Protein Info for TX73_004625 in Rhodopseudomonas palustris CGA009
Annotation: 4-hydroxy-tetrahydrodipicolinate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 44% identical to DAPA2_CLOAB: 4-hydroxy-tetrahydrodipicolinate synthase 2 (dapA2) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 100% identity to rpa:RPA0898)Predicted SEED Role
"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)
MetaCyc Pathways
- aspartate superpathway (24/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
- L-lysine biosynthesis I (9/9 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- L-lysine biosynthesis III (6/7 steps found)
- L-lysine biosynthesis VI (6/7 steps found)
- L-lysine biosynthesis II (7/9 steps found)
- dipicolinate biosynthesis (3/4 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.52, 4.3.3.7
Use Curated BLAST to search for 4.2.1.52 or 4.3.3.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (305 amino acids)
>TX73_004625 4-hydroxy-tetrahydrodipicolinate synthase (Rhodopseudomonas palustris CGA009) METSLDATAEQPRGLWLPLITPFRDGELDAASLRRLIAHYARAPLDGLILGATTGEGLTL DEAELERLVMLTADALAASDRKLPVYLGLSGSDTRKLVKTLARTAHWPIDGVLIACPYYT RPSQRGLVLHFEAAADATARPILIYNIPYRTGVNLQNEAMLRLAERANIVGVKDCCADPA QTAELLRLRPPGFAVLTGEDALAFDALSRGCDGAILASAHLETEAFAAMMHRLQAGDRLG GATEWQRLADLPKLLFAEPSPAPVKYALWRRGLIDSPEVRLPMTPVSPTLAAAIDARMLP GLSAA