Protein Info for Xcc-8004.4073.1 in Xanthomonas campestris pv. campestris strain 8004
Annotation: Amidophosphoribosyltransferase (EC 2.4.2.14)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 62% identical to PUR1_PSEAE: Amidophosphoribosyltransferase (purF) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG orthology group: K00764, amidophosphoribosyltransferase [EC: 2.4.2.14] (inferred from 100% identity to xca:xccb100_3399)MetaCyc: 62% identical to amidophosphoribosyltransferase (Escherichia coli K-12 substr. MG1655)
Amidophosphoribosyltransferase. [EC: 2.4.2.14]
Predicted SEED Role
"Amidophosphoribosyltransferase (EC 2.4.2.14)" in subsystem De Novo Purine Biosynthesis (EC 2.4.2.14)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
- superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.4.2.14
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0H2XA22 at UniProt or InterPro
Protein Sequence (488 amino acids)
>Xcc-8004.4073.1 Amidophosphoribosyltransferase (EC 2.4.2.14) (Xanthomonas campestris pv. campestris strain 8004) MCGIVGIVGNQNVAGQLYDGLTVLQHRGQDAAGIATADGTRLRVQKANGLVRDVFDEKKM AVLEGRVGIAHCRYPTAGSEGMDEAQPFYVNSPYGIALAHNGNLINTEALRQQVFEADRR NINTDSDSEVLLNVFAYELDAQRMLTPEAAIRAVAGVHRRCKGGYAVVSVVLGLGLVAFR DPHGIRPLVLGKREHAEGTEYIVSSESAALDILGYQRVRDVRPGEALVITARGELFSEIC AAPTDHAPCIFEYVYFARPDSMIDNISVHKARMRMGLKLGEKILRLRPDHDIDTIIPIPD TSRDVALEMSNVLGVKYREGFVKNRYVGRTFIMPGQGERQKSVRRKLNPIHLEFRNRVVL LVDDSIVRGTTSRQIVQMARDAGARKVYLASAAPPVRYPNIYGIDMPAAEELIAHGRSEQ EIQEFLGCDWLIYQDLEDLEVAVREGNPDIKQFDSSCFNGEYITGIEPGYFERIQQLRSD DAKKRRRA