Experiment set13S586 for Methanococcus maripaludis S2

Compare to:

McCas_formate_complete 5-Fluorouracil 4.16666666666667E-05 mM

200 most important genes:

  gene name fitness t score description  
MMP_RS06355 -5.4 -1.7 molybdenum cofactor biosynthesis protein MoaE compare
MMP_RS03960 -4.8 -0.6 hypothetical protein compare
MMP_RS08210 -4.3 -1.6 phosphatidylglycerophosphatase A compare
MMP_RS08715 -4.0 -1.1 formylmethanofuran dehydrogenase subunit B compare
MMP_RS06350 -3.6 -4.6 HesA/MoeB/ThiF family protein compare
MMP_RS03015 -3.5 -6.2 GTP 3' 8-cyclase MoaA compare
MMP_RS01500 -3.2 -1.2 CBS domain-containing protein compare
MMP_RS05515 -3.1 -5.1 cyclic pyranopterin monophosphate synthase MoaC compare
MMP_RS05920 -3.0 -0.4 50S ribosomal protein L37e compare
MMP_RS08300 -2.9 -0.7 metal-sulfur cluster assembly factor compare
MMP_RS00520 -2.9 -1.4 RNA polymerase Rpb4 family protein compare
MMP_RS06625 -2.9 -1.3 DNA primase compare
MMP_RS08785 -2.9 -0.8 RNA-protein complex protein Nop10 compare
MMP_RS07635 -2.8 -5.0 MogA/MoaB family molybdenum cofactor biosynthesis protein compare
MMP_RS08435 -2.7 -1.6 Era-like GTP-binding protein compare
MMP_RS05845 -2.6 -1.4 tRNA-intron lyase compare
MMP_RS03580 -2.6 -2.3 signal recognition particle-docking protein FtsY compare
MMP_RS07755 -2.6 -0.8 DUF555 domain-containing protein compare
MMP_RS07600 -2.6 -1.6 Ni-sirohydrochlorin a c-diamide synthase compare
MMP_RS08460 -2.6 -2.1 proteasome-activating nucleotidase compare
MMP_RS08720 -2.3 -1.0 4Fe-4S binding protein compare
MMP_RS01380 -2.3 -4.0 PHP domain-containing protein compare
MMP_RS04585 -2.3 -9.4 AIR synthase related protein compare
MMP_RS05930 -2.3 -1.8 3-isopropylmalate dehydratase large subunit compare
MMP_RS04890 -2.3 -0.6 adenylyltransferase/cytidyltransferase family protein compare
MMP_RS05815 -2.2 -1.5 NOL1/NOP2/sun family putative RNA methylase compare
MMP_RS06630 -2.1 -0.4 UPF0058 family protein compare
MMP_RS02240 -2.1 -1.8 methanogenesis marker 7 protein compare
MMP_RS03025 -2.1 -3.6 molybdenum cofactor guanylyltransferase compare
MMP_RS04090 -2.1 -2.2 hypothetical protein compare
MMP_RS07605 -2.1 -2.2 diadenylate cyclase compare
MMP_RS03400 -2.0 -1.6 archease compare
MMP_RS00895 -2.0 -2.2 hypothetical protein compare
MMP_RS01180 -2.0 -1.3 XTP/dITP diphosphatase compare
MMP_RS01755 -2.0 -0.7 DUF2097 domain-containing protein compare
MMP_RS07425 -1.9 -4.7 GTP-binding protein compare
MMP_RS05265 -1.9 -1.4 2-isopropylmalate synthase compare
MMP_RS03035 -1.9 -2.7 4-hydroxy-tetrahydrodipicolinate synthase compare
MMP_RS06400 -1.9 -0.8 4Fe-4S binding protein compare
MMP_RS01610 -1.9 -2.0 hypothetical protein compare
MMP_RS05245 -1.9 -7.7 archaeosine biosynthesis radical SAM protein RaSEA compare
MMP_RS06485 -1.8 -0.6 zinc ribbon domain-containing protein compare
MMP_RS01175 -1.8 -1.5 triphosphoribosyl-dephospho-CoA synthase compare
MMP_RS08645 -1.8 -6.2 UPF0179 family protein compare
MMP_RS08650 -1.8 -2.3 glutamine--fructose-6-phosphate transaminase (isomerizing) compare
MMP_RS04780 -1.8 -1.8 ribonuclease P compare
MMP_RS07200 -1.7 -5.1 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase compare
MMP_RS01005 -1.7 -0.7 riboflavin synthase compare
MMP_RS01020 -1.7 -0.6 3 4-dihydroxy-2-butanone-4-phosphate synthase compare
MMP_RS08820 -1.7 -4.3 hypothetical protein compare
MMP_RS02875 -1.7 -6.4 chorismate pyruvate-lyase family protein compare
MMP_RS04485 -1.7 -6.7 putative beta-lysine N-acetyltransferase compare
MMP_RS00695 -1.7 -0.5 biotin--[acetyl-CoA-carboxylase] ligase compare
MMP_RS07615 -1.6 -5.5 energy-coupling factor ABC transporter permease compare
MMP_RS03600 -1.6 -1.3 triose-phosphate isomerase compare
MMP_RS05430 -1.6 -4.1 TIGR00288 family NYN domain-containing protein compare
MMP_RS00110 -1.6 -1.7 hypothetical protein compare
MMP_RS06020 -1.6 -2.7 archaeoflavoprotein AfpA compare
MMP_RS08370 -1.6 -0.4 cation:proton antiporter subunit C compare
MMP_RS02280 -1.6 -0.6 DUF211 domain-containing protein compare
MMP_RS03205 -1.6 -0.8 peptidyl-tRNA hydrolase Pth2 compare
MMP_RS07845 -1.6 -1.0 LL-diaminopimelate aminotransferase compare
MMP_RS06840 -1.5 -0.6 DNA-directed RNA polymerase subunit N compare
MMP_RS00515 -1.5 -0.6 DUF655 domain-containing protein compare
MMP_RS02900 -1.5 -0.4 imidazoleglycerol-phosphate dehydratase HisB compare
MMP_RS07545 -1.5 -0.5 HTH domain-containing protein compare
MMP_RS07090 -1.5 -5.8 tRNA (adenine-N1)-methyltransferase compare
MMP_RS01720 -1.5 -1.3 replication factor C large subunit compare
MMP_RS00115 -1.5 -7.5 radical SAM protein compare
MMP_RS02020 -1.4 -3.1 gamma-glutamylcyclotransferase compare
MMP_RS00900 -1.4 -1.2 50S ribosomal protein L39e compare
MMP_RS07625 -1.4 -1.9 cobalt ECF transporter T component CbiQ compare
MMP_RS01800 -1.4 -2.1 TIGR00303 family protein compare
MMP_RS08165 -1.4 -1.5 phosphoglycerate dehydrogenase compare
MMP_RS06885 -1.4 -1.3 50S ribosome-binding GTPase compare
MMP_RS08350 -1.4 -0.6 hypothetical protein compare
MMP_RS01325 -1.3 -1.0 dihydroneopterin aldolase family protein compare
MMP_RS01225 -1.3 -2.7 DUF5379 domain-containing protein compare
MMP_RS04740 -1.3 -2.5 DUF473 domain-containing protein compare
MMP_RS02145 -1.3 -4.4 winged helix-turn-helix transcriptional regulator compare
MMP_RS01620 -1.3 -2.0 hypothetical protein compare
MMP_RS02800 -1.3 -3.7 nucleotidyltransferase domain-containing protein compare
MMP_RS06475 -1.3 -2.7 FAD-dependent oxidoreductase compare
MMP_RS08745 -1.3 -2.6 CDP-2 3-bis-(O-geranylgeranyl)-sn-glycerol synthase compare
MMP_RS01365 -1.3 -2.2 archaeal proteasome endopeptidase complex subunit alpha compare
MMP_RS08600 -1.3 -1.6 flagellar protein D compare
MMP_RS03095 -1.3 -3.0 diphthine synthase compare
MMP_RS03550 -1.3 -1.4 DUF2124 domain-containing protein compare
MMP_RS00535 -1.3 -1.8 TIGR00375 family protein compare
MMP_RS01840 -1.3 -4.2 TIGR00289 family protein compare
MMP_RS01265 -1.3 -1.7 hypothetical protein compare
MMP_RS03140 -1.3 -4.6 hypothetical protein compare
MMP_RS00735 -1.2 -2.8 5 10-methenyltetrahydromethanopterin hydrogenase compare
MMP_RS07750 -1.2 -2.7 DUF357 domain-containing protein compare
MMP_RS06345 -1.2 -3.7 formate dehydrogenase accessory sulfurtransferase FdhD compare
MMP_RS06685 -1.2 -4.2 formate dehydrogenase H subunit alpha selenocysteine-containing compare
MMP_RS03210 -1.2 -6.3 tRNA guanosine(15) transglycosylase TgtA compare
MMP_RS03145 -1.2 -3.7 fibrillarin-like rRNA/tRNA 2'-O-methyltransferase compare
MMP_RS07620 -1.2 -2.8 energy-coupling factor ABC transporter substrate-binding protein compare
MMP_RS04480 -1.1 -6.6 lysine 2 3-aminomutase compare
MMP_RS01725 -1.1 -2.2 class I SAM-dependent methyltransferase family protein compare
MMP_RS00810 -1.1 -4.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein compare
MMP_RS03220 -1.1 -1.6 RNA 2' 3'-cyclic phosphodiesterase compare
MMP_RS06120 -1.1 -1.1 UPF0147 family protein compare
MMP_RS05985 -1.1 -1.7 hypothetical protein compare
MMP_RS07700 -1.1 -4.7 DUF1188 domain-containing protein compare
MMP_RS05510 -1.1 -2.9 Rrf2 family transcriptional regulator compare
MMP_RS00320 -1.1 -0.9 class I SAM-dependent methyltransferase compare
MMP_RS05560 -1.1 -3.2 deoxyuridine 5'-triphosphate nucleotidohydrolase compare
MMP_RS06680 -1.1 -3.9 Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain compare
MMP_RS06230 -1.1 -1.3 helix-turn-helix domain-containing protein compare
MMP_RS01240 -1.0 -1.0 7-cyano-7-deazaguanine synthase QueC compare
MMP_RS06980 -1.0 -3.2 tRNA 2-thiocytidine biosynthesis TtcA family protein compare
MMP_RS01700 -1.0 -0.4 dihydroxy-acid dehydratase compare
MMP_RS00315 -1.0 -2.4 Nif3-like dinuclear metal center hexameric protein compare
MMP_RS01335 -1.0 -1.2 prefoldin subunit beta compare
MMP_RS07525 -1.0 -3.7 4Fe-4S binding protein compare
MMP_RS06290 -1.0 -1.6 DNA repair and recombination protein RadA compare
MMP_RS00850 -1.0 -1.9 TIGR01177 family methyltransferase compare
MMP_RS08940 -1.0 -0.6 MetS family NSS transporter small subunit compare
MMP_RS01960 -1.0 -0.4 hypothetical protein compare
MMP_RS03300 -1.0 -0.3 TOBE domain-containing protein compare
MMP_RS06725 -1.0 -4.2 hypothetical protein compare
MMP_RS03755 -1.0 -4.1 MarR family transcriptional regulator compare
MMP_RS08290 -0.9 -3.3 DNA-binding protein Alba compare
MMP_RS02235 -0.9 -3.0 CBS domain-containing protein compare
MMP_RS05910 -0.9 -1.9 cell division ATPase MinD compare
MMP_RS01075 -0.9 -0.9 hypothetical protein compare
MMP_RS06395 -0.9 -1.9 ThiF family adenylyltransferase compare
MMP_RS00730 -0.9 -3.2 5 10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdB compare
MMP_RS02740 -0.9 -1.8 hypothetical protein compare
MMP_RS03440 -0.9 -0.6 MoaD/ThiS family protein compare
MMP_RS01250 -0.9 -2.9 tRNA (guanine(26)-N(2))-dimethyltransferase compare
MMP_RS07775 -0.9 -2.6 alanine dehydrogenase compare
MMP_RS06015 -0.9 -2.6 flavodoxin family protein compare
MMP_RS06295 -0.9 -2.2 methanogenesis marker 14 protein compare
MMP_RS05875 -0.9 -2.2 hydroxyethylthiazole kinase compare
MMP_RS08200 -0.9 -5.0 archaeosine synthase subunit alpha compare
MMP_RS04775 -0.9 -1.1 adenosylhomocysteinase compare
MMP_RS00455 -0.9 -2.7 orotate phosphoribosyltransferase-like protein compare
MMP_RS06675 -0.9 -3.2 ADP-specific phosphofructokinase compare
MMP_RS07685 -0.8 -3.8 TIGR01212 family radical SAM protein compare
MMP_RS01445 -0.8 -2.8 hypothetical protein compare
MMP_RS06600 -0.8 -0.5 class III signal peptide-containing protein compare
MMP_RS08240 -0.8 -2.1 methanogenesis marker 16 metalloprotein compare
MMP_RS07765 -0.8 -2.7 sodium:alanine symporter family protein compare
MMP_RS00555 -0.8 -3.0 MFS transporter compare
MMP_RS00050 -0.8 -2.9 AarF/UbiB family protein compare
MMP_RS07445 -0.8 -2.6 helix-turn-helix domain-containing protein compare
MMP_RS07580 -0.8 -1.1 DUF356 domain-containing protein compare
MMP_RS07880 -0.8 -2.4 AAA family ATPase compare
MMP_RS08615 -0.8 -0.8 flagellar protein G compare
MMP_RS01830 -0.8 -0.5 tRNA-Val compare
MMP_RS00305 -0.8 -0.7 phosphoribosyl-ATP diphosphatase compare
MMP_RS00905 -0.8 -2.0 phenylacetate--CoA ligase compare
MMP_RS08260 -0.8 -2.4 DUF99 family protein compare
MMP_RS04850 -0.8 -4.4 UPF0254 family protein compare
MMP_RS01790 -0.8 -3.5 restriction endonuclease compare
MMP_RS02635 -0.8 -2.8 class I SAM-dependent methyltransferase compare
MMP_RS08570 -0.8 -2.8 coenzyme F420-0:L-glutamate ligase compare
MMP_RS05865 -0.8 -1.5 hypothetical protein compare
MMP_RS05540 -0.8 -1.6 hypothetical protein compare
MMP_RS02940 -0.8 -3.6 TatD family hydrolase compare
MMP_RS02195 -0.8 -1.2 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase compare
MMP_RS06915 -0.8 -2.8 metallophosphoesterase compare
MMP_RS01675 -0.8 -0.7 hypothetical protein compare
MMP_RS00880 -0.7 -1.3 ribosome assembly RNA-binding protein YhbY compare
MMP_RS01660 -0.7 -1.1 hypothetical protein compare
MMP_RS02695 -0.7 -2.0 formylmethanofuran dehydrogenase subunit A compare
MMP_RS00130 -0.7 -0.4 nickel-responsive transcriptional regulator NikR compare
MMP_RS05800 -0.7 -2.2 B12-binding domain-containing radical SAM protein compare
MMP_RS02610 -0.7 -1.7 DUF2162 domain-containing protein compare
MMP_RS01600 -0.7 -1.0 50S ribosomal protein L15e compare
MMP_RS06315 -0.7 -0.3 cobalt-precorrin-7 (C(5))-methyltransferase compare
MMP_RS07115 -0.7 -1.6 MBL fold metallo-hydrolase compare
MMP_RS08105 -0.7 -2.2 6-carboxyhexanoate--CoA ligase compare
MMP_RS04900 -0.7 -5.0 hypothetical protein compare
MMP_RS06270 -0.7 -1.6 TIGR00300 family protein compare
MMP_RS06460 -0.7 -1.2 pyrimidine dimer DNA glycosylase/endonuclease V compare
MMP_RS08690 -0.7 -2.7 RNA-guided pseudouridylation complex pseudouridine synthase subunit Cbf5 compare
MMP_RS08090 -0.7 -1.3 hypothetical protein compare
MMP_RS07840 -0.7 -0.6 ribonuclease III compare
MMP_RS06920 -0.7 -3.1 AAA family ATPase compare
MMP_RS05795 -0.7 -1.5 redox-regulated ATPase YchF compare
MMP_RS00540 -0.7 -1.8 PLP-dependent aminotransferase family protein compare
MMP_RS03700 -0.7 -2.5 sodium:proton antiporter compare
MMP_RS02840 -0.7 -2.0 DUF123 domain-containing protein compare
MMP_RS01665 -0.7 -1.5 DUF2111 domain-containing protein compare
MMP_RS02025 -0.7 -2.6 DNA-directed DNA polymerase compare
MMP_RS06055 -0.7 -1.8 peroxiredoxin compare
MMP_RS07195 -0.6 -2.5 M20 family metallo-hydrolase compare
MMP_RS04685 -0.6 -1.0 DUF126 domain-containing protein compare
MMP_RS01575 -0.6 -1.3 aldolase compare
MMP_RS02930 -0.6 -1.0 class I SAM-dependent methyltransferase compare
MMP_RS02245 -0.6 -1.1 hypothetical protein compare
MMP_RS03490 -0.6 -0.6 DUF2115 domain-containing protein compare
MMP_RS03845 -0.6 -2.6 DNA adenine methylase compare
MMP_RS01220 -0.6 -2.0 hypothetical protein compare
MMP_RS03230 -0.6 -1.3 flavodoxin family protein compare
MMP_RS01980 -0.6 -2.7 trimeric intracellular cation channel family protein compare


Specific Phenotypes

For 2 genes in this experiment

For stress 5-fluorouracil in Methanococcus maripaludis S2

For stress 5-fluorouracil across organisms