Protein Info for Synpcc7942_2265 in Synechococcus elongatus PCC 7942

Name: proA
Annotation: glutamate-5-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to PROA_SYNP6: Gamma-glutamyl phosphate reductase (proA) from Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 100% identity to syc:syc1833_c)

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
L-ornithine biosynthesis II (2/3 steps found)
L-citrulline biosynthesis (5/8 steps found)
superpathway of L-citrulline metabolism (7/12 steps found)
L-N^δ-acetylornithine biosynthesis (3/7 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.41

Use Curated BLAST to search for 1.2.1.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31KX4 at UniProt or InterPro

Protein Sequence (431 amino acids)

>Synpcc7942_2265 glutamate-5-semialdehyde dehydrogenase (Synechococcus elongatus PCC 7942)
VATLSVDLEVQAQATRAAARQLAQWSGADRQRLLSAIATTLEQEAPRILAANQADCEAAT
TEGIAPALYARLKLDADKLAAAIAGVRDLAQLPDPLGQIQIDRELDEGLILQRLTCPVGV
LGVIFEARPDAVIQIASLAIKSGNGAILKGGREAICSCQAIVAAIAQALAEQQAPVEAIR
LLTSREETLALLKLDRYVDLIIPRGSNSFVRFVQDNTHIPVLGHADGICHLYVDQAAAIE
KTVTITVDAKTQYPAACNAIETLLIHEAIAPQFLPVVAAALHEKGVSLRGDAAAQTIVPM
EAATEEDWRTEYSDLVLAVRLVPSLDAAIAHINEYGSGHTDAIATEDAAAAAQFFSQVDS
AGVYHNCSTRFADGFRYGFGAEVGISTQKLPPRGPVGLEGLVTYKYVLSGDGQIAATYSG
AQAKPFLHRDR