| Pathway | #Steps | #Present | #Specific |
|---|
| cis-cyclopropane fatty acid (CFA) biosynthesis | 1 | 1 | 1 |
| long-chain fatty acid activation | 1 | 1 | 1 |
| L-glutamate degradation I | 1 | 1 | 1 |
| adenosylcobalamin salvage from cobalamin | 5 | 5 | 4 |
| L-proline degradation I | 3 | 3 | 2 |
| adenosylcobinamide-GDP salvage from cobinamide I | 5 | 5 | 3 |
| adenosine nucleotides degradation II | 5 | 4 | 3 |
| adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide | 6 | 6 | 3 |
| putrescine biosynthesis I | 2 | 2 | 1 |
| L-arginine degradation III (arginine decarboxylase/agmatinase pathway) | 2 | 2 | 1 |
| proline to cytochrome bo oxidase electron transfer | 2 | 2 | 1 |
| adenosylcobinamide-GDP salvage from cobinamide II | 6 | 5 | 3 |
| cobalamin salvage (eukaryotic) | 8 | 4 | 4 |
| sterculate biosynthesis | 2 | 1 | 1 |
| linoleate biosynthesis II (animals) | 2 | 1 | 1 |
| allantoin degradation to ureidoglycolate I (urea producing) | 2 | 1 | 1 |
| γ-linolenate biosynthesis II (animals) | 2 | 1 | 1 |
| adipate degradation | 5 | 5 | 2 |
| superpathway of adenosylcobalamin salvage from cobinamide I | 8 | 8 | 3 |
| ppGpp metabolism | 6 | 6 | 2 |
| fatty acid salvage | 6 | 6 | 2 |
| L-arginine degradation I (arginase pathway) | 3 | 3 | 1 |
| cardiolipin biosynthesis II | 3 | 3 | 1 |
| L-alanine degradation II (to D-lactate) | 3 | 3 | 1 |
| superpathway of adenosylcobalamin salvage from cobinamide II | 9 | 8 | 3 |
| pyruvate fermentation to acetate V | 3 | 2 | 1 |
| propanoyl CoA degradation I | 3 | 2 | 1 |
| allantoin degradation to glyoxylate I | 3 | 2 | 1 |
| ethene biosynthesis IV (engineered) | 3 | 2 | 1 |
| 3-methyl-branched fatty acid α-oxidation | 6 | 3 | 2 |
| alkane biosynthesis II | 3 | 1 | 1 |
| pyruvate fermentation to acetate VI | 3 | 1 | 1 |
| adenine and adenosine salvage V | 3 | 1 | 1 |
| conversion of succinate to propanoate | 3 | 1 | 1 |
| purine deoxyribonucleosides degradation II | 3 | 1 | 1 |
| oleate biosynthesis I (plants) | 3 | 1 | 1 |
| purine nucleotides degradation II (aerobic) | 11 | 8 | 3 |
| L-histidine degradation I | 4 | 4 | 1 |
| superpathway of putrescine biosynthesis | 4 | 4 | 1 |
| ethene biosynthesis II (microbes) | 4 | 4 | 1 |
| guanosine nucleotides degradation II | 4 | 4 | 1 |
| adenosine nucleotides degradation I | 8 | 7 | 2 |
| cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) | 4 | 3 | 1 |
| guanosine nucleotides degradation III | 4 | 3 | 1 |
| inosine 5'-phosphate degradation | 4 | 3 | 1 |
| phytol degradation | 4 | 3 | 1 |
| guanosine nucleotides degradation I | 4 | 3 | 1 |
| adenine and adenosine salvage III | 4 | 2 | 1 |
| 2-oxobutanoate degradation I | 4 | 2 | 1 |
| phosphatidylcholine acyl editing | 4 | 1 | 1 |
| 3,3'-disulfanediyldipropannoate degradation | 4 | 1 | 1 |
| wax esters biosynthesis II | 4 | 1 | 1 |
| purine deoxyribonucleosides degradation I | 4 | 1 | 1 |
| long chain fatty acid ester synthesis (engineered) | 4 | 1 | 1 |
| sporopollenin precursors biosynthesis | 18 | 8 | 4 |
| NAD salvage pathway V (PNC V cycle) | 5 | 4 | 1 |
| L-histidine degradation II | 5 | 4 | 1 |
| adipate biosynthesis | 5 | 4 | 1 |
| anaerobic energy metabolism (invertebrates, mitochondrial) | 10 | 5 | 2 |
| sphingosine and sphingosine-1-phosphate metabolism | 10 | 4 | 2 |
| octane oxidation | 5 | 2 | 1 |
| purine nucleotides degradation I (plants) | 12 | 10 | 2 |
| superpathway of guanosine nucleotides degradation (plants) | 6 | 5 | 1 |
| TCA cycle VIII (Chlamydia) | 6 | 5 | 1 |
| stearate biosynthesis II (bacteria and plants) | 6 | 5 | 1 |
| superpathway of purines degradation in plants | 18 | 14 | 3 |
| purine nucleobases degradation II (anaerobic) | 24 | 16 | 4 |
| stearate biosynthesis IV | 6 | 4 | 1 |
| superpathway of allantoin degradation in yeast | 6 | 4 | 1 |
| L-histidine degradation III | 6 | 4 | 1 |
| 6-gingerol analog biosynthesis (engineered) | 6 | 3 | 1 |
| stearate biosynthesis I (animals) | 6 | 2 | 1 |
| (5R)-carbapenem carboxylate biosynthesis | 6 | 1 | 1 |
| purine ribonucleosides degradation | 6 | 1 | 1 |
| methylaspartate cycle | 19 | 11 | 3 |
| NAD salvage pathway I (PNC VI cycle) | 7 | 6 | 1 |
| L-Nδ-acetylornithine biosynthesis | 7 | 6 | 1 |
| ureide biosynthesis | 7 | 5 | 1 |
| incomplete reductive TCA cycle | 7 | 3 | 1 |
| 4-aminobutanoate degradation V | 7 | 3 | 1 |
| pyruvate fermentation to propanoate I | 7 | 3 | 1 |
| capsaicin biosynthesis | 7 | 3 | 1 |
| ceramide degradation by α-oxidation | 7 | 2 | 1 |
| L-glutamate degradation XI (reductive Stickland reaction) | 7 | 2 | 1 |
| superpathway of purine deoxyribonucleosides degradation | 7 | 1 | 1 |
| arachidonate biosynthesis III (6-desaturase, mammals) | 7 | 1 | 1 |
| icosapentaenoate biosynthesis III (8-desaturase, mammals) | 7 | 1 | 1 |
| icosapentaenoate biosynthesis II (6-desaturase, mammals) | 7 | 1 | 1 |
| caffeine degradation III (bacteria, via demethylation) | 7 | 1 | 1 |
| L-citrulline biosynthesis | 8 | 8 | 1 |
| superpathway of polyamine biosynthesis I | 8 | 7 | 1 |
| L-histidine degradation VI | 8 | 7 | 1 |
| superpathway of allantoin degradation in plants | 8 | 4 | 1 |
| 2-deoxy-D-ribose degradation II | 8 | 3 | 1 |
| ceramide and sphingolipid recycling and degradation (yeast) | 16 | 4 | 2 |
| superpathway of anaerobic energy metabolism (invertebrates) | 17 | 12 | 2 |
| oleate β-oxidation | 35 | 31 | 4 |
| TCA cycle V (2-oxoglutarate synthase) | 9 | 8 | 1 |
| TCA cycle II (plants and fungi) | 9 | 7 | 1 |
| theophylline degradation | 9 | 1 | 1 |
| TCA cycle I (prokaryotic) | 10 | 9 | 1 |
| TCA cycle III (animals) | 10 | 7 | 1 |
| L-glutamate degradation V (via hydroxyglutarate) | 10 | 5 | 1 |
| suberin monomers biosynthesis | 20 | 5 | 2 |
| caffeine degradation IV (bacteria, via demethylation and oxidation) | 10 | 1 | 1 |
| superpathway of fatty acid biosynthesis II (plant) | 43 | 38 | 4 |
| adenosylcobalamin biosynthesis II (aerobic) | 33 | 29 | 3 |
| NAD salvage (plants) | 11 | 6 | 1 |
| superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation | 11 | 6 | 1 |
| reductive TCA cycle I | 11 | 6 | 1 |
| L-glutamate degradation VIII (to propanoate) | 11 | 3 | 1 |
| superpathway of glyoxylate bypass and TCA | 12 | 11 | 1 |
| superpathway of L-citrulline metabolism | 12 | 10 | 1 |
| adenosylcobalamin biosynthesis I (anaerobic) | 36 | 29 | 3 |
| reductive TCA cycle II | 12 | 6 | 1 |
| superpathway of cardiolipin biosynthesis (bacteria) | 13 | 9 | 1 |
| superpathway of L-arginine and L-ornithine degradation | 13 | 8 | 1 |
| 3-hydroxypropanoate cycle | 13 | 8 | 1 |
| (S)-lactate fermentation to propanoate, acetate and hydrogen | 13 | 6 | 1 |
| superpathway of NAD biosynthesis in eukaryotes | 14 | 10 | 1 |
| 2-methyl-branched fatty acid β-oxidation | 14 | 9 | 1 |
| crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) | 14 | 2 | 1 |
| palmitate biosynthesis II (type II fatty acid synthase) | 31 | 29 | 2 |
| superpathway of L-methionine salvage and degradation | 16 | 6 | 1 |
| cutin biosynthesis | 16 | 3 | 1 |
| superpathway of arginine and polyamine biosynthesis | 17 | 16 | 1 |
| 3-hydroxypropanoate/4-hydroxybutanate cycle | 18 | 10 | 1 |
| superpathway of the 3-hydroxypropanoate cycle | 18 | 8 | 1 |
| superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle | 22 | 17 | 1 |
| superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass | 26 | 23 | 1 |
| superpathway of fatty acids biosynthesis (E. coli) | 53 | 50 | 2 |
| palmitate biosynthesis III | 29 | 28 | 1 |
| Methanobacterium thermoautotrophicum biosynthetic metabolism | 56 | 19 | 1 |
| mycolate biosynthesis | 205 | 25 | 3 |
| superpathway of mycolate biosynthesis | 239 | 26 | 3 |