Experiment set11H43 for Pseudomonas stutzeri RCH2

Compare to:

LB with D-Cycloserine 0.032 mg/ml

200 most detrimental genes:

  gene name fitness t score description  
Psest_1249 +2.6 10.3 serine O-acetyltransferase compare
Psest_3159 +2.4 9.9 phosphoribosylformylglycinamidine synthase, single chain form compare
Psest_2579 +2.4 10.9 amidophosphoribosyltransferase compare
Psest_1805 +2.4 2.8 integration host factor, beta subunit compare
Psest_0466 +2.4 6.6 Lipopolysaccharide kinase (Kdo/WaaP) family. compare
Psest_3202 +2.3 6.0 Flavodoxins compare
Psest_1474 +2.3 9.5 phosphoribosylaminoimidazole synthetase compare
Psest_3226 +2.2 2.6 Predicted membrane protein compare
Psest_0999 +2.2 5.6 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains compare
Psest_1974 +2.2 7.1 integration host factor, alpha subunit compare
Psest_0170 +2.1 8.3 5,10-methenyltetrahydrofolate synthetase compare
Psest_3114 +2.0 7.8 electron transport complex, RnfABCDGE type, C subunit compare
Psest_1881 +1.8 5.0 Nitroreductase compare
Psest_1000 +1.8 9.1 PAS domain S-box compare
Psest_0771 +1.8 10.8 Acyl-CoA hydrolase compare
Psest_0449 +1.8 10.4 Glutamine synthetase adenylyltransferase compare
Psest_3762 +1.8 7.2 iron donor protein CyaY compare
Psest_0872 +1.7 1.2 Helix-turn-helix. compare
Psest_3115 +1.7 6.9 electron transport complex, RnfABCDGE type, D subunit compare
Psest_3112 +1.7 7.0 electron transport complex, RnfABCDGE type, A subunit compare
Psest_0799 +1.6 2.7 Uncharacterized protein involved in response to NO compare
Psest_3881 +1.6 2.3 hypothetical protein compare
Psest_1752 +1.6 1.5 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB compare
Psest_3377 +1.5 1.7 FKBP-type peptidyl-prolyl cis-trans isomerases 2 compare
Psest_2940 +1.5 3.0 Predicted membrane protein compare
Psest_1888 +1.5 1.6 Sua5/YciO/YrdC/YwlC family protein compare
Psest_3117 +1.5 4.1 electron transport complex, RnfABCDGE type, E subunit compare
Psest_3988 +1.5 5.0 phosphoenolpyruvate carboxykinase (ATP) compare
Psest_0532 +1.4 5.0 tRNA-N(6)-(isopentenyl)adenosine-37 thiotransferase enzyme MiaB compare
Psest_0259 +1.4 2.1 cell division ATP-binding protein FtsE compare
Psest_0959 +1.4 2.8 Uncharacterized protein conserved in bacteria compare
Psest_3116 +1.4 6.7 electron transport complex, RnfABCDGE type, G subunit compare
Psest_4110 +1.4 7.9 Deoxycytidylate deaminase compare
Psest_3113 +1.4 2.5 electron transport complex, RnfABCDGE type, B subunit compare
Psest_1013 +1.4 3.4 phosphoribosylamine--glycine ligase compare
Psest_0064 +1.4 4.4 Transcriptional regulator compare
Psest_1920 +1.4 1.4 Uncharacterized protein conserved in bacteria compare
Psest_1994 +1.3 3.7 Amidases related to nicotinamidase compare
Psest_1809 +1.3 7.1 Membrane protein involved in the export of O-antigen and teichoic acid compare
Psest_3456 +1.3 2.3 RNA polymerase sigma factor, sigma-70 family compare
Psest_3670 +1.3 7.6 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) compare
Psest_4256 +1.3 2.1 ABC-type transport system involved in resistance to organic solvents, ATPase component compare
Psest_1121 +1.3 5.2 Hypoxanthine-guanine phosphoribosyltransferase compare
Psest_3727 +1.3 3.4 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases compare
Psest_2083 +1.3 4.0 Putative sterol carrier protein compare
Psest_1640 +1.3 7.5 (p)ppGpp synthetase, RelA/SpoT family compare
Psest_1819 +1.3 9.2 Nucleoside-diphosphate-sugar epimerases compare
Psest_3834 +1.2 4.4 NAD(P)H-nitrite reductase compare
Psest_2001 +1.2 1.7 2-phosphoglycolate phosphatase, prokaryotic compare
Psest_1248 +1.2 3.5 RNA methyltransferase, TrmH family, group 1 compare
Psest_3045 +1.2 1.9 Cold shock proteins compare
Psest_0013 +1.2 4.9 Lauroyl/myristoyl acyltransferase compare
Psest_4325 +1.2 1.6 hypothetical protein compare
Psest_1082 +1.2 2.7 Enoyl-CoA hydratase/carnithine racemase compare
Psest_2218 +1.2 1.5 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit compare
Psest_0660 +1.2 1.4 Methyl-accepting chemotaxis protein compare
Psest_1326 +1.2 2.1 Uncharacterized conserved protein compare
Psest_4342 +1.2 2.6 Putative GTPases (G3E family) compare
Psest_3813 +1.1 5.2 ribonuclease PH compare
Psest_4364 +1.1 2.8 16S rRNA (guanine(527)-N(7))-methyltransferase GidB compare
Psest_0119 +1.1 1.3 hypothetical protein compare
Psest_1001 +1.1 1.8 hypothetical protein compare
Psest_2003 +1.1 6.2 Cytosine deaminase and related metal-dependent hydrolases compare
Psest_1242 +1.1 1.8 tRNA-guanine transglycosylase, queuosine-34-forming compare
Psest_0320 +1.1 2.4 ABC-type multidrug transport system, ATPase component compare
Psest_2344 +1.1 2.1 Methyl-accepting chemotaxis protein compare
Psest_0243 +1.1 1.3 hypothetical protein compare
Psest_2066 +1.1 2.1 ABC-type uncharacterized transport system, permease component compare
Psest_2383 +1.1 5.5 Predicted transcriptional regulators compare
Psest_0482 +1.1 2.3 yqiA-like hydrolase, affects the cell envelope (from data) compare
Psest_1179 +1.1 2.2 2-hydroxy-3-oxopropionate reductase compare
Psest_3700 +1.1 1.5 hypothetical protein compare
Psest_3536 +1.1 1.1 hypothetical protein compare
Psest_2670 +1.0 2.6 Uncharacterized conserved protein compare
Psest_1498 +1.0 1.7 tol-pal system-associated acyl-CoA thioesterase compare
Psest_3230 +1.0 3.8 Uncharacterized conserved protein compare
Psest_1963 +1.0 2.3 Peptidase inhibitor I78 family. compare
Psest_3174 +1.0 5.9 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase compare
Psest_3400 +1.0 0.8 Copper resistance protein D. compare
Psest_1344 +1.0 4.9 rRNA methylases compare
Psest_0459 +1.0 5.8 Predicted carbamoyl transferase, NodU family compare
Psest_2901 +1.0 1.3 hypothetical protein compare
Psest_0549 +1.0 3.3 Predicted acetyltransferase compare
Psest_1635 +1.0 8.5 Signal transduction histidine kinase compare
Psest_3123 +0.9 2.2 dihydroorotase, homodimeric type compare
Psest_1473 +0.9 2.9 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent compare
Psest_1986 +0.9 0.9 3-phosphoshikimate 1-carboxyvinyltransferase compare
Psest_1510 +0.9 2.3 Putative Zn-dependent protease, contains TPR repeats compare
Psest_3853 +0.9 1.8 ABC-type branched-chain amino acid transport systems, ATPase component compare
Psest_1597 +0.9 1.7 Protein of unknown function (DUF2933). compare
Psest_2569 +0.9 3.7 Transcriptional regulator compare
Psest_0351 +0.9 3.4 hypothetical protein compare
Psest_1823 +0.9 4.5 Nucleoside-diphosphate-sugar epimerases compare
Psest_3936 +0.9 2.8 ATP-dependent protease HslVU, peptidase subunit compare
Psest_2543 +0.9 2.4 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component compare
Psest_1696 +0.9 4.2 hydrolase, TatD family compare
Psest_3136 +0.9 3.5 Putative Mg2+ and Co2+ transporter CorB compare
Psest_2260 +0.9 7.7 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain compare
Psest_2500 +0.9 1.3 hypothetical protein compare
Psest_1058 +0.9 2.2 ribosomal-protein-alanine acetyltransferase compare
Psest_2752 +0.9 2.0 Uncharacterized protein conserved in bacteria compare
Psest_0505 +0.9 2.1 Putative effector of murein hydrolase compare
Psest_0718 +0.9 1.9 nicotinate-nucleotide pyrophosphorylase compare
Psest_1697 +0.9 6.1 Gamma-aminobutyrate permease and related permeases compare
Psest_0462 +0.9 7.6 Lipid A core - O-antigen ligase and related enzymes compare
Psest_0998 +0.9 1.5 poly(A) polymerase compare
Psest_1709 +0.9 1.1 Outer membrane protein and related peptidoglycan-associated (lipo)proteins compare
Psest_0363 +0.9 2.7 tripartite ATP-independent periplasmic transporter solute receptor, DctP family compare
Psest_1177 +0.9 1.7 pyruvate kinase compare
Psest_3396 +0.9 4.7 Predicted ATP-dependent protease compare
Psest_0484 +0.8 2.9 hypothetical protein compare
Psest_2253 +0.8 2.4 small redox-active disulfide protein 2 compare
Psest_0417 +0.8 2.0 Acyl-CoA dehydrogenases compare
Psest_0455 +0.8 3.8 ADP-heptose:LPS heptosyltransferase compare
Psest_0691 +0.8 5.3 ribonuclease R compare
Psest_1639 +0.8 2.3 23S rRNA (uracil-5-)-methyltransferase RumA compare
Psest_2744 +0.8 0.6 Uncharacterized conserved protein compare
Psest_0538 +0.8 7.9 Signal transduction histidine kinase compare
Psest_3651 +0.8 1.9 2-phosphoglycolate phosphatase, prokaryotic compare
Psest_1817 +0.8 3.0 hypothetical protein compare
Psest_1840 +0.8 7.8 Undecaprenyl-phosphate glucose phosphotransferase compare
Psest_0437 +0.8 1.6 hypothetical protein compare
Psest_1677 +0.8 1.2 Protein-tyrosine-phosphatase compare
Psest_0529 +0.8 3.8 Putative Mg2+ and Co2+ transporter CorC compare
Psest_0192 +0.8 3.3 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains compare
Psest_0725 +0.8 0.8 Negative regulator of beta-lactamase expression compare
Psest_2510 +0.8 3.8 chromosome segregation protein SMC, common bacterial type compare
Psest_1022 +0.8 4.3 Thiol:disulfide interchange protein compare
Psest_0457 +0.8 2.0 Lipopolysaccharide kinase (Kdo/WaaP) family. compare
Psest_1896 +0.8 2.3 ABC-type sugar transport system, periplasmic component compare
Psest_1018 +0.8 2.0 ribosomal protein L11 methyltransferase compare
Psest_1026 +0.8 1.7 Uncharacterized iron-regulated protein compare
Psest_0277 +0.8 0.6 non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family compare
Psest_2953 +0.8 0.8 Histone acetyltransferase compare
Psest_4004 +0.8 1.6 Uncharacterized conserved protein compare
Psest_0722 +0.8 3.8 Predicted ATPase compare
Psest_1180 +0.8 2.0 hydroxypyruvate isomerase compare
Psest_3323 +0.8 2.2 ribonuclease, Rne/Rng family compare
Psest_2875 +0.8 3.4 DNA mismatch repair protein MutS compare
Psest_0639 +0.8 2.8 Uncharacterised protein family (UPF0259). compare
Psest_1887 +0.8 2.3 Predicted metal-dependent phosphoesterases (PHP family) compare
Psest_4075 +0.8 4.6 symporter for L-glutamate, L-glutamine, and L-proline (from data) compare
Psest_4145 +0.8 1.6 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) compare
Psest_2102 +0.8 5.6 5-methyltetrahydrofolate--homocysteine methyltransferase compare
Psest_1890 +0.8 3.4 Uncharacterized conserved protein compare
Psest_4010 +0.8 0.8 peroxiredoxin, OsmC subfamily compare
Psest_3191 +0.8 1.7 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases compare
Psest_4009 +0.8 1.8 conserverd hypothetical protein compare
Psest_4067 +0.8 1.7 Predicted membrane protein compare
Psest_0021 +0.8 2.0 ribosomal RNA small subunit methyltransferase RsmB compare
Psest_1810 +0.7 5.0 UDP-N-acetylglucosamine 4,6-dehydratase compare
Psest_2067 +0.7 0.6 ABC-type oligopeptide transport system, periplasmic component compare
Psest_1686 +0.7 1.5 fatty acid/phospholipid synthesis protein PlsX compare
Psest_2015 +0.7 1.4 Type II secretory pathway, component PulD compare
Psest_1700 +0.7 1.6 Transcriptional regulator compare
Psest_0146 +0.7 2.6 Uncharacterized protein involved in outer membrane biogenesis compare
Psest_2458 +0.7 1.1 MoxR-like ATPases compare
Psest_1721 +0.7 2.0 Flagellar biosynthesis/type III secretory pathway protein compare
Psest_0230 +0.7 2.2 Uncharacterized BCR, YitT family COG1284. compare
Psest_3360 +0.7 2.5 hypothetical protein compare
Psest_1371 +0.7 1.5 hypothetical protein compare
Psest_2227 +0.7 2.4 hypothetical protein compare
Psest_3938 +0.7 1.2 Uncharacterized protein conserved in bacteria compare
Psest_1619 +0.7 2.4 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 compare
Psest_2084 +0.7 2.0 Fructose-2,6-bisphosphatase compare
Psest_2094 +0.7 2.2 Predicted Fe-S-cluster redox enzyme compare
Psest_2950 +0.7 1.9 putative NAD(P)H quinone oxidoreductase, PIG3 family compare
Psest_3071 +0.7 1.9 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit compare
Psest_4290 +0.7 2.3 N-carbamoylputrescine amidase compare
Psest_0186 +0.7 2.1 Protein-disulfide isomerase compare
Psest_2903 +0.7 2.1 Site-specific recombinase XerD compare
Psest_1952 +0.7 1.8 hypothetical protein compare
Psest_1822 +0.7 3.4 Glycosyltransferases involved in cell wall biogenesis compare
Psest_2463 +0.7 2.3 Predicted esterase of the alpha-beta hydrolase superfamily compare
Psest_1725 +0.7 4.6 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain compare
Psest_0045 +0.7 1.7 hypothetical protein compare
Psest_4411 +0.7 2.3 Phage terminase, small subunit compare
Psest_1542 +0.7 2.1 Uncharacterized proteins, homologs of lactam utilization protein B compare
Psest_1825 +0.7 3.6 Predicted nucleoside-diphosphate sugar epimerases compare
Psest_1435 +0.7 2.3 Predicted SAM-dependent methyltransferases compare
Psest_4163 +0.7 2.0 hypothetical protein compare
Psest_2758 +0.7 1.1 Predicted transcriptional regulators compare
Psest_1818 +0.7 3.7 GDP-mannose 4,6-dehydratase compare
Psest_2183 +0.7 1.7 Transcriptional regulator compare
Psest_2288 +0.7 1.9 trigger factor compare
Psest_0871 +0.7 2.6 maltose ABC transporter, ATPase component MalK (from data) compare
Psest_2650 +0.7 1.6 hypothetical protein compare
Psest_0067 +0.7 1.0 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain compare
Psest_3093 +0.7 2.4 hypothetical protein compare
Psest_3824 +0.7 1.4 Predicted membrane protein compare
Psest_2954 +0.7 1.6 hypothetical protein compare
Psest_0450 +0.7 2.6 Branched-chain amino acid aminotransferase (EC 2.6.1.42) (from data) compare
Psest_4403 +0.6 3.3 hypothetical protein compare
Psest_2232 +0.6 4.7 UTP-glucose-1-phosphate uridylyltransferase compare
Psest_0720 +0.6 2.3 Predicted hydrolase of the alpha/beta superfamily compare
Psest_3960 +0.6 0.6 3'(2'),5'-bisphosphate nucleotidase, bacterial compare
Psest_4178 +0.6 1.5 hypothetical protein compare
Psest_1522 +0.6 0.7 hypothetical protein compare
Psest_1025 +0.6 2.0 ABC-type hemin transport system, ATPase component compare
Psest_2713 +0.6 1.7 hypothetical protein compare


Specific Phenotypes

For 11 genes in this experiment

For stress D-Cycloserine in Pseudomonas stutzeri RCH2

For stress D-Cycloserine across organisms