Protein Info for Synpcc7942_0454 in Synechococcus elongatus PCC 7942

Name: cobS
Annotation: cobalamin synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00317: cobalamin 5'-phosphate synthase
  • amino acids 8 to 242 (235 residues), 168.9 bits, E=8.3e-54
• PF02654: CobS
  • amino acids 12 to 243 (232 residues), 179.7 bits, E=4.2e-57

Best Hits

Swiss-Prot: 100% identical to COBS_SYNP6: Adenosylcobinamide-GDP ribazoletransferase (cobS) from Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)

KEGG orthology group: K02233, adenosylcobinamide-GDP ribazoletransferase [EC: 2.7.8.26] (inferred from 100% identity to syc:syc1064_d)

Predicted SEED Role

"Cobalamin synthase (EC 2.7.8.26)" (EC 2.7.8.26)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (29/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (31/36 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide I (8/8 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide II (8/9 steps found)
• 2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
• 5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
• 5-methoxy-6-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
• 5-methoxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
• 5-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
• adeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
• adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I (3/3 steps found)
• benzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
• 4-methylphenyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (2/3 steps found)
• phenyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (2/3 steps found)
• adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II (2/4 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.26

Sequence Analysis Tools

See Q8GMS2 at UniProt or InterPro

Protein Sequence (251 amino acids)

>Synpcc7942_0454 cobalamin synthase (Synechococcus elongatus PCC 7942)
MIRQLWTELNAAILFYTVLPLPQRWPTQFAGMSRWAPIVGLILGLILAVSDRLLAVGQFP
LPLRSLLIVLLAIALTGGLHLDGAMDTADGLAVPNPDRRLEVMSDSHTGAFGAIAAIAII
SLKTIALCYLPAPRSLLILLIPVWGRWAQVLAIVRYPYLKAEGKGAIHKQTGRGAIDLLP
GAIALVLGIGAIARFHSLTVALQLLAIGLLWAWATGAWLQKKLGGQTGDTYGAIVEWTEA
LIWVSFTIGQV