Protein Info for Xcc-8004.580.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: Homogentisate 1,2-dioxygenase (EC 1.13.11.5)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 TIGR01015: homogentisate 1,2-dioxygenase" amino acids 26 to 449 (424 residues), 671.8 bits, see alignment E=1.9e-206 PF20510: HgmA_N" amino acids 27 to 295 (269 residues), 414.7 bits, see alignment E=1.6e-128 PF04209: HgmA_C" amino acids 296 to 449 (154 residues), 249.6 bits, see alignment E=1e-78

Best Hits

Swiss-Prot: 100% identical to HGD_XANCP: Homogentisate 1,2-dioxygenase (hmgA) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

KEGG orthology group: K00451, homogentisate 1,2-dioxygenase [EC: 1.13.11.5] (inferred from 100% identity to xcb:XC_0452)

MetaCyc: 49% identical to Homogentisate 1,2-dioxygenase (Homo sapiens)
Homogentisate 1,2-dioxygenase. [EC: 1.13.11.5]

Predicted SEED Role

"Homogentisate 1,2-dioxygenase (EC 1.13.11.5)" in subsystem Homogentisate pathway of aromatic compound degradation (EC 1.13.11.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.13.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q4UZI9 at UniProt or InterPro

Protein Sequence (455 amino acids)

>Xcc-8004.580.1 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Xanthomonas campestris pv. campestris strain 8004)
LIQLDPTLLLSWRAGQHPDAPMHNDQRYMTGFGNEFASEAVADTLPVGQNSPQRVAHGLY
AEQLSGTAFTAPRGENRRSWLYRMRPAAVHGTFSLIEQSQFHNDFGHGPVPPDQLRWSPL
PLPQTPTDFIDGLYTMAGNGSPEAMNGVAVHLYAANASMQDRFFYNADGELLLVPQLGRL
RVHTELGMLELEPQQIGVIPRGVRFRVELRDGTARGYVCENFGGLLHLPDLGPIGSNGLA
NPRDFETPCAAFEQREGRFELVAKFQGHLWRADIGHSPLDVVAWHGNYAPYRYDLRRFNT
IGSISFDHPDPSIFTVLTSPSDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMG
LVHGVYDAKADGFAPGGASLHNCMSGHGPDAATFDKASQADLSRPDVITETMAFMFETRA
VLRPTAQALHAPHRQGDYQQCWAGLRKAFQAPPAS