| Pathway | #Steps | #Present | #Specific |
|---|
| L-arginine degradation II (AST pathway) | 5 | 5 | 5 |
| L-serine degradation | 3 | 3 | 3 |
| L-glutamate biosynthesis I | 2 | 2 | 2 |
| L-threonine degradation II | 2 | 2 | 2 |
| acetate and ATP formation from acetyl-CoA III | 1 | 1 | 1 |
| long-chain fatty acid activation | 1 | 1 | 1 |
| L-asparagine degradation I | 1 | 1 | 1 |
| L-glutamine degradation II | 1 | 1 | 1 |
| L-glutamine degradation I | 1 | 1 | 1 |
| acetate conversion to acetyl-CoA | 1 | 1 | 1 |
| adenosine nucleotides degradation III | 1 | 1 | 1 |
| D-gluconate degradation | 1 | 1 | 1 |
| ethanol degradation II | 3 | 3 | 2 |
| glycine degradation | 3 | 3 | 2 |
| pentose phosphate pathway (partial) | 3 | 3 | 2 |
| glycerol degradation I | 3 | 3 | 2 |
| glycine cleavage | 3 | 3 | 2 |
| glycine biosynthesis II | 3 | 3 | 2 |
| ethanol degradation IV | 3 | 3 | 2 |
| L-homoserine biosynthesis | 3 | 3 | 2 |
| D-serine degradation | 3 | 3 | 2 |
| ammonia assimilation cycle III | 3 | 3 | 2 |
| L-threonine degradation III (to methylglyoxal) | 3 | 2 | 2 |
| ethanol degradation III | 3 | 2 | 2 |
| L-tryptophan degradation II (via pyruvate) | 3 | 2 | 2 |
| L-cysteine degradation II | 3 | 2 | 2 |
| neolinustatin bioactivation | 3 | 2 | 2 |
| glycerol and glycerophosphodiester degradation | 4 | 4 | 2 |
| siroheme biosynthesis | 4 | 4 | 2 |
| L-alanine degradation I | 2 | 2 | 1 |
| glutathione degradation (DUG pathway) | 2 | 2 | 1 |
| trehalose degradation VI (periplasmic) | 2 | 2 | 1 |
| arsenate detoxification III | 2 | 2 | 1 |
| ethylene glycol degradation | 2 | 2 | 1 |
| trehalose degradation II (cytosolic) | 2 | 2 | 1 |
| phytol degradation | 4 | 3 | 2 |
| 3-methyl-branched fatty acid α-oxidation | 6 | 3 | 3 |
| aminopropanol phosphate biosynthesis II | 4 | 2 | 2 |
| linustatin bioactivation | 4 | 2 | 2 |
| putrescine degradation I | 2 | 1 | 1 |
| linamarin degradation | 2 | 1 | 1 |
| proline to cytochrome bo oxidase electron transfer | 2 | 1 | 1 |
| γ-linolenate biosynthesis II (animals) | 2 | 1 | 1 |
| phenylethanol degradation | 2 | 1 | 1 |
| phenylethylamine degradation I | 2 | 1 | 1 |
| lotaustralin degradation | 2 | 1 | 1 |
| linoleate biosynthesis II (animals) | 2 | 1 | 1 |
| phenylethylamine degradation II | 2 | 1 | 1 |
| putrescine degradation V | 2 | 1 | 1 |
| glycine betaine degradation III | 7 | 4 | 3 |
| L-histidine degradation II | 5 | 5 | 2 |
| pentose phosphate pathway (non-oxidative branch) I | 5 | 5 | 2 |
| sphingosine and sphingosine-1-phosphate metabolism | 10 | 4 | 4 |
| felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis | 5 | 2 | 2 |
| octane oxidation | 5 | 2 | 2 |
| glycogen degradation I | 8 | 8 | 3 |
| glycine betaine degradation I | 8 | 4 | 3 |
| superpathway of L-threonine biosynthesis | 6 | 6 | 2 |
| 2-deoxy-α-D-ribose 1-phosphate degradation | 3 | 3 | 1 |
| superpathway of acetate utilization and formation | 3 | 3 | 1 |
| L-methionine biosynthesis II | 6 | 5 | 2 |
| pentose phosphate pathway (non-oxidative branch) II | 6 | 5 | 2 |
| glycogen degradation II | 6 | 5 | 2 |
| cellulose degradation II (fungi) | 3 | 2 | 1 |
| D-apiose degradation I | 3 | 2 | 1 |
| putrescine degradation IV | 3 | 2 | 1 |
| L-asparagine degradation III (mammalian) | 3 | 2 | 1 |
| L-idonate degradation | 3 | 2 | 1 |
| L-proline degradation I | 3 | 2 | 1 |
| sorbitol biosynthesis II | 3 | 2 | 1 |
| L-phenylalanine degradation II (anaerobic) | 3 | 2 | 1 |
| L-isoleucine biosynthesis V | 3 | 2 | 1 |
| hypotaurine degradation | 3 | 2 | 1 |
| glutathione-peroxide redox reactions | 3 | 2 | 1 |
| styrene degradation | 3 | 1 | 1 |
| L-arginine degradation I (arginase pathway) | 3 | 1 | 1 |
| alkane biosynthesis II | 3 | 1 | 1 |
| histamine degradation | 3 | 1 | 1 |
| oleate biosynthesis I (plants) | 3 | 1 | 1 |
| Rubisco shunt | 10 | 9 | 3 |
| L-glutamate and L-glutamine biosynthesis | 7 | 6 | 2 |
| factor 430 biosynthesis | 7 | 3 | 2 |
| ceramide degradation by α-oxidation | 7 | 2 | 2 |
| superpathway of L-lysine, L-threonine and L-methionine biosynthesis II | 15 | 13 | 4 |
| superpathway of L-homoserine and L-methionine biosynthesis | 8 | 8 | 2 |
| pentose phosphate pathway | 8 | 8 | 2 |
| muropeptide degradation | 4 | 4 | 1 |
| queuosine biosynthesis I (de novo) | 4 | 4 | 1 |
| L-histidine degradation I | 4 | 4 | 1 |
| superpathway of L-aspartate and L-asparagine biosynthesis | 4 | 4 | 1 |
| dTDP-N-acetylthomosamine biosynthesis | 4 | 4 | 1 |
| glutaminyl-tRNAgln biosynthesis via transamidation | 4 | 3 | 1 |
| starch degradation V | 4 | 3 | 1 |
| arsenic detoxification (bacteria) | 4 | 3 | 1 |
| L-asparagine biosynthesis III (tRNA-dependent) | 4 | 3 | 1 |
| dipicolinate biosynthesis | 4 | 3 | 1 |
| chitin deacetylation | 4 | 3 | 1 |
| L-mimosine degradation | 8 | 4 | 2 |
| dTDP-β-D-fucofuranose biosynthesis | 4 | 2 | 1 |
| dTDP-N-acetylviosamine biosynthesis | 4 | 2 | 1 |
| dTDP-6-deoxy-α-D-allose biosynthesis | 4 | 2 | 1 |
| spermidine biosynthesis II | 4 | 2 | 1 |
| phosphatidylcholine acyl editing | 4 | 2 | 1 |
| L-methionine biosynthesis IV | 4 | 2 | 1 |
| long chain fatty acid ester synthesis (engineered) | 4 | 2 | 1 |
| fatty acid α-oxidation I (plants) | 4 | 2 | 1 |
| putrescine degradation III | 4 | 2 | 1 |
| starch degradation III | 4 | 2 | 1 |
| glutathione-mediated detoxification I | 8 | 3 | 2 |
| ceramide and sphingolipid recycling and degradation (yeast) | 16 | 4 | 4 |
| D-arabinose degradation II | 4 | 1 | 1 |
| L-tryptophan degradation X (mammalian, via tryptamine) | 4 | 1 | 1 |
| NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane) | 4 | 1 | 1 |
| wax esters biosynthesis II | 4 | 1 | 1 |
| photosynthesis light reactions | 4 | 1 | 1 |
| ethene biosynthesis II (microbes) | 4 | 1 | 1 |
| superpathway of S-adenosyl-L-methionine biosynthesis | 9 | 9 | 2 |
| superpathway of L-methionine biosynthesis (transsulfuration) | 9 | 9 | 2 |
| formaldehyde assimilation II (assimilatory RuMP Cycle) | 9 | 8 | 2 |
| Entner-Doudoroff pathway II (non-phosphorylative) | 9 | 6 | 2 |
| reductive glycine pathway of autotrophic CO2 fixation | 9 | 5 | 2 |
| sporopollenin precursors biosynthesis | 18 | 5 | 4 |
| peptidoglycan recycling I | 14 | 14 | 3 |
| tRNA processing | 10 | 10 | 2 |
| L-ornithine biosynthesis I | 5 | 5 | 1 |
| superpathway of enterobacterial common antigen biosynthesis | 10 | 8 | 2 |
| peptidoglycan recycling II | 10 | 7 | 2 |
| enterobacterial common antigen biosynthesis | 5 | 3 | 1 |
| queuosine biosynthesis III (queuosine salvage) | 5 | 3 | 1 |
| dTDP-β-L-rhamnose biosynthesis | 5 | 3 | 1 |
| mitochondrial NADPH production (yeast) | 5 | 3 | 1 |
| ectoine biosynthesis | 5 | 3 | 1 |
| dTDP-α-D-mycaminose biosynthesis | 5 | 2 | 1 |
| N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation | 5 | 2 | 1 |
| L-ascorbate degradation I (bacterial, anaerobic) | 5 | 2 | 1 |
| coumarin biosynthesis (via 2-coumarate) | 5 | 2 | 1 |
| 2-methylcitrate cycle I | 5 | 2 | 1 |
| dTDP-3-acetamido-α-D-fucose biosynthesis | 5 | 2 | 1 |
| dTDP-3-acetamido-3,6-dideoxy-α-D-glucose biosynthesis | 5 | 2 | 1 |
| dTDP-4-O-demethyl-β-L-noviose biosynthesis | 5 | 2 | 1 |
| dopamine degradation | 5 | 1 | 1 |
| 1-butanol autotrophic biosynthesis (engineered) | 27 | 19 | 5 |
| superpathway of glucose and xylose degradation | 17 | 16 | 3 |
| oxygenic photosynthesis | 17 | 11 | 3 |
| purine ribonucleosides degradation | 6 | 6 | 1 |
| superpathway of pyrimidine deoxyribonucleosides degradation | 6 | 6 | 1 |
| formaldehyde assimilation III (dihydroxyacetone cycle) | 12 | 11 | 2 |
| superpathway of L-threonine metabolism | 18 | 15 | 3 |
| superpathway of L-methionine biosynthesis (by sulfhydrylation) | 12 | 10 | 2 |
| γ-glutamyl cycle | 6 | 5 | 1 |
| stearate biosynthesis II (bacteria and plants) | 6 | 5 | 1 |
| TCA cycle VIII (Chlamydia) | 6 | 5 | 1 |
| norspermidine biosynthesis | 6 | 4 | 1 |
| pyruvate fermentation to butanol II (engineered) | 6 | 4 | 1 |
| fatty acid salvage | 6 | 4 | 1 |
| L-isoleucine biosynthesis IV | 6 | 4 | 1 |
| L-histidine degradation III | 6 | 4 | 1 |
| arsenate detoxification I | 6 | 4 | 1 |
| arsenic detoxification (plants) | 6 | 4 | 1 |
| stearate biosynthesis IV | 6 | 4 | 1 |
| 2-methylcitrate cycle II | 6 | 2 | 1 |
| 6-gingerol analog biosynthesis (engineered) | 6 | 2 | 1 |
| dTDP-α-D-ravidosamine and dTDP-4-acetyl-α-D-ravidosamine biosynthesis | 6 | 2 | 1 |
| dTDP-D-desosamine biosynthesis | 6 | 2 | 1 |
| superpathway of photosynthetic hydrogen production | 6 | 2 | 1 |
| dTDP-L-daunosamine biosynthesis | 6 | 2 | 1 |
| dTDP-sibirosamine biosynthesis | 6 | 2 | 1 |
| superpathway of bitter acids biosynthesis | 18 | 3 | 3 |
| adlupulone and adhumulone biosynthesis | 6 | 1 | 1 |
| colupulone and cohumulone biosynthesis | 6 | 1 | 1 |
| β-alanine biosynthesis II | 6 | 1 | 1 |
| α-tomatine degradation | 6 | 1 | 1 |
| lupulone and humulone biosynthesis | 6 | 1 | 1 |
| alkane oxidation | 6 | 1 | 1 |
| stearate biosynthesis I (animals) | 6 | 1 | 1 |
| superpathway of L-isoleucine biosynthesis I | 13 | 13 | 2 |
| Calvin-Benson-Bassham cycle | 13 | 10 | 2 |
| photosynthetic 3-hydroxybutanoate biosynthesis (engineered) | 26 | 19 | 4 |
| noradrenaline and adrenaline degradation | 13 | 4 | 2 |
| cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) | 13 | 2 | 2 |
| superpathway of purine deoxyribonucleosides degradation | 7 | 7 | 1 |
| pyridoxal 5'-phosphate biosynthesis I | 7 | 7 | 1 |
| L-lysine biosynthesis III | 7 | 6 | 1 |
| superpathway of glycol metabolism and degradation | 7 | 6 | 1 |
| fatty acid β-oxidation I (generic) | 7 | 6 | 1 |
| L-lysine biosynthesis VI | 7 | 6 | 1 |
| anaerobic energy metabolism (invertebrates, cytosol) | 7 | 5 | 1 |
| dTDP-β-L-olivose biosynthesis | 7 | 3 | 1 |
| dTDP-β-L-digitoxose biosynthesis | 7 | 3 | 1 |
| incomplete reductive TCA cycle | 7 | 3 | 1 |
| 3-dehydroquinate biosynthesis II (archaea) | 7 | 3 | 1 |
| serotonin degradation | 7 | 3 | 1 |
| cremeomycin biosynthesis | 7 | 2 | 1 |
| pyruvate fermentation to propanoate I | 7 | 2 | 1 |
| dTDP-β-L-mycarose biosynthesis | 7 | 2 | 1 |
| arachidonate biosynthesis III (6-desaturase, mammals) | 7 | 1 | 1 |
| limonene degradation IV (anaerobic) | 7 | 1 | 1 |
| icosapentaenoate biosynthesis III (8-desaturase, mammals) | 7 | 1 | 1 |
| icosapentaenoate biosynthesis II (6-desaturase, mammals) | 7 | 1 | 1 |
| capsaicin biosynthesis | 7 | 1 | 1 |
| Bifidobacterium shunt | 15 | 14 | 2 |
| cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) | 15 | 3 | 2 |
| mixed acid fermentation | 16 | 14 | 2 |
| ketogluconate metabolism | 8 | 7 | 1 |
| partial TCA cycle (obligate autotrophs) | 8 | 7 | 1 |
| L-histidine degradation VI | 8 | 7 | 1 |
| sucrose biosynthesis II | 8 | 6 | 1 |
| superpathway of ornithine degradation | 8 | 6 | 1 |
| purine nucleobases degradation II (anaerobic) | 24 | 16 | 3 |
| superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) | 8 | 5 | 1 |
| L-citrulline biosynthesis | 8 | 5 | 1 |
| superpathway of polyamine biosynthesis III | 8 | 4 | 1 |
| dTDP-β-L-4-epi-vancosamine biosynthesis | 8 | 3 | 1 |
| 2-deoxy-D-ribose degradation II | 8 | 3 | 1 |
| dTDP-β-L-megosamine biosynthesis | 8 | 3 | 1 |
| grixazone biosynthesis | 8 | 2 | 1 |
| aromatic biogenic amine degradation (bacteria) | 8 | 1 | 1 |
| ethene biosynthesis V (engineered) | 25 | 18 | 3 |
| superpathway of anaerobic energy metabolism (invertebrates) | 17 | 10 | 2 |
| oleate β-oxidation | 35 | 29 | 4 |
| superpathway of L-lysine, L-threonine and L-methionine biosynthesis I | 18 | 18 | 2 |
| L-arginine biosynthesis I (via L-ornithine) | 9 | 9 | 1 |
| folate transformations III (E. coli) | 9 | 9 | 1 |
| L-lysine biosynthesis I | 9 | 9 | 1 |
| L-arginine biosynthesis III (via N-acetyl-L-citrulline) | 9 | 8 | 1 |
| Entner-Doudoroff pathway I | 9 | 8 | 1 |
| Entner-Doudoroff pathway III (semi-phosphorylative) | 9 | 7 | 1 |
| TCA cycle V (2-oxoglutarate synthase) | 9 | 7 | 1 |
| L-lysine biosynthesis II | 9 | 7 | 1 |
| TCA cycle II (plants and fungi) | 9 | 7 | 1 |
| chitin biosynthesis | 9 | 6 | 1 |
| TCA cycle VI (Helicobacter) | 9 | 6 | 1 |
| TCA cycle VII (acetate-producers) | 9 | 6 | 1 |
| TCA cycle IV (2-oxoglutarate decarboxylase) | 9 | 6 | 1 |
| photorespiration III | 9 | 5 | 1 |
| photorespiration I | 9 | 5 | 1 |
| L-phenylalanine degradation IV (mammalian, via side chain) | 9 | 4 | 1 |
| dTDP-α-D-forosamine biosynthesis | 9 | 3 | 1 |
| dTDP-α-D-olivose, dTDP-α-D-oliose and dTDP-α-D-mycarose biosynthesis | 9 | 3 | 1 |
| L-lysine degradation V | 9 | 3 | 1 |
| cis-geranyl-CoA degradation | 9 | 1 | 1 |
| L-arginine biosynthesis II (acetyl cycle) | 10 | 9 | 1 |
| TCA cycle I (prokaryotic) | 10 | 9 | 1 |
| TCA cycle III (animals) | 10 | 8 | 1 |
| glycolysis IV | 10 | 8 | 1 |
| glycolysis V (Pyrococcus) | 10 | 7 | 1 |
| photorespiration II | 10 | 6 | 1 |
| superpathway of coenzyme A biosynthesis II (plants) | 10 | 5 | 1 |
| anaerobic energy metabolism (invertebrates, mitochondrial) | 10 | 5 | 1 |
| suberin monomers biosynthesis | 20 | 3 | 2 |
| superpathway of fatty acid biosynthesis II (plant) | 43 | 38 | 4 |
| glycolysis III (from glucose) | 11 | 11 | 1 |
| glycolysis II (from fructose 6-phosphate) | 11 | 11 | 1 |
| folate transformations II (plants) | 11 | 10 | 1 |
| superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle | 22 | 18 | 2 |
| superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation | 11 | 8 | 1 |
| O-antigen building blocks biosynthesis (E. coli) | 11 | 8 | 1 |
| glycolysis VI (from fructose) | 11 | 8 | 1 |
| pyruvate fermentation to hexanol (engineered) | 11 | 7 | 1 |
| reductive TCA cycle I | 11 | 6 | 1 |
| superpathway of phenylethylamine degradation | 11 | 4 | 1 |
| L-glutamate degradation VIII (to propanoate) | 11 | 2 | 1 |
| superpathway of pyridoxal 5'-phosphate biosynthesis and salvage | 12 | 12 | 1 |
| homolactic fermentation | 12 | 11 | 1 |
| superpathway of glyoxylate bypass and TCA | 12 | 11 | 1 |
| chorismate biosynthesis II (archaea) | 12 | 8 | 1 |
| superpathway of L-citrulline metabolism | 12 | 7 | 1 |
| reductive TCA cycle II | 12 | 5 | 1 |
| arsenic detoxification (yeast) | 12 | 4 | 1 |
| aspartate superpathway | 25 | 24 | 2 |
| glycolysis I (from glucose 6-phosphate) | 13 | 13 | 1 |
| superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass | 26 | 25 | 2 |
| superpathway of L-arginine and L-ornithine degradation | 13 | 10 | 1 |
| folate transformations I | 13 | 9 | 1 |
| (S)-lactate fermentation to propanoate, acetate and hydrogen | 13 | 5 | 1 |
| superpathway of glyoxylate cycle and fatty acid degradation | 14 | 11 | 1 |
| firefly bioluminescence | 14 | 2 | 1 |
| palmitate biosynthesis II (type II fatty acid synthase) | 31 | 29 | 2 |
| glycerol degradation to butanol | 16 | 11 | 1 |
| cutin biosynthesis | 16 | 2 | 1 |
| adenosylcobalamin biosynthesis II (aerobic) | 33 | 13 | 2 |
| superpathway of arginine and polyamine biosynthesis | 17 | 16 | 1 |
| superpathway of glycolysis and the Entner-Doudoroff pathway | 17 | 16 | 1 |
| arsenic detoxification (mammals) | 17 | 8 | 1 |
| superpathway of hexitol degradation (bacteria) | 18 | 16 | 1 |
| heterolactic fermentation | 18 | 16 | 1 |
| adenosylcobalamin biosynthesis I (anaerobic) | 36 | 12 | 2 |
| hexitol fermentation to lactate, formate, ethanol and acetate | 19 | 17 | 1 |
| superpathway of anaerobic sucrose degradation | 19 | 17 | 1 |
| methylaspartate cycle | 19 | 9 | 1 |
| superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis | 19 | 5 | 1 |
| superpathway of novobiocin biosynthesis | 19 | 3 | 1 |
| superpathway of erythromycin biosynthesis | 19 | 2 | 1 |
| superpathway of N-acetylneuraminate degradation | 22 | 18 | 1 |
| superpathway of megalomicin A biosynthesis | 22 | 3 | 1 |
| superpathway of dTDP-glucose-derived antibiotic building blocks biosynthesis | 23 | 3 | 1 |
| platensimycin biosynthesis | 26 | 6 | 1 |
| superpathway of fatty acids biosynthesis (E. coli) | 53 | 51 | 2 |
| anaerobic aromatic compound degradation (Thauera aromatica) | 27 | 3 | 1 |
| palmitate biosynthesis III | 29 | 21 | 1 |
| superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis | 33 | 11 | 1 |
| superpathway of pentose and pentitol degradation | 42 | 12 | 1 |
| superpathway of L-lysine degradation | 43 | 12 | 1 |
| Methanobacterium thermoautotrophicum biosynthetic metabolism | 56 | 21 | 1 |