Protein Info for SMc04122 in Sinorhizobium meliloti 1021

Annotation: thymidine phosphorylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02643: thymidine phosphorylase
  • amino acids 3 to 436 (434 residues), 763.4 bits, E=7e-234
• TIGR02644: pyrimidine-nucleoside phosphorylase
  • amino acids 6 to 422 (417 residues), 564.1 bits, E=1.7e-173
• PF02885: Glycos_trans_3N
  • amino acids 6 to 68 (63 residues), 68.6 bits, E=4.8e-23
• PF00591: Glycos_transf_3
  • amino acids 79 to 308 (230 residues), 170.1 bits, E=1.1e-53
• PF07831: PYNP_C
  • amino acids 349 to 422 (74 residues), 79 bits, E=2.5e-26

Best Hits

Swiss-Prot: 100% identical to TYPH_RHIME: Thymidine phosphorylase (deoA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: None (inferred from 100% identity to smk:Sinme_3461)

MetaCyc: 54% identical to thymidine phosphorylase (Escherichia coli K-12 substr. MG1655)
Pyrimidine-nucleoside phosphorylase. [EC: 2.4.2.2, 2.4.2.3]; Thymidine phosphorylase. [EC: 2.4.2.2, 2.4.2.3, 2.4.2.4]

Predicted SEED Role

"Thymidine phosphorylase (EC 2.4.2.4)" in subsystem Deoxyribose and Deoxynucleoside Catabolism (EC 2.4.2.4)

MetaCyc Pathways

• superpathway of pyrimidine ribonucleosides degradation (5/5 steps found)
• pyrimidine deoxyribonucleosides degradation (3/3 steps found)
• superpathway of pyrimidine deoxyribonucleosides degradation (5/6 steps found)
• pyrimidine ribonucleosides degradation (2/2 steps found)
• nucleoside and nucleotide degradation (archaea) (4/10 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.2 or 2.4.2.3 or 2.4.2.4

Sequence Analysis Tools

See Q92T50 at UniProt or InterPro

Protein Sequence (440 amino acids)

>SMc04122 thymidine phosphorylase (Sinorhizobium meliloti 1021)
MAMLPQEIIRKKRDGDRLDPAEIAGFIAGVTDGSVSEGQAAAFAMAVWFSGMNRDECVAL
TLAMRDSGETLDWSDLARPIVDKHSTGGVGDNVSLMLAPIVAACGAAVPMISGRGLGHTG
GTLDKLESIPGYDIQPSPELFRRVADEVGCAIIGQTADLAPADKRLYAIRDVTATVDSVP
LITASILSKKLAAGLRSLVLDVKLGNGSFMTDPAETEVLARSLVEVANGAGVRTSALITD
MNEPLADAAGNALEIENCLAYLRGEKAGTRLDQVVMALAAEMLVAAGIAAHEAEAEAMAR
RVLGSGEAMERFGLMVHRLGGPADFVDRPGAYLAKAPAILAVPAGRHGYLTSCKTRELGM
AVIELGGGRIRPDDRIDHRVGLTGLRPLGTKVEKGEPIAFVHAADQSQAEAIAKRVVTLY
AIADEEPARRPVIVSKLRAG