7 -0.9 methanogenesis marker 17 protein compare
MMP_RS03435 -2.6 -1.6 ketol-acid reductoisomerase compare
MMP_RS06110 -2.6 -3.9 ATP-dependent protease LonB compare
MMP_RS03600 -2.6 -1.9 triose-phosphate isomerase compare
MMP_RS07615 -2.5 -7.1 energy-coupling factor ABC transporter permease compare
MMP_RS00695 -2.5 -0.8 biotin--[acetyl-CoA-carboxylase] ligase compare
MMP_RS06120 -2.5 -2.3 UPF0147 family protein compare
MMP_RS01005 -2.4 -1.1 riboflavin synthase compare
MMP_RS08645 -2.4 -7.1 UPF0179 family protein compare
MMP_RS07755 -2.4 -1.2 DUF555 domain-containing protein compare
MMP_RS08820 -2.4 -5.3 hypothetical protein compare
MMP_RS03015 -2.4 -7.7 GTP 3' 8-cyclase MoaA compare
MMP_RS03305 -2.3 -7.7 winged helix-turn-helix domain-containing protein compare
MMP_RS04585 -2.3 -8.7 AIR synthase related protein compare
MMP_RS06700 -2.3 -10.3 hypothetical protein compare
MMP_RS06685 -2.3 -8.9 formate dehydrogenase H subunit alpha selenocysteine-containing compare
MMP_RS07525 -2.3 -7.1 4Fe-4S binding protein compare
MMP_RS07600 -2.3 -1.7 Ni-sirohydrochlorin a c-diamide synthase compare
MMP_RS00305 -2.2 -1.8 phosphoribosyl-ATP diphosphatase compare
MMP_RS01800 -2.2 -3.2 TIGR00303 family protein compare
MMP_RS06355 -2.2 -1.8 molybdenum cofactor biosynthesis protein MoaE compare
MMP_RS06175 -2.2 -5.7 winged helix-turn-helix transcriptional regulator compare
MMP_RS08720 -2.2 -1.3 4Fe-4S binding protein compare
MMP_RS05430 -2.2 -4.3 TIGR00288 family NYN domain-containing protein compare
MMP_RS01700 -2.2 -0.9 dihydroxy-acid dehydratase compare
MMP_RS06340 -2.2 -8.0 phosphoadenosine phosphosulfate reductase family protein compare
MMP_RS09020 -2.1 -1.2 hypothetical protein compare
MMP_RS02165 -2.1 -7.8 tRNA-dihydrouridine synthase compare
MMP_RS07445 -2.1 -6.1 helix-turn-helix domain-containing protein compare
MMP_RS05920 -2.1 -0.4 50S ribosomal protein L37e compare
MMP_RS07620 -2.1 -4.7 energy-coupling factor ABC transporter substrate-binding protein compare
MMP_RS06680 -2.1 -7.9 Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain compare
MMP_RS03555 -2.1 -8.6 transcriptional regulator compare
MMP_RS00685 -2.1 -3.0 2-phospho-L-lactate guanylyltransferase compare
MMP_RS04780 -2.1 -2.5 ribonuclease P compare
MMP_RS03315 -2.1 -0.9 ferrous iron transport protein A compare
MMP_RS03110 -2.1 -5.4 glycosyltransferase family 2 protein compare
MMP_RS04685 -2.1 -2.4 DUF126 domain-containing protein compare
MMP_RS01500 -2.0 -1.4 CBS domain-containing protein compare
MMP_RS06270 -2.0 -5.5 TIGR00300 family protein compare
MMP_RS02175 -2.0 -0.8 DUF1611 domain-containing protein compare
MMP_RS00115 -2.0 -10.3 radical SAM protein compare
MMP_RS02800 -2.0 -7.4 nucleotidyltransferase domain-containing protein compare
MMP_RS07625 -2.0 -3.5 cobalt ECF transporter T component CbiQ compare
MMP_RS02280 -1.9 -0.8 DUF211 domain-containing protein compare
MMP_RS01265 -1.9 -1.9 hypothetical protein compare
MMP_RS07200 -1.9 -5.8 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase compare
MMP_RS03035 -1.9 -2.3 4-hydroxy-tetrahydrodipicolinate synthase compare
MMP_RS01325 -1.9 -1.5 dihydroneopterin aldolase family protein compare
MMP_RS03580 -1.9 -2.5 signal recognition particle-docking protein FtsY compare
MMP_RS01100 -1.9 -1.6 ABC transporter ATP-binding protein compare
MMP_RS06315 -1.8 -0.7 cobalt-precorrin-7 (C(5))-methyltransferase compare
MMP_RS06295 -1.8 -4.8 methanogenesis marker 14 protein compare
MMP_RS06630 -1.8 -0.5 UPF0058 family protein compare
MMP_RS06020 -1.8 -3.3 archaeoflavoprotein AfpA compare
MMP_RS00895 -1.8 -4.1 hypothetical protein compare
MMP_RS02875 -1.8 -7.1 chorismate pyruvate-lyase family protein compare
MMP_RS06345 -1.8 -7.6 formate dehydrogenase accessory sulfurtransferase FdhD compare
MMP_RS05815 -1.8 -1.4 NOL1/NOP2/sun family putative RNA methylase compare
MMP_RS08940 -1.7 -1.2 MetS family NSS transporter small subunit compare
MMP_RS06730 -1.7 -1.7 phosphopantothenate/pantothenate synthetase compare
MMP_RS07425 -1.7 -5.0 GTP-binding protein compare
MMP_RS06975 -1.7 -1.6 sulfide-dependent adenosine diphosphate thiazole synthase compare
MMP_RS01380 -1.7 -4.7 PHP domain-containing protein compare
MMP_RS07730 -1.7 -1.6 pyruvate synthase subunit beta compare
MMP_RS03960 -1.7 -0.8 hypothetical protein compare
MMP_RS03025 -1.7 -4.3 molybdenum cofactor guanylyltransferase compare
MMP_RS06395 -1.6 -3.8 ThiF family adenylyltransferase compare
MMP_RS03475 -1.6 -0.5 hypothetical protein compare
MMP_RS05095 -1.6 -5.3 CO dehydrogenase/acetyl-CoA synthase complex subunit epsilon compare
MMP_RS02340 -1.6 -2.2 DNA-directed RNA polymerase subunit E'' compare
MMP_RS04775 -1.6 -2.6 adenosylhomocysteinase compare
MMP_RS05525 -1.6 -5.5 calcium/sodium antiporter compare
MMP_RS05865 -1.6 -2.8 hypothetical protein compare
MMP_RS01865 -1.6 -1.3 GPR1/FUN34/YaaH family transporter compare
MMP_RS08435 -1.5 -1.7 Era-like GTP-binding protein compare
MMP_RS06770 -1.5 -6.2 DHH family phosphoesterase compare
MMP_RS08570 -1.5 -7.0 coenzyme F420-0:L-glutamate ligase compare
MMP_RS04870 -1.5 -4.2 TIGR02253 family HAD-type hydrolase compare
MMP_RS05425 -1.5 -3.4 monovalent cation/H+ antiporter complex subunit F compare
MMP_RS01250 -1.5 -3.9 tRNA (guanine(26)-N(2))-dimethyltransferase compare
MMP_RS06215 -1.5 -2.4 30S ribosomal protein S6e compare
MMP_RS05930 -1.5 -1.8 3-isopropylmalate dehydratase large subunit compare
MMP_RS00515 -1.5 -0.7 DUF655 domain-containing protein compare
MMP_RS00735 -1.5 -3.7 5 10-methenyltetrahydromethanopterin hydrogenase compare
MMP_RS06105 -1.5 -4.8 hydrogenase maturation peptidase HycI compare
MMP_RS06725 -1.5 -4.7 hypothetical protein compare
MMP_RS00295 -1.5 -1.5 gamma carbonic anhydrase family protein compare
MMP_RS08300 -1.4 -0.9 metal-sulfur cluster assembly factor compare
MMP_RS01980 -1.4 -8.1 trimeric intracellular cation channel family protein compare
MMP_RS08100 -1.4 -4.6 8-amino-7-oxononanoate synthase compare
MMP_RS00810 -1.4 -5.8 topoisomerase DNA-binding C4 zinc finger domain-containing protein compare
MMP_RS02345 -1.4 -2.7 GTP-dependent dephospho-CoA kinase family protein compare
MMP_RS03400 -1.4 -1.8 archease compare
MMP_RS01180 -1.4 -1.1 XTP/dITP diphosphatase compare
MMP_RS01545 -1.4 -0.8 CBS domain-containing protein compare
MMP_RS05075 -1.4 -9.9 acetyl-CoA decarbonylase/synthase complex subunit gamma compare
MMP_RS05080 -1.4 -6.9 acetyl-CoA decarbonylase/synthase complex subunit delta compare
MMP_RS00315 -1.4 -5.5 Nif3-like dinuclear metal center hexameric protein compare
MMP_RS08330 -1.4 -4.9 NADH-quinone oxidoreductase subunit H compare
MMP_RS08350 -1.4 -0.7 hypothetical protein compare
MMP_RS01985 -1.3 -3.7 F420-dependent methylenetetrahydromethanopterin dehydrogenase compare
MMP_RS00130 -1.3 -0.9 nickel-responsive transcriptional regulator NikR compare
MMP_RS05100 -1.3 -10.1 CO dehydrogenase/acetyl-CoA synthase complex subunit alpha compare
MMP_RS08105 -1.3 -4.0 6-carboxyhexanoate--CoA ligase compare
MMP_RS08790 -1.3 -1.9 translation initiation factor IF-2 subunit alpha compare
MMP_RS05090 -1.3 -5.3 CO dehydrogenase/CO-methylating acetyl-CoA synthase complex subunit beta compare
MMP_RS00730 -1.3 -4.7 5 10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdB compare
MMP_RS05845 -1.3 -1.2 tRNA-intron lyase compare
MMP_RS03490 -1.3 -1.3 DUF2115 domain-containing protein compare
MMP_RS08165 -1.3 -1.9 phosphoglycerate dehydrogenase compare
MMP_RS05540 -1.3 -2.3 hypothetical protein compare
MMP_RS08635 -1.3 -1.1 UbiA family prenyltransferase compare
MMP_RS04485 -1.2 -5.2 putative beta-lysine N-acetyltransferase compare
MMP_RS07545 -1.2 -0.6 HTH domain-containing protein compare
MMP_RS00040 -1.2 -4.1 TIGR03576 family pyridoxal phosphate-dependent enzyme compare
MMP_RS06930 -1.2 -6.3 MBL fold metallo-hydrolase compare
MMP_RS00725 -1.2 -3.8 5 10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdC compare
MMP_RS08715 -1.2 -0.8 formylmethanofuran dehydrogenase subunit B compare
MMP_RS01600 -1.2 -1.5 50S ribosomal protein L15e compare
MMP_RS07355 -1.2 -0.6 transcription factor S compare
MMP_RS07630 -1.2 -1.0 ATP-binding cassette domain-containing protein compare
MMP_RS07365 -1.2 -6.0 2-phosphoglycerate kinase compare
MMP_RS03540 -1.2 -3.3 DUF2178 domain-containing protein compare
MMP_RS04850 -1.1 -6.3 UPF0254 family protein compare
MMP_RS08200 -1.1 -7.8 archaeosine synthase subunit alpha compare
MMP_RS08590 -1.1 -2.9 flagellin compare
MMP_RS07575 -1.1 -1.9 RNA ligase partner protein compare
MMP_RS03080 -1.1 -2.1 universal stress protein compare
MMP_RS02235 -1.1 -5.5 CBS domain-containing protein compare
MMP_RS05060 -1.1 -5.3 AAA family ATPase compare
MMP_RS07750 -1.1 -3.0 DUF357 domain-containing protein compare
MMP_RS07195 -1.1 -5.4 M20 family metallo-hydrolase compare
MMP_RS05345 -1.1 -3.5 hypothetical protein compare
MMP_RS01085 -1.1 -1.2 hypothetical protein compare
MMP_RS02410 -1.1 -1.7 ABC transporter substrate-binding protein compare
MMP_RS06200 -1.1 -5.1 M24 family metallopeptidase compare
MMP_RS08745 -1.1 -2.1 CDP-2 3-bis-(O-geranylgeranyl)-sn-glycerol synthase compare
MMP_RS00320 -1.1 -0.9 class I SAM-dependent methyltransferase compare
MMP_RS07605 -1.1 -1.8 diadenylate cyclase compare
MMP_RS07765 -1.0 -4.1 sodium:alanine symporter family protein compare
MMP_RS05285 -1.0 -4.3 MMPL family transporter compare
MMP_RS05085 -1.0 -6.4 AAA family ATPase compare
MMP_RS06370 -1.0 -2.7 biotin synthase BioB compare
MMP_RS05355 -1.0 -0.6 hypothetical protein compare
MMP_RS00185 -1.0 -5.0 potassium channel protein compare
MMP_RS08725 -1.0 -1.1 Ni/Fe hydrogenase subunit alpha compare
MMP_RS06900 -1.0 -1.3 coenzyme F420-reducing hydrogenase FrhD protein compare
MMP_RS00050 -1.0 -4.4 AarF/UbiB family protein compare
MMP_RS03440 -1.0 -0.8 MoaD/ThiS family protein compare
MMP_RS07700 -1.0 -4.2 DUF1188 domain-containing protein compare
MMP_RS02190 -1.0 -1.9 sulfopyruvate decarboxylase subunit alpha compare
MMP_RS00900 -1.0 -1.1 50S ribosomal protein L39e compare
MMP_RS01495 -1.0 -4.7 TraB/GumN family protein compare
MMP_RS05510 -1.0 -2.2 Rrf2 family transcriptional regulator compare
MMP_RS01275 -1.0 -3.0 class III signal peptide-containing protein compare
MMP_RS01220 -1.0 -2.9 hypothetical protein compare
MMP_RS07580 -1.0 -1.8 DUF356 domain-containing protein compare
MMP_RS08650 -0.9 -1.6 glutamine--fructose-6-phosphate transaminase (isomerizing) compare
MMP_RS01365 -0.9 -1.6 archaeal proteasome endopeptidase complex subunit alpha compare
MMP_RS01830 -0.9 -0.8 tRNA-Val compare
MMP_RS05245 -0.9 -5.0 archaeosine biosynthesis radical SAM protein RaSEA compare
MMP_RS05070 -0.9 -2.8 4Fe-4S dicluster domain-containing protein compare
MMP_RS02550 -0.9 -3.0 helix-turn-helix transcriptional regulator compare
MMP_RS02170 -0.9 -2.7 CBS domain-containing protein compare
MMP_RS00915 -0.9 -2.9 DUF116 domain-containing protein compare
MMP_RS05875 -0.9 -1.5 hydroxyethylthiazole kinase compare
MMP_RS01030 -0.9 -1.5 MTAP family purine nucleoside phosphorylase compare
MMP_RS06860 -0.9 -0.8 4Fe-4S binding protein compare
MMP_RS08225 -0.9 -4.1 RimK family alpha-L-glutamate ligase compare
MMP_RS01795 -0.9 -0.6 methanogenesis marker 6 protein compare
MMP_RS04500 -0.9 -5.1 adenosylmethionine--8-amino-7-oxononanoate transaminase compare
MMP_RS05925 -0.9 -1.6 small nuclear ribonucleoprotein compare
MMP_RS08195 -0.9 -4.2 hypothetical protein compare
MMP_RS05800 -0.9 -3.3 B12-binding domain-containing radical SAM protein compare
MMP_RS06760 -0.9 -1.4 hypothetical protein compare
MMP_RS03140 -0.9 -3.9 hypothetical protein compare
MMP_RS07535 -0.9 -4.3 4Fe-4S binding protein compare


Specific Phenotypes

None in this experiment

For Methanococcus maripaludis S2 in stress experiments

For stress Thioridazine hydrochloride across organisms