Protein Info for Xcc-8004.2214.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 47% identical to GABD_SYNY3: Probable succinate-semialdehyde dehydrogenase [NADP(+)] (gabD) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 100% identity to xcb:XC_1780)

MetaCyc: 47% identical to NAD-dependent succinate-semialdehyde dehydrogenase (Synechocystis sp. PCC 6803)
Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.24]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

4-aminobutanoate degradation I (1/2 steps found)
4-aminobutanoate degradation III (1/2 steps found)
4-aminobutanoate degradation IV (1/3 steps found)
N-methylpyrrolidone degradation (1/3 steps found)
superpathway of 4-aminobutanoate degradation (1/3 steps found)
GABA shunt I (1/4 steps found)
GABA shunt II (1/4 steps found)
superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)
superpathway of L-arginine and L-ornithine degradation (4/13 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.24

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H2X6L8 at UniProt or InterPro

Protein Sequence (454 amino acids)

>Xcc-8004.2214.1 Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) (Xanthomonas campestris pv. campestris strain 8004)
MSYDTVNPANGQVEHTQHTLDAAAIEARLAASAKAFPEWAALPLAERGALLRRVGEELTK
RREDLQRIMTAEMGKLRREALAEIDKCAQGCAYYAEHAAEYLAPRAIPTEAQSSYVRYEP
LGCVFAVMPWNFPLWQAFRFLAPGLMAGNVALLKHASNVPRCADAMKEVLDAAGIPPGVF
DVLHIDNDQAAEVLRDDRIAAVTLTGSERAGRSLAANAGDQLKKCVMELGGSDAFVVLDD
ADLERTVQSAVQSRFDNSGQTCIAAKRFIVVDAIADQFVERFVAAAAQRVLGDPQQDATT
LAPMARADLRDELHKQVQESVSKGAKVLLGGEPVAGSHAGYPATILDQVGPGMPAYEQEL
FGPVAAVIRVADEAEAVRVANDTTFGLGGSVWTADAKRGERVAQQLQCGAAFVNSVVKSD
VRLPFGGIKRSGFGRELAEHGIHEFMNIKTIYVA