Protein Info for SMc03181 in Sinorhizobium meliloti 1021

Annotation: monovalent cation/H+ antiporter subunit D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 539 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 36 to 57 (22 residues), see Phobius details amino acids 77 to 102 (26 residues), see Phobius details amino acids 117 to 134 (18 residues), see Phobius details amino acids 137 to 156 (20 residues), see Phobius details amino acids 168 to 192 (25 residues), see Phobius details amino acids 214 to 240 (27 residues), see Phobius details amino acids 242 to 277 (36 residues), see Phobius details amino acids 287 to 305 (19 residues), see Phobius details amino acids 312 to 330 (19 residues), see Phobius details amino acids 336 to 357 (22 residues), see Phobius details amino acids 395 to 437 (43 residues), see Phobius details amino acids 439 to 440 (2 residues), see Phobius details amino acids 448 to 468 (21 residues), see Phobius details amino acids 484 to 504 (21 residues), see Phobius details TIGR00944: multicomponent K+:H+antiporter" amino acids 7 to 507 (501 residues), 718.1 bits, see alignment E=3.1e-220 PF00361: Proton_antipo_M" amino acids 135 to 442 (308 residues), 118.1 bits, see alignment E=2.3e-38

Best Hits

Swiss-Prot: 100% identical to PHAD_RHIME: Probable K(+)/H(+) antiporter subunit D (phaD) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K05561, multicomponent K+:H+ antiporter subunit D (inferred from 100% identity to smk:Sinme_2966)

Predicted SEED Role

"Na(+) H(+) antiporter subunit D" in subsystem Sodium Hydrogen Antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q52981 at UniProt or InterPro

Protein Sequence (539 amino acids)

>SMc03181 monovalent cation/H+ antiporter subunit D (Sinorhizobium meliloti 1021)
MTDWLDHLLILPILLPLAVAAVLIPINERDRTLKGAIGFASTLVVFILSMILMRLAAAGT
GSLPGSGVYQLGNWPAPFGIVLVLDRLSALMLCLTSGLALAAQAYSMARWHTAGHHFHSL
FQLLVAGLNGAFLTGDLFNLFVFFEMMLAASYGLLLHGSGPLRVKAGLHYIAVNLAASAL
FLIGVSLIYGAAGTLNMADLATKLAALEPRSRTLVEMGSAILGVAFLVKAGMWPLSFWLP
TAYAAATPPVAGVFAVLTKVGIYVIIRLHLLVFGTAAGASSGFGQEWLVTGGMLTIAFGG
IGVLASQAMGRLAGYSVLVSSGTLLAAVGLGHDGMLAGALFYLVSSTLTIGAFFLLIELV
ERGRDAGADVLAVTMEAYGDFDEDEEEEEVGAAIPGTMAVLGLCFCLCALLLAGLPPLSG
FIAKFALISGLFDMPAAELATAMSAADWTYVTLLILSGLAAMIAMNRIGIRTFWASIEGT
IPRVVVIEITPVVVLLGACIFLSLQAGPAMRYMQATADDLLAPLTHSERVLSAPRAGSQ