Protein Info for TX73_007700 in Rhodopseudomonas palustris CGA009

Annotation: multidrug efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1055 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 394 to 413 (20 residues), see Phobius details amino acids 437 to 459 (23 residues), see Phobius details amino acids 471 to 496 (26 residues), see Phobius details amino acids 540 to 559 (20 residues), see Phobius details amino acids 868 to 887 (20 residues), see Phobius details amino acids 894 to 914 (21 residues), see Phobius details amino acids 920 to 944 (25 residues), see Phobius details amino acids 965 to 989 (25 residues), see Phobius details amino acids 1001 to 1023 (23 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1023 (1023 residues), 1152.2 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1035 (1035 residues), 1412.2 bits, see alignment E=0 PF03176: MMPL" amino acids 335 to 523 (189 residues), 29.6 bits, see alignment E=5.3e-11 amino acids 839 to 1023 (185 residues), 33.5 bits, see alignment E=3.4e-12

Best Hits

Swiss-Prot: 51% identical to ACRB_ECOLI: Multidrug efflux pump subunit AcrB (acrB) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 83% identity to bja:blr1516)

MetaCyc: 51% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1055 amino acids)

>TX73_007700 multidrug efflux RND transporter permease subunit (Rhodopseudomonas palustris CGA009)
MPAFFIDRPIFAWVIALFICLIGAISIPFLPVAQYPIIAPPSISVSTQYPGASPENLYNS
VTRLIEEELNGANGILNFESTSDSLGQVEIIANFEPGTDTEMASVNVQNRIKRIEARLPR
AVLQQGILVEEASSAVLQIITLTSTDGSLDEVGLGDFMIRNVLGEIRRIPGVGRATLYST
ERALRIWIDPAKLIGYNLTADDVTKAIEAQNAQVASGSIGAEPTPKGQKISALVLVKGQL
SSADEFGAVVLRANSDGSTVRLRDVARIEIGGFSYQFNTRLNGKPTAGLSVLMSPTGNAL
ATASAVEAKMKELSRFFPANIKYEIPYNITPVVEASITKVLHTLVEAVVLVFVVMFLFLQ
NIRYTIIPTIVVPVALLGTCASLLMFGYSINMLSMFGMVLAIGILVDDAIVVVENVERIM
AEEGLPPKEATRKAMSQITSAIIGITLVLIAVFLPMAFFPGSVGIIYRQFSVTMVSAIAF
SALMALSLTPALCATLLKPVTKGHAHAERGVFGWFNRTLDSVRERYSGIVRWNLGRTGRL
MLIYAVLVGVLGFAMARMPGGFLPIDDQGFVTVDVQTPSDSSYNRTYDVVKQVEDYLLKR
DGVQNVTFLTGFSFLGQGMNAAQAFVTLKDWGERDANSSAVAIVDDANRKLGSIRDARIS
ALQPPPVDNLGNSSGFSFRLQDRGQKGHAALVQASEQLVAAANASPVLQKVYVEGLPPAP
VLNLMIDREKAGAFGVTFEDINTTISTNLGSAYINDFPNRGRMQRVIVQADAEGRMNADD
ILGYTVKNSRGQLVPFSSFATVEWAKGPTQIVGFNYYPAIRISGEARPGFTSGDAIAEME
RLADQLPRGFGYDWTGQSLQEKLSGSQAPIILALSALVVFLVLAALYESWTIPLSVLLTV
PLGIAGAVIAATMRSLPNDVYFTVGLITIIGLAAKDAILIVEFAKDLRKEGKSLREATME
ACHLRFRPILMTGLAFCSGVLPMVIASGAGGKSQQALGTGVMGGMIAVVVLALLFVPVFF
VAVQRLFGRDRSDDPVGETLTHQVPLHPQLPHDPA