Protein Info for Xcc-8004.646.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: NADH pyrophosphatase (EC 3.6.1.22)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF09297: zf-NADH-PPase
  • amino acids 127 to 158 (32 residues), 35.7 bits, 5.7e-13
• PF00293: NUDIX
  • amino acids 163 to 267 (105 residues), 62.4 bits, E=4.7e-21

Best Hits

KEGG orthology group: K03426, NAD+ diphosphatase [EC: 3.6.1.22] (inferred from 100% identity to xcc:XCC0489)

Predicted SEED Role

"NADH pyrophosphatase (EC 3.6.1.22)" in subsystem Nudix proteins (nucleoside triphosphate hydrolases) (EC 3.6.1.22)

MetaCyc Pathways

• NAD salvage pathway II (PNC IV cycle) (5/5 steps found)
• NAD salvage pathway I (PNC VI cycle) (6/7 steps found)
• NAD salvage pathway III (to nicotinamide riboside) (2/3 steps found)
• NAD salvage (plants) (6/11 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.22

Sequence Analysis Tools

See A0A0H2X3I7 at UniProt or InterPro

Protein Sequence (299 amino acids)

>Xcc-8004.646.1 NADH pyrophosphatase (EC 3.6.1.22) (Xanthomonas campestris pv. campestris strain 8004)
MSEPLFSLSAFAFTHAPLDRGDVLRDDPDAIARLWPTGRVLLIDAKGTAAADAQGQPLLS
DGAALADTPGAAIFLGLRDGVGWFALAAEQVATELPHRVDLRQAAADWPAELSTAFSYGR
AMLHWQSRTRFCGVCGGAIAFRRAGFIAHCTQCQTEHYPRVDPAIIVAVSDGQRLLLGRQ
ASWAPRRYSVIAGFVEPGESLEQTVEREVFEETRVQVQGCQYLGAQPWPFPGALMLGFAA
TAAPTELPQVTGELEDARWVSHAEIGTALAGESGDTGIGLPPAISIARALIEHWYRTHG