Protein Info for Synpcc7942_0297 in Synechococcus elongatus PCC 7942

Name: ftsH
Annotation: FtsH peptidase homologue, chloroplast. Metallo peptidase. MEROPS family M41

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 613 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 104 to 126 (23 residues), see Phobius details PF06480: FtsH_ext" amino acids 10 to 99 (90 residues), 39.2 bits, see alignment E=2.1e-13 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 105 to 602 (498 residues), 786.2 bits, see alignment E=6.5e-241 PF07728: AAA_5" amino acids 193 to 313 (121 residues), 25.1 bits, see alignment E=4.8e-09 PF00004: AAA" amino acids 194 to 326 (133 residues), 160 bits, see alignment E=1.3e-50 PF17862: AAA_lid_3" amino acids 349 to 391 (43 residues), 57.6 bits, see alignment 2.1e-19 PF01434: Peptidase_M41" amino acids 407 to 601 (195 residues), 250.7 bits, see alignment E=3e-78

Best Hits

Swiss-Prot: 83% identical to FTSH3_SYNY3: ATP-dependent zinc metalloprotease FtsH 3 (ftsH3) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 100% identity to syc:syc1215_c)

MetaCyc: 55% identical to ATP-dependent zinc metalloprotease FtsH (Escherichia coli K-12 substr. MG1655)
3.4.24.-

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31RJ0 at UniProt or InterPro

Protein Sequence (613 amino acids)

>Synpcc7942_0297 FtsH peptidase homologue, chloroplast. Metallo peptidase. MEROPS family M41 (Synechococcus elongatus PCC 7942)
VKKRWKNAGLYALLAIVVIALGTALLDQRGTETVATWRYSEFVQRVENKQVAKVILSPDR
SSALVQAEDGDKVQVNLPNDPQLLKILTDNNVDISVRPQNQDSVWLRALSSLFFPILLLV
GLFFILRRAQGGPGNQAMNFGKSKARVQMEPQTQVTFNDVAGIDQAKLELTEVVDFLKNA
DRFTAVGAQIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSEFVEMFVGVGASRVR
DLFEQAKASAPCIVFIDEIDAVGRQRGAGLGGGNDEREQTLNQLLTEMDGFEGNSGIIIV
AATNRPDVLDAALMRPGRFDRQVVVDRPDYNGRLEILRVHARGKSLSKDIDLDKIARRTP
GFTGADLSNLLNEAAILAARRSLAEISMDEVNDAIDRVLAGPEKKDRVMSEKRKVLVAYH
EAGHALVGALMPDYDPVQKISIIPRGRAGGLTWFTPSEERMESGLYSRTYLQNQMAVALG
GRLAEEIVFGEEEVTTGASNDLQQVARVARQMVTRFGMSDRLGPVALGRQQGNMFLGRDI
AAERDFSEETAATIDDEVRQLVDVAYDRAKKVLIENRSILDQLAKMLVEKETVDAEELQD
LLNNNEVRMAAIA