Protein Info for Synpcc7942_2271 in Synechococcus elongatus PCC 7942

Annotation: ADP-ribose pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 36% identical to ACT_BACMT: Methanol dehydrogenase activator (act) from Bacillus methanolicus

KEGG orthology group: K01515, ADP-ribose pyrophosphatase [EC: 3.6.1.13] (inferred from 100% identity to syc:syc1828_d)

Predicted SEED Role

"ADP-ribose pyrophosphatase (EC 3.6.1.13)" in subsystem NAD and NADP cofactor biosynthesis global or Nudix proteins (nucleoside triphosphate hydrolases) (EC 3.6.1.13)

KEGG Metabolic Maps

Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.13

Use Curated BLAST to search for 3.6.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31KW8 at UniProt or InterPro

Protein Sequence (183 amino acids)

>Synpcc7942_2271 ADP-ribose pyrophosphatase (Synechococcus elongatus PCC 7942)
MDRTPPEILRQTLSYRSRKFDFEVNQLRLPNQVEGEWACIRHPGGALAVPVLPDGRLVLV
RQYRFAAEGWLLEFPAGTVEDHEDPAATIAREIEEETGYRAGTWQHLGDFFLAPGYSDEV
IYAYLATDLEKLEHPPAGDEDEDIEVLALTPEELIAAIRDGEPVDAKTVTAFWLYQQLNS
AEL