Protein Info for SMc04309 in Sinorhizobium meliloti 1021

Annotation: cobyric acid synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 484 PF13500: AAA_26" amino acids 3 to 229 (227 residues), 58.2 bits, see alignment E=1.6e-19 TIGR00313: cobyric acid synthase CobQ" amino acids 5 to 475 (471 residues), 443.5 bits, see alignment E=4.8e-137 PF01656: CbiA" amino acids 5 to 237 (233 residues), 77.3 bits, see alignment E=1.5e-25 PF07685: GATase_3" amino acids 253 to 437 (185 residues), 186.7 bits, see alignment E=5.8e-59

Best Hits

Swiss-Prot: 100% identical to COBQ_RHIME: Cobyric acid synthase (cobQ) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to smk:Sinme_1935)

MetaCyc: 86% identical to CobQ (Pseudomonas denitrificans (nom. rej.))
Adenosylcobyric acid synthase (glutamine-hydrolyzing). [EC: 6.3.5.10]

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92P31 at UniProt or InterPro

Protein Sequence (484 amino acids)

>SMc04309 cobyric acid synthase (Sinorhizobium meliloti 1021)
MTRKIMLQGTGSDVGKSVLVAGLCRLASNHGLSVKPFKPQNMSNNAAVADDGGEIGRAQW
LQALAARVPSSVHMNPVLLKPQTDVGSQVVVQGRVAGQAKGKEYQALKPSLLGSVMESFE
QVSAGADLVIVEGAGSPAEINLRAGDIANMGFATRADVPVVLVGDIDRGGVIASLVGTHA
ILPGDDRRMVTGYLINKFRGDVTLFDDGIASVRQFTGWPCFGVVPWLKSAGRLPAEDSVV
LERLTRGGGKALKVAVPVLSRIANFDDLDPLAAEPDVDIVFVRPGTPLPDDAGLIVIPGS
KSTIADLDDFRRQGWDRDLDRHMRRGGRVVGICGGYQMLGSRVADPLGIEGGKREIEGLG
LLSVETEMAPEKTVRNSRAWSREYDVALEGYEIHLGKTTGADCSRAPVEIDGRPDGAMSA
DGRVMGTYLHGLFGSDAYRSALLKSFGIEGGGGNYRRSVDAALDEIALELETVLDRAWLG
TLLG