Protein Info for Synpcc7942_1359 in Synechococcus elongatus PCC 7942

Annotation: coenzyme F420 hydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 77% identical to Y1601_NOSS1: Uncharacterized protein all1601 (all1601) from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

KEGG orthology group: K00441, coenzyme F420 hydrogenase beta subunit [EC: 1.12.98.1] (inferred from 100% identity to syc:syc0195_d)

MetaCyc: 76% identical to divinyl chlorophyllide a 8-vinyl-reductase (Synechocystis sp. PCC 6803)
RXN-17486 [EC: 1.3.7.13]; 1.3.7.13 [EC: 1.3.7.13]; 1.3.7.13 [EC: 1.3.7.13]; 1.3.7.13 [EC: 1.3.7.13]

Predicted SEED Role

"Coenzyme F420-reducing hydrogenase related protein"

MetaCyc Pathways

chlorophyll a biosynthesis III (2/2 steps found)
coenzyme B/coenzyme M regeneration I (methanophenazine-dependent) (1/4 steps found)
bacteriochlorophyll a biosynthesis (2/13 steps found)
superpathway of bacteriochlorophyll a biosynthesis (11/26 steps found)
bacteriochlorophyll d biosynthesis (2/14 steps found)
bacteriochlorophyll c biosynthesis (2/18 steps found)
bacteriochlorophyll e biosynthesis (6/30 steps found)

KEGG Metabolic Maps

Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.12.98.1 or 1.3.7.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31NI0 at UniProt or InterPro

Protein Sequence (401 amino acids)

>Synpcc7942_1359 coenzyme F420 hydrogenase (Synechococcus elongatus PCC 7942)
MTAALPHRRARALKPGSRRPAKDLCSECGLCDTSYVHYVKEACAFLNQQFEPLEQQVHGR
SRDLENPDELYFGVHQSMTAAQKREPIEGAQWTGIVSALACRMLEQGWVEGVVCVQNSPS
DRFQPMPVIARTTDEILAARVNKPTLSPNLNILDLIEQSGLKRLLVIGVGCQIQALRAVQ
DKLGLDKLYVLGTPCVDNVSRAGLQKFLETTSRSPETVVHYEFMQDFRIHFKHEDGSIEM
VPFFGLKTKELKDVFAPSCLSCFDYTNGLADLVVGYMGAPFGWQWLVVRNEIGQEMFDLI
QDDLRLQPVQSSGDRRAAVQNSIPAYEQGVQLPMWAAKLMGLVIERIGPKGLEYARFSID
SHFTRNALYVRRNYPEKAETHIPEFAKRIVSQYQLPPIEEK